WO2006084112A3 - Implantable biomedical devices including biocompatible polyurethanes - Google Patents

Implantable biomedical devices including biocompatible polyurethanes Download PDF

Info

Publication number
WO2006084112A3
WO2006084112A3 PCT/US2006/003813 US2006003813W WO2006084112A3 WO 2006084112 A3 WO2006084112 A3 WO 2006084112A3 US 2006003813 W US2006003813 W US 2006003813W WO 2006084112 A3 WO2006084112 A3 WO 2006084112A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyurethane materials
disclosed
chain extenders
linking
cross
Prior art date
Application number
PCT/US2006/003813
Other languages
French (fr)
Other versions
WO2006084112A2 (en
Inventor
Jianrong Feng
Matthew R Gevaert
Martine Laberge
Original Assignee
Univ Clemson
Thordon Bearings Inc
Jianrong Feng
Matthew R Gevaert
Martine Laberge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Clemson, Thordon Bearings Inc, Jianrong Feng, Matthew R Gevaert, Martine Laberge filed Critical Univ Clemson
Publication of WO2006084112A2 publication Critical patent/WO2006084112A2/en
Publication of WO2006084112A3 publication Critical patent/WO2006084112A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/44—Polycarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4205—Polycondensates having carboxylic or carbonic ester groups in the main chain containing cyclic groups
    • C08G18/423—Polycondensates having carboxylic or carbonic ester groups in the main chain containing cyclic groups containing cycloaliphatic groups
    • C08G18/4233—Polycondensates having carboxylic or carbonic ester groups in the main chain containing cyclic groups containing cycloaliphatic groups derived from polymerised higher fatty acids or alcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • C08L75/06—Polyurethanes from polyesters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/06—Polyethene

Abstract

Disclosed are implantable devices that include biocompatible polyurethane materials. In particular, the disclosed polyurethane materials can maintain desired elastomeric characteristics while exhibiting thermoset-like behavior and can exhibit improved characteristics so as to be suitable in load-bearing applications. For example, the disclosed polyurethane materials can be suitable for use in artificial joints, including total joint replacement applications. The disclosed polyurethane materials include biocompatible cross-linking agents as chain extenders, more particularly chain extenders comprising a terminal group capable of side reactions and further comprising an electron withdrawing group immediately adjacent the terminal group. In addition, the reaction materials and conditions can be selected to encourage intermediate levels of cross-linking without the use of traditional cross-linking trifunctional reagents. In addition, the chain extenders can also include substantially inflexible moieties so as to increase the rigidity of the product polyurethanes.
PCT/US2006/003813 2005-02-04 2006-02-02 Implantable biomedical devices including biocompatible polyurethanes WO2006084112A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/051,992 US20060178497A1 (en) 2005-02-04 2005-02-04 Implantable biomedical devices including biocompatible polyurethanes
US11/051,992 2005-02-04

Publications (2)

Publication Number Publication Date
WO2006084112A2 WO2006084112A2 (en) 2006-08-10
WO2006084112A3 true WO2006084112A3 (en) 2007-02-15

Family

ID=36777957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/003813 WO2006084112A2 (en) 2005-02-04 2006-02-02 Implantable biomedical devices including biocompatible polyurethanes

Country Status (2)

