WO2006045010A3 - Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases - Google Patents

Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases Download PDF

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Publication number
WO2006045010A3
WO2006045010A3 PCT/US2005/037719 US2005037719W WO2006045010A3 WO 2006045010 A3 WO2006045010 A3 WO 2006045010A3 US 2005037719 W US2005037719 W US 2005037719W WO 2006045010 A3 WO2006045010 A3 WO 2006045010A3
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Prior art keywords
prevention
treatment
chalcones
stilbenes
cardiovascular diseases
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PCT/US2005/037719
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French (fr)
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WO2006045010A2 (en
Inventor
Norman C W Wong
Joseph E L Tucker
Henrik C Hansen
Fabrizio S Chiacchia
David Mccaffrey
Original Assignee
Resverlogix Corp
Norman C W Wong
Joseph E L Tucker
Henrik C Hansen
Fabrizio S Chiacchia
David Mccaffrey
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Application filed by Resverlogix Corp, Norman C W Wong, Joseph E L Tucker, Henrik C Hansen, Fabrizio S Chiacchia, David Mccaffrey filed Critical Resverlogix Corp
Priority to CA2584485A priority Critical patent/CA2584485C/en
Publication of WO2006045010A2 publication Critical patent/WO2006045010A2/en
Publication of WO2006045010A3 publication Critical patent/WO2006045010A3/en

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
PCT/US2005/037719 2004-10-20 2005-10-20 Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases WO2006045010A2 (en)

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