WO2007104636A1 - An injection device and a method of changing a cartridge in the device - Google Patents

An injection device and a method of changing a cartridge in the device Download PDF

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Publication number
WO2007104636A1
WO2007104636A1 PCT/EP2007/051757 EP2007051757W WO2007104636A1 WO 2007104636 A1 WO2007104636 A1 WO 2007104636A1 EP 2007051757 W EP2007051757 W EP 2007051757W WO 2007104636 A1 WO2007104636 A1 WO 2007104636A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
dose
rod
injection device
dose setting
Prior art date
Application number
PCT/EP2007/051757
Other languages
French (fr)
Inventor
Claus MØLLER
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36383690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007104636(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Priority to CN2007800084113A priority Critical patent/CN101400393B/en
Priority to US12/282,442 priority patent/US8298194B2/en
Priority to EP07712304A priority patent/EP1996259B1/en
Priority to JP2008558759A priority patent/JP5062768B2/en
Publication of WO2007104636A1 publication Critical patent/WO2007104636A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2411—Ampoule inserted into the ampoule holder from the front
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button

Definitions

  • the dose rod and a dose setting member In order to ensure proper operation of the injection device during setting of a desired dose, the dose rod and a dose setting member must be rotationally locked when the cartridge is positioned correctly. This is usually obtained by letting the dose rod and the dose setting member engage, e.g. by means of mating sets of teeth positioned on the dose rod and the dose setting member, respectively. This may cause stress to be introduced in the piston rod, and this tension may have the consequence that liquid drug will be expelled from the injection device when a needle is subsequently attached to the new cartridge.
  • the above and other objects are fulfilled by providing a method of changing a cartridge in an injection device, the injection device comprising a dose setting mechanism operable to set a desired dose, the dose setting mechanism comprising a dose setting member and a dose rod, the dose setting member being adapted to be in a first position in which the dose setting member and the dose rod engage, and a second position in which the dose setting member and the dose rod do not engage, the injection device further comprising a cartridge holder being operatively connected to the dose rod, the method comprising the steps of:
  • Fig. 1 is a perspective view of an injection device 1 according to an embodiment of the invention.
  • the injection device 1 comprises a housing 2 with a display 3 mounted thereon.
  • the display 3 may show the amount of drug left in a cartridge, a set dose, etc.
  • the injection device 1 further comprises a dose setting member 4 being rotationally operable to set a desired dose, and an injection button 5 being operable to cause a set dose to be expelled from the injection device 1.
  • the injection device 1 comprises a cartridge holder 6 for releasably holding a cartridge 7.
  • the cartridge holder 6 may be released by means of release buttons 8.
  • the injection device 1 is in a position in which it is ready for setting a dose, i.e. a cartridge 7 is positioned in the cartridge holder 6, and the cartridge holder 6 has not been released.

Abstract

A refillable injection device (1) having a dose setting mechanism with a dose setting member (4) and a dose rod (11) . The dose setting member and the dose rod engage during normal operation of the injection device, and they do not engage during change of cartridge . The dose setting member and the dose rod need to be moved into engagement when a new cartridge is inserted in the injection device. Thereby there is a risk that stress is build-up in the piston rod. In order to prevent this, the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an axial direction, at least while the dose setting member and the dose rod are moved into engagement .