Country Link
US (1) US20060178497A1 (en)
WO (1) WO2006084112A2 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8407067B2 (en) 2007-04-17 2013-03-26 Biomet Manufacturing Corp. Method and apparatus for manufacturing an implant
US9339278B2 (en) 2006-02-27 2016-05-17 Biomet Manufacturing, Llc Patient-specific acetabular guides and associated instruments
US8608748B2 (en) 2006-02-27 2013-12-17 Biomet Manufacturing, Llc Patient specific guides
US8473305B2 (en) 2007-04-17 2013-06-25 Biomet Manufacturing Corp. Method and apparatus for manufacturing an implant
US8377066B2 (en) 2006-02-27 2013-02-19 Biomet Manufacturing Corp. Patient-specific elbow guides and associated methods
US8568487B2 (en) 2006-02-27 2013-10-29 Biomet Manufacturing, Llc Patient-specific hip joint devices
US8535387B2 (en) 2006-02-27 2013-09-17 Biomet Manufacturing, Llc Patient-specific tools and implants
US10278711B2 (en) 2006-02-27 2019-05-07 Biomet Manufacturing, Llc Patient-specific femoral guide
US8133234B2 (en) * 2006-02-27 2012-03-13 Biomet Manufacturing Corp. Patient specific acetabular guide and method
US9918740B2 (en) 2006-02-27 2018-03-20 Biomet Manufacturing, Llc Backup surgical instrument system and method
US8282646B2 (en) 2006-02-27 2012-10-09 Biomet Manufacturing Corp. Patient specific knee alignment guide and associated method
US8092465B2 (en) 2006-06-09 2012-01-10 Biomet Manufacturing Corp. Patient specific knee alignment guide and associated method
US8241293B2 (en) 2006-02-27 2012-08-14 Biomet Manufacturing Corp. Patient specific high tibia osteotomy
US8603180B2 (en) 2006-02-27 2013-12-10 Biomet Manufacturing, Llc Patient-specific acetabular alignment guides
US8858561B2 (en) 2006-06-09 2014-10-14 Blomet Manufacturing, LLC Patient-specific alignment guide
US9173661B2 (en) 2006-02-27 2015-11-03 Biomet Manufacturing, Llc Patient specific alignment guide with cutting surface and laser indicator
US9289253B2 (en) 2006-02-27 2016-03-22 Biomet Manufacturing, Llc Patient-specific shoulder guide
US9113971B2 (en) 2006-02-27 2015-08-25 Biomet Manufacturing, Llc Femoral acetabular impingement guide
US8608749B2 (en) 2006-02-27 2013-12-17 Biomet Manufacturing, Llc Patient-specific acetabular guides and associated instruments
US8070752B2 (en) 2006-02-27 2011-12-06 Biomet Manufacturing Corp. Patient specific alignment guide and inter-operative adjustment
US7967868B2 (en) 2007-04-17 2011-06-28 Biomet Manufacturing Corp. Patient-modified implant and associated method
US9907659B2 (en) 2007-04-17 2018-03-06 Biomet Manufacturing, Llc Method and apparatus for manufacturing an implant
US20150335438A1 (en) 2006-02-27 2015-11-26 Biomet Manufacturing, Llc. Patient-specific augments
US8298237B2 (en) 2006-06-09 2012-10-30 Biomet Manufacturing Corp. Patient-specific alignment guide for multiple incisions
US9345548B2 (en) 2006-02-27 2016-05-24 Biomet Manufacturing, Llc Patient-specific pre-operative planning
US8864769B2 (en) 2006-02-27 2014-10-21 Biomet Manufacturing, Llc Alignment guides with patient-specific anchoring elements
US8591516B2 (en) 2006-02-27 2013-11-26 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US9795399B2 (en) 2006-06-09 2017-10-24 Biomet Manufacturing, Llc Patient-specific knee alignment guide and associated method
DE102007031669A1 (en) * 2006-08-04 2008-09-11 Ceramtec Ag Innovative Ceramic Engineering Asymmetrical design of acetabular cups to reduce cup deformations
US20080097606A1 (en) * 2006-10-19 2008-04-24 Cragg Andrew H Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
US20090035350A1 (en) * 2007-08-03 2009-02-05 John Stankus Polymers for implantable devices exhibiting shape-memory effects
US8170641B2 (en) 2009-02-20 2012-05-01 Biomet Manufacturing Corp. Method of imaging an extremity of a patient
CA2706233C (en) * 2009-06-04 2015-05-05 Howmedica Osteonics Corp. Orthopedic peek-on-polymer bearings
DE102009028503B4 (en) 2009-08-13 2013-11-14 Biomet Manufacturing Corp. Resection template for the resection of bones, method for producing such a resection template and operation set for performing knee joint surgery
DE102009046525B4 (en) * 2009-11-09 2012-04-26 Charité - Universitätsmedizin Berlin Method and kit for testing various selected materials and / or surface structures for the culture of cells
US8632547B2 (en) 2010-02-26 2014-01-21 Biomet Sports Medicine, Llc Patient-specific osteotomy devices and methods
US9066727B2 (en) 2010-03-04 2015-06-30 Materialise Nv Patient-specific computed tomography guides
US9271744B2 (en) 2010-09-29 2016-03-01 Biomet Manufacturing, Llc Patient-specific guide for partial acetabular socket replacement
US9968376B2 (en) 2010-11-29 2018-05-15 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US9241745B2 (en) 2011-03-07 2016-01-26 Biomet Manufacturing, Llc Patient-specific femoral version guide
US8715289B2 (en) 2011-04-15 2014-05-06 Biomet Manufacturing, Llc Patient-specific numerically controlled instrument
