WO2007056433A3 - Methods of treating tissue defects - Google Patents

Methods of treating tissue defects Download PDF

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Publication number
WO2007056433A3
WO2007056433A3 PCT/US2006/043443 US2006043443W WO2007056433A3 WO 2007056433 A3 WO2007056433 A3 WO 2007056433A3 US 2006043443 W US2006043443 W US 2006043443W WO 2007056433 A3 WO2007056433 A3 WO 2007056433A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
growth factors
treating tissue
tissue defects
stem cells
Prior art date
Application number
PCT/US2006/043443
Other languages
French (fr)
Other versions
WO2007056433A2 (en
Inventor
Bruce Simon
Original Assignee
Ebi Lp
Bruce Simon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/268,696 external-priority patent/US7744869B2/en
Priority claimed from US11/268,699 external-priority patent/US20070105769A1/en
Application filed by Ebi Lp, Bruce Simon filed Critical Ebi Lp
Publication of WO2007056433A2 publication Critical patent/WO2007056433A2/en
Publication of WO2007056433A3 publication Critical patent/WO2007056433A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Abstract

Methods of treating tissue defects, including defects such as bone fractures, vertebrae fusions, and spinal disc repair, using electric or electromagnetic fields and growth factors. In various embodiments, the present invention provides methods for the treatment of a human or other mammal subject in need thereof, by administering electric stimulation and growth factors to stimulate endogeneous stem cells in the subject to facilitate healing. Other embodiments include methods of administering electric stimulation, growth factors, and stem cells to the defect. In various embodiments the amount of growth factor is a subefficacious amount.
PCT/US2006/043443 2005-11-07 2006-11-07 Methods of treating tissue defects WO2007056433A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/268,699 2005-11-07
US11/268,696 2005-11-07
US11/268,696 US7744869B2 (en) 2003-08-20 2005-11-07 Methods of treatment using electromagnetic field stimulated mesenchymal stem cells
US11/268,699 US20070105769A1 (en) 2005-11-07 2005-11-07 Methods of treating tissue defects

Publications (2)

Publication Number Publication Date
WO2007056433A2 WO2007056433A2 (en) 2007-05-18
WO2007056433A3 true WO2007056433A3 (en) 2007-07-05

Family

ID=37943987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043443 WO2007056433A2 (en) 2005-11-07 2006-11-07 Methods of treating tissue defects

Country Status (1)

Country Link
WO (1) WO2007056433A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9050112B2 (en) 2011-08-23 2015-06-09 Flexmedex, LLC Tissue removal device and method
US9149286B1 (en) 2010-11-12 2015-10-06 Flexmedex, LLC Guidance tool and method for use
US9259329B2 (en) 2004-09-21 2016-02-16 Stout Medical Group, L.P. Expandable support device and method of use

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1903949A2 (en) 2005-07-14 2008-04-02 Stout Medical Group, L.P. Expandable support device and method of use
WO2007131002A2 (en) 2006-05-01 2007-11-15 Stout Medical Group, L.P. Expandable support device and method of use
US20100211176A1 (en) 2008-11-12 2010-08-19 Stout Medical Group, L.P. Fixation device and method
WO2010056895A1 (en) 2008-11-12 2010-05-20 Stout Medical Group, L.P. Fixation device and method
CN109289119B (en) * 2018-09-16 2022-05-17 华北理工大学 Magnetic nanoparticle ball mixture for spinal rehabilitation system
CN109289118B (en) * 2018-09-16 2022-04-29 华北理工大学 Respiration indicating device for spinal rehabilitation system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050084962A1 (en) * 2003-08-20 2005-04-21 Bruce Simon Methods of treatment using electromagnetic field stimulated stem cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050084962A1 (en) * 2003-08-20 2005-04-21 Bruce Simon Methods of treatment using electromagnetic field stimulated stem cells

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9259329B2 (en) 2004-09-21 2016-02-16 Stout Medical Group, L.P. Expandable support device and method of use
US9314349B2 (en) 2004-09-21 2016-04-19 Stout Medical Group, L.P. Expandable support device and method of use
US9149286B1 (en) 2010-11-12 2015-10-06 Flexmedex, LLC Guidance tool and method for use
US9050112B2 (en) 2011-08-23 2015-06-09 Flexmedex, LLC Tissue removal device and method

Also Published As

Publication number Publication date
WO2007056433A2 (en) 2007-05-18

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