WO2007035629A2 - Process for the preparation of pyrimidinedione derivatives - Google Patents
Process for the preparation of pyrimidinedione derivatives Download PDFInfo
- Publication number
- WO2007035629A2 WO2007035629A2 PCT/US2006/036276 US2006036276W WO2007035629A2 WO 2007035629 A2 WO2007035629 A2 WO 2007035629A2 US 2006036276 W US2006036276 W US 2006036276W WO 2007035629 A2 WO2007035629 A2 WO 2007035629A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- hetero
- cycloalkyl
- bicycloaryl
- group
- Prior art date
Links
- 0 CN(C(C=C(*)N1)=O)C1=O Chemical compound CN(C(C=C(*)N1)=O)C1=O 0.000 description 10
- GZBQHUMIMKAYHA-CYBMUJFWSA-N CN(C(C=C(N1Cc2cc(F)ccc2Cl)N(CCC2)C[C@@H]2N)=O)C1=O Chemical compound CN(C(C=C(N1Cc2cc(F)ccc2Cl)N(CCC2)C[C@@H]2N)=O)C1=O GZBQHUMIMKAYHA-CYBMUJFWSA-N 0.000 description 1
- IVAOJCUUEIWNIT-UHFFFAOYSA-N N#Cc1c(CI)cccc1 Chemical compound N#Cc1c(CI)cccc1 IVAOJCUUEIWNIT-UHFFFAOYSA-N 0.000 description 1
- WKSHWJJTTMKYRY-LJQANCHMSA-N N[C@H](CCC1)CN1C(N(Cc(cccc1)c1C#N)C(N1Cc2nc(cccc3)c3[nH]2)=O)=CC1=O Chemical compound N[C@H](CCC1)CN1C(N(Cc(cccc1)c1C#N)C(N1Cc2nc(cccc3)c3[nH]2)=O)=CC1=O WKSHWJJTTMKYRY-LJQANCHMSA-N 0.000 description 1
- QWCRMWNCTSFODM-CYBMUJFWSA-N N[C@H](CCC1)CN1C(N(Cc1ccccc1C#N)C(NC1=O)=O)=C1Cl Chemical compound N[C@H](CCC1)CN1C(N(Cc1ccccc1C#N)C(NC1=O)=O)=C1Cl QWCRMWNCTSFODM-CYBMUJFWSA-N 0.000 description 1
- PEUGKEHLRUVPAN-RXMQYKEDSA-N N[C@H]1CNCCC1 Chemical compound N[C@H]1CNCCC1 PEUGKEHLRUVPAN-RXMQYKEDSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008531408A JP5122462B2 (en) | 2005-09-16 | 2006-09-15 | Dipeptidyl peptidase inhibitor |
US12/066,769 US8222411B2 (en) | 2005-09-16 | 2006-09-15 | Dipeptidyl peptidase inhibitors |
KR1020087007951A KR101368988B1 (en) | 2005-09-16 | 2006-09-15 | Dipeptidyl peptidase inhibitors |
CA2622642A CA2622642C (en) | 2005-09-16 | 2006-09-15 | Dipeptidyl peptidase inhibitors |
EP06814853A EP1924567B1 (en) | 2005-09-16 | 2006-09-15 | Process for the preparation of pyrimidinedione derivatives |
IL190135A IL190135A (en) | 2005-09-16 | 2008-03-12 | Process for the preparation of pyrimidinedione derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71808405P | 2005-09-16 | 2005-09-16 | |
US60/718,084 | 2005-09-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007035629A2 true WO2007035629A2 (en) | 2007-03-29 |
WO2007035629A3 WO2007035629A3 (en) | 2007-06-14 |
Family
ID=37889413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/036276 WO2007035629A2 (en) | 2005-09-16 | 2006-09-15 | Process for the preparation of pyrimidinedione derivatives |
Country Status (8)
Country | Link |
---|---|
US (1) | US8222411B2 (en) |
EP (1) | EP1924567B1 (en) |
JP (1) | JP5122462B2 (en) |
KR (1) | KR101368988B1 (en) |
CN (2) | CN102675221A (en) |
CA (1) | CA2622642C (en) |
IL (1) | IL190135A (en) |
WO (1) | WO2007035629A2 (en) |
Cited By (34)
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WO2009099172A1 (en) * | 2008-02-07 | 2009-08-13 | Takeda Pharmaceutical Company Limited | Pharmaceutical product |
WO2009099171A1 (en) * | 2008-02-07 | 2009-08-13 | Takeda Pharmaceutical Company Limited | Pharmaceutical product |
WO2010072680A1 (en) | 2008-12-23 | 2010-07-01 | Sandoz Ag | Crystalline form of an organic compound |
WO2010079197A1 (en) | 2009-01-07 | 2010-07-15 | Boehringer Ingelheim International Gmbh | Treatment of diabetes in patients with inadequate glycemic control despite metformin therapy comprising a dpp-iv inhibitor |
WO2010086411A1 (en) | 2009-01-29 | 2010-08-05 | Boehringer Ingelheim International Gmbh | Dpp-iv inhibitors for treatment of diabetes in paediatric patients |
WO2010092125A1 (en) | 2009-02-13 | 2010-08-19 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof |
