WO2006102395A3 - Delivery systems and methods for diagnosing and treating cardiovascular diseases - Google Patents

Delivery systems and methods for diagnosing and treating cardiovascular diseases Download PDF

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Publication number
WO2006102395A3
WO2006102395A3 PCT/US2006/010371 US2006010371W WO2006102395A3 WO 2006102395 A3 WO2006102395 A3 WO 2006102395A3 US 2006010371 W US2006010371 W US 2006010371W WO 2006102395 A3 WO2006102395 A3 WO 2006102395A3
Authority
WO
WIPO (PCT)
Prior art keywords
relates
diagnosing
methods
delivery systems
cardiovascular diseases
Prior art date
Application number
PCT/US2006/010371
Other languages
French (fr)
Other versions
WO2006102395A2 (en
Inventor
Stephen E Epstein
Mary Susan Burnett
Martin A Mullins
Original Assignee
Medstar Health Inc
Univ Georgetown
Stephen E Epstein
Mary Susan Burnett
Martin A Mullins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medstar Health Inc, Univ Georgetown, Stephen E Epstein, Mary Susan Burnett, Martin A Mullins filed Critical Medstar Health Inc
Priority to EP06739249A priority Critical patent/EP1866416A2/en
Priority to JP2008503125A priority patent/JP2008534508A/en
Priority to CA002602946A priority patent/CA2602946A1/en
Priority to AU2006227133A priority patent/AU2006227133A1/en
Publication of WO2006102395A2 publication Critical patent/WO2006102395A2/en
Publication of WO2006102395A3 publication Critical patent/WO2006102395A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/221—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The invention relates relates to pharmaceutical compositions comprising a phosphorylcholine conjugate, or an antibiody preparation, for example a monoclonal antibody, with specificity to a phosphorylcholine conjugate, and the use of these compositions in the treatment or prevention of atherosclerosis, for example in the treatment, prevention or reduction of further progression of atherosclerosis. Furthermore, the invention also relates to the use of phoshorylcholine conjugates or said antibody preparation, for example monoclonal antibody to produce a pharmaceutical composition optionally with an adjuvant. Furthermore the invention relates to diagnosing the presence or absence of antibodies, for example IgM or IgG antibodies, related to increased or decreased risk of developing ischemic cardivascular diseases.
PCT/US2006/010371 2005-03-22 2006-03-22 Delivery systems and methods for diagnosing and treating cardiovascular diseases WO2006102395A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP06739249A EP1866416A2 (en) 2005-03-22 2006-03-22 Delivery systems and methods for diagnosing and treating cardiovascular diseases
JP2008503125A JP2008534508A (en) 2005-03-22 2006-03-22 Delivery system and method for diagnosing and treating cardiovascular disease
CA002602946A CA2602946A1 (en) 2005-03-22 2006-03-22 Delivery systems and methods for diagnosing and treating cardiovascular diseases
AU2006227133A AU2006227133A1 (en) 2005-03-22 2006-03-22 Delivery systems and methods for diagnosing and treating cardiovascular diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66430005P 2005-03-22 2005-03-22
US60/664,300 2005-03-22

Publications (2)

Publication Number Publication Date
WO2006102395A2 WO2006102395A2 (en) 2006-09-28
WO2006102395A3 true WO2006102395A3 (en) 2007-05-10

Family

ID=36930417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/010371 WO2006102395A2 (en) 2005-03-22 2006-03-22 Delivery systems and methods for diagnosing and treating cardiovascular diseases

Country Status (6)

Country Link
EP (1) EP1866416A2 (en)
JP (1) JP2008534508A (en)
CN (1) CN101189339A (en)
AU (1) AU2006227133A1 (en)
CA (1) CA2602946A1 (en)
WO (1) WO2006102395A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9066978B2 (en) 2010-05-26 2015-06-30 Selecta Biosciences, Inc. Dose selection of adjuvanted synthetic nanocarriers