Description

AN INJECTION DEVICE AND A METHOD OF CHANGING A CARTRIDGE IN THE DEVICE
FIELD OF THE INVENTION
The present invention relates to an injection device in which it is possible to exchange an empty cartridge with a new cartridge containing a liquid drug to be injected into a person. Such an injection device is also known as a refillable injection device. More particularly, the present invention relates to an injection device with a dose setting mechanism comprising a dose rod. The injection device of the present invention is particularly suitable for repetitive self-injection, e.g. of insulin or growth hormone. The injection device may preferably be in the form of a so-called injection pen. The present invention further relates to a method of changing a cartridge in such an injection device.
BACKGROUND OF THE INVENTION
When changing the cartridge of a refillable injection device it is desirable to let the piston of the new cartridge push the piston rod of the injection device back into the injection device. Thereby it is ensured that the piston rod contacts the piston when the cartridge is positioned correctly, and the injection device is therefore ready for use. Thereby the need for very large air shots before taking the injection device into use is avoided.
However, in prior art refillable injection devices having a dose rod, the piston rod is pushed, pulled or rotated back manually, thereby introducing the problem that it can not be ensured that the piston rod contacts the piston, and very large air shots are therefore necessary in order to ensure correct use of the injection device.
In order to ensure proper operation of the injection device during setting of a desired dose, the dose rod and a dose setting member must be rotationally locked when the cartridge is positioned correctly. This is usually obtained by letting the dose rod and the dose setting member engage, e.g. by means of mating sets of teeth positioned on the dose rod and the dose setting member, respectively. This may cause stress to be introduced in the piston rod, and this tension may have the consequence that liquid drug will be expelled from the injection device when a needle is subsequently attached to the new cartridge.
In WO 02/092153 an attempt to solve the above mentioned problem is disclosed. Thus, WO 02/092153 discloses a medication injector apparatus, such as an injection pen. The injection pen includes a resettable cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. Thereby drooling of the pen is limited.
The injection device of WO 02/092153 is not of the kind having a dose setting mechanism comprising a dose rod, and the mechanism disclosed therein is not suitable for use in such an injection device.
SUMMARY OF THE INVENTION
It is, thus, an object of the invention to provide an injection device of the kind having a dose setting mechanism comprising a dose rod, and in which the above mentioned problems of introducing stress in the piston rod are avoided, or at least minimised.
According to a first aspect of the invention, the above and other objects are fulfilled by providing an injection device comprising:
- a dose setting mechanism operable to set a desired dose, the dose setting mechanism comprising a dose setting member and a dose rod, the dose setting mechanism being adapted to be in a first position in which the dose setting member and the dose rod engage, and a second position in which the dose setting member and the dose rod do not engage, the dose setting mechanism being in the first position during normal operation of the injection device, and in the second position during cartridge change,
- a piston rod adapted to cooperate with a piston in a cartridge in order to expel a dose of liquid from the cartridge,
- an injection mechanism operable to cause the piston rod and the piston to expel a previously set dose of liquid from the cartridge, and
- a cartridge holder for releasably holding a cartridge, wherein the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an at least substantially axial direction, at least while the dose setting mechanism is moved from the second position to the first position.
The injection device is preferably of the kind having an elongated shape, i.e. a so-called injection pen.
The dose setting mechanism comprises a dose setting member and a dose rod. The dose setting member is a part of the dose setting mechanism which is actually operated by the user during setting of a desired dose, e.g. by dialling the dose setting member or pulling it in a direction away from a housing enclosing the injection device. The dose setting member may, thus, be or comprise a dose knob, such as a rotatable dose knob. The dose setting member is preferably positioned at or near a proximal end of the injection device, i.e. opposite the end where an injection needle would normally be positioned.
The dose rod is an elongated part extending along a longitudinal direction of the injection device. When the dose setting member is operated to set a desired dose, the dose rod is caused to move along with the dose setting member, preferably in a rotational movement. The dose rod thereby causes the injection mechanism to be moved to a position where it is ready for causing injection of the set dose. This may, e.g., be done by moving an injection button in a proximal direction, as will be further explained below. The dose rod preferably extends from the dose setting member to a position at or near a proximal end of the cartridge holder.
During normal operation of the injection device, the dose setting mechanism is adapted to be in a first position in which the dose setting member and the dose rod engage. Thereby it is ensured that when a user operates the dose setting member, the desired dose is actually set. When the cartridge is being changed, on the other hand, the dose setting mechanism is in a second position in which the dose setting member and the dose rod do not engage. Thus, during cartridge change the dose setting member and the dose rod are allowed to move independently, preferably in a rotational manner. Accordingly, when a new cartridge is being inserted, the dose setting mechanism will need to be moved from the second position to the first position during this operation, i.e. the dose setting member and the dose rod need to be moved into engagement. As mentioned above, the dose rod will be prevented from performing a rotational movement relatively to the dose setting member during this operation. This will be described further below. The injection mechanism preferably comprises an injection button which is moved in a proximal direction during setting of a desired dose. When the set dose is subsequently injected, the user pushes the injection button in a distal direction, i.e. in a direction opposite the direction in which it was moved during setting of the dose. The injection button is, in this case, connected to the piston in such a manner that moving the injection button in the distal direction causes the piston rod to also be moved in the distal direction, possibly with a suitable gearing. Since the piston rod cooperates with the piston of the cartridge, preferably by abutting the piston, the piston is moved a corresponding distance, and the set dose is thereby expelled from the cartridge.
The cartridge holder is releasably holding a cartridge. This should be interpreted to mean that it is possible to remove the cartridge from the cartridge holder, e.g. when the cartridge is empty, and replace it by another cartridge. Thus, the injection device is of the refillable kind. However, during normal operation of the injection device, the cartridge holder should be positioned in such a manner that it is not possible to remove the cartridge. Furthermore, the cartridge holder is preferably movable relatively to the remaining parts of the injection device during change of cartridge. In this embodiment the cartridge holder, holding the cartridge, is at least partly removed from the injection device, the cartridge is replaced by a new cartridge, and the cartridge holder, holding the new cartridge, is inserted into the injection device.
The cartridge holder is operatively connected to the dose rod. This has the consequence that when a new cartridge is being inserted in the injection device by means of the cartridge holder, the dose rod is caused to move along with the piston rod in an at least substantially axial direction while the dose rod and the dose setting member are moved into engagement. As mentioned above, the piston rod is pushed in a proximal direction by the piston of the new cartridge during insertion of the cartridge. By causing the dose rod to move along with the piston rod while the dose rod and the dose setting member are moved into engagement, and the dose rod is therefore prevented from rotating relatively to the dose setting member, the piston rod is allowed to continue its axial movement. Thereby a build-up of stress in the piston rod is prevented, and when an injection needle is subsequently inserted in the cartridge, no drug will be expelled due to such a stress. This is very advantageous.
This may advantageously be obtained in the following manner. When the new cartridge is being inserted in the injection device, the piston of the cartridge pushes the piston rod back. During this movement a nut will cause the dose rod to perform a rotational movement. When the cartridge is almost in position, the cartridge holder pushes a carrier which is also connected to the nut. Thereby the nut is also pushed back. Accordingly, the dose rod and the nut will be moved back in an axial direction with the same velocity, and the nut will therefore no longer cause a rotational movement of the dose rod. Thereby the dose rod and the dose setting member may be moved into engagement without the risk of introducing stress in the piston rod.
The first position of the dose setting mechanism may be defined by engagement of a set of teeth positioned on the dose setting member and a mating set of teeth positioned on the dose rod. In this case the dose rod will be prevented from rotating relatively to the dose setting member as soon as the mating teeth start to move into engagement. From this point until the teeth have been moved fully into engagement, the dose rod is moved along with the piston rod as described above.
The cartridge holder may comprise a cartridge holding member comprising a set of jaws adapted to clamp a distal end of a cartridge. In this embodiment the cartridge is held by the cartridge holder by means of the set of jaws. The set of jaws is preferably movable in such a manner, that during normal operation of the injection device they firmly clamp the cartridge, thereby securing it with respect to the remaining parts of the injection device. During cartridge change, on the other hand, the jaws may be moved to a position in which they release the grip on the cartridge, thereby allowing one cartridge to be removed from and another to be positioned in the cartridge holder. The injection device in this case preferably comprises a releasable locking mechanism which locks the jaws in the clamping position during normal operation of the injection device, and which may be operated to release the grip when it is desired to replace the cartridge.
Alternatively, the cartridge holder may comprise a frame member adapted to carry the cartridge, and the cartridge may be moved along with and by means of the frame member during cartridge change. According to this embodiment the cartridge holder is preferably in the form of a 'drawer' in which the cartridge may be positioned. When a cartridge is removed from the injection device the complete frame member is pulled at least partly out of the injection device. The cartridge is removed, a new cartridge is positioned in the frame member, and the complete frame member, holding the new cartridge, is repositioned in the injection device.
The injection device may further comprise a biasing mechanism causing the dose setting mechanism to be in the second position when no cartridge is positioned in the cartridge holder, and when the cartridge holder is open. Thereby the dose setting member and the dose rod will automatically be moved out of engagement when the cartridge is being replaced. The biasing mechanism may advantageously comprise a spring member. According to a second aspect of the invention, the above and other objects are fulfilled by providing a method of changing a cartridge in an injection device, the injection device comprising a dose setting mechanism operable to set a desired dose, the dose setting mechanism comprising a dose setting member and a dose rod, the dose setting member being adapted to be in a first position in which the dose setting member and the dose rod engage, and a second position in which the dose setting member and the dose rod do not engage, the injection device further comprising a cartridge holder being operatively connected to the dose rod, the method comprising the steps of:
moving the cartridge holder holding an empty cartridge in such a manner that the empty cartridge is accessible, and in such a manner that the dose setting mechanism is caused to move from the first position to the second position,
- removing the empty cartridge from the cartridge holder,
- inserting a new cartridge into the cartridge holder,
- moving the cartridge holder holding the new cartridge in such a manner that a piston rod of the injecting device is moved along with a piston of the new cartridge, and
- moving the dose setting mechanism from the second position to the first position while causing the dose rod to move along with the piston rod in an at least substantially axial direction.
It should be noted that a person skilled in the art would readily recognise that any feature which has been described in combination with the first aspect could also be combined with the second aspect, and vice versa.
The method according to the second aspect of the invention is, thus, performed using an injection device according to the first aspect of the invention.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention will now be described in further details with reference to the accompanying drawings in which
Fig. 1 is a perspective view of an injection device according to an embodiment of the invention, the injection device being in a position in which it is ready for operation, Fig. 2 is a perspective view of the injection device of Fig. 1, in which an old cartridge is about to be removed,
Fig. 3 shows selected parts of the injection device of Figs. 1 and 2 in a position where it is ready for normal operation,
Fig. 4 shows selected parts of the injection device of Figs. 1-3 during insertion of a new cartridge,
Fig. 5 shows the injection device of Fig. 4 with an additional part removed, and
Fig. 6 is an exploded view of selected parts of the injection device of Figs. 1-5.
DETAILED DESCRIPTION OF THE DRAWINGS
Fig. 1 is a perspective view of an injection device 1 according to an embodiment of the invention. The injection device 1 comprises a housing 2 with a display 3 mounted thereon. The display 3 may show the amount of drug left in a cartridge, a set dose, etc. The injection device 1 further comprises a dose setting member 4 being rotationally operable to set a desired dose, and an injection button 5 being operable to cause a set dose to be expelled from the injection device 1. Furthermore, the injection device 1 comprises a cartridge holder 6 for releasably holding a cartridge 7. The cartridge holder 6 may be released by means of release buttons 8. In Fig. 1 the injection device 1 is in a position in which it is ready for setting a dose, i.e. a cartridge 7 is positioned in the cartridge holder 6, and the cartridge holder 6 has not been released.
Fig. 2 is a perspective view of the injection device 1 of Fig. 1. In Fig. 2 the cartridge 7 is being exchanged. Thus, the release buttons 8 have been pushed in order to release the cartridge holder 6. Thereby a set of jaws 9 of the cartridge holder 6 has been moved out of the housing 2, and the jaws 9 are no longer gripping the cartridge 7 firmly. Accordingly, the cartridge 7 can be removed from the injection device 1. In Fig. 2 the cartridge 7 has been pulled partly out. A piston rod 10 is visible.
Fig. 3 shows selected parts of the injection device 1 of Figs. 1 and 2. For clarity only the parts which are essential for explaining the change of cartridge are shown, the remaining parts being omitted. Fig. 3 corresponds to Fig. 1 in that it shows the injection device 1 in a position where it is ready for use. The jaws 9 of the cartridge holder 6 are in a position where they are adapted to clamp a cartridge firmly. The piston rod 10 is positioned as close to the dose setting member 4 as possible, indicating that the cartridge (not shown) is full, i.e. it has just been inserted in the injection device 1. In Fig. 3 a dose rod 11 is further visible. The dose rod 11 and the dose setting member 4 engage at a position which is hidden by member 12. This will be explained below with reference to Fig. 5.
Fig. 4 shows selected parts of the injection device 1 of Figs. 1-3. Fig. 4 corresponds to Fig. 2 in that it shows the injection device 1 during a cartridge change. The jaws 9 of the cartridge holder 6 are positioned further apart than is the case in Fig. 3, thereby indicating that they have been released by means of the release buttons 8, and that they are therefore no longer firmly gripping a cartridge. The piston rod 10 is shown in a position which is relatively far from the dose setting member 4, thereby indicating that a cartridge has been emptied. In Fig. 4 the dose rod 11 is more clearly visible than in Fig. 3.
Fig. 5 shows the injection device 1 of Fig. 4 with the only exception that member 12 has been removed. Thereby it is possible to see that the dose setting member 4 is provided with a first set of teeth 13, and the dose rod 11 is provided with a second set of teeth 14. The second set of teeth 14 is adapted to slide into the first set of teeth 13, thereby causing the dose setting member 4 and the dose rod 11 to engage. As soon as the teeth 13, 14 start to engage, the dose rod 11 can no longer rotate relatively to dose setting member 4.
When a new cartridge is being inserted into the injection device 1, it is positioned between the jaws 9 and moved into the injection device 1. During this movement the piston of the cartridge will push the piston rod 10 backwards from the position shown in Fig. 5, and the dose rod 11 will rotate. When the cartridge is almost in position, it will press against the cartridge holder 6 which is thereby moved into the injection device 1. The cartridge holder 6 thereby presses against a carrier 15 which, via a nut (16, not shown in Fig. 5), prevents further rotation of the dose rod 11. The teeth 13, 14 are then moved into engagement by means of an axial movement of the dose rod 11. Thereby it is ensured that no stress is build- up in the piston rod 10.
Fig. 6 is an exploded view of selected parts of the injection device 1 of Figs. 1-5.

