WO2007028003B1 - Biologically integrated electrode devices - Google Patents

Biologically integrated electrode devices

Info

Publication number
WO2007028003B1
WO2007028003B1 PCT/US2006/034199 US2006034199W WO2007028003B1 WO 2007028003 B1 WO2007028003 B1 WO 2007028003B1 US 2006034199 W US2006034199 W US 2006034199W WO 2007028003 B1 WO2007028003 B1 WO 2007028003B1
Authority
WO
WIPO (PCT)
Prior art keywords
electrically conductive
biological component
conductive substrate
polymer
bioelectrode
Prior art date
Application number
PCT/US2006/034199
Other languages
French (fr)
Other versions
WO2007028003A2 (en
WO2007028003A3 (en
Inventor
David C Martin
Sarah Richardson-Burns
Kim Donghwan
Jeffrey L Hendricks
Laura Povlich
Mohammad Reza Abidian
Matthew Meier
Original Assignee
Univ Michigan
David C Martin
Sarah Richardson-Burns
Kim Donghwan
Jeffrey L Hendricks
Laura Povlich
Mohammad Reza Abidian
Matthew Meier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, David C Martin, Sarah Richardson-Burns, Kim Donghwan, Jeffrey L Hendricks, Laura Povlich, Mohammad Reza Abidian, Matthew Meier filed Critical Univ Michigan
Priority to JP2008529303A priority Critical patent/JP2009506836A/en
Priority to EP06824877.2A priority patent/EP1931248B1/en
Priority to AU2006284625A priority patent/AU2006284625B2/en
Priority to CA002621174A priority patent/CA2621174A1/en
Publication of WO2007028003A2 publication Critical patent/WO2007028003A2/en
Publication of WO2007028003A3 publication Critical patent/WO2007028003A3/en
Publication of WO2007028003B1 publication Critical patent/WO2007028003B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
    • A61B5/268—Bioelectric electrodes therefor characterised by the electrode materials containing conductive polymers, e.g. PEDOT:PSS polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
    • A61B5/266—Bioelectric electrodes therefor characterised by the electrode materials containing electrolytes, conductive gels or pastes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0217—Electrolyte containing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes

Abstract

Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.