US9675400B2 (en) 2011-04-19 2017-06-13 Biomet Manufacturing, Llc Patient-specific fracture fixation instrumentation and method
US8668700B2 (en) 2011-04-29 2014-03-11 Biomet Manufacturing, Llc Patient-specific convertible guides
US8956364B2 (en) 2011-04-29 2015-02-17 Biomet Manufacturing, Llc Patient-specific partial knee guides and other instruments
US8532807B2 (en) 2011-06-06 2013-09-10 Biomet Manufacturing, Llc Pre-operative planning and manufacturing method for orthopedic procedure
US9084618B2 (en) 2011-06-13 2015-07-21 Biomet Manufacturing, Llc Drill guides for confirming alignment of patient-specific alignment guides
US20130001121A1 (en) 2011-07-01 2013-01-03 Biomet Manufacturing Corp. Backup kit for a patient-specific arthroplasty kit assembly
US8764760B2 (en) 2011-07-01 2014-07-01 Biomet Manufacturing, Llc Patient-specific bone-cutting guidance instruments and methods
US8597365B2 (en) 2011-08-04 2013-12-03 Biomet Manufacturing, Llc Patient-specific pelvic implants for acetabular reconstruction
US9066734B2 (en) 2011-08-31 2015-06-30 Biomet Manufacturing, Llc Patient-specific sacroiliac guides and associated methods
US9295497B2 (en) 2011-08-31 2016-03-29 Biomet Manufacturing, Llc Patient-specific sacroiliac and pedicle guides
US9386993B2 (en) 2011-09-29 2016-07-12 Biomet Manufacturing, Llc Patient-specific femoroacetabular impingement instruments and methods
US9554910B2 (en) 2011-10-27 2017-01-31 Biomet Manufacturing, Llc Patient-specific glenoid guide and implants
EP3384858A1 (en) 2011-10-27 2018-10-10 Biomet Manufacturing, LLC Patient-specific glenoid guides
KR20130046337A (en) 2011-10-27 2013-05-07 삼성전자주식회사 Multi-view device and contol method thereof, display apparatus and contol method thereof, and display system
US9301812B2 (en) 2011-10-27 2016-04-05 Biomet Manufacturing, Llc Methods for patient-specific shoulder arthroplasty
US9451973B2 (en) 2011-10-27 2016-09-27 Biomet Manufacturing, Llc Patient specific glenoid guide
US9237950B2 (en) 2012-02-02 2016-01-19 Biomet Manufacturing, Llc Implant with patient-specific porous structure
EP2636452A1 (en) * 2012-03-06 2013-09-11 Greiner Bio-One GmbH Spotting plate and process for its production
US9204977B2 (en) 2012-12-11 2015-12-08 Biomet Manufacturing, Llc Patient-specific acetabular guide for anterior approach
US9060788B2 (en) 2012-12-11 2015-06-23 Biomet Manufacturing, Llc Patient-specific acetabular guide for anterior approach
US9839438B2 (en) 2013-03-11 2017-12-12 Biomet Manufacturing, Llc Patient-specific glenoid guide with a reusable guide holder
US9579107B2 (en) 2013-03-12 2017-02-28 Biomet Manufacturing, Llc Multi-point fit for patient specific guide
US9498233B2 (en) 2013-03-13 2016-11-22 Biomet Manufacturing, Llc. Universal acetabular guide and associated hardware
US9826981B2 (en) 2013-03-13 2017-11-28 Biomet Manufacturing, Llc Tangential fit of patient-specific guides
US9517145B2 (en) 2013-03-15 2016-12-13 Biomet Manufacturing, Llc Guide alignment system and method
US20150112349A1 (en) 2013-10-21 2015-04-23 Biomet Manufacturing, Llc Ligament Guide Registration
US10282488B2 (en) 2014-04-25 2019-05-07 Biomet Manufacturing, Llc HTO guide with optional guided ACL/PCL tunnels
US9408616B2 (en) 2014-05-12 2016-08-09 Biomet Manufacturing, Llc Humeral cut guide
US9839436B2 (en) 2014-06-03 2017-12-12 Biomet Manufacturing, Llc Patient-specific glenoid depth control
US9561040B2 (en) 2014-06-03 2017-02-07 Biomet Manufacturing, Llc Patient-specific glenoid depth control
US9826994B2 (en) 2014-09-29 2017-11-28 Biomet Manufacturing, Llc Adjustable glenoid pin insertion guide
US9833245B2 (en) 2014-09-29 2017-12-05 Biomet Sports Medicine, Llc Tibial tubercule osteotomy
US9820868B2 (en) 2015-03-30 2017-11-21 Biomet Manufacturing, Llc Method and apparatus for a pin apparatus
US10226262B2 (en) 2015-06-25 2019-03-12 Biomet Manufacturing, Llc Patient-specific humeral guide designs
US10568647B2 (en) 2015-06-25 2020-02-25 Biomet Manufacturing, Llc Patient-specific humeral guide designs
US10722310B2 (en) 2017-03-13 2020-07-28 Zimmer Biomet CMF and Thoracic, LLC Virtual surgery planning system and method
CN115064206B (en) * 2022-06-07 2023-08-08 浙江高裕家居科技股份有限公司 Polyurethane elastomer optimization method and system based on performance evaluation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631298A (en) * 1985-12-16 1986-12-23 Ethyl Corporation Mixed diamine chain extender
US5599874A (en) * 1993-08-25 1997-02-04 Caterpillar Inc. Thermoplastic polyurethane elastomer based on a hydroxyl terminated polyol, an aromatic chain extender and 1,5 naphthalene diisocyanate
US6103851A (en) * 1997-09-26 2000-08-15 The Dow Chemical Company High service temperature polyurethane compositions
US6302916B1 (en) * 1998-12-24 2001-10-16 Biopro, Inc. Polyurethane and so forth containing joints