Claims

1. An injection device comprising :
- a dose setting mechanism operable to set a desired dose, the dose setting mechanism comprising a dose setting member and a dose rod, the dose setting mechanism being adapted to be in a first position in which the dose setting member and the dose rod engage, and a second position in which the dose setting member and the dose rod do not engage, the dose setting mechanism being in the first position during normal operation of the injection device, and in the second position during cartridge change,
- a piston rod adapted to cooperate with a piston in a cartridge in order to expel a dose of liquid from the cartridge,
- an injection mechanism operable to cause the piston rod and the piston to expel a previously set dose of liquid from the cartridge, and
- a cartridge holder for releasably holding a cartridge,
wherein the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an at least substantially axial direction, at least while the dose setting mechanism is moved from the second position to the first position.
2. An injection device according to claim 1, wherein the first position of the dose setting mechanism is defined by engagement of a set of teeth positioned on the dose setting member and a mating set of teeth positioned on the dose rod.
3. An injection device according to claim 1 or 2, wherein the cartridge holder comprises a cartridge holding member comprising a set of jaws adapted to clamp a distal end of a cartridge.
4. An injection device according to claim 1 or 2, wherein the cartridge holder comprises a frame member adapted to carry the cartridge, wherein the cartridge is moved along with and by means of the frame member during cartridge change.
5. An injection device according to any of the preceding claims, further comprising a biasing mechanism causing the dose setting mechanism to be in the second position when no cartridge is positioned in the cartridge holder.
6. A method of changing a cartridge in an injection device, the injection device comprising a dose setting mechanism operable to set a desired dose, the dose setting mechanism comprising a dose setting member and a dose rod, the dose setting member being adapted to be in a first position in which the dose setting member and the dose rod engage, and a second position in which the dose setting member and the dose rod do not engage, the injection device further comprising a cartridge holder being operatively connected to the dose rod, the method comprising the steps of:
moving the cartridge holder holding an empty cartridge in such a manner that the empty cartridge is accessible, and in such a manner that the dose setting mechanism is caused to move from the first position to the second position,
removing the empty cartridge from the cartridge holder,
- inserting a new cartridge into the cartridge holder,
moving the cartridge holder holding the new cartridge in such a manner that a piston rod of the injecting device is moved along with a piston of the new cartridge, and
moving the dose setting mechanism from the second position to the first position while causing the dose rod to move along with the piston rod in an at least substantially axial direction.
PCT/EP2007/051757 2006-03-10 2007-02-23 An injection device and a method of changing a cartridge in the device WO2007104636A1 (en)

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CN2007800084113A CN101400393B (en) 2006-03-10 2007-02-23 An injection device and a method of changing a cartridge in the device
US12/282,442 US8298194B2 (en) 2006-03-10 2007-02-23 Injection device and a method of changing a cartridge in the device
EP07712304A EP1996259B1 (en) 2006-03-10 2007-02-23 An injection device and a method of changing a cartridge in the device
JP2008558759A JP5062768B2 (en) 2006-03-10 2007-02-23 INJECTION DEVICE AND METHOD FOR REPLACING CARTRIDGE OF THE DEVICE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06004933.5 2006-03-10
EP06004933 2006-03-10

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JP (1) JP5062768B2 (en)
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Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009105910A1 (en) * 2008-02-29 2009-09-03 Tecpharma Licensing Ag Injection device comprising a device for preventing erroneous discharges
WO2011092326A1 (en) * 2010-02-01 2011-08-04 Sanofi-Aventis Deutschland Gmbh Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder
WO2013124118A1 (en) * 2012-02-24 2013-08-29 Novo Nordisk A/S Drug delivery device with front loading feature
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9132239B2 (en) 2008-10-24 2015-09-15 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
CN105209094A (en) * 2013-05-21 2015-12-30 诺和诺德股份有限公司 Frontloaded drug delivery device with actuated cartridge holder and piston rod coupling
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9393367B2 (en) 2013-03-12 2016-07-19 Antares Pharma, Inc. Prefilled syringes and kits thereof
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9486583B2 (en) 2012-03-06 2016-11-08 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
US9561333B2 (en) 2008-08-05 2017-02-07 Antares Pharma, Inc. Multiple dosage injector
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US9867949B2 (en) 2008-03-10 2018-01-16 Antares Pharma, Inc. Injector safety device
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10080845B2 (en) 2013-05-21 2018-09-25 Novo Nordisk A/S Drug delivery device with piston rod coupling
US10245383B2 (en) 2000-06-16 2019-04-02 Novo Nordisk A/S Injection device
US10918803B2 (en) 2015-06-03 2021-02-16 Sanofi-Aventis Deutschland Gmbh Syringe carrier for an autoinjector and method of assembling
US11103649B2 (en) 2015-06-03 2021-08-31 Sanofi-Aventis Deutschland Gmbh Autoinjector and method of assembling
EP2600922B2 (en) † 2010-08-06 2022-07-20 Sanofi-Aventis Deutschland GmbH Cartridge holder and method for assembling a cartridge unit for a drug delivery device
US11400221B2 (en) 2011-12-08 2022-08-02 Sanofi-Aventis Deutschland Gmbh Syringe carrier

