WO2007113702A3 - Enzymatic detection techniques - Google Patents

Enzymatic detection techniques Download PDF

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Publication number
WO2007113702A3
WO2007113702A3 PCT/IB2007/050880 IB2007050880W WO2007113702A3 WO 2007113702 A3 WO2007113702 A3 WO 2007113702A3 IB 2007050880 W IB2007050880 W IB 2007050880W WO 2007113702 A3 WO2007113702 A3 WO 2007113702A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme
substrate
reporter
joined
product
Prior art date
Application number
PCT/IB2007/050880
Other languages
French (fr)
Other versions
WO2007113702A2 (en
Inventor
Xuedong Song
Original Assignee
Kimberly Clark Co
Xuedong Song
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co, Xuedong Song filed Critical Kimberly Clark Co
Priority to CN2007800123137A priority Critical patent/CN101416057B/en
Priority to EP07735119.5A priority patent/EP2005180B1/en
Priority to MX2008012849A priority patent/MX2008012849A/en
Priority to KR1020087024205A priority patent/KR101376363B1/en
Priority to JP2009503696A priority patent/JP5420394B2/en
Publication of WO2007113702A2 publication Critical patent/WO2007113702A2/en
Publication of WO2007113702A3 publication Critical patent/WO2007113702A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody

Abstract

A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes substrate conjugates to facilitate the detection of the enzyme or enzyme inhibitor via direct detection of the substrate and/or a product formed in an enzyme-catalyzed reaction of the substrate. The substrate conjugates include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle). In this embodiment, the substrate provides a cleavage target for an enzyme. Specifically, upon contacting the substrate conjugate, the enzyme catalyzes a reaction with the substrate and forms a product conjugate that includes the product of the enzyme catalyzed reaction joined to the reporter. The signal exhibited by the reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.
PCT/IB2007/050880 2006-04-06 2007-03-14 Enzymatic detection techniques WO2007113702A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2007800123137A CN101416057B (en) 2006-04-06 2007-03-14 Enzymatic detection techniques
EP07735119.5A EP2005180B1 (en) 2006-04-06 2007-03-14 Enzymatic detection techniques
MX2008012849A MX2008012849A (en) 2006-04-06 2007-03-14 Enzymatic detection techniques.
KR1020087024205A KR101376363B1 (en) 2006-04-06 2007-03-14 Enzymatic detection techniques
JP2009503696A JP5420394B2 (en) 2006-04-06 2007-03-14 Enzyme detection technology

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/399,687 US8758989B2 (en) 2006-04-06 2006-04-06 Enzymatic detection techniques
US11/399,687 2006-04-06

Publications (2)

Publication Number Publication Date
WO2007113702A2 WO2007113702A2 (en) 2007-10-11
WO2007113702A3 true WO2007113702A3 (en) 2008-03-13

Family

ID=38564045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/050880 WO2007113702A2 (en) 2006-04-06 2007-03-14 Enzymatic detection techniques

Country Status (7)

Country Link
US (1) US8758989B2 (en)
EP (1) EP2005180B1 (en)
JP (1) JP5420394B2 (en)
KR (1) KR101376363B1 (en)
CN (1) CN101416057B (en)
MX (1) MX2008012849A (en)
WO (1) WO2007113702A2 (en)

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US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US20130058923A1 (en) * 2011-08-03 2013-03-07 Qun Huo Biomolecular interactions and interaction products as biomarkers for detection, diagnosis, prognosis and predicting therapeutic responses of human diseases
GB201206977D0 (en) * 2012-04-20 2012-06-06 Mologic Ltd An enzyme detection device
US10254279B2 (en) * 2013-03-29 2019-04-09 Nima Labs, Inc. System and method for detection of target substances
JP6444377B2 (en) * 2014-03-31 2019-01-09 国立大学法人愛媛大学 Functional material, method for producing functional material, and functional liquid
CN106442969B (en) * 2016-08-23 2018-08-31 中国人民解放军军事医学科学院微生物流行病研究所 A kind of kit for detecting botulinum toxin
KR200497491Y1 (en) 2021-03-29 2023-11-29 신정식 A fishing support adjustable in height

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Also Published As

Publication number Publication date
MX2008012849A (en) 2008-10-13
EP2005180A2 (en) 2008-12-24
EP2005180B1 (en) 2014-08-13
JP2009532058A (en) 2009-09-10
US8758989B2 (en) 2014-06-24
US20070238102A1 (en) 2007-10-11
CN101416057B (en) 2013-06-05
KR20090008204A (en) 2009-01-21
WO2007113702A2 (en) 2007-10-11
KR101376363B1 (en) 2014-03-27
JP5420394B2 (en) 2014-02-19
CN101416057A (en) 2009-04-22

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