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2547866A1 (en) * 1975-10-25 1977-05-05 Basf Ag HEAT-RESISTANT POLYURETHANE ELASTOMERS
US4570270A (en) * 1982-09-20 1986-02-18 Oechsle Iii Sixtus J Polyurethane compositions and their use as luting agents
US4672094A (en) * 1986-01-21 1987-06-09 The Dow Chemical Company Method for increasing the molecular weight of polyamides and polyesteramides
US4735982A (en) * 1986-07-25 1988-04-05 The B. F. Goodrich Company Thermoplastic-rubber polymer alloys and method for producing the same
US4873308A (en) * 1988-09-30 1989-10-10 Medtronic, Inc. Biostable, segmented aliphatic polyurethanes and process therefor
CA2038605C (en) * 1990-06-15 2000-06-27 Leonard Pinchuk Crack-resistant polycarbonate urethane polymer prostheses and the like
US5229431A (en) * 1990-06-15 1993-07-20 Corvita Corporation Crack-resistant polycarbonate urethane polymer prostheses and the like
JP3321593B2 (en) * 1990-06-26 2002-09-03 エイオールテック バイオマテリアルズ ピーティーワイ リミテッド Polyurethane elastomer
IT1251953B (en) * 1991-10-18 1995-05-27 M & G Ricerche Spa PROCEDURE FOR THE PRODUCTION OF HIGH MOLECULAR WEIGHT POLYESTER RESINS.
ATE146809T1 (en) * 1992-07-30 1997-01-15 Ciba Geigy Ag HARDENING COMPOSITION FOR THE PRODUCTION OF POLYURETHANE MOLDED BODY
US6140452A (en) * 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
GB9417288D0 (en) * 1994-08-25 1994-10-19 Howmedica Prosthetic bearing element and process for making such an element
US6252638B1 (en) * 1995-05-23 2001-06-26 Colorlink, Inc. Color controllable illumination device, indicator lights, transmissive windows and color filters employing retarder stacks
AUPO251096A0 (en) * 1996-09-23 1996-10-17 Cardiac Crc Nominees Pty Limited Polysiloxane-containing polyurethane elastomeric compositions
US6111052A (en) * 1997-04-30 2000-08-29 Medtronic, Inc. Polyurethane and polyurea biomaterials for use in medical devices
AUPO787897A0 (en) * 1997-07-14 1997-08-07 Cardiac Crc Nominees Pty Limited Silicon-containing chain extenders
AUPP268898A0 (en) * 1998-03-31 1998-04-23 Cardiac Crc Nominees Pty Limited High modulus polyurethane compositions
US6203844B1 (en) * 1999-04-01 2001-03-20 Joon B. Park Precoated polymeric prosthesis and process for making same
BR0009522A (en) * 1999-04-01 2002-01-15 Imerys Pigments Inc Product, coating composition, and, methods for coating a sheet of paper and calendering the paper to form a gloss coating on it, and to produce a pigment product
AUPQ170799A0 (en) * 1999-07-20 1999-08-12 Cardiac Crc Nominees Pty Limited Shape memory polyurethane or polyurethane-urea polymers
US6558794B1 (en) * 2000-06-26 2003-05-06 Technology Assessment & Transfer, Inc. Ceramic particulate reinforced orthopedic implants
DE10203058A1 (en) * 2002-01-26 2003-07-31 Bayer Ag Production of dendritically-modified polyurethane involves reacting polyisocyanate with a polyol component containing a hyper-branched polymer with isocyanate-reactive end groups and no ester links

