WO2006045096A3 - Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases - Google Patents

Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases Download PDF

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Publication number
WO2006045096A3
WO2006045096A3 PCT/US2005/038048 US2005038048W WO2006045096A3 WO 2006045096 A3 WO2006045096 A3 WO 2006045096A3 US 2005038048 W US2005038048 W US 2005038048W WO 2006045096 A3 WO2006045096 A3 WO 2006045096A3
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WIPO (PCT)
Prior art keywords
prevention
treatment
isoflavanoids
flavanoids
cardiovascular diseases
Prior art date
Application number
PCT/US2005/038048
Other languages
French (fr)
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WO2006045096A2 (en
Inventor
Norman C W Wong
Joseph E L Tucker
Henrik C Hansen
Fabrizio S Chiacchia
David Mccaffrey
Original Assignee
Resverlogix Corp
Norman C W Wong
Joseph E L Tucker
Henrik C Hansen
Fabrizio S Chiacchia
David Mccaffrey
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Application filed by Resverlogix Corp, Norman C W Wong, Joseph E L Tucker, Henrik C Hansen, Fabrizio S Chiacchia, David Mccaffrey filed Critical Resverlogix Corp
Priority to CA2584507A priority Critical patent/CA2584507C/en
Priority to EP05812325A priority patent/EP1838296B1/en
Publication of WO2006045096A2 publication Critical patent/WO2006045096A2/en
Publication of WO2006045096A3 publication Critical patent/WO2006045096A3/en

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
PCT/US2005/038048 2004-10-20 2005-10-20 Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases WO2006045096A2 (en)

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