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2401009B1 (en) * 2009-02-26 2012-11-28 Tecpharma Licensing AG Product container holder for an injection device and for receiving a product container
US8974423B2 (en) * 2009-06-01 2015-03-10 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
WO2011003817A1 (en) * 2009-07-07 2011-01-13 Sanofi-Aventis Deutschland Gmbh Drug delivery device having mechanical display adjustable by mounting a drug cartridge
US20120253288A1 (en) * 2009-08-27 2012-10-04 Sanofi-Aventis Deutschland Gmbh Reminder device for drug delivery devices
CN102510762B (en) * 2009-09-23 2015-08-12 赛诺菲-安万特德国有限公司 For assembly and the delivery device of delivery device
US9463284B2 (en) * 2009-12-02 2016-10-11 Sanofi-Aventis Deutschland Gmbh Dose display mechanism for drug delivery device with first and second windows and scales
US10188801B2 (en) * 2010-08-13 2019-01-29 Sanofi-Aventis Deutschland Gmbh Mechanism for preventing selection of a dose
CA2811373A1 (en) * 2010-09-30 2012-04-05 Sanofi-Aventis Deutschland Gmbh Non-detachable reservoir holder for a drug delivery device
TWI598122B (en) * 2011-03-25 2017-09-11 賽諾菲阿凡提斯德意志有限公司 Drug delivery device
PT2758101E (en) * 2011-09-22 2016-01-08 Abbvie Inc Automatic injection device
DK2758102T3 (en) 2011-09-22 2015-11-16 Abbvie Inc An automatic injection device
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
RU2628052C2 (en) * 2012-02-13 2017-08-14 Санофи-Авентис Дойчланд Гмбх Auxiliary device for fastening on injection device
EP2988802B1 (en) * 2013-04-22 2018-08-29 Sanofi-Aventis Deutschland GmbH Supplemental device for attachment to an injection device
EP2999502A1 (en) * 2013-05-21 2016-03-30 Novo Nordisk A/S Frontloaded drug delivery device with dynamic axial stop feature
US10512732B2 (en) * 2013-11-22 2019-12-24 Sanofi-Aventis Deutschland Gmbh Drug delivery device with dose knob clutch
EP3148621B1 (en) * 2014-05-26 2020-03-25 Sanofi Display arrangement for an injection device
CA3009221A1 (en) 2014-12-23 2016-06-30 Automed Pty Ltd Delivery apparatus, system and associated methods
USD758567S1 (en) * 2015-01-07 2016-06-07 Sanofi-Aventis Deutschland Gmbh Autoinjector housing
USD779057S1 (en) 2015-01-07 2017-02-14 Sanofi-Aventis Deutschland Gmbh Autoinjector cap
USD758570S1 (en) * 2015-01-07 2016-06-07 Sanofi-Aventis Deutschland Gmbh Autoinjector housing
USD773649S1 (en) * 2015-01-07 2016-12-06 Sanofi-Aventis Deutschland Gmbh Autoinjector housing
USD758568S1 (en) * 2015-01-07 2016-06-07 Sanofi-Aventis Deutschland Gmbh Autoinjector housing
USD773648S1 (en) * 2015-01-07 2016-12-06 Sanofi-Aventis Deutschland Gmbh Autoinjector housing
USD789528S1 (en) 2015-01-07 2017-06-13 Sanofi-Aventis Deutschland Gmbh Autoinjector cap
USD777912S1 (en) 2015-01-07 2017-01-31 Sanofi-Aventis Deutschland Gmbh Autoinjector cap
USD758569S1 (en) * 2015-01-07 2016-06-07 Sanofi-Aventis Deutschland Gmbh Autoinjector housing
USD783816S1 (en) 2015-01-07 2017-04-11 Sanofi-Aventis Deutschland Gmbh Autoinjector cap
USD818587S1 (en) 2016-03-29 2018-05-22 Abbevie Inc. Automatic injection device
USD819198S1 (en) 2016-04-28 2018-05-29 Amgen Inc. Autoinjector with removable cap
USD830539S1 (en) * 2016-05-02 2018-10-09 Amgen Inc. Autoinjector
CN106039475B (en) * 2016-05-18 2019-08-02 苏州鹏烨医疗科技有限公司 A kind of injection pen
US10427122B1 (en) * 2017-10-17 2019-10-01 Innovative Product Brands, Inc. Disposable pre-filled hand-operated dual chamber product dispensing apparatus
JP1631155S (en) 2017-11-06 2019-05-13
USD1010811S1 (en) 2019-09-30 2024-01-09 Amgen Inc. Handheld drug delivery device
USD956211S1 (en) 2020-02-28 2022-06-28 Amgen Inc. Handheld drug delivery device
USD973866S1 (en) 2020-11-05 2022-12-27 Amgen Inc. Handheld drug delivery device
USD962423S1 (en) 2020-11-05 2022-08-30 Amgen Inc. Handheld drug delivery device
USD974547S1 (en) 2020-11-05 2023-01-03 Amgen Inc. Handheld drug delivery device
USD985117S1 (en) 2021-03-10 2023-05-02 Amgen Inc. Handheld drug delivery device
USD985116S1 (en) 2021-03-10 2023-05-02 Amgen Inc. Handheld drug delivery device
USD985118S1 (en) 2021-03-10 2023-05-02 Amgen Inc. Handheld drug delivery device
USD985119S1 (en) 2021-03-30 2023-05-02 Amgen Inc. Handheld drug delivery device

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4498904A (en) * 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
EP0554996A1 (en) * 1992-02-04 1993-08-11 Becton, Dickinson and Company Medication delivery pen with improved dosage setting
WO1996007443A1 (en) * 1994-09-08 1996-03-14 Owen Mumford Limited Improvements relating to injection devices
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
US5688251A (en) * 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
WO2002092153A2 (en) 2001-05-16 2002-11-21 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism

