WO2006029062A1 - Replacement prosthetic heart valve, system and method of implant - Google Patents

Replacement prosthetic heart valve, system and method of implant Download PDF

Info

Publication number
WO2006029062A1
WO2006029062A1 PCT/US2005/031500 US2005031500W WO2006029062A1 WO 2006029062 A1 WO2006029062 A1 WO 2006029062A1 US 2005031500 W US2005031500 W US 2005031500W WO 2006029062 A1 WO2006029062 A1 WO 2006029062A1
Authority
WO
WIPO (PCT)
Prior art keywords
heart valve
prosthetic heart
support structure
previously implanted
coupling means
Prior art date
Application number
PCT/US2005/031500
Other languages
French (fr)
Inventor
Jack D. Lemmon
Timothy J. Ryan
Jose' M. Revuelta
Original Assignee
Medtronic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic, Inc. filed Critical Medtronic, Inc.
Priority to ES18203132T priority Critical patent/ES2933685T3/en
Priority to EP18203132.8A priority patent/EP3466373B1/en
Priority to EP05801202.2A priority patent/EP1804726B1/en
Priority to EP12155264.0A priority patent/EP2455042B1/en
Publication of WO2006029062A1 publication Critical patent/WO2006029062A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409Support rings therefor, e.g. for connecting valves to tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • A61F2220/0016Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0013Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/0078Quadric-shaped hyperboloidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/008Quadric-shaped paraboloidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/006Additional features; Implant or prostheses properties not otherwise provided for modular
    • A61F2250/0063Nested prosthetic parts