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GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
EP1964571B1 (en) * 2007-03-01 2012-05-02 CSL Limited Treatment of endothelial dysfunction in diabetic patients
US7956035B2 (en) 2007-03-01 2011-06-07 Csl Limited Treatment of endothelial dysfunction in diabetic patients
WO2008124639A2 (en) * 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
CN101688252A (en) * 2007-07-11 2010-03-31 皇家飞利浦电子股份有限公司 In vivo expression analysis using ultrasound-induced transfection of reporter constructs
EP2019318A1 (en) * 2007-07-27 2009-01-28 Erasmus University Medical Center Rotterdam Protein markers for cardiovascular events
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
AU2010244431B2 (en) * 2009-05-05 2015-05-14 Lumito Ab A system, method, and luminescent marker for improved diffuse luminescent imaging or tomography in scattering media
AU2010254551B2 (en) 2009-05-27 2016-10-20 Selecta Biosciences, Inc. Immunomodulatory agent-polymeric compounds
JP5463549B2 (en) * 2009-09-08 2014-04-09 学校法人福岡大学 Liposomes for ultrasound therapy and liposomes for promoting ultrasound therapy
WO2011133685A2 (en) * 2010-04-21 2011-10-27 President And Fellows Of Harvard College Nanoparticle targeting to ischemia for imaging and therapy
US20120021010A1 (en) * 2010-04-29 2012-01-26 University Of Calcutta Antiplatelet agent and methods of using the same
WO2012047584A2 (en) * 2010-09-27 2012-04-12 Janssen Biotech, Inc. Macaca fascicularis ccl17
US20130028857A1 (en) 2011-07-29 2013-01-31 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
CN102657875B (en) * 2012-04-11 2013-09-04 中国人民解放军第三军医大学第二附属医院 ANT1 gene-based targeted immunoliposome, preparation method thereof and application thereof
CN103006538A (en) * 2012-11-09 2013-04-03 叶琳 Ultrasonic microbubbles for treating arthritis and use thereof
US9693958B2 (en) 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
WO2014189306A1 (en) * 2013-05-22 2014-11-27 메타볼랩(주) Anti-tnf-α/cxcl10 double-targeting antibody and use thereof
WO2015026884A1 (en) * 2013-08-21 2015-02-26 Boehringer Ingelheim International Gmbh Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease
CN105950660B (en) * 2016-06-27 2019-11-01 姚陈 Adenovirus vector and its application of one species specificity inhibition smooth muscle cell proliferation and migration
CN106474487A (en) * 2016-11-14 2017-03-08 中国人民解放军总医院 A kind of targeting fluorescence medicament-carried nano molecular probe and its preparation method and application
TW201829448A (en) 2016-12-15 2018-08-16 大陸商深圳瑞健生命科學硏究院有限公司 Method and drug for preventing and treating obesity
EP3556387A4 (en) * 2016-12-15 2020-09-09 Talengen International Limited Method for preventing and treating lipid metabolism disorders and related diseases thereof
CA3047175A1 (en) * 2016-12-15 2018-06-21 Talengen International Limited Method for mitigating heart disease
WO2019215300A1 (en) 2018-05-09 2019-11-14 Medirista Biotechnologies Ab Antibodies for use in combination therapy
CN109061139A (en) * 2018-06-19 2018-12-21 温州医科大学附属第医院 Application of the serum inflammatory biomarker in prevention and treatment acute cerebral ischemic infarction
CN114364383A (en) * 2019-06-05 2022-04-15 微脉管治疗有限公司 Compositions and methods for detecting and treating thrombosis and vascular plaque
CN110201194A (en) * 2019-07-23 2019-09-06 山东百多安医疗器械有限公司 A kind of load medicine contrast microbubbles and preparation method thereof for treating atherosclerotic plaque

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9066978B2 (en) 2010-05-26 2015-06-30 Selecta Biosciences, Inc. Dose selection of adjuvanted synthetic nanocarriers

Also Published As

Publication number Publication date
EP1866416A2 (en) 2007-12-19
CN101189339A (en) 2008-05-28
AU2006227133A1 (en) 2006-09-28
JP2008534508A (en) 2008-08-28
WO2006102395A2 (en) 2006-09-28
CA2602946A1 (en) 2006-09-28

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