WO2006032054A3 - Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair - Google Patents

Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair Download PDF

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Publication number
WO2006032054A3
WO2006032054A3 PCT/US2005/033422 US2005033422W WO2006032054A3 WO 2006032054 A3 WO2006032054 A3 WO 2006032054A3 US 2005033422 W US2005033422 W US 2005033422W WO 2006032054 A3 WO2006032054 A3 WO 2006032054A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardiac
differentiation
mesenchymal stem
human mesenchymal
stem cells
Prior art date
Application number
PCT/US2005/033422
Other languages
French (fr)
Other versions
WO2006032054A9 (en
WO2006032054A2 (en
Inventor
Ira S Cohen
Michael R Rosen
Richard B Robinson
Peter R Brink
Glenn Gaudette
Irina Potapova
Original Assignee
Univ Columbia
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Univ New York State Res Found filed Critical Univ Columbia
Priority to EP05812162A priority Critical patent/EP1805300A4/en
Publication of WO2006032054A2 publication Critical patent/WO2006032054A2/en
Publication of WO2006032054A9 publication Critical patent/WO2006032054A9/en
Publication of WO2006032054A3 publication Critical patent/WO2006032054A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C12N2533/92—Amnion; Decellularised dermis or mucosa

Abstract

A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.
PCT/US2005/033422 2004-09-14 2005-09-14 Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair WO2006032054A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05812162A EP1805300A4 (en) 2004-09-14 2005-09-14 Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94103404A 2004-09-14 2004-09-14
US10/941,034 2004-09-14

Publications (3)

Publication Number Publication Date
WO2006032054A2 WO2006032054A2 (en) 2006-03-23
WO2006032054A9 WO2006032054A9 (en) 2006-05-26
WO2006032054A3 true WO2006032054A3 (en) 2009-04-16

Family

ID=36060741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/033422 WO2006032054A2 (en) 2004-09-14 2005-09-14 Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair

Country Status (2)

Country Link
EP (1) EP1805300A4 (en)
WO (1) WO2006032054A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2269461B1 (en) 2004-07-30 2017-03-22 Mayo Foundation For Medical Education And Research Treating cardiovascular tissue
US8431397B2 (en) 2004-09-14 2013-04-30 The Trustees Of Columbia University In The City Of New York Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair
AU2007209870A1 (en) 2006-01-30 2007-08-09 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US9765298B2 (en) 2006-07-24 2017-09-19 Mayo Foundation For Medical Education And Research Methods and materials for providing cardiac cells
US8835170B2 (en) 2006-10-06 2014-09-16 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
US20100189697A1 (en) * 2007-03-07 2010-07-29 Andre Terzic Cardiac-specific progenitor cells
WO2009145761A1 (en) 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Methods and materials for using cells to treat heart tissue
WO2019226803A1 (en) 2018-05-22 2019-11-28 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007993A (en) * 1995-06-28 1999-12-28 Insitut Fur Pflanzengenetik Und Kulturpflanzenforschung In vitro test for embryotoxic and teratogenic agents using differentiation-dependent reporter expression in pluripotent rodent embryonic cells
US20020022259A1 (en) * 2000-01-14 2002-02-21 Lee Ike W. Cardiac-cell specific enhancer elements and uses thereof
US20020076400A1 (en) * 1999-03-10 2002-06-20 University Of Pittsburgh Of The Commonwealth System Of Higher Education Adipose-derived stem cells and lattices

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006029084A2 (en) * 2004-09-03 2006-03-16 Cornell Research Foundation, Inc. Bone marrow derived oct3/4+ stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007993A (en) * 1995-06-28 1999-12-28 Insitut Fur Pflanzengenetik Und Kulturpflanzenforschung In vitro test for embryotoxic and teratogenic agents using differentiation-dependent reporter expression in pluripotent rodent embryonic cells
US20020076400A1 (en) * 1999-03-10 2002-06-20 University Of Pittsburgh Of The Commonwealth System Of Higher Education Adipose-derived stem cells and lattices
US20020022259A1 (en) * 2000-01-14 2002-02-21 Lee Ike W. Cardiac-cell specific enhancer elements and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1805300A4 *

Also Published As

Publication number Publication date
EP1805300A4 (en) 2009-09-09
EP1805300A2 (en) 2007-07-11
WO2006032054A9 (en) 2006-05-26
WO2006032054A2 (en) 2006-03-23

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