Family Cites Families (301)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US598221A (en) * 1898-02-01 Half to leonard weldon
US854399A (en) 1906-04-18 1907-05-21 Walter G Bridge Syringe.
US2392196A (en) 1945-02-24 1946-01-01 Arthur E Smith Syringe
GB664044A (en) 1948-03-02 1951-01-02 Becton Dickinson Co Injection device
US2956563A (en) 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3110310A (en) 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3115135A (en) 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3144178A (en) * 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
US3556099A (en) 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
CH563690A5 (en) 1973-03-09 1975-06-30 Radioelectrique Comp Ind
US3880162A (en) 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4026288A (en) 1975-10-21 1977-05-31 Insulin Injector Inc. Syringe injecting device
US4634431A (en) 1976-11-12 1987-01-06 Whitney Douglass G Syringe injector
DE2812729A1 (en) 1978-03-23 1979-09-27 Michael Becker INJECTION DEVICE FOR INTRAMUSCULAR INJECTION, PRESENTLY OF INSULIN
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4430079A (en) 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
DE2906830C2 (en) 1979-02-22 1981-07-16 B. Braun Melsungen Ag, 3508 Melsungen Device for continuous infusions
US4277227A (en) 1979-07-02 1981-07-07 Imed Corporation Apparatus for converting a pump to a controller
USRE31315E (en) 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4275727A (en) 1980-01-07 1981-06-30 Keeri Szanto Michael Device for monitoring and controlling self-administered intravenous drug dosage
US4368731A (en) 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
US4313439A (en) 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
DE3048135A1 (en) 1980-12-19 1982-07-15 Imed Corp., 92131 San Diego, Calif. Intravenous liquid administration by pump - with external pressure sensing cartridge regulating discharge pressure
IT1168101B (en) 1981-01-15 1987-05-20 Domenico Colombo PERFECTED MANUAL PRESSURE SYRINGE, FOR DENTAL USE
US4393723A (en) 1981-04-16 1983-07-19 Glen Brand Fluid flow meter
AR228395A1 (en) 1981-05-07 1983-02-28 Merck & Co Inc SYRINGE TO REGULATE THE AMOUNT SUPPLIED OF A PLASTIC SUBSTANCE
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
DE3204178C2 (en) 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipetting device
US4515584A (en) 1982-07-06 1985-05-07 Fujisawa Pharmaceutical Co., Ltd. Artificial pancreas
DE3236374A1 (en) 1982-10-01 1984-04-05 Brown, Boveri & Cie Ag, 6800 Mannheim Security paper
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
US4493704A (en) 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus
DE3468173D1 (en) 1983-09-07 1988-02-04 Disetronic Ag Portable infusion apparatus
US4749109A (en) 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
ES277095Y (en) 1984-01-25 1985-02-16 Fernandez-Tresguerres Hernandez Jesus A. SUPPLIER-DISPENSER OF INJECTABLE PRODUCTS
US4676122A (en) 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4812724A (en) 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
FR2583291A1 (en) 1985-06-14 1986-12-19 Hazon Bernard Device for step-by-step advance of syringe plungers by means of a double coaxial screw with control of the injection rate. Application to repetitive intradermic medicinal injections
DE3670768D1 (en) 1985-11-08 1990-06-07 Disetronic Ag INJECTION DEVICE.
DE3609555A1 (en) 1986-03-21 1987-09-24 Josef Porner Blood-collecting syringe
DE3645245C2 (en) 1986-11-14 1994-01-27 Haselmeier Wilhelm Fa Injection appliance
US5716990A (en) 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
NL8701091A (en) 1987-05-08 1988-12-01 Spruyt Hillen Bv INJECTION PEN.
GB8713810D0 (en) 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
US4838860A (en) 1987-06-26 1989-06-13 Pump Controller Corporation Infusion pump
GB8720477D0 (en) 1987-08-29 1987-10-07 Bick P A Resynchronisation of body clock
FR2622457A1 (en) 1987-11-03 1989-05-05 Piccinali Eric Mesotherapeutic injector with microprocessor
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4833379A (en) 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
CH675078A5 (en) 1988-01-22 1990-08-31 Nosta Ag
US4898578A (en) 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
GB8809115D0 (en) * 1988-04-18 1988-05-18 Turner R C Syringes
JP2717808B2 (en) 1988-08-10 1998-02-25 テルモ株式会社 Syringe pump
DE3833821A1 (en) 1988-10-05 1990-04-12 Braun Melsungen Ag INJECTION DEVICE
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
FR2642786B1 (en) 1989-02-07 1991-05-10 Europ Agence Spatiale LINEAR OR CIRCULAR LOCKING DEVICE, OF THE SAID RATCHET TYPE, SELF-LOCKING AND WITH AUTOMATIC RELEASE
GB2229497B (en) 1989-03-10 1992-06-03 Graseby Medical Ltd Infusion pump
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
DE3923079A1 (en) 1989-07-13 1991-01-24 Fresenius Ag Measuring level of electrically conducting liquid - has measuring of infusion liquid or blood from change in capacitance of electrodes in measurement liquid
US5002537A (en) 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
US4990142A (en) 1989-10-23 1991-02-05 Gte Products Corporation Hypodermic syringe
US5122317A (en) * 1990-01-12 1992-06-16 The Regents Of The University Of Michigan Method of superplastically deforming zirconia materials
DK17890A (en) 1990-01-22 1991-07-23 Novo Nordisk As METHOD AND APPARATUS FOR MIXTURE AND INJECTION OF A MEDICINE
US5064098A (en) 1990-02-23 1991-11-12 Physical Systems, Inc. Dual component dispenser gun
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5318540A (en) 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5104388A (en) 1990-05-08 1992-04-14 Fbk International Corporation Membrane splittable tubing
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
US5284480A (en) 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
JPH04256757A (en) * 1991-02-07 1992-09-11 Terumo Corp Quantitative dispenser
US5078698A (en) 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5176646A (en) 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5135485A (en) 1991-02-25 1992-08-04 Louis Cohen Capacitance-type fluid level sensor for i.v. and catheter bags
DE4112259A1 (en) 1991-04-15 1992-10-22 Medico Dev Investment Co INJECTION DEVICE
DK68991D0 (en) 1991-04-17 1991-04-17 Novo Nordisk As HEADER
US5645052A (en) 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
ES2074771T3 (en) 1991-07-24 1995-09-16 Medico Dev Investment Co INJECTOR.
DK175491D0 (en) 1991-10-18 1991-10-18 Novo Nordisk As APPARATUS
US5163904A (en) 1991-11-12 1992-11-17 Merit Medical Systems, Inc. Syringe apparatus with attached pressure gauge
DK194291D0 (en) 1991-11-29 1991-11-29 Novo Nordisk As SPRAY FOR AUTOMATIC INJECTION.
WO1993010839A1 (en) 1991-11-29 1993-06-10 Novo Nordisk A/S A pen-shaped syringe
US5221268A (en) 1991-12-06 1993-06-22 Block Medical, Inc. Multiple dose control apparatus
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
CH682806A5 (en) 1992-02-21 1993-11-30 Medimpex Ets Injection device.
WO1993018812A1 (en) 1992-03-25 1993-09-30 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
GB9219849D0 (en) 1992-09-19 1992-10-28 Hypoguard Uk Ltd Device
DE69329774T2 (en) 1992-10-15 2001-06-21 Gen Hospital Corp INFUSION PUMP WITH ELECTRONICALLY LOADABLE MEDICINE LIBRARY
FR2697434A1 (en) 1992-11-02 1994-05-06 Godillon Jean Francois Surgical syringe plunger withdrawal attachment - has lever and transmission member which allow plunger to be withdrawn with one hand, leaving other one free
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
GB9226423D0 (en) 1992-12-18 1993-02-10 Sams Bernard Incrementing mechanisms
JP2530150Y2 (en) 1993-01-06 1997-03-26 城田電気炉材株式会社 Injection device for dental anesthetic, etc.
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
ZA941881B (en) 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US5292976A (en) 1993-04-27 1994-03-08 Mobil Oil Corporation Process for the selective conversion of naphtha to aromatics and olefins