Definitions

  • the present invention relates to prosthetic heart valves. More particularly, it relates to a device and method for functionally replacing a deficient, previously implanted prosthetic heart valve.
  • Implantable heart valve prostheses have long been used to replace various diseased or damaged natural aortic valves, mitral valves, pulmonic valves, and tricuspid valves of the heart.
  • the actual shape and configuration of any particular prosthetic heart valve is, of course, dependent upon the valve being replaced.
  • the known heart valve prostheses are either bioprostheses or mechanical heart valve prostheses.
  • bioprostheses or "tissue valves” are generally made of a suitable animal tissue or materials (e.g., harvested porcine valve leaflets, bovine or equine pericardial leaflets, synthetic material leaflets, etc.) that may be mounted onto a stationary metal or plastic frame, referred to as a "stent". Regardless of whether a stent is provided, bioprosthetic/synthetic heart valves are generally tubular (i.e., when the leaflets are "open", an internal passage is defined through which fluid (e.g., blood) can flow), and include a sewing or suture ring.
  • fluid e.g., blood
  • the sewing or suture ring provides a means for fixing the prosthetic heart valve to the patient's native heart valve orifice tissue (e.g., native annulus or valvular rim) associated with the native heart valve being repaired or replaced.
  • native heart valve orifice tissue e.g., native annulus or valvular rim
  • an exacting surgical implantation technique is traditionally employed whereby the heart is stopped (cardiopulmonary bypass) and opened followed by surgical removal of damaged or diseased natural valve structure.
  • the prosthetic heart valve is properly oriented within the native valvular area, with the sewing ring being seated against or at the native annulus or valvular rim.
  • Sutures are then used to affix the sewing ring to the natural tissue.
  • a successfully implanted prosthetic heart valve will normally function without problem for many years. In certain instances, however, deficiencies may become evident shortly after implant or within a few years (especially in younger patients). Common functional deficiencies relate to calcification of the prosthetic heart valve leaflets, stenosis, and
  • the prosthetic heart valve does not function properly, or no longer functions properly, and conventionally is surgically removed and replaced. Removal of a previously implanted prosthetic heart valve entails the same surgical intervention described above, coupled with the need to implant a new prosthetic heart valve. As a point of reference, while well-accepted, the conventional surgical intervention described above is difficult to perform and can result in patient injury or more severe complications. In fact, due to physical weakness, implantation of a prosthetic heart valve via the conventional surgical technique may be considered either too high risk or contra-indicated for certain patients.
  • a prosthetic heart valve capable of being delivered percutaneously via transcatheter implantation thus avoiding the complications associated with conventional surgical intervention.
  • the valve prosthesis consists of a support structure with a tissue valve connected to it, whereby the support structure is delivered in a collapsed state through a blood vessel and secured to a desired valve location with the support structure in an expanded state.
  • Prosthetic heart valves continue to be essential tools in the treatment of patient's suffering from cardiac deficiencies. Further, the investigation into percutaneously- delivered prosthetic heart valves appears promising. Unfortunately, the inability to rigidly affix a percutaneous prosthetic heart valve remains problematic. Therefore, a need exists for a prosthetic heart valve and related method of implant that is conducive to percutaneous delivery for replacing a deficient, previously implanted prosthetic heart valve.
  • One aspect of the present invention relates to a method of functionally replacing a previously implanted prosthetic heart valve.
  • the method includes positioning a replacement prosthetic heart valve within an internal region defined by the previously implanted prosthetic heart valve.
  • the replacement prosthetic heart valve is then physically docked to the previously implanted prosthetic heart valve.
  • the previously implanted prosthetic heart valve serves as a platform for securement of the replacement prosthetic heart valve to the patient's native tissue.
  • the prosthetic heart valve for functionally replacing a previously implanted prosthetic heart valve.
  • the prosthetic heart valve includes a support structure, leaflets, and coupling means.
  • the leaflets are mounted to the support structure.
  • the coupling means is associated with the support structure and is adapted to physically dock the prosthetic heart valve to a previously implanted prosthetic heart valve.
  • Another aspect of the present invention relates to a prosthetic heart valve comprising a support structure, leaflets, and connection means.
  • the leaflets are mounted to the support structure.
  • the connection means is associated with the support structure and is adapted to effectuate physical docking of a replacement prosthetic heart valve to the prosthetic heart valve.
  • FIG. IA is a side, perspective view of a prosthetic heart valve in accordance with the present invention.
  • FIG. IB is a side view of the prosthetic heart valve of FIG. IA, with portions removed to better illustrate interior leaflets;
  • FIG. 1C is an end view of the prosthetic heart valve of FIG. IA; FIGS. 2A-2C illustrate percutaneous deployment of the prosthetic heart valve of
  • FIG. IA within a previously implanted prosthetic heart valve
  • FIG. 3 is a side perspective view of an alternative embodiment prosthetic heart valve in accordance with the present invention physically docked or connected to a previously implanted prosthetic heart valve;
  • FIG. 4A is a side view of an alternative embodiment prosthetic heart valve in accordance with the present invention;
  • FIG. 4B is a side view of the prosthetic heart valve of FIG. 4A mounted to a previously implanted prosthetic heart valve;
  • FIG. 5 is a side, cross-sectional view of an alternative embodiment prosthetic heart valve physically connected or docked to a previously implanted prosthetic heart valve;
  • FIG. 6A is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention
  • FIG. 6B is a side view of a replacement prosthetic heart valve physically docked or connected to the prosthetic heart valve of FIG. 6A;
  • FIG. 7 is a side view of an alternative embodiment prosthetic heart valve
  • FIG. 8 is a side view of an alternative embodiment pros ethic heart valve
  • FIG. 9A is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention
  • FIG. 9B is a side view of a replacement prosthetic heart valve physically docking or connecting to the prosthetic heart valve of FIG. 9A;
  • FIG. 1OA is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention.
  • FIG. 1OB is a side view of a replacement prosthetic heart valve physically docked or connected to the prosthetic heart valve of FIG. 1OA.
  • FIG. IA One embodiment of a prosthetic heart valve 10 in accordance with the present invention is shown in FIG. IA.
  • the prosthetic heart valve 10 includes a support structure 12, leaflets 14, and coupling means 16 (referenced generally in FIG. IA). Details on the various components are described below.
  • the support structure 12 is generally tubular, with the leaflets 14 being secured to an interior of the support structure 12.
  • the coupling means 16 extends radially outwardly relative to the leaflets 14.
  • the coupling means 16 is adapted to physically dock or connect the prosthetic heart valve 10 to a previously implanted prosthetic heart valve (not shown) to achieve a connective interface between the physical structures of the prosthetic heart valve 10 and the previously implanted prosthetic heart valve apart from and in addition to any interface that may be effectuated by radial press-fitting of the prosthetic heart valve 10 against the previously implanted prosthetic heart valve.
  • the term "prosthetic heart valve” is in reference to a bioprosthetic heart valve or a heart valve configuration utilizing synthetic leaflets, and excludes mechanical heart valves characterized as having a mechanically coupled, metal occluding disk or leaflet structure.
  • the support structure 12 is, in one embodiment, a wire stent capable of transitioning from a collapsed state to an expanded state (shown in FIG. IA).
  • individual wires 20 comprising the support structure 12 are formed of a metal or other material that facilitates folding of the support structure 12 to a contracted state in which an internal diameter defined by the support structure 12 is greatly reduced from an internal diameter in the expanded state.
  • the support structure 12 in the collapsed state, can be mounted over a delivery device, such as a balloon catheter, as described below.
  • the wires 20 can be formed from a shape memory material such as a nickel titanium alloy (NiTi or Nitinol®).
  • the support structure 12 is self-transitionable from the contracted state to the expanded state, such as by the application of heat, energy, etc.
  • the prosthetic heart valve 10 is, following an implantation procedure, physically docked to a previously implanted prosthetic heart valve (not shown).
  • a longitudinal length and diameter of the support structure 12 in the expanded state is related to the previously implanted prosthetic heart valve to which the prosthetic heart valve 10 is applied.
  • the support structure 12 can assume a variety of different longitudinal lengths and/or diameters.
  • the support structure 12 has a longitudinal length in the expanded state that is slightly greater than a length of the previously implanted prosthetic heart valve, and a free ⁇ standing outer diameter that is greater than an inner diameter of the previously implanted prosthetic heart valve.
  • the support structure 12 upon transitioning toward the expanded state, presses against an inner diameter of the previously implanted prosthetic heart valve.
  • the support structure 12 defines a right cylinder in the expanded state.
  • portions of the support structure 12 can define an enlarged diameter as compared to other portions.
  • the support structure 12 can be less uniform along a longitudinal length thereof, such as when functionally replacing a Freestyle TM bioprosthetic tissue valve available from Medtronic, Inc., or similar prosthetic heart valve whereby the support structure 12 wall can be cut away.
  • the leaflets 14 are secured to an interior of the support structure 12.
  • FIG. IB better illustrate this relationship, whereby portions of the wires 20 are removed from the drawing.
  • the leaflets 14 can be formed from a variety of materials, such as autologous tissue, xenograph material, or synthetics as are known in the art.
  • the leaflets 14 are provided as a homogenous, biological valve structure, such as a porcine, bovine, or equine valve.
  • the leaflets 14 can be provided independent of one another (e.g., bovine or equine pericardial leaflets) and subsequently assembled to the support structure 12.
  • the prosthetic heart valve 10 of the present invention can incorporate more or fewer leaflets than three.
  • the combination support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design.
  • the support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design.
  • the support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design.
  • the support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design.
  • the support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design.
  • the support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design.
  • the support structure 12 can include other features, not specifically described or shown, apart from the coupling means 16.
  • the support structure 12 has a non-expandable design, but is sized and shaped to nest within a previously implanted heart valve (not shown) in a manner that presses features of the previously implanted heart valve (e.g., leaflets) outwardly relative to the native conduit.
  • the coupling means 16 is connected to, or formed as part of, the support structure 12 and, in one embodiment, includes an inflow section 30 and an outflow section 32.
  • the inflow section 30 consists of a plurality of discrete anchors 34 formed as extensions of individual ones of the wires 20 otherwise comprising the support structure 12.
  • the anchors 34 can be separately formed and attached to the support structure 12.
  • the inflow anchors 34 are configured to engage a sewing ring (not shown) of a previously implanted prosthetic heart valve (not shown).
  • the inflow anchors 34 can be configured to engage other structure(s) of the previously implanted prosthetic heart valve.
  • each of the inflow anchors 34 has a hook-like shape and terminates in a barbed end 36. The curvature associated with each of the inflow anchors 34 is such that the respective barbed ends 36 extend inwardly relative to an inflow end 38 of the support structure 12.
  • the outflow section 32 similarly includes, with the one embodiment of FIG. IA, a plurality of outflow anchors 40 each in the form of a hook terminating in a barbed end 42.
  • each of the outflow anchors 40 are adapted to project around the stent structure (not shown) associated with a previously implanted prosthetic heart valve (not shown), with the respective barbed ends 42 engaging within material associated with that stent structure.
  • the radius of curvature associated with the outflow anchors 40 is less than a radius of curvature associated with the inflow anchors 34.
  • the anchors 40 can be configured the physically dock with other structure(s) provided by the previously implanted heart valve.
  • the inflow anchors 34 and/or the outflow anchors 40 can be provided with the prosthetic heart valve 10 of the present invention, and preferably correlates with the previously implanted prosthetic heart valve.
  • the anchors 34, 40 can assume a variety of forms that are or are not identical, such as barbs, clips, staples, hooks, etc.
  • the anchors 34, 40 are illustrated as extending from opposing ends, respectively, of the support structure 12, alternatively, the anchors 34 and/or 40 can be intermediately disposed along a longitudinal length of the support structure 12.
  • the prosthetic heart valve 10 is constructed by securing the leaflets 14 to an interior periphery of the support structure 12. To this end, a wide variety of attachment techniques can be employed.
  • the leaflets 14 can be sewn to the support structure 12.
  • other coupling techniques such as crimping, adhesive, etc.
  • the coupling means 16 are similarly secured to the support structure 12 extending radially outwardly relative to the leaflets 14.
  • FIG. 1C illustrates the outflow section 32 of the coupling means 16.
  • the coupling means 16 or portions thereof can be integrally or homogenously formed with the support structure 12.
  • the coupling means 16, or portions thereof can be separately formed and assembled to the support structure 12.
  • construction and/or attachment of the coupling means 16 is such that in the expanded state of the support structure 12 (FIGS.
  • FIG. 2A illustrates, in simplified form, a native heart valve 50 of a patient to which a previously implanted prosthetic heart valve 52 has been secured.
  • the native heart valve 50 can be any of the human heart valves (i.e., mitral valve, tricuspid valve, aortic valve, or pulmonary valve), it being understood that the type and orientation of the previously implanted prosthetic heart valve 52 will correspond with the particular form, shape, and function of the native heart valve 50. Regardless, the native heart valve 50 defines a valve annulus or valvular rim 54 from which a lumen 56 defined by the native heart valve 50 extends.
  • the previously implanted prosthetic heart valve 52 is, in one embodiment, any known prosthetic heart valve or valved conduit, and thus can assume a variety of forms. In most general terms, the previously implanted prosthetic heart valve 52 includes a valve structure 60 connected to a sewing ring 62.
  • the valve structure 60 may or may not include an internal stent, but is generally tubular in form, defining an internal region 64 (referenced generally) extended from an inflow end 66 to an outflow end 68.
  • the previously implanted prosthetic heart valve 52 includes stent posts 69 (for example, a biological, aortic or mitral prosthetic heart valve including a stent with three commissure posts), it being understood that the prosthetic heart valve of the present invention can be employed to functionally replace stentless prosthetic heart valves as well. Relative to the view of FIG.
  • the internal region 62 is essentially encompassed by the valve structure 60, it being understood that the valve structure 60 selectively allows for fluid flow into or out of the lumen 56 of the natural heart valve 50; thus, the internal region 64 is openable to the lumen 56.
  • leaflets associated with the previously implanted prosthetic heart valve 52 are not shown in FIG. 2A. Regardless, the previously implanted prosthetic heart valve 52 has been implanted via accepted surgical techniques, whereby the sewing ring 62 is sewn or attached to the annulus 54 of the native heart valve 50.
  • the previously implanted prosthetic heart valve 52 is functionally deficient due to one or more of a variety of factors, such as stenosis, valve failure, inflammation, native valve insufficiency, etc. Regardless, rather than removing the previously implanted prosthetic heart valve 52 and implanting a second, similarly formed prosthetic heart valve via rigorous open heart surgical techniques, the method of the present invention leaves the previously implanted prosthetic heart valve 52 in place, and deploys the prosthetic heart valve 10 (FIG. IA) onto the previously implanted prosthetic heart valve 52.
  • the prosthetic heart valve 10 is delivered to the native heart valve 52 percutaneously, as represented in simplified form in FIG. 2B.
  • a transcatheter assembly 70 is provided, including a delivery catheter 72, a balloon catheter 74, and a guide wire 76.
  • the delivery catheter 72 is of a type known in the art, and defines a lumen 78 within which the balloon catheter 74 is received.
  • the balloon catheter 74 defines a lumen (not shown) within which the guide wire 76 is slidably disposed.
  • the balloon catheter 74 includes a balloon 80 that is fluidly connected to an inflation source (not shown).
  • the transcatheter assembly 70 is appropriately sized for a desired percutaneous approach to the native heart valve 50.
  • the transcatheter assembly 70 can be sized for delivery to the native heart valve 50 via an opening at a carotid artery, a jugular vein, a sub-clavian vein, femoral artery or vein, etc. Essentially, any percutaneous intercostals penetration can be made to facilitate use of the transcatheter assembly 70.
  • the prosthetic heart valve 10 prior to delivery, is mounted over the balloon 80 in a contracted state as shown in FIG. 2B.
  • the support structure 12 is compressed onto itself and the balloon 80, thus defining a decreased inner diameter (as compared to an inner diameter in the expanded state).
  • the coupling means 16, including the inflow and outflow anchors 34, 40 are retracted in the contracted state (as compared to an extended orientation of the coupling means 16 in the expanded state of FIG. IA).
  • the transcatheter assembly 70 is delivered through a percutaneous opening (not shown) in the patient via the delivery catheter 72.
  • the native heart valve 50 is located by extending the guide wire 76 from a distal end 82 of the delivery catheter 72, with the balloon catheter 74 otherwise retracted within the delivery catheter 72.
  • the guide wire 76 passes through the internal region 64 defined by the previously implanted prosthetic heart valve 52.
  • the balloon 80/prosthetic heart valve 10 positioned relative to the previously implanted heart valve 52 as shown in FIG. 2B. More particularly, the balloon 80/prosthetic heart valve 10 is positioned within the internal region 64 of the previously implanted prosthetic heart valve 52, with the inflow anchors 34 positioned adjacent the inflow end 66/sewing ring 62 of the previously implanted prosthetic heart valve 52, whereas the outflow anchors 40 are positioned adjacent the outflow end 68 of the previously implanted prosthetic heart valve 52.
  • the prosthetic heart valve 10 is delivered to the previously implanted prosthetic heart valve 52 via a minimally invasive surgical incision (non-percutaneously). In another alternative embodiment, the prosthetic heart valve 10 is delivered via open heart/chest surgery.
  • the support structure 12 readily moves within the internal region 64 of the previously implanted prosthetic heart valve 52, and the coupling means 16, which is otherwise retracted, does not unintentionally contact or engage portions of the previously implanted prosthetic heart valve 52.
  • the prosthetic heart valve 10 includes a radiopaque material to facilitate visual confirmation of proper placement of the prosthetic heart valve 10 relative to the previously implanted prosthetic heart valve 52.
  • other known surgical visual aids can be incorporated into the prosthetic heart valve 10.
  • the balloon catheter 74 is operated to inflate the balloon 80, thus transitioning the prosthetic heart valve 10 to the expanded state as shown in FIG. 2C.
  • the transcatheter assembly
  • the prosthetic heart valve 10 self-transitions to the expanded state of FIG. 2C (and thus can be percutaneously delivered by an appropriate catheter device other than a balloon catheter).
  • the prosthetic heart valve 10 can be unfurled to the expanded state, again without the assistance of a balloon catheter.
  • the support structure 12 expands within the internal region 64 of the previously implanted heart valve 52, radially pressing against the valve structure 60.
  • the previously implanted prosthetic heart valve 52 includes leaflets (not shown), radial expansion of the support structure 12 presses against these leaflets, lodging them against the valve structure 60.
  • the coupling means 16 physically docks or connects the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52.
  • the inflow anchors 34 lodge within the sewing ring 62 of the previously implanted prosthetic heart valve 52, such as via the barbed end 36 (FIG. IA) associated with each of the inflow anchors 34.
  • the outflow anchors 40 wrap around the outflow end 68 of the previously implanted prosthetic heart valve 52, with the corresponding barbed ends 42 lodging within an outer fabric therein.
  • each of the outflow anchors 40 wraps about a corresponding stent post 69 of the previously implanted prosthetic heart valve 52.
  • the physical docking or connection between the coupling means 16 and the previously implanted heart valve 52 is apart from, or in addition to, any frictional, radial interface between the prosthetic heart valve 10 and the previously implanted heart valve 52 otherwise achieved by radial force or pressure exerted by the support structure 12 against the previously implanted heart valve 52 in the expanded state.
  • the prosthetic heart valve 10 serves as a functional replacement for the previously implanted prosthetic heart valve 52, utilizing the sewing ring 62 of the previously implanted prosthetic heart valve 52 as a platform for securement relative to the native heart valve 50.
  • the sewing ring 62 of the previously implanted heart valve 52 has previously been sutured to the annulus or valvular rim 56 of the native heart valve 50; by fastening the prosthetic heart valve 10 to the sewing ring 62, no additional suturing is required.
  • the leaflets 14 serve as replacement valve leaflets, facilitating normal functioning of the native heart valve 50.
  • Attachment of the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52 can be accomplished in a variety of fashions other than that described with respect to the one embodiment of prosthetic heart valve 10 described above.
  • the coupling means 16 need not include inflow and outflow sections, but instead can be directly, physically docked to the previously implanted prosthetic heart valve 52 at only one end thereof.
  • the coupling means 16 has been described as including hooks with barbed ends, other anchoring techniques can be employed whereby the anchors do not necessarily pierce through the previously implanted prosthetic heart valve 52 material. To this end, clip(s), staple(s), or other fastening devices can be employed.
  • FIG. 3 an alternative embodiment prosthetic heart valve 80 internally positioned and physically docked or connected to a previously implanted prosthetic heart valve 52 is shown in FIG. 3.
  • the prosthetic heart valve 80 includes a support structure 82, leaflets (not shown) and coupling means 84 (referenced generally).
  • the support structure 82 and the leaflets can assume any of the forms previously described with respect to the prosthetic heart valve 10 (FIGS. IA- 1C) previously described.
  • the coupling means 84 includes an outflow anchor 86, intermediate anchors 88a, 88b, and inflow anchors 90. As described below, each of the anchors 86 - 90 can achieve physical docking or connection of the prosthetic heart valve
  • the coupling means 84 can include components not specifically shown in FIG. 3.
  • the outflow anchor 86 is a clasp or hook formed as part of the support structure 82 at the outflow end thereof.
  • the support structure 82 can be a wire-formed stent, with an individual wire being bent, or two wires combined, to form the outflow anchor 86.
  • the outflow anchor 86 is generally sized and shaped in accordance with an expected size and shape of a stent post 69 of the previously implanted prosthetic heart valve 52 for reasons described below. To this end, the outflow anchor 86 can be the result of normal manufacture techniques for forming a stent-type support structure.
  • the prosthetic heart valve 80 is positioned, in a contracted state, within the previously implanted prosthetic heart valve 52 with the outflow anchor 86 located beyond the previously implanted prosthetic heart valve 52, and in particular the stent posts 69.
  • the prosthetic heart valve 80 is then transitioned to an expanded state (shown in FIG. 3). Once expanded, the prosthetic heart valve 80 is retracted relative to the previously implanted prosthetic heart valve 52 such that the outflow anchor 86 slides over one of the stent posts 69, thereby physically docking or connecting the prosthetic heart valve 80 to the previously implanted prosthetic heart valve 52.
  • the outflow anchor 86 is sized and shaped so as to readily clear a leading end of the stent post 69, but will more firmly dock or connect to the stent post 69 at an intermediate section thereof that is otherwise wider and/or thicker than the leading end.
  • the previously implanted prosthetic heart valve 52 includes an internal wire frame (not shown) traversing an outflow periphery thereof (e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience)
  • an outflow periphery thereof e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience
  • the prosthetic heart valve 80 is illustrated in FIG. 3 as including a single outflow anchor 86, alternatively two or more of the outflow anchors 86 can be provided.
  • the intermediate anchors 88a, 88b are, in one embodiment, hooks or barbs, and extended generally radially outwardly from the support structure 82 at a location(s) between the opposing ends thereof. To this end, the intermediate anchors 88a, 88b are located to physically dock or connect to portions of the previously implanted prosthetic heart valve 52 at points other than leading ends of the stent posts 69.
  • the intermediate anchor 88a is configured and positioned to pierce into material of the previously implanted prosthetic heart valve 52 (such as between adjacent stent posts 69 and/or along a length of one of the stent posts 69) upon transitioning of the prosthetic heart valve 80 to the expanded state.
  • the intermediate anchor 88a pierces through an interior of the previously implanted prosthetic heart valve 52.
  • the intermediate anchor 88b is configured and positioned to wrap about and contact an area of the previously implanted prosthetic heart valve 52 between adjacent ones of the stent posts 69 with the prosthetic heart valve 80 in the expanded state.
  • the previously implanted prosthetic heart valve 52 includes an internal wire frame (not shown) traversing an outflow periphery thereof (e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience)
  • an outflow periphery thereof e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience
  • the intermediate anchor 88a extends immediately below (relative to the orientation of FIG. 3), and thus braces against the internal wire frame.
  • the inte ⁇ nediate anchor 88b extends immediately above (relative to the orientation of FIG. 3), and thus braces against, the internal wire frame.
  • more or less of the intermediate anchors 88a, 88b can be provided as compared to the one embodiment illustrated in FIG. 3.
  • the inflow anchors 90 are hooks or barbs extending from the support structure 82, although a variety of other constructions are also acceptable. Regardless, the inflow anchors 90 are constructed to facilitate physical docking or connection to the sewing ring 62 of the previously implanted prosthetic heart valve 52.
  • the support structure of the prosthetic heart valve can, in and of itself, be adapted to facilitate physical docking or connection to the previously implanted prosthetic heart valve 52.
  • FIG. 4A an alternative embodiment prosthetic heart valve 100 in accordance with the present invention is shown in FIG. 4A.
  • the prosthetic heart valve 100 is similar to the prosthetic heart valve 10 (FIG. IA) previously described, and is adapted to functionally replace a previously implanted prosthetic heart valve (not shown).
  • the prosthetic heart valve 100 includes a support structure 102, leaflets (not shown), and coupling means 104.
  • the support structure 102 is a tubular, wire stent and defines, in the expanded state of FIG.
  • first and second end portions 106, 108 opposing first and second end portions 106, 108 and an intermediate portion 110.
  • the leaflets are similar to the leaflets 14 (FIG. IA) previously described and are interiorly secured to the support structure 102 along the intermediate portion 110.
  • the first and second end portions 106, 108 serve as the coupling means 104.
  • the support structure 102 is constructed such that in the expanded state of FIG. 4A, the first and second end portions 106, 108 define an increased outer diameter as compared to the intermediate portion 110.
  • a maximum diameter defined by one or both of the first and second end portions 106, 108 corresponds with a diameter of a previously implanted prosthetic heart valve (not shown in FIG. 4A), with the maximum diameter being greater than a diameter of the previously implanted prosthetic heart valve.
  • the support structure 102 need not assume the hourglass-like shape of FIG.4A in a contracted state (not shown), but instead can be a substantially right cylinder amenable for delivery to a target site. Transition to the expanded state can be achieved in a variety of fashions, such as by an appropriately devised balloon catheter (e.g., a balloon catheter having three balloon sections inflatable to different outer diameters), or by employing a shape memory material for the support structure 102.
  • an appropriately devised balloon catheter e.g., a balloon catheter having three balloon sections inflatable to different outer diameters
  • a shape memory material for the support structure 102.
  • the prosthetic heart valve 100 is delivered in the contracted state, according to the techniques previously described.
  • the prosthetic heart valve 100 is positioned within the internal region
  • the prosthetic heart valve 100 has been transitioned to the expanded state.
  • the prosthetic heart valve 100 is transitioned to the expanded state, with the first and second end portions 106, 108 assuming the increased outer diameter as compared to the intermediate section 110.
  • the support structure 102 presses against the previously implanted prosthetic heart valve 52 that is otherwise secured to the native heart valve 50 (FIG. 2A).
  • the coupling means 104 i.e., the first and second end portions 106, 108) nest about the previously implanted prosthetic heart valve 52, thereby physically docking or connecting the prosthetic heart valve 100 to the previously implanted prosthetic heart valve 52.
  • FIGS. 4A and 4B can be used alone or in conjunction with the coupling means 16 (FIG. IA) previously described.
  • the coupling means associated with the prosthetic heart valve of the present invention need not effectuate a rigid, locking engagement with the previously implanted prosthetic heart valve 52. In fact, depending upon the exact form of the previously implanted prosthetic heart valve, effectuating a rigid engagement may be difficult. In more general terms, however, the coupling means associated with the prosthetic heart valve of the present invention is capable of remaining physically docked or connected to the previously implanted prosthetic heart valve 52 under backpressure conditions of at least 200 mHg.
  • FIG. 5 depicts the previously implanted prosthetic heart valve 52 in conjunction with an alternative embodiment prosthetic heart valve 10' that is highly similar to the prosthetic heart valve 10 (FIG. IA) previously described and further includes the gasket material 130.
  • the gasket material 130 is, in one embodiment, attached to an outer circumference of the support structure 12 at or adjacent an annulus portion 132 that is otherwise expected to be positioned adjacent the annulus or valvular rim 54 of the previously implanted prosthetic heart valve 52.
  • the gasket material 130 can encompass a more significant exterior length of the support structure 12.
  • the gasket material 130 can be made from fabric, felt, Teflon®, silicone, pericardium, or other polymeric or biological materials.
  • the gasket material 130 serves as a filler to prevent holes from forming between the prosthetic heart valve 10' and the previously implanted prosthetic heart valve 52 adjacent the annulus or valvular rim 54, thus preventing leaching of blood back through this region.
  • providing the prosthetic heart valve 10 FIG.
  • the present invention includes providing the previously implanted prosthetic heart valve with features that further facilitate the desired physical docking or connection.
  • first implanted prosthetic heart valve a "first implanted prosthetic heart valve”
  • the subsequently implanted, functional replacement prosthetic heart valve e.g., the prosthetic heart valve 10 of FIG. IA
  • replacement prosthetic heart valve e.g., the prosthetic heart valve 10 of FIG. IA
  • the first implanted prosthetic heart valve 200 can assume a variety of forms, but generally includes a support structure 202, leaflets (not shown), and connection means 206.
  • the support structure 202 maintains the leaflets and facilitates attachment of the prosthetic valve 200 to a native heart valve (not shown).
  • the connection means 206 is connected to, or formed by, the support structure 202, and promotes physical docking or connection of a replacement prosthetic heart valve (not shown, but for example, the prosthetic heart valve 10 of FIG. IA) to the first prosthetic heart valve 200.
  • the support structure 202 defines a sewing ring
  • stent forming stent posts 210 and encompassed by a covering 212, such as with a Medtronic® Hancock II® or Musiac® stented tissue valve.
  • a stent hidden
  • a covering 212 such as with a Medtronic® Hancock II® or Musiac® stented tissue valve.
  • stented tissue valves such as those described in U.S. Patent Nos. 4,680,031, 4,892,541, and 5,032,128, the teachings of which are incorporated herein by reference, can be employed as the support structure 202.
  • the support structure 202 can be stentless, such as, for example, with a Freestyle® stentless bioprosthesis, available from Medtronic, Inc.
  • Other acceptable stentless configurations are described in U.S. Patent Nos.
  • leaflets are attached to the support structure 202 (e.g., by sewing, crimping, adhesive, etc.), and can assume a variety of forms (autologous tissue, xenograph tissue, or synthetic material).
  • connection means 206 associated with the embodiment of FIG. 6A includes a wire ring 214 extending between the stent posts 210 (either adjacent the leading (or outflow) ends thereof as illustrated, or more closely positioned to the sewing ring 208).
  • the wire ring 214 can be fastened to the support structure 202 in a variety of manners, including, for example, sewing the wire ring 214 to the fabric covering 212. While the wire ring 214 is illustrated as being a single, continuous structure, in an alternative embodiment, two or more individual wire segments are provided and secured to the support structure, with the segments combining to define a continuous or discontinuous ring-like structure 202.
  • the wire ring 214 is positioned so as to not interfere with functioning/movement of the leaflets adjacent an outflow (or inflow) end of the first prosthetic heart valve 200.
  • the connection means 206 and in particular the wire ring 214, is adapted to promote physical docking or connecting of a replacement prosthetic heart valve 220 to the first prosthetic heart valve 200.
  • the replacement prosthetic heart valve 220 is akin to the prosthetic heart valve 10 (FIG. IA) previously described, and includes a support structure 222 and a coupling means in the form of outflow anchors or hooks 224.
  • the first prosthetic heart valve 200 is initially implanted in a patient (not shown) and secured to native tissue (not shown), for example via the sewing ring 208.
  • the first prosthetic heart valve 200 can be functionally replaced by the replacement prosthetic heart valve 220.
  • the replacement prosthetic heart valve 220 can be delivered and positioned in a contracted state within the first prosthetic heart valve 220 pursuant to any of the techniques previously described.
  • the replacement prosthetic heart valve 220 then transitions to the expanded state (shown in FIG. 6B), thereby deploying the coupling means or outflow hooks 224.
  • the replacement prosthetic heart valve 220 is then maneuvered such that the hooks 224 engage the wire ring 214, thereby physically docking or connecting the replacement prosthetic heart valve 220 to the first prosthetic heart valve 200.
  • the replacement prosthetic heart valve 220 can include differing coupling means, such as a detent, for capturing or physically connecting to the wire ring
  • connection means 206 associated with the first prosthetic heart valve 200 can assume a number of other configurations.
  • FIG. 7 illustrates an alternative embodiment first prosthetic heart valve 250 including a support structure 252, leaflets (not shown), and connection means 254 (referenced generally).
  • the support structure 252 and the leaflets can assume any of the forms previously described.
  • the connection means 254 includes a plurality of rings 256, respective ones of which extend from individual stent posts 258. Each of the rings 256 preferably extends in a radially outward fashion relative to the corresponding stent post 258, and is longitudinally open relative to a central axis defined by the support structure 252.
  • first prosthetic heart valve 250 can be functionally replaced by a replacement prosthetic heart valve (not shown, but akin to the prosthetic heart valve 10 of FIG. IA) by physically docking or connecting the coupling means (e.g., hooks) of the replacement prosthetic heart valve within the rings 256.
  • first prosthetic heart valve 280 in accordance with the present invention is shown in FIG. 8 and includes a support structure 282, leaflets (not shown) and connection means 284 (referenced generally).
  • the support structure 282 and the leaflets can assume any of the forms previously described.
  • the connection means 284 is attached to, or formed by, the support structure 282 and includes a plurality of protrusions 286.
  • the protrusions 286 are hooks, although other configurations, such as posts, barbs, eyelets, etc., are equally acceptable. Regardless, the protrusions are positioned, in one embodiment, at an inflow side of the prosthetic heart valve 280, and are adapted to facilitate physical docking or connection with a corresponding coupling means or feature (e.g., post, hook, eyelet, etc.) of a replacement prosthetic heart valve (not shown) following a procedure to functionally replace the first prosthetic heart valve 280.
  • first prosthetic heart valve 300 in accordance with the present invention is shown in FIG. 9A and includes a support structure 302, leaflets (not shown), and connection means 304 (referenced generally).
  • the support structure 302 and the leaflets can assume any of the forms previously described.
  • the connection means 304 is formed by the support structure 302 and, with the embodiment of FIG. 9A, includes a plurality of apertures 306 (shown generally in FIG. 9A).
  • the apertures 306 are sized to capture corresponding tabs 312 provided by the replacement prosthetic heat valve 310, thus physically docking or connecting the replacement prosthetic heart valve 310 to the first prosthetic heart valve 300.
  • additional coupling means 314 e.g., barbed hooks
  • first prosthetic heart valve 330 is shown in FIG. 1OA and includes a support structure 332, leaflets (not shown) and connection means 334 (referenced generally).
  • the support structure 332 and the leaflets can assume any of the forms previously described, with the support structure 332 including stent posts 336 and a sewing ring 338.
  • the connection means 334 is connected to, or formed by, the support structure 332 and includes, with the one embodiment of FIG. 1OA, a plurality of outflow ribs 340 and an inflow rib 342.
  • Respective ones of the outflow ribs 340 extend radially outwardly relative to respective ones of the stent posts 336 and are positioned along a length thereof, in one embodiment adjacent a leading end of the respective stent post 336.
  • the inflow rib 342 is contiguous with, and extends axially from, the sewing ring 338.
  • the connection means 334 is configured to facilitate physical docking or connection of a replacement prosthetic heart valve, such as the replacement valve 350 as shown in FIG. 1OB.
  • the replacement prosthetic heart valve 350 has coupling means 352 (referenced generally) including tabs 354 and protrusions 356.
  • the tabs 354 define capture slots 358 relative to a support structure 360 of the replacement prosthetic heart valve 350.
  • FIGS. 6A - 1OB above are but a few examples of combination first prosthetic heart valve/replacement prosthetic heart valve configurations in accordance with the present invention.
  • the first prosthetic heart valve includes a magnetic material (such as internal, magnetic ring) whereas the replacement prosthetic heart valve includes a magnetic material connected to or provided as part of its support structure.
  • any magnetic material could be employed, such as ferrous or ferritic materials, rare earth magnetic materials such as
  • the replacement prosthetic heart valve is magnetically attracted to the magnetic material of the first prosthetic heart valve, thus facilitating physical docking or connection to the first prosthetic heart valve.
  • the first prosthetic heart valve and the corresponding replacement valve are configured to provide complimentary features that promote physical docking or connection of the replacement prosthetic heart valve to the first prosthetic heart valve as part of a procedure to functionally replace the first prosthetic heart valve.
  • the complimentary first prosthetic heart valve and replacement prosthetic heart valve can be packaged together and sold as a kit.
  • the prosthetic heart valve and related method of implantation presents a marked improvement over previous designs.
  • the prosthetic heart valve of the present invention is highly amenable to percutaneous delivery. Further, by functionally replacing a previously implanted prosthetic heart valve, the deficient prosthetic heart valve need not be physically removed from the patient.
  • the prosthetic heart valve and related method of implantation of the present invention can be used at any point during the "useful life" of a conventional prosthetic heart valve. Further, the methodology associated with the present invention can be repeated multiple times, such that several prosthetic heart valves of the present invention can be mounted on top of or within one another.