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631298A (en) * 1985-12-16 1986-12-23 Ethyl Corporation Mixed diamine chain extender
US5599874A (en) * 1993-08-25 1997-02-04 Caterpillar Inc. Thermoplastic polyurethane elastomer based on a hydroxyl terminated polyol, an aromatic chain extender and 1,5 naphthalene diisocyanate
US6103851A (en) * 1997-09-26 2000-08-15 The Dow Chemical Company High service temperature polyurethane compositions
US6302916B1 (en) * 1998-12-24 2001-10-16 Biopro, Inc. Polyurethane and so forth containing joints

Also Published As

Publication number Publication date
WO2006084112A2 (en) 2006-08-10
US20060178497A1 (en) 2006-08-10

Similar Documents

Publication Publication Date Title
WO2006084112A3 (en) Implantable biomedical devices including biocompatible polyurethanes
WO2005117764A8 (en) A joint prosthesis, use of such and a method for the application of a joint prosthesis
WO2007030743A3 (en) Cochlear implants containing biological cells and uses thereof
TW200700487A (en) Polymeric hydrogel compositions
WO2007030934A3 (en) Methods of modulating neurotrophin-mediated activity
WO2006083991A3 (en) Fiber-reinforced composite absorbable endoureteral stent
WO2006130352A3 (en) Medical devices
WO2006071613A3 (en) Injectable non-aqueous suspension
WO2006071693A3 (en) Injectable non-aqueous suspension
WO2007064881A3 (en) Implantable microbial cellulose materials for various medical applications
WO2006044639A3 (en) Intervertebral implant and associated method
EP2487192A3 (en) Microencapsulation of clomazone by means of a refined process and specific microcapsules produced thereof
WO2008084495A3 (en) Novel agricultural composition
EP1582541A3 (en) Silane-Terminated Polyurethanes with high stregth and high elongation
WO2009091661A3 (en) Implantable medical devices fabricated from polyurethanes with biodegradable hard and soft blocks and blends thereof
EP1669382A3 (en) High solids Polyurethane-Polyurea dispersions
WO2006032786A3 (en) Impurity inerting compositions
WO2007067623A3 (en) Biocompatible tissue sealants and adhesives
WO2008087215A3 (en) Partially bioabsorbable implant
WO2004094618A3 (en) Modulation of diacylglycerol acyltransferase 1 expression
WO2006118801A3 (en) Multi-purpose medical implant devices
ZA200707353B (en) 4-cyclopropyl-1,2,3-thiadiazole compound, agrohorticultural plant disease controlling agent and method of using the same
WO2005113515A8 (en) Pyrimidines for use as plk inhibitors
EP1736489A3 (en) Polyurethane elastomers, process of their preparation and their use
WO2007137071A3 (en) Compositions of r(+) and s(-) pramipexole and methods of using the same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06734271

Country of ref document: EP

Kind code of ref document: A2