WO2006103657A3 - A solid composition for intra-oral delivery of insulin - Google Patents

A solid composition for intra-oral delivery of insulin Download PDF

Info

Publication number
WO2006103657A3
WO2006103657A3 PCT/IL2006/000381 IL2006000381W WO2006103657A3 WO 2006103657 A3 WO2006103657 A3 WO 2006103657A3 IL 2006000381 W IL2006000381 W IL 2006000381W WO 2006103657 A3 WO2006103657 A3 WO 2006103657A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
intra
solid composition
oral delivery
phospholipid
Prior art date
Application number
PCT/IL2006/000381
Other languages
French (fr)
Other versions
WO2006103657A2 (en
Inventor
Adel Pinhasi
Mila Gomberg
Original Assignee
Dexcel Pharma Technologies Ltd
Adel Pinhasi
Mila Gomberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL174387A external-priority patent/IL174387A0/en
Application filed by Dexcel Pharma Technologies Ltd, Adel Pinhasi, Mila Gomberg filed Critical Dexcel Pharma Technologies Ltd
Priority to US11/887,653 priority Critical patent/US20090274758A1/en
Publication of WO2006103657A2 publication Critical patent/WO2006103657A2/en
Publication of WO2006103657A3 publication Critical patent/WO2006103657A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Abstract

The invention provides a solid composition for intra-oral delivery of insulin, comprising; insulin; a hydrophilic polymer matrix; and a phospholipid, providing insulin bioavailability of at least 5%.
PCT/IL2006/000381 2005-03-31 2006-03-27 A solid composition for intra-oral delivery of insulin WO2006103657A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/887,653 US20090274758A1 (en) 2005-03-31 2006-03-27 Solid Composition for Intra-Oral Delivery of Insulin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66658105P 2005-03-31 2005-03-31
US60/666,581 2005-03-31
IL174387A IL174387A0 (en) 2005-03-31 2006-03-19 A solid composition for intra-oral delivery of insulin
IL174,387 2006-03-19

Publications (2)

Publication Number Publication Date
WO2006103657A2 WO2006103657A2 (en) 2006-10-05
WO2006103657A3 true WO2006103657A3 (en) 2007-05-31

Family

ID=36717145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/000381 WO2006103657A2 (en) 2005-03-31 2006-03-27 A solid composition for intra-oral delivery of insulin

Country Status (1)

Country Link
WO (1) WO2006103657A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883201B2 (en) 2006-04-07 2014-11-11 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US8999383B2 (en) 2008-05-07 2015-04-07 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1980240A1 (en) * 2007-04-11 2008-10-15 Cephalon France Lyophilized pharmaceutical compositions and methods of making and using same
EP2164466A1 (en) * 2007-06-01 2010-03-24 Novo Nordisk A/S Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
PL2910570T3 (en) 2008-03-18 2017-06-30 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
WO2010020978A1 (en) 2008-08-18 2010-02-25 Oramed Pharmaceuticals Ltd Methods and compositions for oral administration of proteins
EP2526971A1 (en) 2011-05-25 2012-11-28 ArisGen SA Mucosal delivery of drugs
AU2013247047A1 (en) 2012-04-11 2014-10-23 Novo Nordisk A/S Insulin formulations
WO2015188946A1 (en) 2014-06-13 2015-12-17 Fricker, Gert Matrix stabilized liposomes
RU2665367C2 (en) * 2014-11-12 2018-08-29 Общество с ограниченной ответственностью "Изварино Фарма" Preoral delivery system for protein substance (options), protective coating for delivery system (options)
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
CN110087674B (en) 2016-12-16 2023-01-03 诺和诺德股份有限公司 Pharmaceutical composition containing insulin
CN110464835B (en) * 2018-05-11 2023-06-16 中国医学科学院药物研究所 Insulin flexible particles and preparation thereof
US20210386858A1 (en) * 2019-02-19 2021-12-16 Bluepharma - Industria Farmacêutica, S.A. Mucoadhesive compositions and uses thereof
WO2021029467A1 (en) * 2019-08-14 2021-02-18 Sam Chun Dang Pharm. Co., Ltd. A solid dosage form for orally administration

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
WO2000033817A1 (en) * 1998-12-08 2000-06-15 Phares Pharmaceutical Research N.V. Phospholipid compositions
WO2004041118A2 (en) * 2002-10-31 2004-05-21 Umd, Inc. Therapeutic compositions for drug delivery to and through covering epithelia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
WO2000033817A1 (en) * 1998-12-08 2000-06-15 Phares Pharmaceutical Research N.V. Phospholipid compositions
WO2004041118A2 (en) * 2002-10-31 2004-05-21 Umd, Inc. Therapeutic compositions for drug delivery to and through covering epithelia

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DE GIM I TUNCER ET AL: "ORAL ADMINISTRATION OF LIPOSOMAL INSULIN", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, AMERICAN SCIENTIFIC PUBLISHERS, US, vol. 6, no. 9-10, September 2006 (2006-09-01), pages 2945 - 2949, XP009078004, ISSN: 1533-4880 *
DUBOLAZOV ARTEM V ET AL: "Design of mucoadhesive polymeric films based on blends of poly(acrylic acid) and (hydroxypropyl)cellulose", BIOMACROMOLECULES, vol. 7, no. 5, May 2006 (2006-05-01), pages 1637 - 1643, XP002419441, ISSN: 1525-7797 *
IWANAGA K ET AL: "APPLICATION OF SURFACE-COATED LIPOSOMES FOR ORAL DELIVERY OF PEPTIDE: EFFECTS OF COATING THE LIPOSOME'S SURFACE ON THE GL TRANSIT OF INSULIN", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 88, no. 2, February 1999 (1999-02-01), pages 248 - 252, XP000792262, ISSN: 0022-3549 *
LAÏLA BOULMEDARAT ET AL: "Cyclodextrin-Mediated Drug Release from Liposomes Dispersed Within a Bioadhesive Gel", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 22, no. 6, 1 June 2005 (2005-06-01), pages 962 - 971, XP019370873, ISSN: 1573-904X *
TAKEUCHI H ET AL: "ENTERAL ABSORPTION OF INSULIN IN RATS FROM MUCOADHESIVE CHITOSAN- COATED LIPOSOMES", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 13, no. 6, June 1996 (1996-06-01), pages 896 - 901, XP002055070, ISSN: 0724-8741 *
TAO S L ET AL: "Gastrointestinal patch systems for oral drug delivery", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 10, no. 13, 1 July 2005 (2005-07-01), pages 909 - 915, XP004966897, ISSN: 1359-6446 *
YANG T-Z ET AL: "PHOSPHOLIPID DEFORMABLE VESCILES FOR BUCCAL DELIVERY OF INSULIN", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 50, no. 6, 2002, pages 749 - 753, XP001116742, ISSN: 0009-2363 *
ZHANG N ET AL: "Investigation of lectin-modified insulin liposomes as carriers for oral administration", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 294, no. 1-2, 27 April 2005 (2005-04-27), pages 247 - 259, XP004825478, ISSN: 0378-5173 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883201B2 (en) 2006-04-07 2014-11-11 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US8883203B2 (en) 2006-04-07 2014-11-11 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US8999383B2 (en) 2008-05-07 2015-04-07 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration

Also Published As

Publication number Publication date
WO2006103657A2 (en) 2006-10-05

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