Claims

received by the International Bureau on 05 October2007(05.10.2007)CLAIMSWhat is claimed is:
1. 1. A biologically integrated bioelectrode device comprising: (i) a first electrically conductive substrate; (ii) a biological component;
(iii) a dopant; and
(iv) a conjugated conductive polymer electrically coupling said first electrically conductive substrate to said biological component to collectively define a bioelectrode, said bioelectrode transmitting or receiving an electrical signal between the first electrically conductive substrate any one of said biological component and conductive polymer.
2. The biologically integrated bioelectrode device according to claim 1 , wherein said biological component includes one or more of a tissue, organic living cell, a cellular constituent or combinations thereof.
3. The biologically integrated bioelectrode device according to claim 2, wherein said organic living cell is selected from the group consisting essentially of natural or recombinant eukaryotic cells and prokaryotic cells.
4. The biologically integrated bioelectrode device according to claim 2, said cellular constituent is selected from the group consisting essentially of a membrane, an organelle, an ion-channel, a lipid bi-layer, a receptor, an enzyme, a protein, an antibody, an antigen, a nucleic acid or combinations thereof.
5. The biologically integrated bioelectrode device according to claim 3, wherein said eukaryotic cells is selected from the group consisting essentially of cardiac cells, neural cells, muscle cells, stem cells, stromal cells, hematopoietic cells and combinations thereof.
6. The biologically integrated bioelectrode device according to claim 5, wherein said neural cells comprise neurons.
7. The biologically integrated bioelectrode device according to claim 1 , wherein said bioelectrode further comprises at least one hydrogel in proximate contact with said conductive polymer.
8. The biologically integrated bioelectrode device according to claim 7, wherein said hydrogel further comprises a bioactive molecule.
9. The biologically integrated bioelectrode device according to claim 1 , wherein said conjugated conductive polymer is chosen from the group consisting essentially of copolymers and homopolymers of EDOT, pyrrole, and their functionalized derivatives
56 and copolymers, polyanilines, salt of polyaniline, polyacetylenes, polythiophenes, a poly(3,4-ethylenedithiathiophene), polymer blends thereof, hybrid polymer-metal materials and combinations thereof.
10. The biologically integrated bioelectrode device according to claim 9, wherein the polymers of EDOT and pyrrole is chosen from the group consisting essentially of poly(3,4-ethylenedioxythiophene) (PEDOT), poly(pyrrole), their derivatives and combinations thereof.
11. The biologically integrated bioelectrode device according to claim 1 , wherein said conjugated conductive polymer is polymerized around said biological component and said first electrically conductive substrate.
12. The biologically integrated bioelectrode device according to claim 1 , wherein said first electrically conductive substrate contains a conductor chosen from the group consisting essentially of gold, silver, platinum, palladium, tungsten, nickel, titanium, indium tin oxide, copper, carbon, carbon black, carbon fiber, carbon paste, graphite, doped silicon, ceramic, conductive polymer, and combinations thereof.
13. The biologically integrated bioelectrode device according to claim 1 , wherein said bioelectrode further comprises one or more dopants participating in polymerization of the conjugated conducting polymer and transmitting or receiving said electrical signal between the first electrically conductive substrate and said conductive polymer.
14. The biologically integrated bioelectrode device according to claim 1 , further comprising a second electrically conductive substrate.
15. The biologically integrated bioelectrode device according to claim 1 , further comprising an electrical source of power or current operable to communicate with said first and second electrode substrates and the biological component using one or more electrical signals with the device.
16. A biologically compatible electrode comprising:
(a) an electrically conductive substrate;
(b) a dopant; and
(c) a coating on at least some portion of at least one surface of said electrically conductive substrate, the coating comprising:
(i) a biological component, and
(ii) a conjugated conductive polymer, wherein at least some of said conjugated conductive polymer is disposed and polymerized in proximate contact with said biological component and the electrically conductive substrate.
57
17. A biocompatible and biomimetic coating for an electrically conductive substrate comprising:
(a) an electrically conjugated conductive polymer, and
(b) a biological component, wherein at least some of said electrically conjugated conductive polymer is disposed and polymerized in proximate contact with said biological component and the electrically conductive substrate.
18. The biocompatible and biomimetic coating according to claim 17, wherein said coating is applied to microelectrode arrays, lab on chip devices and target analyte detection devices.
19. A method of electrically detecting a transfer of electrical signals between living cells, comprising the steps:
(a) providing a bioelectrode device comprising a first electrically conductive substrate in intimate contact with tissue capable of transferring electronic charge, said bioelectrode device comprising:
(i) a first electrically conductive substrate; (ii) a biological component; and
(iii) a conjugated conductive polymer electrically coupling said first electrically conductive substrate to said biological component to collectively define a bioelectrode, said bioelectrode transmitting or receiving an electrical signal between said first electrically conductive substrate any one of said biological component and conjugated conductive polymer,
(b) electrically connecting said bioelectrode device and a second electrically conductive substrate electrically coupled with said bioelectrode to a power source; and (c) applying a voltage or current across said first and second electrically conductive substrates, thereby inducing a voltage or current across said conjugated conductive polymer;
(d) detecting the transfer of electrical signals with said bioelectrode device.