Abstract

A method of functionally replacing a previously implanted prosthetic heart valve. The method includes positioning a replacement prosthetic heart valve within an internal region defined by the previously implanted prosthetic heart valve. The replacement prosthetic heart valve is then physically docked to the previously implanted prosthetic heart valve. With this technique, the previously implanted prosthetic heart valve serves as a platform for securement of the replacement prosthetic heart valve to the patient's native tissue.

Description

REPLACEMENTPROSTHETICHEARTVALVE,SYSTEMANDMETHODOF
IMPLANT
Background
The present invention relates to prosthetic heart valves. More particularly, it relates to a device and method for functionally replacing a deficient, previously implanted prosthetic heart valve.
Implantable heart valve prostheses have long been used to replace various diseased or damaged natural aortic valves, mitral valves, pulmonic valves, and tricuspid valves of the heart. The actual shape and configuration of any particular prosthetic heart valve is, of course, dependent upon the valve being replaced. Generally, the known heart valve prostheses are either bioprostheses or mechanical heart valve prostheses.
The bioprostheses or "tissue valves" are generally made of a suitable animal tissue or materials (e.g., harvested porcine valve leaflets, bovine or equine pericardial leaflets, synthetic material leaflets, etc.) that may be mounted onto a stationary metal or plastic frame, referred to as a "stent". Regardless of whether a stent is provided, bioprosthetic/synthetic heart valves are generally tubular (i.e., when the leaflets are "open", an internal passage is defined through which fluid (e.g., blood) can flow), and include a sewing or suture ring.
The sewing or suture ring provides a means for fixing the prosthetic heart valve to the patient's native heart valve orifice tissue (e.g., native annulus or valvular rim) associated with the native heart valve being repaired or replaced. In particular, an exacting surgical implantation technique is traditionally employed whereby the heart is stopped (cardiopulmonary bypass) and opened followed by surgical removal of damaged or diseased natural valve structure. Subsequently, the prosthetic heart valve is properly oriented within the native valvular area, with the sewing ring being seated against or at the native annulus or valvular rim. Sutures are then used to affix the sewing ring to the natural tissue. A successfully implanted prosthetic heart valve will normally function without problem for many years. In certain instances, however, deficiencies may become evident shortly after implant or within a few years (especially in younger patients). Common functional deficiencies relate to calcification of the prosthetic heart valve leaflets, stenosis, and prosthetic heart valve insufficiency.
Under these and other circumstances, the prosthetic heart valve does not function properly, or no longer functions properly, and conventionally is surgically removed and replaced. Removal of a previously implanted prosthetic heart valve entails the same surgical intervention described above, coupled with the need to implant a new prosthetic heart valve. As a point of reference, while well-accepted, the conventional surgical intervention described above is difficult to perform and can result in patient injury or more severe complications. In fact, due to physical weakness, implantation of a prosthetic heart valve via the conventional surgical technique may be considered either too high risk or contra-indicated for certain patients. Further, removal of a previously implanted prosthetic heart valve requires cutting of the sutures that otherwise secure the prosthesis to the native annulus/valvular rim, and re-stitching of a new sewing ring. These activities can further compromise the integrity of the valvular rim and lead to recovery complications, morbidity and mortality.
Though unrelated to the specifically addressing prosthetic heart valve replacement concerns, efforts have been made to devise a prosthetic heart valve capable of being delivered percutaneously via transcatheter implantation thus avoiding the complications associated with conventional surgical intervention. For example, Andersen et al., U.S. Patent No. 6,168,614, the teachings of which are incorporated herein by reference, describes a heart valve prosthesis for implantation in the body by use of a catheter. The valve prosthesis consists of a support structure with a tissue valve connected to it, whereby the support structure is delivered in a collapsed state through a blood vessel and secured to a desired valve location with the support structure in an expanded state. Other percutaneously-delivered prosthetic heart valves have been suggested having a generally similar configuration, such as by Bonhoeffer, P. et al., "Transcatheter Implantation of a Bovine Valve in Pulmonary Position." Circulation, 2002; 102:813-816 and Cribier, A. et al. "Percutaneous Transcatheter Implantation of an Aortic Valve Prosthesis for Calcific Aortic Stenosis." Circulation, 2002; 106:3006-3008, the teachings of which are incorporated herein by reference. These techniques appear to rely upon a frictional engagement between the expanded support structure and the native tissue to maintain a position of the delivered prosthesis. That is to say, with the transcatheter technique, conventional sewing of the prosthetic heart valve to the patient's native tissue cannot be performed. Similarly, Bonhoeffer, P. et al., "Percutaneous Insertion of the Pulmonary Valve." JAm Coll Cardiol, 2002; 39:1664-1669, the teachings of which are incorporated herein by reference, describe percutaneous delivery of a biological valve, sutured to an expandable stent, within a previously implanted valved or non-valved conduit, or a previously implanted valve. Again, it appears that radial expansion of the secondary valve stent is the sole means for placing and maintaining the replacement valve.
Prosthetic heart valves continue to be essential tools in the treatment of patient's suffering from cardiac deficiencies. Further, the investigation into percutaneously- delivered prosthetic heart valves appears promising. Unfortunately, the inability to rigidly affix a percutaneous prosthetic heart valve remains problematic. Therefore, a need exists for a prosthetic heart valve and related method of implant that is conducive to percutaneous delivery for replacing a deficient, previously implanted prosthetic heart valve.
Summary
One aspect of the present invention relates to a method of functionally replacing a previously implanted prosthetic heart valve. The method includes positioning a replacement prosthetic heart valve within an internal region defined by the previously implanted prosthetic heart valve. The replacement prosthetic heart valve is then physically docked to the previously implanted prosthetic heart valve. With this technique, the previously implanted prosthetic heart valve serves as a platform for securement of the replacement prosthetic heart valve to the patient's native tissue.
Another aspect of the present invention relates to a prosthetic heart valve for functionally replacing a previously implanted prosthetic heart valve. The prosthetic heart valve includes a support structure, leaflets, and coupling means. The leaflets are mounted to the support structure. The coupling means is associated with the support structure and is adapted to physically dock the prosthetic heart valve to a previously implanted prosthetic heart valve. Another aspect of the present invention relates to a prosthetic heart valve comprising a support structure, leaflets, and connection means. The leaflets are mounted to the support structure. The connection means is associated with the support structure and is adapted to effectuate physical docking of a replacement prosthetic heart valve to the prosthetic heart valve.
Another aspect of the present invention relates to a prosthetic heart valve system comprising a first prosthetic heart valve and a replacement heart valve. The first prosthetic heart valve is configured for initial implantation to native heart tissue and includes a support structure, leaflets, and connection means. The leaflets are mounted to the support structure and the connection means is associated with the support structure. The replacement prosthetic heart valve includes a support structure, leaflets, and coupling means. The leaflets are mounted to the support structure and the coupling means is associated with the support structure. With this in mind, the connection means and the coupling means are configured such that the coupling means engages the connection means to physically dock the replacement prosthetic heart valve to the first prosthetic heart valve following implantation of the first prosthetic heart valve. Brief Description of the Drawings FIG. IA is a side, perspective view of a prosthetic heart valve in accordance with the present invention;
FIG. IB is a side view of the prosthetic heart valve of FIG. IA, with portions removed to better illustrate interior leaflets;
FIG. 1C is an end view of the prosthetic heart valve of FIG. IA; FIGS. 2A-2C illustrate percutaneous deployment of the prosthetic heart valve of
FIG. IA within a previously implanted prosthetic heart valve;
FIG. 3 is a side perspective view of an alternative embodiment prosthetic heart valve in accordance with the present invention physically docked or connected to a previously implanted prosthetic heart valve; FIG. 4A is a side view of an alternative embodiment prosthetic heart valve in accordance with the present invention;
FIG. 4B is a side view of the prosthetic heart valve of FIG. 4A mounted to a previously implanted prosthetic heart valve;
FIG. 5 is a side, cross-sectional view of an alternative embodiment prosthetic heart valve physically connected or docked to a previously implanted prosthetic heart valve;
FIG. 6A is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention; FIG. 6B is a side view of a replacement prosthetic heart valve physically docked or connected to the prosthetic heart valve of FIG. 6A;
FIG. 7 is a side view of an alternative embodiment prosthetic heart valve;
FIG. 8 is a side view of an alternative embodiment pros ethic heart valve; FIG. 9A is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention;
FIG. 9B is a side view of a replacement prosthetic heart valve physically docking or connecting to the prosthetic heart valve of FIG. 9A;
FIG. 1OA is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention; and
FIG. 1OB is a side view of a replacement prosthetic heart valve physically docked or connected to the prosthetic heart valve of FIG. 1OA.
Detailed Description One embodiment of a prosthetic heart valve 10 in accordance with the present invention is shown in FIG. IA. The prosthetic heart valve 10 includes a support structure 12, leaflets 14, and coupling means 16 (referenced generally in FIG. IA). Details on the various components are described below. In general terms, however, the support structure 12 is generally tubular, with the leaflets 14 being secured to an interior of the support structure 12. The coupling means 16 extends radially outwardly relative to the leaflets 14.
As described below, the coupling means 16 is adapted to physically dock or connect the prosthetic heart valve 10 to a previously implanted prosthetic heart valve (not shown) to achieve a connective interface between the physical structures of the prosthetic heart valve 10 and the previously implanted prosthetic heart valve apart from and in addition to any interface that may be effectuated by radial press-fitting of the prosthetic heart valve 10 against the previously implanted prosthetic heart valve. As used throughout this specification, the term "prosthetic heart valve" is in reference to a bioprosthetic heart valve or a heart valve configuration utilizing synthetic leaflets, and excludes mechanical heart valves characterized as having a mechanically coupled, metal occluding disk or leaflet structure.
The support structure 12 is, in one embodiment, a wire stent capable of transitioning from a collapsed state to an expanded state (shown in FIG. IA). In one embodiment, individual wires 20 comprising the support structure 12 are formed of a metal or other material that facilitates folding of the support structure 12 to a contracted state in which an internal diameter defined by the support structure 12 is greatly reduced from an internal diameter in the expanded state. Thus, for example, in the collapsed state, the support structure 12 can be mounted over a delivery device, such as a balloon catheter, as described below. Alternatively, the wires 20 can be formed from a shape memory material such as a nickel titanium alloy (NiTi or Nitinol®). With this configuration, the support structure 12 is self-transitionable from the contracted state to the expanded state, such as by the application of heat, energy, etc. As described in greater detail below, the prosthetic heart valve 10 is, following an implantation procedure, physically docked to a previously implanted prosthetic heart valve (not shown). With this in mind, a longitudinal length and diameter of the support structure 12 in the expanded state is related to the previously implanted prosthetic heart valve to which the prosthetic heart valve 10 is applied. Thus, the support structure 12 can assume a variety of different longitudinal lengths and/or diameters. In one embodiment, for example, the support structure 12 has a longitudinal length in the expanded state that is slightly greater than a length of the previously implanted prosthetic heart valve, and a free¬ standing outer diameter that is greater than an inner diameter of the previously implanted prosthetic heart valve. With this one embodiment, upon transitioning toward the expanded state, the support structure 12 presses against an inner diameter of the previously implanted prosthetic heart valve. With the one embodiment of FIG. IA, the support structure 12 defines a right cylinder in the expanded state. However, as described in greater detail below, other shapes are equally acceptable. For example, portions of the support structure 12 can define an enlarged diameter as compared to other portions. Further, depending upon the previously implanted heart valve being functionally replaced, the support structure 12 can be less uniform along a longitudinal length thereof, such as when functionally replacing a Freestyle ™ bioprosthetic tissue valve available from Medtronic, Inc., or similar prosthetic heart valve whereby the support structure 12 wall can be cut away. The leaflets 14 are secured to an interior of the support structure 12. FIG. IB better illustrate this relationship, whereby portions of the wires 20 are removed from the drawing. The leaflets 14 can be formed from a variety of materials, such as autologous tissue, xenograph material, or synthetics as are known in the art. With the embodiment of FIGS. IA and IB, the leaflets 14 are provided as a homogenous, biological valve structure, such as a porcine, bovine, or equine valve. Alternatively, the leaflets 14 can be provided independent of one another (e.g., bovine or equine pericardial leaflets) and subsequently assembled to the support structure 12. Further, while three of the leaflets 14 are illustrated in FIGS. IA and IB, the prosthetic heart valve 10 of the present invention can incorporate more or fewer leaflets than three.
In more general terms, the combination support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design. In one embodiment, the support structure 12/leaflets
14 is any known expandable prosthetic heart valve configuration, whether balloon expandable, self-expanding, or unfurling (as described, for example, in U.S. Patent Nos. 3,671,979; 4,056,854; 4,994,077; 5,332,402; 5,370,685; 5,397,351; 5,554,185; 5,855,601; and 6,168,614; U.S. Patent Application Publication No. 2004/0034411; Bonhoeffer P., et al., "Percutaneous Insertion of the Pulmonary Valve", Pediatric Cardiology, 2002;
39:1664-1669; Anderson HR, et al., "Transluminal Implantation of Artificial Heart Valves", EUR Heart J., 1992; 13:704-708; Anderson, J.R., et al., "Transluminal Catheter Implantation of New Expandable Artificial Cardiac Valve", EUR Heart J., 1990, 11 : (Suppl) 224a; Hubert S.L., "Evaluation of Explanted Polyurethane Trileaflet Cardiac Valve Prosthesis", J Thorac Cardiovascular Surgery, 1989; 94:419-29; Block PC,
"Clinical and Hemodyamic Follow-Up After Percutaneous Aortic Valvuloplasty in the Elderly", The American Journal of Cardiology, Vol. 62, October 1, 1998; Boudjemline, Y., "Steps Toward Percutaneous Aortic Valve Replacement", Circulation, 2002; 105:775- 558; Bonhoeffer, P., "Transcatheter Implantation of a Bovine Valve in Pulmonary Position, a Lamb Study", Circulation, 2000:102:813-816; Boudjemline, Y., "Percutaneous
Implantation of a Valve in the Descending Aorta In Lambs", EUR Heart J, 2002; 23:1045- 1049; Kulkinski, D., "Future Horizons in Surgical Aortic Valve Replacement: Lessons Learned During the Early Stages of Developing a Transluminal Implantation Technique", ASAIOJ, 2004; 50:364-68; the teachings of all of which are incorporated herein by reference. Thus, the support structure 12 can include other features, not specifically described or shown, apart from the coupling means 16. In an alternative embodiment, the support structure 12 has a non-expandable design, but is sized and shaped to nest within a previously implanted heart valve (not shown) in a manner that presses features of the previously implanted heart valve (e.g., leaflets) outwardly relative to the native conduit. Regardless of the exact configuration of the support structure 12 and leaflets 14, the coupling means 16 is connected to, or formed as part of, the support structure 12 and, in one embodiment, includes an inflow section 30 and an outflow section 32. With the one embodiment of FIG. IA, the inflow section 30 consists of a plurality of discrete anchors 34 formed as extensions of individual ones of the wires 20 otherwise comprising the support structure 12. Alternatively, the anchors 34 can be separately formed and attached to the support structure 12. As described in greater detail below, the inflow anchors 34 are configured to engage a sewing ring (not shown) of a previously implanted prosthetic heart valve (not shown). Alternatively, the inflow anchors 34 can be configured to engage other structure(s) of the previously implanted prosthetic heart valve. With this in mind, in one embodiment each of the inflow anchors 34 has a hook-like shape and terminates in a barbed end 36. The curvature associated with each of the inflow anchors 34 is such that the respective barbed ends 36 extend inwardly relative to an inflow end 38 of the support structure 12.
The outflow section 32 similarly includes, with the one embodiment of FIG. IA, a plurality of outflow anchors 40 each in the form of a hook terminating in a barbed end 42. As described in greater detail below, each of the outflow anchors 40 are adapted to project around the stent structure (not shown) associated with a previously implanted prosthetic heart valve (not shown), with the respective barbed ends 42 engaging within material associated with that stent structure. Thus, with the one embodiment of FIG. IA, the radius of curvature associated with the outflow anchors 40 is less than a radius of curvature associated with the inflow anchors 34. Alternatively, the anchors 40 can be configured the physically dock with other structure(s) provided by the previously implanted heart valve.
Any number of the inflow anchors 34 and/or the outflow anchors 40 can be provided with the prosthetic heart valve 10 of the present invention, and preferably correlates with the previously implanted prosthetic heart valve. Further, the anchors 34, 40 can assume a variety of forms that are or are not identical, such as barbs, clips, staples, hooks, etc. Also, while the anchors 34, 40 are illustrated as extending from opposing ends, respectively, of the support structure 12, alternatively, the anchors 34 and/or 40 can be intermediately disposed along a longitudinal length of the support structure 12. With additional reference to FIG. 1C, the prosthetic heart valve 10 is constructed by securing the leaflets 14 to an interior periphery of the support structure 12. To this end, a wide variety of attachment techniques can be employed. For example, the leaflets 14 can be sewn to the support structure 12. Alternatively, other coupling techniques, such as crimping, adhesive, etc., can be employed. The coupling means 16 are similarly secured to the support structure 12 extending radially outwardly relative to the leaflets 14. As a point of reference, FIG. 1C illustrates the outflow section 32 of the coupling means 16. Regardless, the coupling means 16 or portions thereof, can be integrally or homogenously formed with the support structure 12. Alternatively, the coupling means 16, or portions thereof, can be separately formed and assembled to the support structure 12. In one embodiment, construction and/or attachment of the coupling means 16 is such that in the expanded state of the support structure 12 (FIGS. IA - 1C), the coupling means extends radially outwardly, whereas in the contracted state (not shown), the coupling means 16 is retracted. The prosthetic heart valve 10 of the present invention is uniquely adapted to facilitate an implantation technique whereby the prosthetic heart valve 10 is mounted to a previously implanted prosthetic heart valve. By way of reference, FIG. 2A illustrates, in simplified form, a native heart valve 50 of a patient to which a previously implanted prosthetic heart valve 52 has been secured. The native heart valve 50 can be any of the human heart valves (i.e., mitral valve, tricuspid valve, aortic valve, or pulmonary valve), it being understood that the type and orientation of the previously implanted prosthetic heart valve 52 will correspond with the particular form, shape, and function of the native heart valve 50. Regardless, the native heart valve 50 defines a valve annulus or valvular rim 54 from which a lumen 56 defined by the native heart valve 50 extends. The previously implanted prosthetic heart valve 52 is, in one embodiment, any known prosthetic heart valve or valved conduit, and thus can assume a variety of forms. In most general terms, the previously implanted prosthetic heart valve 52 includes a valve structure 60 connected to a sewing ring 62. The valve structure 60 may or may not include an internal stent, but is generally tubular in form, defining an internal region 64 (referenced generally) extended from an inflow end 66 to an outflow end 68. With the exemplary embodiment of FIG. 2A, the previously implanted prosthetic heart valve 52 includes stent posts 69 (for example, a biological, aortic or mitral prosthetic heart valve including a stent with three commissure posts), it being understood that the prosthetic heart valve of the present invention can be employed to functionally replace stentless prosthetic heart valves as well. Relative to the view of FIG. 2A, the internal region 62 is essentially encompassed by the valve structure 60, it being understood that the valve structure 60 selectively allows for fluid flow into or out of the lumen 56 of the natural heart valve 50; thus, the internal region 64 is openable to the lumen 56. For ease of illustration, leaflets associated with the previously implanted prosthetic heart valve 52 are not shown in FIG. 2A. Regardless, the previously implanted prosthetic heart valve 52 has been implanted via accepted surgical techniques, whereby the sewing ring 62 is sewn or attached to the annulus 54 of the native heart valve 50.
At some time following implant, it may be discovered that the previously implanted prosthetic heart valve 52 is functionally deficient due to one or more of a variety of factors, such as stenosis, valve failure, inflammation, native valve insufficiency, etc. Regardless, rather than removing the previously implanted prosthetic heart valve 52 and implanting a second, similarly formed prosthetic heart valve via rigorous open heart surgical techniques, the method of the present invention leaves the previously implanted prosthetic heart valve 52 in place, and deploys the prosthetic heart valve 10 (FIG. IA) onto the previously implanted prosthetic heart valve 52.
In one embodiment, the prosthetic heart valve 10 is delivered to the native heart valve 52 percutaneously, as represented in simplified form in FIG. 2B. In general terms, a transcatheter assembly 70 is provided, including a delivery catheter 72, a balloon catheter 74, and a guide wire 76. The delivery catheter 72 is of a type known in the art, and defines a lumen 78 within which the balloon catheter 74 is received. The balloon catheter 74, in turn, defines a lumen (not shown) within which the guide wire 76 is slidably disposed. Further, the balloon catheter 74 includes a balloon 80 that is fluidly connected to an inflation source (not shown). The transcatheter assembly 70 is appropriately sized for a desired percutaneous approach to the native heart valve 50. For example, the transcatheter assembly 70 can be sized for delivery to the native heart valve 50 via an opening at a carotid artery, a jugular vein, a sub-clavian vein, femoral artery or vein, etc. Essentially, any percutaneous intercostals penetration can be made to facilitate use of the transcatheter assembly 70. With the above in mind, prior to delivery, the prosthetic heart valve 10 is mounted over the balloon 80 in a contracted state as shown in FIG. 2B. As compared to the expanded state of FIG. IA, the support structure 12 is compressed onto itself and the balloon 80, thus defining a decreased inner diameter (as compared to an inner diameter in the expanded state). Further, the coupling means 16, including the inflow and outflow anchors 34, 40, are retracted in the contracted state (as compared to an extended orientation of the coupling means 16 in the expanded state of FIG. IA).
With the prosthetic heart valve 10 mounted to the balloon 80, the transcatheter assembly 70 is delivered through a percutaneous opening (not shown) in the patient via the delivery catheter 72. The native heart valve 50 is located by extending the guide wire 76 from a distal end 82 of the delivery catheter 72, with the balloon catheter 74 otherwise retracted within the delivery catheter 72. In this regard, the guide wire 76 passes through the internal region 64 defined by the previously implanted prosthetic heart valve 52. Once the native heart valve 50 has been located, the balloon catheter 74 is advanced distally from the delivery catheter 72 along the guide wire 76, with the balloon
80/prosthetic heart valve 10 positioned relative to the previously implanted heart valve 52 as shown in FIG. 2B. More particularly, the balloon 80/prosthetic heart valve 10 is positioned within the internal region 64 of the previously implanted prosthetic heart valve 52, with the inflow anchors 34 positioned adjacent the inflow end 66/sewing ring 62 of the previously implanted prosthetic heart valve 52, whereas the outflow anchors 40 are positioned adjacent the outflow end 68 of the previously implanted prosthetic heart valve 52. In an alternative embodiment, the prosthetic heart valve 10 is delivered to the previously implanted prosthetic heart valve 52 via a minimally invasive surgical incision (non-percutaneously). In another alternative embodiment, the prosthetic heart valve 10 is delivered via open heart/chest surgery. Regardless, with the prosthetic heart valve 10 in the contracted state, the support structure 12 readily moves within the internal region 64 of the previously implanted prosthetic heart valve 52, and the coupling means 16, which is otherwise retracted, does not unintentionally contact or engage portions of the previously implanted prosthetic heart valve 52. In one embodiment, the prosthetic heart valve 10 includes a radiopaque material to facilitate visual confirmation of proper placement of the prosthetic heart valve 10 relative to the previously implanted prosthetic heart valve 52. Alternatively, other known surgical visual aids can be incorporated into the prosthetic heart valve 10.
