WO2007030616A3 - Composite bone graft substitute cement and articles produced therefrom - Google Patents

Composite bone graft substitute cement and articles produced therefrom Download PDF

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Publication number
WO2007030616A3
WO2007030616A3 PCT/US2006/034854 US2006034854W WO2007030616A3 WO 2007030616 A3 WO2007030616 A3 WO 2007030616A3 US 2006034854 W US2006034854 W US 2006034854W WO 2007030616 A3 WO2007030616 A3 WO 2007030616A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone graft
graft substitute
particulate composition
substitute cement
powder
Prior art date
Application number
PCT/US2006/034854
Other languages
French (fr)
Other versions
WO2007030616A2 (en
Inventor
Jon P Moseley
Michael E Carroll
Jonathan D Mccanless
Original Assignee
Wright Medical Tech Inc
Jon P Moseley
Michael E Carroll
Jonathan D Mccanless
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wright Medical Tech Inc, Jon P Moseley, Michael E Carroll, Jonathan D Mccanless filed Critical Wright Medical Tech Inc
Priority to CA2619469A priority Critical patent/CA2619469C/en
Priority to CN200680032810.9A priority patent/CN101257934B/en
Priority to BRPI0617086A priority patent/BRPI0617086B8/en
Priority to ES06803115T priority patent/ES2402651T3/en
Priority to AU2006287478A priority patent/AU2006287478B2/en
Priority to DK06803115.2T priority patent/DK1933892T3/en
Priority to JP2008530197A priority patent/JP5582702B2/en
Priority to KR1020087005643A priority patent/KR101270876B1/en
Priority to EP06803115A priority patent/EP1933892B1/en
Publication of WO2007030616A2 publication Critical patent/WO2007030616A2/en
Publication of WO2007030616A3 publication Critical patent/WO2007030616A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, including i) a calcium sulfate hemihydrate powder having a bimodal particle distribution and a median particle size of about 5 to about 20 microns, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 70 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; and iii) a β-tricalcium phosphate powder having a median particle size of less than about 20 microns. Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.
PCT/US2006/034854 2005-09-09 2006-09-08 Composite bone graft substitute cement and articles produced therefrom WO2007030616A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA2619469A CA2619469C (en) 2005-09-09 2006-09-08 Composite bone graft cement comprising calcium sulfate dihydrate and brushite
CN200680032810.9A CN101257934B (en) 2005-09-09 2006-09-08 Composite bone graft substitute cement and articles produced therefrom
BRPI0617086A BRPI0617086B8 (en) 2005-09-09 2006-09-08 bone graft substitute composite cement and articles originated from it
ES06803115T ES2402651T3 (en) 2005-09-09 2006-09-08 Cement substitute for bone graft of composite material and articles produced from it
AU2006287478A AU2006287478B2 (en) 2005-09-09 2006-09-08 Composite bone graft substitute cement and articles produced therefrom
DK06803115.2T DK1933892T3 (en) 2005-09-09 2006-09-08 Composite bone graft replacement cement and articles made therefrom
JP2008530197A JP5582702B2 (en) 2005-09-09 2006-09-08 Synthetic bone graft substitute cement and products made therefrom
KR1020087005643A KR101270876B1 (en) 2005-09-09 2006-09-08 Composite bone graft substitute cement and articles produced therefrom
EP06803115A EP1933892B1 (en) 2005-09-09 2006-09-08 Composite bone graft substitute cement and articles produced therefrom

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71554205P 2005-09-09 2005-09-09
US60/715,542 2005-09-09
US11/530,085 2006-09-08
US11/530,085 US7754246B2 (en) 2005-09-09 2006-09-08 Composite bone graft substitute cement and articles produced therefrom

Publications (2)

Publication Number Publication Date
WO2007030616A2 WO2007030616A2 (en) 2007-03-15
WO2007030616A3 true WO2007030616A3 (en) 2008-04-03

Family

ID=37744075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/034854 WO2007030616A2 (en) 2005-09-09 2006-09-08 Composite bone graft substitute cement and articles produced therefrom

Country Status (11)

Country Link
US (3) US7754246B2 (en)
EP (1) EP1933892B1 (en)
JP (1) JP5582702B2 (en)
KR (1) KR101270876B1 (en)
CN (1) CN103349793B (en)
AU (1) AU2006287478B2 (en)
BR (1) BRPI0617086B8 (en)
CA (1) CA2619469C (en)
DK (1) DK1933892T3 (en)
ES (1) ES2402651T3 (en)
WO (1) WO2007030616A2 (en)

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