SE9301494D0 (en) 1993-04-30 1993-04-30 Kabi Pharmacia Ab A DEVICE FOR DOSING LIQUID PREPARATION
ATE209052T1 (en) 1993-06-30 2001-12-15 Hamilton Co MANUAL DISPENSING AID FOR AN INJECTION SYRINGE
DK83093D0 (en) 1993-07-09 1993-07-09 Novo Nordisk As COURSE OF ACTION
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
CA2129284C (en) 1993-11-24 1999-03-09 Kenneth J. Niehoff Controlling plunger drives for fluid injection in animals
EP0736183B1 (en) 1993-12-22 2002-07-31 Continental Teves AG & Co. oHG Device for detecting rotary or angular movements
US5505697A (en) 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
AUPM348594A0 (en) 1994-01-21 1994-02-17 University Of Melbourne, The Improvements in syringe pumps
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5562623A (en) 1994-02-14 1996-10-08 Univec Single-use syringe assembly including spring clip lock and plunger
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
DE4414744C1 (en) 1994-04-27 1995-11-02 Eppendorf Geraetebau Netheler Repeater pipette
JP4201345B2 (en) 1994-05-30 2008-12-24 ビィ ディ メディコ ソシエタ ア レスポンサビリタ リミタータ Injection device
DE4419235C2 (en) 1994-06-01 1999-03-11 Thomas Braeger Hypodermic syringe with a receptacle
WO1995034334A1 (en) 1994-06-15 1995-12-21 Interventional Research Technologies, Inc. Locking device for syringe or like instrument
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US5720733A (en) 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US5496286A (en) 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
CA2186869A1 (en) 1994-08-24 1996-02-29 Hideto Yamagata Injection apparatus
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
WO1996008974A1 (en) 1994-09-20 1996-03-28 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation
ZA958073B (en) 1994-09-28 1996-04-23 Anthony William Manicom Method of and apparatus for administering a drug to a patient
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
DE19503230A1 (en) 1995-02-02 1996-08-08 Dietmar Dr Med Enk Syringe with a damping and pressure measuring device integrated in the piston and method for uniform and pressure-controlled injection by means of this syringe
AU696439B2 (en) 1995-03-07 1998-09-10 Eli Lilly And Company Recyclable medication dispensing device
GB2309644B (en) 1995-05-22 2000-05-31 Wolfgang Wagner A method and device for diagnosis and injection
US5700904A (en) 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
DE29513214U1 (en) 1995-08-21 1997-01-02 Adamaszek Franz Heinz Dosing and automatic injection system
AU1860697A (en) 1995-09-08 1997-07-28 Visionary Medical Products Corporation Pen-type injector drive mechanism
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US5807334A (en) 1995-10-20 1998-09-15 Hodosh; Milton Fluid dispensing apparatus
US6159161A (en) 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
FR2740345A1 (en) 1995-10-26 1997-04-30 Neftel Frederic AUTOMATION DEVICE
US5899879A (en) 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
RU2181299C2 (en) 1996-02-23 2002-04-20 Ново Нордиск А/С Syringe with electronic parameter presentation
FR2745637B1 (en) 1996-03-04 1998-05-22 Motorola Semiconducteurs SEMICONDUCTOR CHEMICAL SENSOR DEVICE AND THERMOCOUPLE FORMING METHOD THEREFOR
PL185605B1 (en) 1996-03-12 2003-06-30 Novo Nordisk As Injection making instrument with electronic pre-setting of specific doses
PT828527E (en) 1996-04-02 2002-12-31 Disetronic Licensing Ag INJECTION DEVICE
DE59609696D1 (en) 1996-04-02 2002-10-24 Disetronic Licensing Ag INJECTION DEVICE
DE29606540U1 (en) 1996-04-10 1997-08-07 Muehlbauer Ernst Dental mass application device
AU724937B2 (en) 1996-04-24 2000-10-05 Novo Nordisk A/S Injection needle
PL330757A1 (en) 1996-07-05 1999-05-24 Novo Nordisk As Elastic piston rod
EP0910419B1 (en) 1996-07-05 2004-05-26 Novo Nordisk A/S Dose setting device
EP0910418B1 (en) 1996-07-05 2003-09-10 Novo Nordisk A/S Automatic needle insertion mechanism
DE19632402C1 (en) 1996-08-02 1998-04-09 Schering Ag Method of making a prefilled, sterile syringe
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US5709662A (en) 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US6379339B1 (en) 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
ATE209935T1 (en) 1996-09-20 2001-12-15 Novo Nordisk As WORKING CYLINDER
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
GB2321419B (en) 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer
JP2001511033A (en) 1997-02-04 2001-08-07 ノボ ノルディスク アクティーゼルスカブ Liquid drug suspension dosing device
DE29703820U1 (en) 1997-03-03 1998-07-02 Medico Dev Investment Co Injection device
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US20010020155A1 (en) 1997-03-25 2001-09-06 Soren Mikkelsen Injection system
RU2111019C1 (en) 1997-05-22 1998-05-20 Сергей Александрович Хворостов General-purpose injector
DE19723647C1 (en) 1997-06-05 1998-12-24 Disetronic Licensing Ag Fluid dosing unit indicator for e.g. insulin or for pipetting laboratory fluids
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US6074372A (en) 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
JP2001509426A (en) 1997-07-11 2001-07-24 ノボ ノルディスク アクティーゼルスカブ Equipment for display of medical equipment settings
JP2003514587A (en) 1997-07-14 2003-04-22 ノボ ノルディスク アクティーゼルスカブ Injection parts
DE69814859T2 (en) 1997-07-14 2004-02-19 Novo Nordisk A/S CYLINDRICAL AMPOULE
DE19730999C1 (en) 1997-07-18 1998-12-10 Disetronic Licensing Ag Injection pen dosing selected volume of fluid, especially insulin
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US5957896A (en) 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
FR2767479B1 (en) 1997-08-22 1999-10-22 Aguettant Lab DRUG INJECTION DEVICE
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
CN1243578C (en) 1998-01-30 2006-03-01 诺沃挪第克公司 An injection syringe
US6770288B2 (en) 1998-02-13 2004-08-03 Pfizer Products Inc. Drug delivery system
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6096010A (en) 1998-02-20 2000-08-01 Becton, Dickinson And Company Repeat-dose medication delivery pen
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
JP3436683B2 (en) 1998-03-17 2003-08-11 株式会社日立ユニシアオートモティブ Rotation angle detector
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
JP3017167B2 (en) 1998-05-20 2000-03-06 インターナショナル・ビジネス・マシーンズ・コーポレイション Method and apparatus for binarizing a read signal from a data storage medium
GB9812472D0 (en) 1998-06-11 1998-08-05 Owen Mumford Ltd A dose setting device for medical injectors
AU4435399A (en) 1998-06-11 1999-12-30 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
US6743202B2 (en) 1998-06-15 2004-06-01 Medrad, Inc. Encoding of syringe information
US5933671A (en) 1998-07-07 1999-08-03 Eastman Kodak Company Camera with touch sensitive switch
WO2000002605A1 (en) 1998-07-08 2000-01-20 Novo Nordisk A/S A medical delivery device and a cartridge assembly for use in the same
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
DE19838760A1 (en) 1998-08-26 2000-04-20 Bauer Jlona Injection unit, especially for injecting medicines such as insulin, consists of a housing with a chamber for holding a needle, a cartridge and a release mechanism.
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
DE19900792C1 (en) 1999-01-12 2000-06-15 Disetronic Licensing Ag Injection unit forming part of e.g. pen-type self-injection syringe has continuous dosing stop in spiral form with constant pitch ensuring close fine control and accuracy in use
DE29900482U1 (en) 1999-01-14 2000-08-31 Medico Dev Investment Co Injection device
US6036675A (en) 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
JP2000237308A (en) 1999-02-22 2000-09-05 Ckd Corp Infusion pump
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
DE19909602A1 (en) 1999-03-05 2000-09-07 Roche Diagnostics Gmbh Device for drawing blood for diagnostic purposes