Once the prosthetic heart valve 10 is properly positioned, the balloon catheter 74 is operated to inflate the balloon 80, thus transitioning the prosthetic heart valve 10 to the expanded state as shown in FIG. 2C. As a point of reference, the transcatheter assembly
70 is removed from the view of FIG. 2C. Alternatively, where the support structure 12 is formed of a shape memory material, the prosthetic heart valve 10 self-transitions to the expanded state of FIG. 2C (and thus can be percutaneously delivered by an appropriate catheter device other than a balloon catheter). Similarly, with an alternative configuration, the prosthetic heart valve 10 can be unfurled to the expanded state, again without the assistance of a balloon catheter. Regardless, the support structure 12 expands within the internal region 64 of the previously implanted heart valve 52, radially pressing against the valve structure 60. To this end, where the previously implanted prosthetic heart valve 52 includes leaflets (not shown), radial expansion of the support structure 12 presses against these leaflets, lodging them against the valve structure 60.
With the prosthetic heart valve 10 in the expanded state, the coupling means 16 physically docks or connects the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52. For example, as shown in FIG. 2C, the inflow anchors 34 lodge within the sewing ring 62 of the previously implanted prosthetic heart valve 52, such as via the barbed end 36 (FIG. IA) associated with each of the inflow anchors 34. The outflow anchors 40 wrap around the outflow end 68 of the previously implanted prosthetic heart valve 52, with the corresponding barbed ends 42 lodging within an outer fabric therein. For example, each of the outflow anchors 40 wraps about a corresponding stent post 69 of the previously implanted prosthetic heart valve 52. Notably, the physical docking or connection between the coupling means 16 and the previously implanted heart valve 52 is apart from, or in addition to, any frictional, radial interface between the prosthetic heart valve 10 and the previously implanted heart valve 52 otherwise achieved by radial force or pressure exerted by the support structure 12 against the previously implanted heart valve 52 in the expanded state. With the above-described technique, the prosthetic heart valve 10 serves as a functional replacement for the previously implanted prosthetic heart valve 52, utilizing the sewing ring 62 of the previously implanted prosthetic heart valve 52 as a platform for securement relative to the native heart valve 50. That is to say the sewing ring 62 of the previously implanted heart valve 52 has previously been sutured to the annulus or valvular rim 56 of the native heart valve 50; by fastening the prosthetic heart valve 10 to the sewing ring 62, no additional suturing is required. Following fastening of the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52, the leaflets 14 (one of which is shown in FIG. 2C) serve as replacement valve leaflets, facilitating normal functioning of the native heart valve 50.
Attachment of the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52 can be accomplished in a variety of fashions other than that described with respect to the one embodiment of prosthetic heart valve 10 described above. For example, the coupling means 16 need not include inflow and outflow sections, but instead can be directly, physically docked to the previously implanted prosthetic heart valve 52 at only one end thereof. Further, while the coupling means 16 has been described as including hooks with barbed ends, other anchoring techniques can be employed whereby the anchors do not necessarily pierce through the previously implanted prosthetic heart valve 52 material. To this end, clip(s), staple(s), or other fastening devices can be employed. For example, an alternative embodiment prosthetic heart valve 80 internally positioned and physically docked or connected to a previously implanted prosthetic heart valve 52 is shown in FIG. 3. The prosthetic heart valve 80 includes a support structure 82, leaflets (not shown) and coupling means 84 (referenced generally). In general terms, the support structure 82 and the leaflets can assume any of the forms previously described with respect to the prosthetic heart valve 10 (FIGS. IA- 1C) previously described. With the embodiment of FIG. 3, the coupling means 84 includes an outflow anchor 86, intermediate anchors 88a, 88b, and inflow anchors 90. As described below, each of the anchors 86 - 90 can achieve physical docking or connection of the prosthetic heart valve
80 to the previously implanted heart valve 52, such that one or more of the features 86 - 90 can be eliminated. Alternatively, or in addition, the coupling means 84 can include components not specifically shown in FIG. 3.
In one embodiment, the outflow anchor 86 is a clasp or hook formed as part of the support structure 82 at the outflow end thereof. For example, the support structure 82 can be a wire-formed stent, with an individual wire being bent, or two wires combined, to form the outflow anchor 86. The outflow anchor 86 is generally sized and shaped in accordance with an expected size and shape of a stent post 69 of the previously implanted prosthetic heart valve 52 for reasons described below. To this end, the outflow anchor 86 can be the result of normal manufacture techniques for forming a stent-type support structure. During implantation, the prosthetic heart valve 80 is positioned, in a contracted state, within the previously implanted prosthetic heart valve 52 with the outflow anchor 86 located beyond the previously implanted prosthetic heart valve 52, and in particular the stent posts 69. The prosthetic heart valve 80 is then transitioned to an expanded state (shown in FIG. 3). Once expanded, the prosthetic heart valve 80 is retracted relative to the previously implanted prosthetic heart valve 52 such that the outflow anchor 86 slides over one of the stent posts 69, thereby physically docking or connecting the prosthetic heart valve 80 to the previously implanted prosthetic heart valve 52. In one embodiment, the outflow anchor 86 is sized and shaped so as to readily clear a leading end of the stent post 69, but will more firmly dock or connect to the stent post 69 at an intermediate section thereof that is otherwise wider and/or thicker than the leading end. Where the previously implanted prosthetic heart valve 52 includes an internal wire frame (not shown) traversing an outflow periphery thereof (e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience), a more rigid physical docking or connection can be achieved. While the prosthetic hart valve 80 is illustrated in FIG. 3 as including a single outflow anchor 86, alternatively two or more of the outflow anchors 86 can be provided. The intermediate anchors 88a, 88b are, in one embodiment, hooks or barbs, and extended generally radially outwardly from the support structure 82 at a location(s) between the opposing ends thereof. To this end, the intermediate anchors 88a, 88b are located to physically dock or connect to portions of the previously implanted prosthetic heart valve 52 at points other than leading ends of the stent posts 69. For example, the intermediate anchor 88a is configured and positioned to pierce into material of the previously implanted prosthetic heart valve 52 (such as between adjacent stent posts 69 and/or along a length of one of the stent posts 69) upon transitioning of the prosthetic heart valve 80 to the expanded state. In one embodiment, the intermediate anchor 88a pierces through an interior of the previously implanted prosthetic heart valve 52. The intermediate anchor 88b, on the other hand, is configured and positioned to wrap about and contact an area of the previously implanted prosthetic heart valve 52 between adjacent ones of the stent posts 69 with the prosthetic heart valve 80 in the expanded state. Where the previously implanted prosthetic heart valve 52 includes an internal wire frame (not shown) traversing an outflow periphery thereof (e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience), a more rigid physical docking or connection can be achieved. For example, the intermediate anchor 88a extends immediately below (relative to the orientation of FIG. 3), and thus braces against the internal wire frame. Additionally, the inteπnediate anchor 88b extends immediately above (relative to the orientation of FIG. 3), and thus braces against, the internal wire frame. In alternative embodiments, more or less of the intermediate anchors 88a, 88b can be provided as compared to the one embodiment illustrated in FIG. 3. In one embodiment, the inflow anchors 90 are hooks or barbs extending from the support structure 82, although a variety of other constructions are also acceptable. Regardless, the inflow anchors 90 are constructed to facilitate physical docking or connection to the sewing ring 62 of the previously implanted prosthetic heart valve 52.
In addition or as an alternative to the coupling means described above, the support structure of the prosthetic heart valve can, in and of itself, be adapted to facilitate physical docking or connection to the previously implanted prosthetic heart valve 52. For example, an alternative embodiment prosthetic heart valve 100 in accordance with the present invention is shown in FIG. 4A. The prosthetic heart valve 100 is similar to the prosthetic heart valve 10 (FIG. IA) previously described, and is adapted to functionally replace a previously implanted prosthetic heart valve (not shown). With this in mind, the prosthetic heart valve 100 includes a support structure 102, leaflets (not shown), and coupling means 104. With the one embodiment of FIG. 4A, the support structure 102 is a tubular, wire stent and defines, in the expanded state of FIG. 4A, opposing first and second end portions 106, 108 and an intermediate portion 110. The leaflets are similar to the leaflets 14 (FIG. IA) previously described and are interiorly secured to the support structure 102 along the intermediate portion 110. As made clear below, the first and second end portions 106, 108 serve as the coupling means 104.
In particular, the support structure 102 is constructed such that in the expanded state of FIG. 4A, the first and second end portions 106, 108 define an increased outer diameter as compared to the intermediate portion 110. For example, the first end portion
106 increases in diameter from the intermediate portion 110 to a first end 112. Similarly, the second end portion 108 increases in diameter from the intermediate portion 110 to a second end 114. Alternatively, other shapes can be defined, and only one of the first or second end portions 106, 108 need define the increased diameter in the expanded state. Regardless, a maximum diameter defined by one or both of the first and second end portions 106, 108 corresponds with a diameter of a previously implanted prosthetic heart valve (not shown in FIG. 4A), with the maximum diameter being greater than a diameter of the previously implanted prosthetic heart valve. The support structure 102 need not assume the hourglass-like shape of FIG.4A in a contracted state (not shown), but instead can be a substantially right cylinder amenable for delivery to a target site. Transition to the expanded state can be achieved in a variety of fashions, such as by an appropriately devised balloon catheter (e.g., a balloon catheter having three balloon sections inflatable to different outer diameters), or by employing a shape memory material for the support structure 102.
Regardless of exact construction, the prosthetic heart valve 100 is delivered in the contracted state, according to the techniques previously described. In particular, and with reference to FIG. 4B, the prosthetic heart valve 100 is positioned within the internal region
64 of the previously implanted prosthetic heart valve 52 (it being understood that in the view of FIG. 4B, the prosthetic heart valve 100 has been transitioned to the expanded state). Once properly positioned, the prosthetic heart valve 100 is transitioned to the expanded state, with the first and second end portions 106, 108 assuming the increased outer diameter as compared to the intermediate section 110. Once again, the support structure 102 presses against the previously implanted prosthetic heart valve 52 that is otherwise secured to the native heart valve 50 (FIG. 2A). Once in the expanded state, the coupling means 104 (i.e., the first and second end portions 106, 108) nest about the previously implanted prosthetic heart valve 52, thereby physically docking or connecting the prosthetic heart valve 100 to the previously implanted prosthetic heart valve 52.
Notably, the coupling means 104 associated with FIGS. 4A and 4B can be used alone or in conjunction with the coupling means 16 (FIG. IA) previously described.
Regardless of exact form, the coupling means associated with the prosthetic heart valve of the present invention need not effectuate a rigid, locking engagement with the previously implanted prosthetic heart valve 52. In fact, depending upon the exact form of the previously implanted prosthetic heart valve, effectuating a rigid engagement may be difficult. In more general terms, however, the coupling means associated with the prosthetic heart valve of the present invention is capable of remaining physically docked or connected to the previously implanted prosthetic heart valve 52 under backpressure conditions of at least 200 mHg.
To ensure a sealing relationship between the prosthetic heart valve 10, 100, and the previously implanted prosthetic heart valve 52, in an alternative embodiment, a gasket material can be provided as shown, for example, at 130 in FIG. 5. As a point of reference, FIG. 5 depicts the previously implanted prosthetic heart valve 52 in conjunction with an alternative embodiment prosthetic heart valve 10' that is highly similar to the prosthetic heart valve 10 (FIG. IA) previously described and further includes the gasket material 130. The gasket material 130 is, in one embodiment, attached to an outer circumference of the support structure 12 at or adjacent an annulus portion 132 that is otherwise expected to be positioned adjacent the annulus or valvular rim 54 of the previously implanted prosthetic heart valve 52. Alternatively, the gasket material 130 can encompass a more significant exterior length of the support structure 12. Regardless, the gasket material 130 can be made from fabric, felt, Teflon®, silicone, pericardium, or other polymeric or biological materials. As shown in FIG. 5, the gasket material 130 serves as a filler to prevent holes from forming between the prosthetic heart valve 10' and the previously implanted prosthetic heart valve 52 adjacent the annulus or valvular rim 54, thus preventing leaching of blood back through this region. In addition to, in one embodiment, providing the prosthetic heart valve 10 (FIG.
IA) with coupling means adapted to achieve physical docking or connection with a previously implanted prosthetic heart valve, in other embodiments, the present invention includes providing the previously implanted prosthetic heart valve with features that further facilitate the desired physical docking or connection. In this context, it is possible to reference the initial, first implanted prosthetic heart valve as a "first implanted prosthetic heart valve" and the subsequently implanted, functional replacement prosthetic heart valve (e.g., the prosthetic heart valve 10 of FIG. IA) as a "replacement prosthetic heart valve". With these definitions in mind, FIG. 6A illustrates one embodiment of a first implanted prosthetic heart valve 200 in accordance with the present invention. The first implanted prosthetic heart valve 200 can assume a variety of forms, but generally includes a support structure 202, leaflets (not shown), and connection means 206. The support structure 202 maintains the leaflets and facilitates attachment of the prosthetic valve 200 to a native heart valve (not shown). The connection means 206 is connected to, or formed by, the support structure 202, and promotes physical docking or connection of a replacement prosthetic heart valve (not shown, but for example, the prosthetic heart valve 10 of FIG. IA) to the first prosthetic heart valve 200. In the one embodiment of FIG. 6A , the support structure 202 defines a sewing ring
208 and includes a stent (hidden) forming stent posts 210 and encompassed by a covering 212, such as with a Medtronic® Hancock II® or Musiac® stented tissue valve. A wide variety of other stented tissue valves, such as those described in U.S. Patent Nos. 4,680,031, 4,892,541, and 5,032,128, the teachings of which are incorporated herein by reference, can be employed as the support structure 202. Alternatively, the support structure 202 can be stentless, such as, for example, with a Freestyle® stentless bioprosthesis, available from Medtronic, Inc. Other acceptable stentless configurations are described in U.S. Patent Nos. 5,156,621; 5,197,979; 5,336,258; 5,509,930; 6,001,126; 6,254,436; 6,342,070; 6,364,905; and 6,558,417, the teachings of all of which are incorporated herein by reference, to name but a few. Regardless, the leaflets (not shown) are attached to the support structure 202 (e.g., by sewing, crimping, adhesive, etc.), and can assume a variety of forms (autologous tissue, xenograph tissue, or synthetic material).
With the general construction of the support structure 202/leaflets in mind, the connection means 206 associated with the embodiment of FIG. 6A includes a wire ring 214 extending between the stent posts 210 (either adjacent the leading (or outflow) ends thereof as illustrated, or more closely positioned to the sewing ring 208). The wire ring 214 can be fastened to the support structure 202 in a variety of manners, including, for example, sewing the wire ring 214 to the fabric covering 212. While the wire ring 214 is illustrated as being a single, continuous structure, in an alternative embodiment, two or more individual wire segments are provided and secured to the support structure, with the segments combining to define a continuous or discontinuous ring-like structure 202. Regardless, the wire ring 214 is positioned so as to not interfere with functioning/movement of the leaflets adjacent an outflow (or inflow) end of the first prosthetic heart valve 200. With further reference to FIG. 6B, the connection means 206, and in particular the wire ring 214, is adapted to promote physical docking or connecting of a replacement prosthetic heart valve 220 to the first prosthetic heart valve 200. By way of reference, the replacement prosthetic heart valve 220 is akin to the prosthetic heart valve 10 (FIG. IA) previously described, and includes a support structure 222 and a coupling means in the form of outflow anchors or hooks 224. With this in mind, the first prosthetic heart valve 200 is initially implanted in a patient (not shown) and secured to native tissue (not shown), for example via the sewing ring 208. When desired, the first prosthetic heart valve 200 can be functionally replaced by the replacement prosthetic heart valve 220. More particular, the replacement prosthetic heart valve 220 can be delivered and positioned in a contracted state within the first prosthetic heart valve 220 pursuant to any of the techniques previously described. The replacement prosthetic heart valve 220 then transitions to the expanded state (shown in FIG. 6B), thereby deploying the coupling means or outflow hooks 224. The replacement prosthetic heart valve 220 is then maneuvered such that the hooks 224 engage the wire ring 214, thereby physically docking or connecting the replacement prosthetic heart valve 220 to the first prosthetic heart valve 200. Alternatively, the replacement prosthetic heart valve 220 can include differing coupling means, such as a detent, for capturing or physically connecting to the wire ring
214.
The connection means 206 associated with the first prosthetic heart valve 200 can assume a number of other configurations. For example, FIG. 7 illustrates an alternative embodiment first prosthetic heart valve 250 including a support structure 252, leaflets (not shown), and connection means 254 (referenced generally). The support structure 252 and the leaflets can assume any of the forms previously described. The connection means 254 includes a plurality of rings 256, respective ones of which extend from individual stent posts 258. Each of the rings 256 preferably extends in a radially outward fashion relative to the corresponding stent post 258, and is longitudinally open relative to a central axis defined by the support structure 252. Following initial implant, the first prosthetic heart valve 250 can be functionally replaced by a replacement prosthetic heart valve (not shown, but akin to the prosthetic heart valve 10 of FIG. IA) by physically docking or connecting the coupling means (e.g., hooks) of the replacement prosthetic heart valve within the rings 256. Yet another alternative embodiment first prosthetic heart valve 280 in accordance with the present invention is shown in FIG. 8 and includes a support structure 282, leaflets (not shown) and connection means 284 (referenced generally). The support structure 282 and the leaflets can assume any of the forms previously described. The connection means 284 is attached to, or formed by, the support structure 282 and includes a plurality of protrusions 286. With the one embodiment of FIG. 8, the protrusions 286 are hooks, although other configurations, such as posts, barbs, eyelets, etc., are equally acceptable. Regardless, the protrusions are positioned, in one embodiment, at an inflow side of the prosthetic heart valve 280, and are adapted to facilitate physical docking or connection with a corresponding coupling means or feature (e.g., post, hook, eyelet, etc.) of a replacement prosthetic heart valve (not shown) following a procedure to functionally replace the first prosthetic heart valve 280. Yet another alternative embodiment first prosthetic heart valve 300 in accordance with the present invention is shown in FIG. 9A and includes a support structure 302, leaflets (not shown), and connection means 304 (referenced generally). The support structure 302 and the leaflets can assume any of the forms previously described. The connection means 304 is formed by the support structure 302 and, with the embodiment of FIG. 9A, includes a plurality of apertures 306 (shown generally in FIG. 9A). During a procedure to functionally replace the first prosthetic heart valve 300 with a replacement prosthetic heart valve 310 and as shown in FIG. 9B, the apertures 306 are sized to capture corresponding tabs 312 provided by the replacement prosthetic heat valve 310, thus physically docking or connecting the replacement prosthetic heart valve 310 to the first prosthetic heart valve 300. Further, with the one embodiment of FIG. 9B, additional coupling means 314 (e.g., barbed hooks) are provided with the replacement prosthetic heart valve 310 and also physically dock or connect to the first prosthetic heart valve 300.
Yet another alternative embodiment first prosthetic heart valve 330 is shown in FIG. 1OA and includes a support structure 332, leaflets (not shown) and connection means 334 (referenced generally). The support structure 332 and the leaflets can assume any of the forms previously described, with the support structure 332 including stent posts 336 and a sewing ring 338. The connection means 334 is connected to, or formed by, the support structure 332 and includes, with the one embodiment of FIG. 1OA, a plurality of outflow ribs 340 and an inflow rib 342. Respective ones of the outflow ribs 340 extend radially outwardly relative to respective ones of the stent posts 336 and are positioned along a length thereof, in one embodiment adjacent a leading end of the respective stent post 336. The inflow rib 342 is contiguous with, and extends axially from, the sewing ring 338. The connection means 334 is configured to facilitate physical docking or connection of a replacement prosthetic heart valve, such as the replacement valve 350 as shown in FIG. 1OB. In one embodiment, the replacement prosthetic heart valve 350 has coupling means 352 (referenced generally) including tabs 354 and protrusions 356. The tabs 354 define capture slots 358 relative to a support structure 360 of the replacement prosthetic heart valve 350. Following a functional replacement procedure, the outflow ribs 340 are lodged within the capture slots 358 (formed, for example, by corresponding recess and radial extension features), and the protrusions 356 engage the inflow rib 342. The embodiments of FIGS. 6A - 1OB above are but a few examples of combination first prosthetic heart valve/replacement prosthetic heart valve configurations in accordance with the present invention. In other alternative embodiments, the first prosthetic heart valve includes a magnetic material (such as internal, magnetic ring) whereas the replacement prosthetic heart valve includes a magnetic material connected to or provided as part of its support structure. Virtually any magnetic material could be employed, such as ferrous or ferritic materials, rare earth magnetic materials such as
Neodymium (Nd-Fe-B) and Samarium cobalt magnets (SmCo), etc. During use, the replacement prosthetic heart valve is magnetically attracted to the magnetic material of the first prosthetic heart valve, thus facilitating physical docking or connection to the first prosthetic heart valve. In more general terms, the first prosthetic heart valve and the corresponding replacement valve are configured to provide complimentary features that promote physical docking or connection of the replacement prosthetic heart valve to the first prosthetic heart valve as part of a procedure to functionally replace the first prosthetic heart valve. To this end, the complimentary first prosthetic heart valve and replacement prosthetic heart valve can be packaged together and sold as a kit. The prosthetic heart valve and related method of implantation presents a marked improvement over previous designs. In particular, by utilizing a previously implanted prosthetic heart valve as a platform to facilitate mounting relative to a native heart valve, the prosthetic heart valve of the present invention is highly amenable to percutaneous delivery. Further, by functionally replacing a previously implanted prosthetic heart valve, the deficient prosthetic heart valve need not be physically removed from the patient.
Thus, the prosthetic heart valve and related method of implantation of the present invention can be used at any point during the "useful life" of a conventional prosthetic heart valve. Further, the methodology associated with the present invention can be repeated multiple times, such that several prosthetic heart valves of the present invention can be mounted on top of or within one another.
Although the present invention has been described with reference to preferred embodiments, workers skilled in the art will recognize that changes can be made in form and detail without departing from the spirit and scope of the present invention.

