WO2006062962A3 - Materials and methods for treating and managing plaque disease - Google Patents

Materials and methods for treating and managing plaque disease Download PDF

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Publication number
WO2006062962A3
WO2006062962A3 PCT/US2005/044090 US2005044090W WO2006062962A3 WO 2006062962 A3 WO2006062962 A3 WO 2006062962A3 US 2005044090 W US2005044090 W US 2005044090W WO 2006062962 A3 WO2006062962 A3 WO 2006062962A3
Authority
WO
WIPO (PCT)
Prior art keywords
plaque
lesion
interior lumen
implantable material
treating
Prior art date
Application number
PCT/US2005/044090
Other languages
French (fr)
Other versions
WO2006062962A2 (en
Inventor
Elazer Edelman
Anupam Dalal
Helen Marie Nugent
Steve Bollinger
Original Assignee
Pervasis Therapeutics Inc
Elazer Edelman
Anupam Dalal
Helen Marie Nugent
Steve Bollinger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2005314312A priority Critical patent/AU2005314312B2/en
Priority to PCT/US2005/043844 priority patent/WO2006062871A2/en
Application filed by Pervasis Therapeutics Inc, Elazer Edelman, Anupam Dalal, Helen Marie Nugent, Steve Bollinger filed Critical Pervasis Therapeutics Inc
Priority to CN201210448869.3A priority patent/CN103055350B/en
Priority to EP05848586A priority patent/EP1824526B1/en
Priority to US11/792,335 priority patent/US20080125858A1/en
Priority to JP2007545539A priority patent/JP5674256B2/en
Priority to CA002589871A priority patent/CA2589871A1/en
Priority to AU2005314226A priority patent/AU2005314226B2/en
Priority to JP2007545559A priority patent/JP2008522738A/en
Priority to CA2589588A priority patent/CA2589588C/en
Priority to EP05853101A priority patent/EP1824417A2/en
Priority to CN200580042372XA priority patent/CN101076360B/en
Publication of WO2006062962A2 publication Critical patent/WO2006062962A2/en
Publication of WO2006062962A3 publication Critical patent/WO2006062962A3/en
Priority to IL183785A priority patent/IL183785A/en
Priority to IL183784A priority patent/IL183784A/en
Priority to US12/880,860 priority patent/US20110045054A1/en
Priority to IL209574A priority patent/IL209574A/en
Priority to AU2010249280A priority patent/AU2010249280B2/en
Priority to JP2012110766A priority patent/JP2012148164A/en
Priority to JP2012256581A priority patent/JP2013039431A/en
Priority to JP2014239567A priority patent/JP2015042682A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof

Abstract

Disclosed herein are materials and methods suitable for treating and managing plaque disease, including vulnerable plaque. An implantable material comprising cells, such as but not limited to endothelial cells, and a biocompatible matrix can reduce progression or deterioration of a plaque-associated lesion situated on the interior lumen of said blood vessel. The implantable material is implanted directly on an exterior surface of a blood vessel at or adjacent or in the vicinity of the site of a lesion on an interior lumen. Alternatively, the implantable material is deposited on an exterior surface at or adjacent or in the vicinity of the site of a lesion on an interior lumen by an intraluminal delivery device which traverses or penetrates the vessel wall or by a percutaneous delivery device which enters the perivascular space. Both modes of administration can be preceded by or coincident with an imaging step. The present invention can treat hemorrhage, erosion, fissure, plaque-associated thrombosis and occlusion, rupture, displacement and/or dislodgement of a plaque lesion.
PCT/US2005/044090 2004-12-08 2005-12-06 Materials and methods for treating and managing plaque disease WO2006062962A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
EP05853101A EP1824417A2 (en) 2004-12-08 2005-12-06 Materials and methods for treating and managing plaque disease
CA2589588A CA2589588C (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
CN201210448869.3A CN103055350B (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of cell-containing flowable composition
EP05848586A EP1824526B1 (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
US11/792,335 US20080125858A1 (en) 2004-12-08 2005-12-06 Materials and Methods For Treating and Managing Plaque Disease
JP2007545539A JP5674256B2 (en) 2004-12-08 2005-12-06 Materials and methods for minimally invasive administration of cell-containing flowable compositions
PCT/US2005/043844 WO2006062871A2 (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
AU2005314226A AU2005314226B2 (en) 2004-12-08 2005-12-06 Materials and methods for treating and managing plaque disease
CN200580042372XA CN101076360B (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
AU2005314312A AU2005314312B2 (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
CA002589871A CA2589871A1 (en) 2004-12-08 2005-12-06 Materials and methods for treating and managing plaque disease
JP2007545559A JP2008522738A (en) 2004-12-08 2005-12-06 Materials and methods for treating and monitoring plaque disease
IL183784A IL183784A (en) 2004-12-08 2007-06-07 Materials for minimally-invasive administration of a cell-containing flowable composition
IL183785A IL183785A (en) 2004-12-08 2007-06-07 Materials and metals for treating and managing plaque disease
US12/880,860 US20110045054A1 (en) 2004-12-08 2010-09-13 Materials and methods for treating and managing plaque disease
IL209574A IL209574A (en) 2004-12-08 2010-11-25 Materials for minimally-invasive administration of a cell-containing flowable composition
AU2010249280A AU2010249280B2 (en) 2004-12-08 2010-12-10 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
JP2012110766A JP2012148164A (en) 2004-12-08 2012-05-14 Material and method for minimally-invasive administration of cell-containing flowable composition
JP2012256581A JP2013039431A (en) 2004-12-08 2012-11-22 Material and method for minimally-invasive administration of cell-containing flowable composition
JP2014239567A JP2015042682A (en) 2004-12-08 2014-11-27 Material and method for minimally-invasive administration of cell-containing flowable composition

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63415504P 2004-12-08 2004-12-08
US60/634,155 2004-12-08
US66385905P 2005-03-21 2005-03-21
US60/663,859 2005-03-21
US68205405P 2005-05-18 2005-05-18
US60/682,054 2005-05-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/880,860 Continuation US20110045054A1 (en) 2004-12-08 2010-09-13 Materials and methods for treating and managing plaque disease

Publications (2)

Publication Number Publication Date
WO2006062962A2 WO2006062962A2 (en) 2006-06-15
WO2006062962A3 true WO2006062962A3 (en) 2006-10-12

Family

ID=36578486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044090 WO2006062962A2 (en) 2004-12-08 2005-12-06 Materials and methods for treating and managing plaque disease

Country Status (12)

Country Link
US (8) US20080119946A1 (en)
EP (5) EP1824526B1 (en)
JP (8) JP5674256B2 (en)
CN (4) CN101940801B (en)
AT (2) ATE474608T1 (en)
AU (4) AU2005314263B2 (en)
CA (4) CA2589871A1 (en)
DE (2) DE602005022481D1 (en)
ES (2) ES2490610T3 (en)
HK (2) HK1112429A1 (en)
IL (5) IL183785A (en)
WO (1) WO2006062962A2 (en)

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