US6245046B1 (en) 1999-05-03 2001-06-12 University Of New Mexico Reciprocating syringes
SE9901736D0 (en) 1999-05-12 1999-05-12 Pharmacia & Upjohn Ab Injectino device and method for ITS operation
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US6673033B1 (en) 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
US20020173752A1 (en) 2000-02-16 2002-11-21 Polzin U1F Method for reconstituting an injection liquid and an injection appliance for carrying out such a method
GB0007071D0 (en) 2000-03-24 2000-05-17 Sams Bernard One-way clutch mechanisms and injector devices
US6485465B2 (en) 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6692472B2 (en) 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6716198B2 (en) 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
JP2004503337A (en) 2000-07-14 2004-02-05 ノボ　ノルディスク　アクティーゼルスカブ Liquid drug ejection device and method for ejecting a desired dose
BR0112825A (en) 2000-07-28 2003-07-01 Mdc Invest Holdings Inc Process for injecting medicine from a medical device that has a needle with a sharp tip and medical device
US6994261B2 (en) 2000-08-10 2006-02-07 Novo Nirdisk A/S Support for a cartridge for transferring an electronically readable item of information from the cartridge to an electronic circuit
WO2002011629A1 (en) 2000-08-10 2002-02-14 Synthes Ag Chur Device for the introduction of medical items
WO2002024257A1 (en) 2000-09-22 2002-03-28 Novo Nordisk A/S A medication delivery device
JP4975208B2 (en) 2000-10-03 2012-07-11 株式会社根本杏林堂 Automatic injection equipment
US7500959B2 (en) 2000-10-05 2009-03-10 Novo Nordisk A/S Medication delivery system with improved dose accuracy
US6537251B2 (en) 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
EP1404214A2 (en) 2000-11-24 2004-04-07 CKM Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
WO2002064196A1 (en) 2001-02-14 2002-08-22 Novo Nordisk A/S Electronically controlled injection or infusion device
US6854620B2 (en) 2001-04-13 2005-02-15 Nipro Diabetes, Systems, Inc. Drive system for an infusion pump
GB0113881D0 (en) 2001-06-07 2001-08-01 Innovate Biomed Ltd Foil cutting system
US6752781B2 (en) 2001-06-08 2004-06-22 Sergio Landau Durable hypodermic jet injector apparatus and method
US7080936B1 (en) 2001-06-13 2006-07-25 Simpson Frank B Wrap spring clutch syringe ram and frit mixer
DE10133216B4 (en) 2001-07-09 2005-01-27 Tecpharma Licensing Ag position detection
DE10163326A1 (en) 2001-07-30 2003-02-27 Disetronic Licensing Ag Administration device with dosing device
DK200100240U3 (en) 2001-09-18 2001-11-23 Niels Tessing garlic Crusher
EP2319562B1 (en) 2001-12-13 2012-05-30 Panasonic Corporation Administration instrument for medical use
GB0130138D0 (en) 2001-12-18 2002-02-06 Dca Design Int Ltd Improvements in an relating to a medicament injection apparatus
DE10201875C1 (en) 2002-01-18 2003-05-22 Austriamicrosystems Ag Magnetic or electrical field sensor system has modulators with non-inverting and inverting conditions providing for different sensor configurations
US6980852B2 (en) 2002-01-25 2005-12-27 Subqiview Inc. Film barrier dressing for intravascular tissue monitoring system
JP2005527508A (en) 2002-03-07 2005-09-15 ヴェクトゥラ　リミテッド Rapid melting multiparticulate formulation for oral delivery
AU2003216521A1 (en) 2002-03-18 2003-10-08 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
JP4064138B2 (en) 2002-03-28 2008-03-19 スーガン株式会社 Medical tube opener
US20040010204A1 (en) 2002-03-28 2004-01-15 Pearl Technology Holdings, Llc Electronic/fiberoptic tissue differentiation instrumentation
JP2003296915A (en) 2002-03-29 2003-10-17 Tdk Corp Magnetic recording medium
US6913095B2 (en) * 2002-05-15 2005-07-05 Baker Hughes Incorporated Closed loop drilling assembly with electronics outside a non-rotating sleeve
DE10226643A1 (en) 2002-06-14 2004-01-15 Disetronic Licensing Ag Piston stopper for injection device, product container and injection device
DE10229122B4 (en) * 2002-06-28 2006-09-07 Tecpharma Licensing Ag Administration device with resettable actuation lock
EP1521607A1 (en) 2002-07-10 2005-04-13 Novo Nordisk A/S An injection device with a dose setting limiter
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
WO2004007002A1 (en) 2002-07-10 2004-01-22 Novo Nordisk A/S An injection device
EP1391794A1 (en) 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
US6929619B2 (en) 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
JP2005536300A (en) 2002-08-29 2005-12-02 ノボ・ノルデイスク・エー／エス Forward retractable injection device
DE10240165A1 (en) 2002-08-30 2004-03-18 Disetronic Licensing Ag Dispensing unit for use in infusion pumps comprises reservoir for infusion liquid fitted with spring-loaded piston, toothed wheel cooperating with locking bar to prevent piston moving
US20040051368A1 (en) 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
CN1684674B (en) 2002-09-26 2012-05-30 独立行政法人科学技术振兴机构 Therapeutic causing contraction of mucosal tissue, injector and therapeutic set
WO2004035113A2 (en) 2002-10-15 2004-04-29 Eli Lilly And Company Medication dispensing apparatus with squeezable actuator
WO2004066939A2 (en) 2003-01-27 2004-08-12 Sarnoff Corporation Controlled-release drug delivery system
US8016798B2 (en) 2003-02-24 2011-09-13 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
WO2004080306A1 (en) 2003-03-06 2004-09-23 Lifescan, Inc. System and method for piercing dermal tissue
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
WO2004084795A1 (en) 2003-03-24 2004-10-07 Novo Nordisk A/S Transparent electronic marking of a medication cartridge
GB0308267D0 (en) 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
AU2004232865A1 (en) 2003-04-23 2004-11-04 Vasogen Ireland Limited Dispensing systems
US7641668B2 (en) 2003-05-16 2010-01-05 Scimed Life Systems, Inc. Fluid delivery system and related methods of use
FR2857654B1 (en) 2003-07-16 2007-04-27 Prodonta DEVICE FOR EJECTING A LIQUID OR PASTY PRODUCT
DE20317377U1 (en) 2003-11-03 2005-03-17 B D Medico S A R L injection device
JP5342109B2 (en) 2004-03-03 2013-11-13 株式会社根本杏林堂 Chemical injection system
GB0406088D0 (en) 2004-03-18 2004-04-21 Smiths Group Plc Infusion apparatus and methods
ATE526052T1 (en) 2004-03-30 2011-10-15 Lilly Co Eli MEDICATION DISPENSING DEVICE HAVING A GEAR SET WITH AN OPENING FOR RECEIVING A DRIVE ELEMENT
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
JP4925828B2 (en) 2004-07-14 2012-05-09 株式会社根本杏林堂 Chemical injection system
DE102004046003A1 (en) 2004-09-17 2006-03-30 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pharmaceutical package, as a syringe or vial or capsule, has an integrated microchip and antenna to give a unique and tamper-proof identity
EP1645301A1 (en) 2004-10-11 2006-04-12 Novo Nordisk A/S Injection device
JP5185620B2 (en) 2004-10-21 2013-04-17 ノボ・ノルデイスク・エー／エス Injection device with torsion spring and rotary indicator
WO2006045525A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with a processor for collecting ejection information
ITVR20040168A1 (en) 2004-10-25 2005-01-25 C M Tecnologie S R L SELECTOR, PARTICULARLY BUT NOT ONLY FOR AUTOMATIC DRINK DISTRIBUTORS
CA2594764C (en) 2005-01-21 2014-01-14 Novo Nordisk A/S An automatic injection device with a top release mechanism
JP2006250582A (en) 2005-03-08 2006-09-21 Hitachi Plant Technologies Ltd Rfid tag with load sensor
WO2006114396A1 (en) 2005-04-24 2006-11-02 Novo Nordisk A/S Injection device
EP1890751A1 (en) 2005-04-24 2008-02-27 Novo Nordisk A/S An injection device with a gearbox
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
DK1728529T3 (en) 2005-06-01 2008-11-24 Shl Group Ab Device for drug delivery
US20090043253A1 (en) 2005-10-11 2009-02-12 Blake Podaima Smart medical compliance method and system
CN101400394B (en) 2006-03-10 2012-07-04 诺沃-诺迪斯克有限公司 An injection device having a gearing arrangement
US20080306443A1 (en) 2007-06-06 2008-12-11 Mallinckrodt Inc. Medical Fluid Injector Having Wireless Pressure Monitoring Feature