Claims

WHAT IS CLAIMED IS:
1. A method of functionally replacing a previously implanted prosthetic heart valve, the method comprising: positioning a replacement prosthetic heart valve within an internal region defined by the previously implanted prosthetic heart valve; and physically docking the replacement prosthetic heart valve to the previously implanted prosthetic heart valve.
2. The method of claim 1, wherein following fastening, the replacement prosthetic heart valve is anchored relative to native bodily tissue via the previously implanted prosthetic heart valve.
3. The method of claim 1, wherein physically docking the replacement prosthetic heart valve to the previously implanted prosthetic heart valve is characterized by a physical connection apart from an interface provided by a radial pressure of the replacement prosthetic heart valve along an axial length of the previously implanted prosthetic heart valve.
4. The method of claim 1, wherein the replacement prosthetic heart valve includes valve leaflets, and further wherein following fastening, the valve leaflets of the replacement prosthetic heart valve function as natural valve leaflet replacements.
5. The method of claim 4, wherein the previously implanted prosthetic heart valve includes valve leaflets, the method further comprising: preventing movement of the valve leaflets of the previously implanted prosthetic heart valve.
6. The method of claim 1, wherein the replacement prosthetic heart valve includes a support structure transitionable from a collapsed state to an expanded state, and further wherein the step of positioning the replacement prosthetic heart valve with the previously implanted prosthetic heart valve includes deploying the support structure in the collapsed state.
7. The method of claim 6, further comprising: transitioning the support structure to the expanded state following the step of positioning the replacement prosthetic heart valve within the previously implanted prosthetic heart valve.
8. The method of claim 1, wherein the replacement prosthetic heart valve includes coupling means, and further wherein physically docking the replacement prosthetic heart valve includes: securing the coupling means to the previously implanted prosthetic heart valve.
9. The method of claim 8, wherein the coupling means includes an anchor, and further wherein securing the coupling means includes: attaching the anchor to an inflow side of the previously implanted prosthetic heart valve.
10. The method of claim 9, wherein attaching the anchor includes piercing a surface of the previously implanted prosthetic heart valve.
11. The method of claim 8, wherein the coupling means includes an anchor, and further wherein securing the coupling means includes: attaching the anchor to an outflow side of the previously implanted prosthetic heart valve.
12. The method of claim 11, wherein the coupling means includes a second anchor, and further wherein securing the coupling means includes: attaching the second anchor to the inflow side of the previously implanted prosthetic heart valve.
13. The method of claim 8, wherein the coupling means includes a component selected from the group consisting of a barb, clip, staple, eyelet, tab, and hook.
14. The method of claim 8, wherein the replacement prosthetic heart valve includes a support structure transitionable from a contracted state to an expanded state, an end portion of the support structure defining an increased diameter as compared to an inteπnediate portion in the expanded state, and further wherein the coupling means includes the enlarged diameter end portion and further wherein securing the coupling means includes: transitioning the support structure to the expanded state; and lodging the enlarged end portion against the previously implanted prosthetic heart valve.
15. The method of claim 14, wherein the coupling means includes opposing end portions of the support structure having enlarged diameters in the expanded state, and further wherein securing the coupling means further includes: capturing the previously implanted heart valve between the opposing end portions.
16. The method of claim 1, further comprising: deploying a gasket material between the previously implanted prosthetic heart valve and the replacement prosthetic heart valve prior to the step of physically docking the replacement prosthetic heart valve.
17. The method of claim 1, further comprising: deploying a second replacement prosthetic heart valve within an internal region defined by the replacement prosthetic heart valve; and physically docking the second replacement prosthetic heart valve to the previously implanted prosthetic heart valve.
18. The method of claim 1, wherein the previously implanted prosthetic heart valve includes connection means and the replacement prosthetic heart valve includes coupling means, and further wherein physically docking the replacement prosthetic heart valve to the previously implanted prosthetic heart valve includes securing the coupling means to the connection means.
19. A prosthetic heart valve for functionally replacing a previously implanted prosthetic heart valve, the prosthetic heart valve comprising: a support structure; leaflets mounted to the support structure; coupling means associated with the support structure and adapted to physically dock the prosthetic heart valve to a previously implanted heart valve.
20. The prosthetic heart valve of claim 19, wherein the support structure is a stent.
21. The prosthetic heart valve of claim 20, wherein the stent is transitionable from a collapsed state to an expanded state having an enlarged diameter as compared to the collapsed state.
22. The prosthetic heart valve of claim 21, wherein the coupling means is defined, at least in part, by the stent in the expanded state in which at least one end portion of the stent defines an enlarged diameter as compared to a diameter of an intermediate portion of the stent.
23. The prosthetic heart valve of claim 19, wherein the coupling means is attached to the stent.
24. The prosthetic heart valve of claim 23, wherein the coupling means includes an anchor component consisting of a barb, clip, staple, post, eyelet, and hook.
25. The prosthetic heart valve of claim 19, wherein the coupling means is adapted to retract radially in the collapsed state and extend radially in the expanded state.
26. The prosthetic heart valve of claim 19, wherein the leaflets are formed from a material selected from the group consisting of autologous tissue, xenograph material, and synthetic.
27. The prosthetic heart valve of claim 19, wherein the coupling means extends radially outwardly relative to the leaflets.
28. The prosthetic heart valve of claim 19, further comprising: a gasket material mounted to an exterior of the support structure.
29. A prosthetic heart valve comprising: a support structure; leaflets mounted to the support structure; and connection means associated with the support structure and adapted to effectuate physical docking of a replacement heart valve to the prosthetic heart valve.
30. The prosthetic heart valve of claim 29, wherein the connection means includes a component selected from the group consisting of a rib, hook, barb, eyelet, ring, clip and staple.
31. The prosthetic heart valve of claim 29, wherein the support structure includes a covering material to which the leaflets are attached, and further wherein the connection means extends from the covering material.
32. The prosthetic heart valve of claim 29, wherein the support structure defines a sewing ring, and further wherein at least a portion of the connection means extends from the sewing ring.
33. The prosthetic heart valve of claim 29, wherein the support structure defines stent posts, and further wherein at least a portion of the connection means extends from the stent posts.
34. The prosthetic heart valve of claim 33, wherein the connection means includes a plurality of protrusions, respective ones of which extend from respective ones of the stent posts.
35. A prosthetic heart valve system comprising: a first prosthetic heart valve for initial implantation to native heart tissue and including: a support structure, leaflets mounted to the support structure, connection means associated with the support structure; and a replacement prosthetic heart valve for functionally replacing the first prosthetic heart valve following implant of the first prosthetic heart valve, the replacement prosthetic heart valve including: a support structure, leaflets mounted to the support structure, coupling means associated with the support structure; wherein the connection means and the coupling means are configured such that the coupling means engages the connection means to physically dock the replacement prosthetic heart valve to the first prosthetic heart valve.
36. The system of claim 35, wherein the connection means and the coupling means include complimentary components.
37. The system of claim 35, wherein the connection means includes a ring and the coupling means includes a protrusion adapted to engage the ring.
38. The system of claim 35, wherein the connection means includes a component extending from an inflow side of the first prosthetic heart valve and the coupling means includes a component extending from an inflow side of the replacement prosthetic heart valve.
39. The system of claim 35, wherein the connection means includes a component extending form an outflow side of the first prosthetic heart valve and the coupling means includes a component extending from an outflow side of the replacement prosthetic heart valve.
40. The system of claim 35, wherein the connection means and coupling means are adapted to provide a longitudinal interface therebetween relative to a length of the first and replacement prosthetic heart valves.
PCT/US2005/031500 2004-09-07 2005-09-01 Replacement prosthetic heart valve, system and method of implant WO2006029062A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES18203132T ES2933685T3 (en) 2004-09-07 2005-09-01 Prosthetic Heart Valve Replacement System
EP18203132.8A EP3466373B1 (en) 2004-09-07 2005-09-01 Replacement prosthetic heart valve system
EP05801202.2A EP1804726B1 (en) 2004-09-07 2005-09-01 Replacement prosthetic heart valve and system
EP12155264.0A EP2455042B1 (en) 2004-09-07 2005-09-01 Replacement prosthetic heart valve system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/935,730 US20060052867A1 (en) 2004-09-07 2004-09-07 Replacement prosthetic heart valve, system and method of implant
US10/935,730 2004-09-07

Publications (1)

Publication Number Publication Date
WO2006029062A1 true WO2006029062A1 (en) 2006-03-16

Family

ID=35530857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/031500 WO2006029062A1 (en) 2004-09-07 2005-09-01 Replacement prosthetic heart valve, system and method of implant

Country Status (4)