20. The method according to claim 19, wherein step (a)(ii) providing a bioelectrode device comprising a biological component, said biological component is chosen from the group consisting essentially of cardiac cells, neural cells and muscle cells.
21. The method according to claim 19, wherein the detecting step (c) comprises detecting the transfer of electrical signals wherein said signal is selected from the group consisting essentially of impedance, resistance, capacitance, inductance, and current.
58
22. The method according to claim 19, wherein said conjugated conductive polymer is chosen from the group consisting essentially of copolymers and homopolymers of EDOT, pyrrole, and their functionalized derivatives and copolymers, polyanilines, salt of polyaniline, polyacetylenes, polythiophenes, a poly(3,4-ethylenedithiathiophene), polymer blends thereof, hybrid polymer-metal materials and combinations thereof.
23. The method according to claim 22, wherein the copolymers and homopolymers of EDOT and pyrrole is chosen from the group consisting essentially of poly(3,4- ethylenedioxythiophene) (PEDOT), poly(pyrrole), and combinations thereof.
24. A method of detecting a biological material in a liquid or gas comprising the steps of:
(a) disposing a first and second electrically conductive substrate on a support;
(b) applying a conducting gel comprising a biological component, a hydrogel and a conductive monomer to form a layer on a portion of said first electrically conductive substrate;
(c) polymerizing said conductive monomer to form a conducting gel layer comprising conjugated conducting polymer polymerized around said biological component;
(d) providing a receptacle containing a sample comprising a target analyte to be analyzed;
(e) contacting said first electrode and second electrode with said sample to be analyzed in said receptacle, whereby the specific binding of the target analyte to biological component results in a measurable electronic charge difference on the surface of said biological component which is transduced to the conjugated conducting polymer after applying an effective amount of current or voltage for a sufficient time to said first and second electrically conductive substrates; and
(f) detecting said difference in electronic charge transduced to the conjugated conductive polymer.
25. The method according to claim 24, wherein the difference in electronic charge transduced to the conjugated conductive polymer is detected by measuring any one of impedance, resistance, capacitance, inductance, current potential, and combinations thereof.
26. The method according to claim 24, wherein the conductive monomer polymerized in step (d) is chosen from the group consisting essentially of copolymers and homopolymers of EDOT, pyrrole, and their functionalized derivatives, polyanilines,
59 salt of polyaniline, polyacetylenes, polythiophenes, a poly(3,4-ethylenedithiathi-ophene), polymer blends thereof, hybrid polymer-metal materials and combinations thereof.
27. The method according to claim 24, wherein said conjugated conducting polymer is electrochemically polymerized.
28. The method according to claim 24, wherein the polymerizing and detecting step further comprises connecting the first and second electrically conductive substrates to one or more electrical leads connected to any one of a source of power, galvanostatic current, potentiostatic current or combinations thereof.
29. The method according to claim 24, wherein said step of applying a conducting gel comprising a biological component, said biological component includes one or more of: a tissue, a cell, a membrane, an organelle, an ion-channel, a lipid bi-layer, a receptor, a receptor fragment, a protein, an enzyme, an antibody, a nucleic acid or a derivatised nucleic acid.
30. The method according to claim 24, wherein said step of applying a conducting gel, said gel further comprises one or more dopants is selected from the group consisting essentially of poly(styrene sulfonate), LiCIO4, Phosphate-buffered saline, Hank's Balanced Salt Solution, Collagen, Poly-D-Lysine, Poly-L-Lysine, bioactive molecule and poly-ornithine.
31. A biologically integrated bioelectrode device comprising conducting polymer in proximate contact with a first electrically conductive substrate and at least one biological component formed by the steps of:
(a) contacting said biological component with said first electrically conductive substrate, said first electrically conductive substrate chosen from the group consisting essentially of metals, ceramics, carbon, conductive polymers and combinations thereof so as to form a biologically interfaced electrode;
(b) immersing said biologically interfaced electrode in a solution comprising conducting monomer and dopant; and
(c) polymerizing said monomer around said biologically interfaced electrode by inserting a second electrically conductive substrate into said solution of step (b) and applying galvanostatic or potentiostatic current to said first and second electrically conductive substrates for a sufficient time to coat the biologically interfaced electrode with conductive polymer.
60
PCT/US2006/034199 2005-08-31 2006-08-31 Biologically integrated electrode devices WO2007028003A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008529303A JP2009506836A (en) 2005-08-31 2006-08-31 Biologically integrated electrode device
EP06824877.2A EP1931248B1 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices
AU2006284625A AU2006284625B2 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices
CA002621174A CA2621174A1 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71307005P 2005-08-31 2005-08-31
US60/713,070 2005-08-31
US11/512,479 US8005526B2 (en) 2005-08-31 2006-08-30 Biologically integrated electrode devices
US11/512,479 2006-08-30

Publications (3)

Publication Number Publication Date
WO2007028003A2 WO2007028003A2 (en) 2007-03-08
WO2007028003A3 WO2007028003A3 (en) 2007-10-11
WO2007028003B1 true WO2007028003B1 (en) 2007-11-29

Family

ID=37809567

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/034199 WO2007028003A2 (en) 2005-08-31 2006-08-31 Biologically integrated electrode devices

Country Status (6)

Country Link
US (1) US8005526B2 (en)
EP (2) EP2514359A3 (en)
JP (1) JP2009506836A (en)
AU (1) AU2006284625B2 (en)
CA (1) CA2621174A1 (en)
WO (1) WO2007028003A2 (en)

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