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4498904A (en) * 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
EP0554996A1 (en) * 1992-02-04 1993-08-11 Becton, Dickinson and Company Medication delivery pen with improved dosage setting
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
WO1996007443A1 (en) * 1994-09-08 1996-03-14 Owen Mumford Limited Improvements relating to injection devices
US5688251A (en) * 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
WO2002092153A2 (en) 2001-05-16 2002-11-21 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism

Cited By (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10245383B2 (en) 2000-06-16 2019-04-02 Novo Nordisk A/S Injection device
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9737670B2 (en) 2002-02-11 2017-08-22 Antares Pharma, Inc. Intradermal injector
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9629959B2 (en) 2005-01-24 2017-04-25 Antares Pharma, Inc. Prefilled syringe jet injector
US10478560B2 (en) 2005-01-24 2019-11-19 Antares Pharma, Inc. Prefilled syringe injector
US11446441B2 (en) 2005-01-24 2022-09-20 Antares Pharma, Inc. Prefilled syringe injector
US11471600B2 (en) 2006-05-03 2022-10-18 Antares Pharma, Inc. Injector with adjustable dosing
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US10543316B2 (en) 2006-05-03 2020-01-28 Antares Pharma, Inc. Injector with adjustable dosing
US11547808B2 (en) 2006-05-03 2023-01-10 Antares Pharma, Inc. Two-stage reconstituting injector
US10688250B2 (en) 2006-05-03 2020-06-23 Antares Pharma, Inc. Two-stage reconstituting injector
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
WO2009105910A1 (en) * 2008-02-29 2009-09-03 Tecpharma Licensing Ag Injection device comprising a device for preventing erroneous discharges
US9867949B2 (en) 2008-03-10 2018-01-16 Antares Pharma, Inc. Injector safety device
US10709844B2 (en) 2008-03-10 2020-07-14 Antares Pharma, Inc. Injector safety device
US11684723B2 (en) 2008-03-10 2023-06-27 Antares Pharma, Inc. Injector safety device
US11058824B2 (en) 2008-08-05 2021-07-13 Antares Pharma, Inc. Multiple dosage injector
US9561333B2 (en) 2008-08-05 2017-02-07 Antares Pharma, Inc. Multiple dosage injector
US10300212B2 (en) 2008-08-05 2019-05-28 Antares Pharma, Inc. Multiple dosage injector
US9132239B2 (en) 2008-10-24 2015-09-15 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9750881B2 (en) 2009-03-20 2017-09-05 Antares Pharma, Inc. Hazardous agent injection system
US11497753B2 (en) 2009-03-20 2022-11-15 Antares Pharma, Inc. Hazardous agent injection system
US10555954B2 (en) 2009-03-20 2020-02-11 Antares Pharma, Inc. Hazardous agent injection system
EP3782677A1 (en) * 2010-02-01 2021-02-24 Sanofi-Aventis Deutschland GmbH Drug delivery device with cartridge holder
US9775949B2 (en) 2010-02-01 2017-10-03 Sanofi-Aventis Deutschland Gmbh Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder
EP3427779A1 (en) * 2010-02-01 2019-01-16 Sanofi-Aventis Deutschland GmbH Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder
WO2011092326A1 (en) * 2010-02-01 2011-08-04 Sanofi-Aventis Deutschland Gmbh Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder
EP2600922B2 (en) † 2010-08-06 2022-07-20 Sanofi-Aventis Deutschland GmbH Cartridge holder and method for assembling a cartridge unit for a drug delivery device
US11185642B2 (en) 2011-07-15 2021-11-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US10568809B2 (en) 2011-07-15 2020-02-25 Ferring B.V. Liquid-transfer adapter beveled spike
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US10279131B2 (en) 2011-07-15 2019-05-07 Antares Pharma, Inc. Injection device with cammed RAM assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US11406763B2 (en) 2011-12-08 2022-08-09 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11406764B2 (en) 2011-12-08 2022-08-09 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11400223B2 (en) 2011-12-08 2022-08-02 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11400222B2 (en) 2011-12-08 2022-08-02 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11400221B2 (en) 2011-12-08 2022-08-02 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US11511043B2 (en) 2011-12-08 2022-11-29 Sanofi-Aventis Deutschland Gmbh Syringe carrier
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
US11103640B2 (en) 2012-02-24 2021-08-31 Novo Nordisk A/S Drug delivery device with front loading feature
WO2013124118A1 (en) * 2012-02-24 2013-08-29 Novo Nordisk A/S Drug delivery device with front loading feature
US11602597B2 (en) 2012-03-06 2023-03-14 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
US9486583B2 (en) 2012-03-06 2016-11-08 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
US10478559B2 (en) 2012-03-06 2019-11-19 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
US10821072B2 (en) 2012-04-06 2020-11-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US11771646B2 (en) 2012-04-06 2023-10-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US10357609B2 (en) 2012-05-07 2019-07-23 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US10905827B2 (en) 2012-05-07 2021-02-02 Antares Pharma, Inc. Injection device with cammed ram assembly
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US11446440B2 (en) 2012-05-07 2022-09-20 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US11813435B2 (en) 2013-02-11 2023-11-14 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US10881798B2 (en) 2013-02-11 2021-01-05 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US11628260B2 (en) 2013-03-11 2023-04-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US10610649B2 (en) 2013-03-11 2020-04-07 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US10675400B2 (en) 2013-03-12 2020-06-09 Antares Pharma, Inc. Prefilled syringes and kits thereof
US9393367B2 (en) 2013-03-12 2016-07-19 Antares Pharma, Inc. Prefilled syringes and kits thereof
CN105209094A (en) * 2013-05-21 2015-12-30 诺和诺德股份有限公司 Frontloaded drug delivery device with actuated cartridge holder and piston rod coupling
US10080845B2 (en) 2013-05-21 2018-09-25 Novo Nordisk A/S Drug delivery device with piston rod coupling
US10918803B2 (en) 2015-06-03 2021-02-16 Sanofi-Aventis Deutschland Gmbh Syringe carrier for an autoinjector and method of assembling
US11103649B2 (en) 2015-06-03 2021-08-31 Sanofi-Aventis Deutschland Gmbh Autoinjector and method of assembling

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EP1996259B1 (en) 2012-08-15
CN101400393B (en) 2011-09-14
JP2009529395A (en) 2009-08-20
US20090254027A1 (en) 2009-10-08
JP5062768B2 (en) 2012-10-31
CN101400393A (en) 2009-04-01
US8298194B2 (en) 2012-10-30
EP1996259A1 (en) 2008-12-03

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