Country Link
US (6) US20060052867A1 (en)
EP (3) EP3466373B1 (en)
ES (2) ES2708934T3 (en)
WO (1) WO2006029062A1 (en)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US8414641B2 (en) 2007-12-21 2013-04-09 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8460365B2 (en) 2005-09-21 2013-06-11 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8470023B2 (en) 2007-02-05 2013-06-25 Boston Scientific Scimed, Inc. Percutaneous valve, system, and method
US8932349B2 (en) 2004-09-02 2015-01-13 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US9028542B2 (en) 2005-06-10 2015-05-12 Boston Scientific Scimed, Inc. Venous valve, system, and method
US9301843B2 (en) 2003-12-19 2016-04-05 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US9370419B2 (en) 2005-02-23 2016-06-21 Boston Scientific Scimed, Inc. Valve apparatus, system and method
EP1883375B1 (en) * 2005-05-24 2016-12-07 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US9622859B2 (en) 2005-02-01 2017-04-18 Boston Scientific Scimed, Inc. Filter system and method
US9861473B2 (en) 2005-04-15 2018-01-09 Boston Scientific Scimed Inc. Valve apparatus, system and method
EP2861186B1 (en) 2012-06-19 2019-07-24 Boston Scientific Scimed, Inc. Replacement heart valve
EP3050541B1 (en) 2008-05-01 2019-08-14 Edwards Lifesciences Corporation Prosthetic mitral valve assembly
US10595994B1 (en) 2018-09-20 2020-03-24 Vdyne, Llc Side-delivered transcatheter heart valve replacement
US11071627B2 (en) 2018-10-18 2021-07-27 Vdyne, Inc. Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis
US11076956B2 (en) 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
US11109969B2 (en) 2018-10-22 2021-09-07 Vdyne, Inc. Guidewire delivery of transcatheter heart valve
US11166814B2 (en) 2019-08-20 2021-11-09 Vdyne, Inc. Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
US11185409B2 (en) 2019-01-26 2021-11-30 Vdyne, Inc. Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis
EP2358307B1 (en) 2008-09-15 2021-12-15 Medtronic Ventor Technologies Ltd. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US11202706B2 (en) 2019-05-04 2021-12-21 Vdyne, Inc. Cinch device and method for deployment of a side-delivered prosthetic heart valve in a native annulus
US11234813B2 (en) 2020-01-17 2022-02-01 Vdyne, Inc. Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery
US11253359B2 (en) 2018-12-20 2022-02-22 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valves and methods of delivery
US11273033B2 (en) 2018-09-20 2022-03-15 Vdyne, Inc. Side-delivered transcatheter heart valve replacement
US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
US11278437B2 (en) 2018-12-08 2022-03-22 Vdyne, Inc. Compression capable annular frames for side delivery of transcatheter heart valve replacement
US11298227B2 (en) 2019-03-05 2022-04-12 Vdyne, Inc. Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis
US11331186B2 (en) 2019-08-26 2022-05-17 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
US11344413B2 (en) 2018-09-20 2022-05-31 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US11786366B2 (en) 2018-04-04 2023-10-17 Vdyne, Inc. Devices and methods for anchoring transcatheter heart valve

Families Citing this family (375)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US7749245B2 (en) 2000-01-27 2010-07-06 Medtronic, Inc. Cardiac valve procedure methods and devices
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US8366769B2 (en) 2000-06-01 2013-02-05 Edwards Lifesciences Corporation Low-profile, pivotable heart valve sewing ring
AU2001273088A1 (en) 2000-06-30 2002-01-30 Viacor Incorporated Intravascular filter with debris entrapment mechanism
US6409758B2 (en) * 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
US6846325B2 (en) 2000-09-07 2005-01-25 Viacor, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US7556646B2 (en) 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US8771302B2 (en) 2001-06-29 2014-07-08 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
FR2826863B1 (en) 2001-07-04 2003-09-26 Jacques Seguin ASSEMBLY FOR PLACING A PROSTHETIC VALVE IN A BODY CONDUIT
FR2828091B1 (en) 2001-07-31 2003-11-21 Seguin Jacques ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US6752828B2 (en) * 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US7186265B2 (en) * 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US20050137687A1 (en) 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
CA2556077C (en) * 2004-02-05 2012-05-01 Children's Medical Center Corporation Transcatheter delivery of a replacement heart valve
US20090132035A1 (en) * 2004-02-27 2009-05-21 Roth Alex T Prosthetic Heart Valves, Support Structures and Systems and Methods for Implanting the Same
US20070073387A1 (en) * 2004-02-27 2007-03-29 Forster David C Prosthetic Heart Valves, Support Structures And Systems And Methods For Implanting The Same
EP1722711A4 (en) * 2004-02-27 2009-12-02 Aortx Inc Prosthetic heart valve delivery systems and methods
ITTO20040135A1 (en) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa CARDIAC VALVE PROSTHESIS
EP2308425B2 (en) 2004-03-11 2023-10-18 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous Heart Valve Prosthesis
US20050228494A1 (en) * 2004-03-29 2005-10-13 Salvador Marquez Controlled separation heart valve frame
WO2005102015A2 (en) 2004-04-23 2005-11-03 3F Therapeutics, Inc. Implantable prosthetic valve
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
FR2874812B1 (en) * 2004-09-07 2007-06-15 Perouse Soc Par Actions Simpli INTERCHANGEABLE PROTHETIC VALVE
JP2008514345A (en) * 2004-10-02 2008-05-08 クリストフ・ハンス・フーバー Device for treating or replacing a heart valve or surrounding tissue without requiring full cardiopulmonary support
US8562672B2 (en) * 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
ITTO20050074A1 (en) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl CARDIAC VALVE PROSTHESIS
US8574257B2 (en) * 2005-02-10 2013-11-05 Edwards Lifesciences Corporation System, device, and method for providing access in a cardiovascular environment
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
US8211169B2 (en) 2005-05-27 2012-07-03 Medtronic, Inc. Gasket with collar for prosthetic heart valves and methods for using them
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US7682391B2 (en) * 2005-07-13 2010-03-23 Edwards Lifesciences Corporation Methods of implanting a prosthetic mitral heart valve having a contoured sewing ring
WO2007038540A1 (en) 2005-09-26 2007-04-05 Medtronic, Inc. Prosthetic cardiac and venous valves
WO2007058857A2 (en) 2005-11-10 2007-05-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
US20070213813A1 (en) * 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
EP1968491B1 (en) * 2005-12-22 2010-07-07 Symetis SA Stent-valves for valve replacement and associated methods and systems for surgery
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
US7749249B2 (en) * 2006-02-21 2010-07-06 Kardium Inc. Method and device for closing holes in tissue
US8147541B2 (en) * 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US7749266B2 (en) * 2006-02-27 2010-07-06 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
WO2007123658A1 (en) 2006-03-28 2007-11-01 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US7524331B2 (en) * 2006-04-06 2009-04-28 Medtronic Vascular, Inc. Catheter delivered valve having a barrier to provide an enhanced seal
US7740655B2 (en) * 2006-04-06 2010-06-22 Medtronic Vascular, Inc. Reinforced surgical conduit for implantation of a stented valve therein
US20070239269A1 (en) * 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US20070244545A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Prosthetic Conduit With Radiopaque Symmetry Indicators
US20070244546A1 (en) * 2006-04-18 2007-10-18 Medtronic Vascular, Inc. Stent Foundation for Placement of a Stented Valve
WO2007130881A2 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
US8021161B2 (en) * 2006-05-01 2011-09-20 Edwards Lifesciences Corporation Simulated heart valve root for training and testing
JP2009536074A (en) * 2006-05-05 2009-10-08 チルドレンズ・メディカル・センター・コーポレイション Transcatheter heart valve
US8500799B2 (en) * 2006-06-20 2013-08-06 Cardiacmd, Inc. Prosthetic heart valves, support structures and systems and methods for implanting same
JP2009540952A (en) * 2006-06-20 2009-11-26 エーオーテックス, インコーポレイテッド Torque shaft and torque drive
US8142492B2 (en) * 2006-06-21 2012-03-27 Aortx, Inc. Prosthetic valve implantation systems
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
US20080126131A1 (en) * 2006-07-17 2008-05-29 Walgreen Co. Predictive Modeling And Risk Stratification Of A Medication Therapy Regimen
US20090306768A1 (en) 2006-07-28 2009-12-10 Cardiaq Valve Technologies, Inc. Percutaneous valve prosthesis and system and method for implanting same
US7837610B2 (en) 2006-08-02 2010-11-23 Kardium Inc. System for improving diastolic dysfunction
US20100256752A1 (en) * 2006-09-06 2010-10-07 Forster David C Prosthetic heart valves, support structures and systems and methods for implanting the same,
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US8414643B2 (en) 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US11304800B2 (en) 2006-09-19 2022-04-19 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US8784478B2 (en) 2006-10-16 2014-07-22 Medtronic Corevalve, Inc. Transapical delivery system with ventruculo-arterial overlfow bypass
JP5593545B2 (en) 2006-12-06 2014-09-24 メドトロニック シーブイ ルクセンブルク エス.アー.エール.エル. System and method for transapical delivery of a self-expanding valve secured to an annulus
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
EP2129332B1 (en) * 2007-02-16 2019-01-23 Medtronic, Inc. Replacement prosthetic heart valves
US20080208327A1 (en) * 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
FR2915087B1 (en) 2007-04-20 2021-11-26 Corevalve Inc IMPLANT FOR TREATMENT OF A HEART VALVE, IN PARTICULAR OF A MITRAL VALVE, EQUIPMENT INCLUDING THIS IMPLANT AND MATERIAL FOR PLACING THIS IMPLANT.
US8663318B2 (en) * 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Method and apparatus for percutaneous aortic valve replacement
US9308086B2 (en) 2010-09-21 2016-04-12 Hocor Cardiovascular Technologies Llc Method and system for balloon counterpulsation during aortic valve replacement
US8663319B2 (en) 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Methods and apparatus for percutaneous aortic valve replacement
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
DE102007043830A1 (en) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Heart valve stent
WO2009045331A1 (en) 2007-09-28 2009-04-09 St. Jude Medical, Inc. Two-stage collapsible/expandable prosthetic heart valves and anchoring systems
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US10856970B2 (en) 2007-10-10 2020-12-08 Medtronic Ventor Technologies Ltd. Prosthetic heart valve for transfemoral delivery
US20090138079A1 (en) * 2007-10-10 2009-05-28 Vector Technologies Ltd. Prosthetic heart valve for transfemoral delivery
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
EP3744291B1 (en) 2008-01-24 2022-11-23 Medtronic, Inc. Stents for prosthetic heart valves
EP2254512B1 (en) * 2008-01-24 2016-01-06 Medtronic, Inc. Markers for prosthetic heart valves
US9149358B2 (en) 2008-01-24 2015-10-06 Medtronic, Inc. Delivery systems for prosthetic heart valves
US9393115B2 (en) 2008-01-24 2016-07-19 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
WO2009094197A1 (en) 2008-01-24 2009-07-30 Medtronic, Inc. Stents for prosthetic heart valves
AU2009219415B2 (en) * 2008-02-25 2013-01-17 Medtronic Vascular Inc. Infundibular reducer devices
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (en) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart
WO2009108355A1 (en) 2008-02-28 2009-09-03 Medtronic, Inc. Prosthetic heart valve systems
EP2594230B1 (en) 2008-02-29 2021-04-28 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
US9241792B2 (en) * 2008-02-29 2016-01-26 Edwards Lifesciences Corporation Two-step heart valve implantation
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8696689B2 (en) * 2008-03-18 2014-04-15 Medtronic Ventor Technologies Ltd. Medical suturing device and method for use thereof
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
US8696743B2 (en) 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US20090287304A1 (en) 2008-05-13 2009-11-19 Kardium Inc. Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve
ATE554731T1 (en) 2008-05-16 2012-05-15 Sorin Biomedica Cardio Srl ATRAAUMATIC PROSTHETIC HEART VALVE PROSTHESIS
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
US9314335B2 (en) 2008-09-19 2016-04-19 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
US8287591B2 (en) * 2008-09-19 2012-10-16 Edwards Lifesciences Corporation Transformable annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
CA2749026C (en) 2008-09-29 2018-01-09 Impala, Inc. Heart valve
EP2341871B1 (en) 2008-10-01 2017-03-22 Edwards Lifesciences CardiAQ LLC Delivery system for vascular implant
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8449625B2 (en) 2009-10-27 2013-05-28 Edwards Lifesciences Corporation Methods of measuring heart valve annuluses for valve replacement
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
EP2370138B1 (en) 2008-11-25 2020-12-30 Edwards Lifesciences Corporation Apparatus for in situ expansion of prosthetic device
US8591573B2 (en) * 2008-12-08 2013-11-26 Hector Daniel Barone Prosthetic valve for intraluminal implantation
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
EP2201911B1 (en) 2008-12-23 2015-09-30 Sorin Group Italia S.r.l. Expandable prosthetic valve having anchoring appendages
US8366767B2 (en) * 2009-03-30 2013-02-05 Causper Medical Inc. Methods and devices for transapical delivery of a sutureless valve prosthesis
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
JP2012523894A (en) * 2009-04-15 2012-10-11 カルディアック バルブ テクノロジーズ,インコーポレーテッド Vascular implant and its placement system
EP2628465A1 (en) 2009-04-27 2013-08-21 Sorin Group Italia S.r.l. Prosthetic vascular conduit
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
EP2448522A4 (en) * 2009-07-02 2018-01-31 The Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
CN102573703B (en) * 2009-08-27 2014-12-10 麦德托尼克公司 Transcatheter valve delivery systems and methods
US8562673B2 (en) 2009-09-21 2013-10-22 Medtronic, Inc. Stented transcatheter prosthetic heart valve delivery system and method
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
WO2011041571A2 (en) 2009-10-01 2011-04-07 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US20120303132A1 (en) * 2009-12-03 2012-11-29 M.I.Tech Co., Inc. Stent for bile duct
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
AU2010328106A1 (en) 2009-12-08 2012-07-05 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
US10433956B2 (en) * 2010-02-24 2019-10-08 Medtronic Ventor Technologies Ltd. Mitral prosthesis and methods for implantation
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
US9522062B2 (en) 2010-02-24 2016-12-20 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US8795354B2 (en) * 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US20110224785A1 (en) 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US8926692B2 (en) 2010-04-09 2015-01-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with partial deployment and release features and methods
US8512400B2 (en) 2010-04-09 2013-08-20 Medtronic, Inc. Transcatheter heart valve delivery system with reduced area moment of inertia
US8998980B2 (en) 2010-04-09 2015-04-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US8876892B2 (en) 2010-04-21 2014-11-04 Medtronic, Inc. Prosthetic heart valve delivery system with spacing
US8740976B2 (en) 2010-04-21 2014-06-03 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with flush report
US8623075B2 (en) 2010-04-21 2014-01-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
US8568474B2 (en) 2010-04-26 2013-10-29 Medtronic, Inc. Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods
CN102917668B (en) 2010-04-27 2015-01-28 美敦力公司 Transcatheter prosthetic heart valve delivery device with biased release features
WO2011139594A2 (en) 2010-04-27 2011-11-10 Medtronic, Inc. Artificial bursa for intra-articular drug delivery
JP5688865B2 (en) 2010-04-27 2015-03-25 メドトロニック,インコーポレイテッド Transcatheter prosthetic heart valve delivery device with passive trigger release
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CA2793916C (en) 2010-05-10 2016-10-25 Edwards Lifesciences Corporation Prosthetic heart valve
US9554901B2 (en) 2010-05-12 2017-01-31 Edwards Lifesciences Corporation Low gradient prosthetic heart valve
IT1400327B1 (en) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl SUPPORT DEVICE FOR VALVULAR PROSTHESIS AND CORRESPONDING CORRESPONDENT.
CN103002833B (en) 2010-05-25 2016-05-11 耶拿阀门科技公司 Artificial heart valve and comprise artificial heart valve and support through conduit carry interior prosthese
US9561102B2 (en) 2010-06-02 2017-02-07 Medtronic, Inc. Transcatheter delivery system and method with controlled expansion and contraction of prosthetic heart valve
EP2582326B1 (en) 2010-06-21 2016-05-18 Edwards Lifesciences CardiAQ LLC Replacement heart valve
US9474597B2 (en) * 2010-07-21 2016-10-25 Kevin D. Accola Prosthetic heart valves and devices, systems and methods for prosthetic heart valves
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US9763657B2 (en) * 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
JP5874727B2 (en) 2010-09-01 2016-03-02 メドトロニック ヴァスキュラー ゴールウェイ Prosthetic valve support structure
US9370418B2 (en) 2010-09-10 2016-06-21 Edwards Lifesciences Corporation Rapidly deployable surgical heart valves
US9125741B2 (en) 2010-09-10 2015-09-08 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
EP2618784B1 (en) 2010-09-23 2016-05-25 Edwards Lifesciences CardiAQ LLC Replacement heart valves and delivery devices
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
US8882693B2 (en) * 2010-12-07 2014-11-11 Zoll Lifebridge Gmbh Cardiopulmonary apparatus and methods for preserving life
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
EP2486893B1 (en) 2011-02-14 2017-07-05 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
EP2688516B1 (en) 2011-03-21 2022-08-17 Cephea Valve Technologies, Inc. Disk-based valve apparatus
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
US9289282B2 (en) 2011-05-31 2016-03-22 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
DE102011108143A1 (en) * 2011-07-21 2013-01-24 Maximilian Kütting Modular system for producing catheter-based heart valve prostheses and prosthesis for other human flap positions, has sail sheet carrying base element and anchoring elements, which is connected to base element
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
EP3417813B1 (en) 2011-08-05 2020-05-13 Cardiovalve Ltd Percutaneous mitral valve replacement
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9480559B2 (en) 2011-08-11 2016-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
CA2853659C (en) * 2011-11-01 2017-01-10 Curtiss T. Stinis Aortic valve positioning systems, devices, and methods
PT2787926T (en) 2011-12-09 2022-09-20 Edwards Lifesciences Corp Prosthetic heart valve improved commissure supports
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
EP2609893B1 (en) 2011-12-29 2014-09-03 Sorin Group Italia S.r.l. A kit for implanting prosthetic vascular conduits
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
WO2014021905A1 (en) 2012-07-30 2014-02-06 Tendyne Holdings, Inc. Improved delivery systems and methods for transcatheter prosthetic valves
US20140067048A1 (en) 2012-09-06 2014-03-06 Edwards Lifesciences Corporation Heart Valve Sealing Devices
CA2892521C (en) 2012-12-31 2019-05-21 Edwards Lifesciences Corporation Surgical heart valves adapted for post-implant expansion
US10543085B2 (en) 2012-12-31 2020-01-28 Edwards Lifesciences Corporation One-piece heart valve stents adapted for post-implant expansion
WO2014115149A2 (en) 2013-01-24 2014-07-31 Mitraltech Ltd. Ventricularly-anchored prosthetic valves
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9168129B2 (en) 2013-02-12 2015-10-27 Edwards Lifesciences Corporation Artificial heart valve with scalloped frame design
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9333077B2 (en) 2013-03-12 2016-05-10 Medtronic Vascular Galway Limited Devices and methods for preparing a transcatheter heart valve system
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US20140276616A1 (en) * 2013-03-15 2014-09-18 Syntheon Cardiology, Llc Catheter-based devices and methods for identifying specific anatomical landmarks of the human aortic valve
US11007058B2 (en) 2013-03-15 2021-05-18 Edwards Lifesciences Corporation Valved aortic conduits
EP2967945B1 (en) 2013-03-15 2020-10-28 California Institute of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
SG11201506352SA (en) 2013-03-15 2015-09-29 Edwards Lifesciences Corp Valved aortic conduits
US11224510B2 (en) 2013-04-02 2022-01-18 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
EP2991586A1 (en) 2013-05-03 2016-03-09 Medtronic Inc. Valve delivery tool
JP6515088B2 (en) 2013-05-20 2019-05-15 エドワーズ ライフサイエンシーズ コーポレイションEdwards Lifesciences Corporation Prosthetic heart valve delivery device
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US9468527B2 (en) 2013-06-12 2016-10-18 Edwards Lifesciences Corporation Cardiac implant with integrated suture fasteners
JP6461122B2 (en) 2013-06-25 2019-01-30 テンダイン ホールディングス,インコーポレイテッド Thrombus management and structural compliance features of prosthetic heart valves
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
US9724083B2 (en) 2013-07-26 2017-08-08 Edwards Lifesciences Cardiaq Llc Systems and methods for sealing openings in an anatomical wall
JP6465883B2 (en) 2013-08-01 2019-02-06 テンダイン ホールディングス,インコーポレイテッド Epicardial anchor device and method
PL3545906T3 (en) 2013-08-14 2021-07-12 Mitral Valve Technologies Sàrl Replacement heart valve apparatus
US9919137B2 (en) 2013-08-28 2018-03-20 Edwards Lifesciences Corporation Integrated balloon catheter inflation system
CN105491978A (en) 2013-08-30 2016-04-13 耶拿阀门科技股份有限公司 Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
CN105611903B (en) * 2013-08-30 2017-11-21 雪松-西奈医学中心 For taking out the apparatus and method of mechanical heart valve leaflets through conduit
WO2015042135A1 (en) 2013-09-20 2015-03-26 Edwards Lifesciences Corporation Heart valves with increased effective orifice area
WO2015058039A1 (en) 2013-10-17 2015-04-23 Robert Vidlund Apparatus and methods for alignment and deployment of intracardiac devices
US9421094B2 (en) 2013-10-23 2016-08-23 Caisson Interventional, LLC Methods and systems for heart valve therapy
CN105682611B (en) 2013-10-28 2018-06-01 坦迪尼控股股份有限公司 Prosthetic heart valve and the system and method for conveying prosthetic heart valve
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US20150122687A1 (en) 2013-11-06 2015-05-07 Edwards Lifesciences Corporation Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
WO2015120122A2 (en) 2014-02-05 2015-08-13 Robert Vidlund Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
WO2015126711A1 (en) 2014-02-18 2015-08-27 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
CA3205860A1 (en) * 2014-02-20 2015-08-27 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
EP4248914A2 (en) 2014-02-21 2023-09-27 Mitral Valve Technologies Sàrl Prosthetic mitral valve and anchoring device
CN106170269B (en) 2014-02-21 2019-01-11 爱德华兹生命科学卡迪尔克有限责任公司 The delivery apparatus of controlled deployment for valve substitutes
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
AU2015229708B2 (en) 2014-03-10 2019-08-15 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
BR102014006114B1 (en) * 2014-03-14 2022-05-10 Antônio Francisco Neves Filho Mechanical or biological heart valve stent for minimally invasive valve replacement procedure and stent delivery device
US9549816B2 (en) 2014-04-03 2017-01-24 Edwards Lifesciences Corporation Method for manufacturing high durability heart valve
US9585752B2 (en) 2014-04-30 2017-03-07 Edwards Lifesciences Corporation Holder and deployment system for surgical heart valves
CA2948179C (en) 2014-05-07 2023-08-15 Baylor College Of Medicine Artificial, flexible valves and methods of fabricating and serially expanding the same
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
WO2015179423A1 (en) 2014-05-19 2015-11-26 Cardiaq Valve Technologies, Inc. Replacement mitral valve with annular flap
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
USD867594S1 (en) 2015-06-19 2019-11-19 Edwards Lifesciences Corporation Prosthetic heart valve
CA2914094C (en) 2014-06-20 2021-01-05 Edwards Lifesciences Corporation Surgical heart valves identifiable post-implant
CA2955242A1 (en) 2014-07-08 2016-01-14 Avinger, Inc. High speed chronic total occlusion crossing devices
US10195026B2 (en) 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
US10524910B2 (en) 2014-07-30 2020-01-07 Mitraltech Ltd. 3 Ariel Sharon Avenue Articulatable prosthetic valve
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
WO2016093877A1 (en) 2014-12-09 2016-06-16 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
CN107405195B (en) 2015-01-07 2020-09-08 坦迪尼控股股份有限公司 Artificial mitral valve and apparatus and method for delivering artificial mitral valve
CA3162308A1 (en) 2015-02-05 2016-08-11 Cardiovalve Ltd. Prosthetic valve with axially-sliding frames
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
CA2975294A1 (en) 2015-02-05 2016-08-11 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
EP3283010B1 (en) 2015-04-16 2020-06-17 Tendyne Holdings, Inc. Apparatus for delivery and repositioning of transcatheter prosthetic valves
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
EP3632378A1 (en) 2015-05-01 2020-04-08 JenaValve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
EP3294221B1 (en) 2015-05-14 2024-03-06 Cephea Valve Technologies, Inc. Replacement mitral valves
US10849746B2 (en) 2015-05-14 2020-12-01 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
US10779936B2 (en) * 2015-05-18 2020-09-22 Mayo Foundation For Medical Education And Research Percutaneously-deployable prosthetic tricuspid valve
WO2016201024A1 (en) * 2015-06-12 2016-12-15 St. Jude Medical, Cardiology Division, Inc. Heart valve repair and replacement
CA2990872C (en) 2015-06-22 2022-03-22 Edwards Lifescience Cardiaq Llc Actively controllable heart valve implant and methods of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
EP3316823B1 (en) 2015-07-02 2020-04-08 Edwards Lifesciences Corporation Integrated hybrid heart valves
CR20170577A (en) 2015-07-02 2019-05-03 Edwards Lifesciences Corp Hybrid heart valves adapted for post-implant expansion.-
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
EP3344158B1 (en) 2015-09-02 2023-03-01 Edwards Lifesciences Corporation Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
EP3162880A1 (en) * 2015-10-29 2017-05-03 The Procter and Gamble Company Liquid detergent composition
US10376364B2 (en) 2015-11-10 2019-08-13 Edwards Lifesciences Corporation Implant delivery capsule
EP3383322B1 (en) 2015-12-03 2020-02-12 Tendyne Holdings, Inc. Frame features for prosthetic mitral valves
CA3006010C (en) 2015-12-28 2023-09-26 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
EP3397208B1 (en) 2015-12-30 2020-12-02 Caisson Interventional, LLC Systems for heart valve therapy
JP7006940B2 (en) 2016-01-29 2022-01-24 ニオバスク ティアラ インコーポレイテッド Artificial valve to avoid blockage of outflow
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10667904B2 (en) 2016-03-08 2020-06-02 Edwards Lifesciences Corporation Valve implant with integrated sensor and transmitter
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US10456245B2 (en) 2016-05-16 2019-10-29 Edwards Lifesciences Corporation System and method for applying material to a stent
WO2017218375A1 (en) 2016-06-13 2017-12-21 Tendyne Holdings, Inc. Sequential delivery of two-part prosthetic mitral valve
US11331187B2 (en) 2016-06-17 2022-05-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
US11090157B2 (en) 2016-06-30 2021-08-17 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus and methods for delivery of same
EP3484411A1 (en) 2016-07-12 2019-05-22 Tendyne Holdings, Inc. Apparatus and methods for trans-septal retrieval of prosthetic heart valves
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
GB201613219D0 (en) 2016-08-01 2016-09-14 Mitraltech Ltd Minimally-invasive delivery systems
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
US10856975B2 (en) 2016-08-10 2020-12-08 Cardiovalve Ltd. Prosthetic valve with concentric frames
WO2018035375A1 (en) 2016-08-19 2018-02-22 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve and methods of use
EP3503848B1 (en) 2016-08-26 2021-09-22 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
CN110167491A (en) 2016-11-09 2019-08-23 波士顿科学国际有限公司 Bracket with displacement capacity
FR3058631B1 (en) * 2016-11-14 2019-01-25 Laboratoires Invalv IMPLANT FOR TREATING A BIOLOGICAL VALVE
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
USD846122S1 (en) 2016-12-16 2019-04-16 Edwards Lifesciences Corporation Heart valve sizer
CA3051272C (en) 2017-01-23 2023-08-22 Cephea Valve Technologies, Inc. Replacement mitral valves
EP4209196A1 (en) 2017-01-23 2023-07-12 Cephea Valve Technologies, Inc. Replacement mitral valves
CN110392557A (en) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 Heart valve simulation
WO2018145249A1 (en) * 2017-02-07 2018-08-16 上海甲悦医疗器械有限公司 Device for treating regurgitation of tricuspid valve and implantation method therefor
US10463485B2 (en) 2017-04-06 2019-11-05 Edwards Lifesciences Corporation Prosthetic valve holders with automatic deploying mechanisms
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
WO2018200681A1 (en) 2017-04-28 2018-11-01 Edwards Lifesciences Corporation Prosthetic heart valve with collapsible holder
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
CA3065329A1 (en) 2017-06-21 2018-12-27 Edwards Lifesciences Corporation Dual-wireform limited expansion heart valves
CA3067150A1 (en) 2017-07-06 2019-01-10 Edwards Lifesciences Corporation Steerable rail delivery system
US10786352B2 (en) * 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
EP3651695B1 (en) 2017-07-13 2023-04-19 Tendyne Holdings, Inc. Prosthetic heart valves and apparatus for delivery of same
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
EP3672530A4 (en) 2017-08-25 2021-04-14 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
AU2018323900A1 (en) 2017-08-28 2020-02-27 Tendyne Holdings, Inc. Prosthetic heart valves with tether coupling features
US11337802B2 (en) 2017-09-19 2022-05-24 Cardiovalve Ltd. Heart valve delivery systems and methods
US9895226B1 (en) 2017-10-19 2018-02-20 Mitral Tech Ltd. Techniques for use with prosthetic valve leaflets
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
GB201800399D0 (en) 2018-01-10 2018-02-21 Mitraltech Ltd Temperature-control during crimping of an implant
EP3743016A1 (en) 2018-01-23 2020-12-02 Edwards Lifesciences Corporation Prosthetic valve holders, systems, and methods
CN111818877B (en) 2018-01-25 2023-12-22 爱德华兹生命科学公司 Delivery system for assisting in recapture and repositioning of replacement valves after deployment
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
EP3796873B1 (en) 2018-05-23 2022-04-27 Corcym S.r.l. A cardiac valve prosthesis
USD944398S1 (en) 2018-06-13 2022-02-22 Edwards Lifesciences Corporation Expanded heart valve stent
USD908874S1 (en) 2018-07-11 2021-01-26 Edwards Lifesciences Corporation Collapsible heart valve sizer
US10779946B2 (en) 2018-09-17 2020-09-22 Cardiovalve Ltd. Leaflet-testing apparatus
JP7260930B2 (en) 2018-11-08 2023-04-19 ニオバスク ティアラ インコーポレイテッド Ventricular deployment of a transcatheter mitral valve prosthesis
EP3946163A4 (en) 2019-04-01 2022-12-21 Neovasc Tiara Inc. Controllably deployable prosthetic valve
WO2020210652A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
CA3140925A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
EP3831343B1 (en) 2019-12-05 2024-01-31 Tendyne Holdings, Inc. Braided anchor for mitral valve
WO2021126778A1 (en) 2019-12-16 2021-06-24 Edwards Lifesciences Corporation Valve holder assembly with suture looping protection
US11648114B2 (en) 2019-12-20 2023-05-16 Tendyne Holdings, Inc. Distally loaded sheath and loading funnel
US11786355B2 (en) 2020-01-30 2023-10-17 Boston Scientific Scimed, Inc. Radial adjusting self-expanding stent with anti-migration features
US11678980B2 (en) 2020-08-19 2023-06-20 Tendyne Holdings, Inc. Fully-transseptal apical pad with pulley for tensioning
US11701224B1 (en) * 2022-06-28 2023-07-18 Seven Summits Medical, Inc. Prosthetic heart valve for multiple positions and applications