WO2010092163A2 (en) | 2009-02-13 | 2010-08-19 | Boehringer Ingelheim International Gmbh | Antidiabetic medications |
WO2011064352A1 (en) | 2009-11-27 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
WO2011113947A1 (en) | 2010-03-18 | 2011-09-22 | Boehringer Ingelheim International Gmbh | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
WO2011138421A1 (en) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combination therapy |
WO2011161161A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Diabetes therapy |
EP2410855A1 (en) * | 2009-03-26 | 2012-02-01 | Mapi Pharma Limited | Process for the preparation of alogliptin |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
WO2013183784A1 (en) | 2012-06-05 | 2013-12-12 | Takeda Pharmaceutical Company Limited | Solid preparation |
CN103524483A (en) * | 2012-07-02 | 2014-01-22 | 张健 | Preparation method of alogliptin benzoate |
US8648073B2 (en) | 2009-12-30 | 2014-02-11 | Fochon Pharma, Inc. | Certain dipeptidyl peptidase inhibitors |
EP2698152A1 (en) | 2007-08-16 | 2014-02-19 | Boehringer Ingelheim International GmbH | Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivative |
WO2014127735A1 (en) * | 2013-02-22 | 2014-08-28 | 四川海思科制药有限公司 | Solid forms of trelagliptin, preparation method and applications thereof |
US8907086B2 (en) | 2011-03-03 | 2014-12-09 | Merck Sharp & Dohme Corp. | Fused bicyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors |
WO2015092739A1 (en) * | 2013-12-19 | 2015-06-25 | Mylan Laboratories Ltd. | Process for preparation of alogliptin |
WO2015092805A1 (en) * | 2013-12-18 | 2015-06-25 | Harman Finochem Limited | A process for preparation of trelagliptin succinate |
EP2760853A4 (en) * | 2011-09-26 | 2015-10-28 | Hetero Research Foundation | Novel salts of alogliptin |
EP2990037A1 (en) | 2008-08-06 | 2016-03-02 | Boehringer Ingelheim International GmbH | Treatment for diabetes in patients inappropriate for metformin therapy |
WO2016178246A1 (en) * | 2015-05-04 | 2016-11-10 | Indoco Remedies Limited | Process for the preparation of alogliptin |
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US9809569B2 (en) | 2014-03-14 | 2017-11-07 | Takeda Pharmaceutical Company Limited | Process for producing heterocyclic compound |
CN108017614A (en) * | 2018-01-25 | 2018-05-11 | 中国科学院海洋研究所 | DPP-4 inhibitor and its application in treatment diabetes B medicine is prepared |
RU2677660C2 (en) * | 2014-01-24 | 2019-01-18 | Шанхай Фокон Фармасьютикал Ко., Лтд. | CRYSTAL FORM α OF COMPOUND OF MONOBENZOATE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME |
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CN104725349A (en) * | 2013-12-23 | 2015-06-24 | 湖北华世通生物医药科技有限公司 | Polycrystalline A-type crystal of alogliptin polycrystalline, preparation method and production purpose thereof |
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CN103980249B (en) * | 2014-05-30 | 2016-01-20 | 安徽省新星药物开发有限责任公司 | A kind of process for purification of SYR-322 |
CN105315256B (en) * | 2014-07-07 | 2018-02-06 | 广州朗圣药业有限公司 | A kind of preparation method for being adapted to industrialized high-purity amber love song Ge Lieting |
WO2016024224A1 (en) * | 2014-08-11 | 2016-02-18 | Sun Pharmaceutical Industries Limited | A process for the preparation of 4-fluoro-2-methylbenzonitrile |
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US20090275750A1 (en) | 2009-11-05 |
JP2009508873A (en) | 2009-03-05 |
CN102675221A (en) | 2012-09-19 |
JP5122462B2 (en) | 2013-01-16 |
CA2622642C (en) | 2013-12-31 |
KR20080045262A (en) | 2008-05-22 |
EP1924567B1 (en) | 2012-08-22 |
US8222411B2 (en) | 2012-07-17 |
WO2007035629A3 (en) | 2007-06-14 |
IL190135A0 (en) | 2008-08-07 |
EP1924567A2 (en) | 2008-05-28 |
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