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680031A (en) 1982-11-29 1987-07-14 Tascon Medical Technology Corporation Heart valve prosthesis
US4892541A (en) 1982-11-29 1990-01-09 Tascon Medical Technology Corporation Heart valve prosthesis
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US5156621A (en) 1988-03-22 1992-10-20 Navia Jose A Stentless bioprosthetic cardiac valve
US5197979A (en) 1990-09-07 1993-03-30 Baxter International Inc. Stentless heart valve and holder
US5509930A (en) 1993-12-17 1996-04-23 Autogenics Stentless heart valve
US6001126A (en) 1997-12-24 1999-12-14 Baxter International Inc. Stentless bioprosthetic heart valve with coronary protuberances and related methods for surgical repair of defective heart valves
US6168614B1 (en) * 1990-05-18 2001-01-02 Heartport, Inc. Valve prosthesis for implantation in the body
US6254436B1 (en) 1997-12-10 2001-07-03 Koito Manufacturing Co., Ltd. Electrical connector for automotive lamp
US6364905B1 (en) 1999-01-27 2002-04-02 Sulzer Carbomedics Inc. Tri-composite, full root, stentless valve
FR2826863A1 (en) * 2001-07-04 2003-01-10 Jacques Seguin ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT
US6558417B2 (en) 1998-06-26 2003-05-06 St. Jude Medical, Inc. Single suture biological tissue aortic stentless valve
WO2005013860A2 (en) * 2003-07-29 2005-02-17 PFM PRODUKTE FüR DIE MEDIZIN AKTIENGESELLSCHAFT Implantable device as organ valve replacement
US20050251251A1 (en) * 1996-12-31 2005-11-10 Alain Cribier Valve prosthesis for implantation in body channels

Family Cites Families (407)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US456854A (en) 1891-07-28 William j
US334629A (en) * 1886-01-19 Elevated filter bed
DE1057460B (en) 1956-09-28 1959-05-14 Auergesellschaft Ag Device for closing and quickly opening a gas-tight container for respiratory protection and / or rescue equipment
DE1088529B (en) 1958-03-15 1960-09-08 Knorr Bremse Gmbh Acceleration device for compressed air brakes, especially for rail vehicles
DE1271508B (en) 1962-12-21 1968-06-27 Hurth Masch Zahnrad Carl Shaving wheel suitable for machining a specific gear
US3334629A (en) 1964-11-09 1967-08-08 Bertram D Cohn Occlusive device for inferior vena cava
GB1127325A (en) 1965-08-23 1968-09-18 Henry Berry Improved instrument for inserting artificial heart valves
US3587115A (en) 1966-05-04 1971-06-28 Donald P Shiley Prosthetic sutureless heart valves and implant tools therefor
US3540431A (en) 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3671979A (en) 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3628535A (en) 1969-11-12 1971-12-21 Nibot Corp Surgical instrument for implanting a prosthetic heart valve or the like
US3642004A (en) * 1970-01-05 1972-02-15 Life Support Equipment Corp Urethral valve
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3714671A (en) * 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3755823A (en) 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
US3868956A (en) * 1972-06-05 1975-03-04 Ralph J Alfidi Vessel implantable appliance and method of implanting it
US3839741A (en) 1972-11-17 1974-10-08 J Haller Heart valve and retaining means therefor
US3795246A (en) * 1973-01-26 1974-03-05 Bard Inc C R Venocclusion device
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4291420A (en) 1973-11-09 1981-09-29 Medac Gesellschaft Fur Klinische Spezialpraparate Mbh Artificial heart valve
US4035849A (en) 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
CA1069652A (en) 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4233690A (en) 1978-05-19 1980-11-18 Carbomedics, Inc. Prosthetic device couplings
US4222126A (en) 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
US4574803A (en) * 1979-01-19 1986-03-11 Karl Storz Tissue cutter
GB2056023B (en) 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4339831A (en) 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4470157A (en) 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
US4345340A (en) 1981-05-07 1982-08-24 Vascor, Inc. Stent for mitral/tricuspid heart valve
US4501030A (en) * 1981-08-17 1985-02-26 American Hospital Supply Corporation Method of leaflet attachment for prosthetic heart valves
US4425908A (en) * 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
FR2523810B1 (en) * 1982-03-23 1988-11-25 Carpentier Alain ORGANIC GRAFT FABRIC AND PROCESS FOR ITS PREPARATION
SE445884B (en) 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
US4610688A (en) 1983-04-04 1986-09-09 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
US4834755A (en) 1983-04-04 1989-05-30 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
US4612011A (en) 1983-07-22 1986-09-16 Hans Kautzky Central occluder semi-biological heart valve
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4681908A (en) 1983-11-09 1987-07-21 Dow Corning Corporation Hard organopolysiloxane release coating
US4787899A (en) 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4627436A (en) 1984-03-01 1986-12-09 Innoventions Biomedical Inc. Angioplasty catheter and method for use thereof
US4592340A (en) 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US4979939A (en) 1984-05-14 1990-12-25 Surgical Systems & Instruments, Inc. Atherectomy system with a guide wire
US5007896A (en) * 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4883458A (en) 1987-02-24 1989-11-28 Surgical Systems & Instruments, Inc. Atherectomy system and method of using the same
DE3426300A1 (en) 1984-07-17 1986-01-30 Doguhan Dr.med. 6000 Frankfurt Baykut TWO-WAY VALVE AND ITS USE AS A HEART VALVE PROSTHESIS
US4580568A (en) 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US5232445A (en) 1984-11-23 1993-08-03 Tassilo Bonzel Dilatation catheter
SU1271508A1 (en) 1984-11-29 1986-11-23 Горьковский государственный медицинский институт им.С.М.Кирова Artificial heart valve
DE3530262A1 (en) * 1985-08-22 1987-02-26 Siemens Ag CIRCUIT ARRANGEMENT FOR TESTING A PASSIVE BUS NETWORK SYSTEM (CSMA / CD ACCESS METHOD)
US4662885A (en) 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
DE3640745A1 (en) * 1985-11-30 1987-06-04 Ernst Peter Prof Dr M Strecker Catheter for producing or extending connections to or between body cavities
US4710192A (en) 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US5061273A (en) 1989-06-01 1991-10-29 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
US4748982A (en) * 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US4878495A (en) 1987-05-15 1989-11-07 Joseph Grayzel Valvuloplasty device with satellite expansion means
US4872874A (en) 1987-05-29 1989-10-10 Taheri Syde A Method and apparatus for transarterial aortic graft insertion and implantation
US4796629A (en) * 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4819751A (en) 1987-10-16 1989-04-11 Baxter Travenol Laboratories, Inc. Valvuloplasty catheter and method
US4909252A (en) * 1988-05-26 1990-03-20 The Regents Of The Univ. Of California Perfusion balloon catheter
US4917102A (en) 1988-09-14 1990-04-17 Advanced Cardiovascular Systems, Inc. Guidewire assembly with steerable adjustable tip
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4966604A (en) 1989-01-23 1990-10-30 Interventional Technologies Inc. Expandable atherectomy cutter with flexibly bowed blades
US4994077A (en) * 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
WO1990014804A1 (en) * 1989-05-31 1990-12-13 Baxter International Inc. Biological valvular prosthesis
US5609626A (en) * 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5047041A (en) 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US4986830A (en) * 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US5089015A (en) * 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5002559A (en) * 1989-11-30 1991-03-26 Numed PTCA catheter
US5059177A (en) 1990-04-19 1991-10-22 Cordis Corporation Triple lumen balloon catheter
US5085635A (en) * 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5217483A (en) 1990-11-28 1993-06-08 Numed, Inc. Intravascular radially expandable stent
US5161547A (en) 1990-11-28 1992-11-10 Numed, Inc. Method of forming an intravascular radially expandable stent
US6165292A (en) * 1990-12-18 2000-12-26 Advanced Cardiovascular Systems, Inc. Superelastic guiding member
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5295958A (en) 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5272909A (en) 1991-04-25 1993-12-28 Baxter International Inc. Method and device for testing venous valves
US5167628A (en) 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5350398A (en) 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
IT1245750B (en) * 1991-05-24 1994-10-14 Sorin Biomedica Emodialisi S R CARDIAC VALVE PROSTHESIS, PARTICULARLY FOR REPLACING THE AORTIC VALVE
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5558644A (en) 1991-07-16 1996-09-24 Heartport, Inc. Retrograde delivery catheter and method for inducing cardioplegic arrest
US20060058775A1 (en) * 1991-07-16 2006-03-16 Stevens John H System and methods for performing endovascular procedures
US5584803A (en) 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5795325A (en) 1991-07-16 1998-08-18 Heartport, Inc. Methods and apparatus for anchoring an occluding member
US5766151A (en) 1991-07-16 1998-06-16 Heartport, Inc. Endovascular system for arresting the heart
US6866650B2 (en) * 1991-07-16 2005-03-15 Heartport, Inc. System for cardiac procedures
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
US5163953A (en) 1992-02-10 1992-11-17 Vince Dennis J Toroidal artificial heart valve stent
CA2089302C (en) * 1992-03-30 2004-07-06 Joseph Frank Savelli Double annular combustor
DE69333161T2 (en) 1992-05-08 2004-06-03 Schneider (Usa) Inc., Plymouth Stent for the esophagus
US5332402A (en) 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
WO1994015549A1 (en) * 1992-12-30 1994-07-21 Schneider (Usa) Inc. Apparatus for deploying body implantable stents
US5431676A (en) 1993-03-05 1995-07-11 Innerdyne Medical, Inc. Trocar system having expandable port
US5415633A (en) * 1993-07-28 1995-05-16 Active Control Experts, Inc. Remotely steered catheterization device
KR970004845Y1 (en) 1993-09-27 1997-05-21 주식회사 수호메디테크 Stent for expanding a lumen
US5545209A (en) * 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
US5389106A (en) * 1993-10-29 1995-02-14 Numed, Inc. Impermeable expandable intravascular stent
US5480424A (en) 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5713950A (en) 1993-11-01 1998-02-03 Cox; James L. Method of replacing heart valves using flexible tubes
US5489294A (en) * 1994-02-01 1996-02-06 Medtronic, Inc. Steroid eluting stitch-in chronic cardiac lead
US5609627A (en) 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5549663A (en) 1994-03-09 1996-08-27 Cordis Corporation Endoprosthesis having graft member and exposed welded end junctions, method and procedure
US5695607A (en) 1994-04-01 1997-12-09 James River Corporation Of Virginia Soft-single ply tissue having very low sidedness
AU2391795A (en) 1994-04-22 1995-11-16 Medtronic, Inc. Stented bioprosthetic heart valve
US5765418A (en) 1994-05-16 1998-06-16 Medtronic, Inc. Method for making an implantable medical device from a refractory metal
CA2149290C (en) * 1994-05-26 2006-07-18 Carl T. Urban Optical trocar
JP3970341B2 (en) 1994-06-20 2007-09-05 テルモ株式会社 Vascular catheter
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5674277A (en) 1994-12-23 1997-10-07 Willy Rusch Ag Stent for placement in a body tube
US5575818A (en) 1995-02-14 1996-11-19 Corvita Corporation Endovascular stent with locking ring
US5849005A (en) 1995-06-07 1998-12-15 Heartport, Inc. Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity
ATE269742T1 (en) 1995-03-30 2004-07-15 Heartport Inc SYSTEM FOR PERFORMING ENDOVASCULAR PROCEDURES
US5667523A (en) 1995-04-28 1997-09-16 Impra, Inc. Dual supported intraluminal graft
US5824064A (en) 1995-05-05 1998-10-20 Taheri; Syde A. Technique for aortic valve replacement with simultaneous aortic arch graft insertion and apparatus therefor
US5580922A (en) 1995-06-06 1996-12-03 Weyerhaeuser Company Cellulose products treated with isocyanate compositions
CA2223001A1 (en) * 1995-06-07 1996-12-19 St. Jude Medical, Inc. Direct suture orifice for mechanical heart valve
AU6280396A (en) 1995-06-20 1997-01-22 Efstathios A. Agathos Human valve replacement with marine mammal valve
DE19532846A1 (en) 1995-09-06 1997-03-13 Georg Dr Berg Valve for use in heart
US5591195A (en) * 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
DE19546692C2 (en) 1995-12-14 2002-11-07 Hans-Reiner Figulla Self-expanding heart valve prosthesis for implantation in the human body via a catheter system
US5861028A (en) * 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
WO1997027959A1 (en) 1996-01-30 1997-08-07 Medtronic, Inc. Articles for and methods of making stents
JPH09215753A (en) * 1996-02-08 1997-08-19 Schneider Usa Inc Self-expanding stent made of titanium alloy
US20020068949A1 (en) 1996-02-23 2002-06-06 Williamson Warren P. Extremely long wire fasteners for use in minimally invasive surgery and means and method for handling those fasteners
JPH09226463A (en) * 1996-02-28 1997-09-02 Suzuki Motor Corp Glove compartment structure
US5695498A (en) 1996-02-28 1997-12-09 Numed, Inc. Stent implantation system
US5891191A (en) 1996-04-30 1999-04-06 Schneider (Usa) Inc Cobalt-chromium-molybdenum alloy stent and stent-graft
FR2748198B1 (en) * 1996-05-02 1998-08-21 Braun Celsa Sa PROSTHESIS IN PARTICULAR FOR THE TREATMENT OF ANNEVRISMS OVERFLOWING ON ILIAC VESSELS
EP0897288A4 (en) 1996-05-14 2000-04-05 Embol X Inc Aortic occluder with associated filter and methods of use during cardiac surgery
EP0808614B1 (en) 1996-05-23 2003-02-26 Samsung Electronics Co., Ltd. Flexible self-expandable stent and method for making the same
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US6702851B1 (en) 1996-09-06 2004-03-09 Joseph A. Chinn Prosthetic heart valve with surface modification
US6764509B2 (en) 1996-09-06 2004-07-20 Carbomedics Inc. Prosthetic heart valve with surface modification
US5968068A (en) 1996-09-12 1999-10-19 Baxter International Inc. Endovascular delivery system
JP2000501328A (en) * 1996-10-01 2000-02-08 ヌームド インコーポレーテッド Expandable stent
US5749890A (en) * 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
NL1004827C2 (en) 1996-12-18 1998-06-19 Surgical Innovations Vof Device for regulating blood circulation.
GB9701479D0 (en) * 1997-01-24 1997-03-12 Aortech Europ Ltd Heart valve
US6241757B1 (en) 1997-02-04 2001-06-05 Solco Surgical Instrument Co., Ltd. Stent for expanding body's lumen
CA2281519A1 (en) 1997-02-19 1998-08-27 Condado Medical Devices Corporation Multi-purpose catheters, catheter systems, and radiation treatment
US5830229A (en) 1997-03-07 1998-11-03 Micro Therapeutics Inc. Hoop stent
US5817126A (en) 1997-03-17 1998-10-06 Surface Genesis, Inc. Compound stent
US5824053A (en) 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Helical mesh endoprosthesis and methods of use
US5868783A (en) * 1997-04-16 1999-02-09 Numed, Inc. Intravascular stent with limited axial shrinkage
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6245102B1 (en) 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6162245A (en) 1997-05-07 2000-12-19 Iowa-India Investments Company Limited Stent valve and stent graft
US5911734A (en) 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6258120B1 (en) 1997-12-23 2001-07-10 Embol-X, Inc. Implantable cerebral protection device and methods of use
US5984957A (en) 1997-08-12 1999-11-16 Schneider (Usa) Inc Radially expanded prostheses with axial diameter control
WO1999012483A1 (en) 1997-09-11 1999-03-18 Genzyme Corporation Articulating endoscopic implant rotator surgical apparatus and method for using same
US5954766A (en) 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US6056722A (en) * 1997-09-18 2000-05-02 Iowa-India Investments Company Limited Of Douglas Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use
US6361545B1 (en) 1997-09-26 2002-03-26 Cardeon Corporation Perfusion filter catheter
US5925063A (en) 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6530952B2 (en) * 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
EP2258312B9 (en) 1997-12-29 2012-09-19 The Cleveland Clinic Foundation Deployable surgical platform and system for the removal and delivery of a medical device comprising such deployable surgical platform
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
EP1054634A4 (en) 1998-02-10 2006-03-29 Artemis Medical Inc Entrapping apparatus and method for use
ATE454098T1 (en) 1998-02-10 2010-01-15 Artemis Medical Inc OCCLUSION, ANCHORING, CHIPING OR POWER CONTROL DEVICE
US6059809A (en) * 1998-02-16 2000-05-09 Medicorp, S.A. Protective angioplasty device
US6280467B1 (en) 1998-02-26 2001-08-28 World Medical Manufacturing Corporation Delivery system for deployment and endovascular assembly of a multi-stage stented graft
EP0943300A1 (en) * 1998-03-17 1999-09-22 Medicorp S.A. Reversible action endoprosthesis delivery device.
US6074418A (en) 1998-04-20 2000-06-13 St. Jude Medical, Inc. Driver tool for heart valve prosthesis fasteners
US6627873B2 (en) 1998-04-23 2003-09-30 Baker Hughes Incorporated Down hole gas analyzer method and apparatus
US6218662B1 (en) * 1998-04-23 2001-04-17 Western Atlas International, Inc. Downhole carbon dioxide gas analyzer
US6450989B2 (en) 1998-04-27 2002-09-17 Artemis Medical, Inc. Dilating and support apparatus with disease inhibitors and methods for use
US6890330B2 (en) 2000-10-27 2005-05-10 Viacor, Inc. Intracardiovascular access (ICVATM) system
DK1087727T3 (en) 1998-06-02 2005-01-31 Cook Inc Multilateral, intraluminal, medical device
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US6630001B2 (en) 1998-06-24 2003-10-07 International Heart Institute Of Montana Foundation Compliant dehyrated tissue for implantation and process of making the same
US6159239A (en) * 1998-08-14 2000-12-12 Prodesco, Inc. Woven stent/graft structure
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6475239B1 (en) 1998-10-13 2002-11-05 Sulzer Carbomedics Inc. Method for making polymer heart valves with leaflets having uncut free edges
US6051014A (en) 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US6146366A (en) 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
DE19857887B4 (en) 1998-12-15 2005-05-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anchoring support for a heart valve prosthesis
FR2788217A1 (en) 1999-01-12 2000-07-13 Brice Letac PROSTHETIC VALVE IMPLANTABLE BY CATHETERISM, OR SURGICAL
US6896690B1 (en) 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
US7018401B1 (en) 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
AU772868C (en) 1999-02-01 2005-08-11 Board Of Regents, The University Of Texas System Woven bifurcated and trifurcated stents and methods for making the same
DE19904975A1 (en) * 1999-02-06 2000-09-14 Impella Cardiotech Ag Device for intravascular heart valve surgery
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
AU3999700A (en) 1999-02-12 2000-08-29 Johns Hopkins University, The Venous valve implant bioprosthesis and endovascular treatment for venous insufficiency
US6110201A (en) 1999-02-18 2000-08-29 Venpro Bifurcated biological pulmonary valved conduit
DE19907646A1 (en) 1999-02-23 2000-08-24 Georg Berg Valve for blood vessels uses flap holders and counterpart holders on stent to latch together in place and all channeled for guide wire.
IL128938A0 (en) 1999-03-11 2000-02-17 Mind Guard Ltd Implantable stroke treating device
US6673089B1 (en) 1999-03-11 2004-01-06 Mindguard Ltd. Implantable stroke treating device
US7147663B1 (en) 1999-04-23 2006-12-12 St. Jude Medical Atg, Inc. Artificial heart valve attachment apparatus and methods
US6309417B1 (en) * 1999-05-12 2001-10-30 Paul A. Spence Heart valve and apparatus for replacement thereof
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
EP1057460A1 (en) 1999-06-01 2000-12-06 Numed, Inc. Replacement valve assembly and method of implanting same
EP1057459A1 (en) 1999-06-01 2000-12-06 Numed, Inc. Radially expandable stent
WO2001005331A1 (en) 1999-07-16 2001-01-25 Biocompatibles Ltd Braided stent
US6371970B1 (en) 1999-07-30 2002-04-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
JP2001054075A (en) * 1999-08-06 2001-02-23 Hitachi Ltd Motion compensation scanning conversion circuit for image signal
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
IT1307268B1 (en) 1999-09-30 2001-10-30 Sorin Biomedica Cardio Spa DEVICE FOR HEART VALVE REPAIR OR REPLACEMENT.
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
FR2799364B1 (en) 1999-10-12 2001-11-23 Jacques Seguin MINIMALLY INVASIVE CANCELING DEVICE
US6352708B1 (en) 1999-10-14 2002-03-05 The International Heart Institute Of Montana Foundation Solution and method for treating autologous tissue for implant operation
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
US6585758B1 (en) 1999-11-16 2003-07-01 Scimed Life Systems, Inc. Multi-section filamentary endoluminal stent
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US20070043435A1 (en) * 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
FR2800984B1 (en) 1999-11-17 2001-12-14 Jacques Seguin DEVICE FOR REPLACING A HEART VALVE PERCUTANEOUSLY
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US6379383B1 (en) 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
US7300457B2 (en) 1999-11-19 2007-11-27 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7195641B2 (en) * 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6936066B2 (en) 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
HUP0204398A2 (en) 2000-01-27 2003-03-28 3F Therapeutics Prosthetic heart valve
US6872226B2 (en) * 2001-01-29 2005-03-29 3F Therapeutics, Inc. Method of cutting material for use in implantable medical device
US7749245B2 (en) * 2000-01-27 2010-07-06 Medtronic, Inc. Cardiac valve procedure methods and devices
US6769434B2 (en) 2000-06-30 2004-08-03 Viacor, Inc. Method and apparatus for performing a procedure on a cardiac valve
US7296577B2 (en) 2000-01-31 2007-11-20 Edwards Lifescience Ag Transluminal mitral annuloplasty with active anchoring
US6398807B1 (en) 2000-01-31 2002-06-04 Scimed Life Systems, Inc. Braided branching stent, method for treating a lumen therewith, and process for manufacture therefor
US6652571B1 (en) 2000-01-31 2003-11-25 Scimed Life Systems, Inc. Braided, branched, implantable device and processes for manufacture thereof
US6989028B2 (en) * 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6622604B1 (en) 2000-01-31 2003-09-23 Scimed Life Systems, Inc. Process for manufacturing a braided bifurcated stent
ES2286097T7 (en) * 2000-01-31 2009-11-05 Cook Biotech, Inc ENDOPROTESIS VALVES.
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
DE10010073B4 (en) * 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anchoring for implantable heart valve prostheses
DE10010074B4 (en) * 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for fastening and anchoring heart valve prostheses
US6468303B1 (en) 2000-03-27 2002-10-22 Aga Medical Corporation Retrievable self expanding shunt
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
WO2001082836A2 (en) 2000-05-04 2001-11-08 Oregon Health Sciences University Endovascular stent graft
SE522805C2 (en) 2000-06-22 2004-03-09 Jan Otto Solem Stent Application System
US6527800B1 (en) 2000-06-26 2003-03-04 Rex Medical, L.P. Vascular device and method for valve leaflet apposition
US6695878B2 (en) 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
US6676698B2 (en) * 2000-06-26 2004-01-13 Rex Medicol, L.P. Vascular device with valve for approximating vessel wall
AU2001273088A1 (en) * 2000-06-30 2002-01-30 Viacor Incorporated Intravascular filter with debris entrapment mechanism
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US6846325B2 (en) * 2000-09-07 2005-01-25 Viacor, Inc. Fixation band for affixing a prosthetic heart valve to tissue
JP4660026B2 (en) * 2000-09-08 2011-03-30 パナソニック株式会社 Display panel drive device
US20060142848A1 (en) 2000-09-12 2006-06-29 Shlomo Gabbay Extra-anatomic aortic valve placement
US7510572B2 (en) * 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
DE10049814B4 (en) 2000-10-09 2006-10-19 Universitätsklinikum Freiburg Device for supporting surgical procedures within a vessel, in particular for minimally invasive explantation and implantation of heart valves
DE10049813C1 (en) 2000-10-09 2002-04-18 Universitaetsklinikum Freiburg Instrument for the local removal of built-up matter at an aortic valve, in a human or animal heart, is a hollow catheter with a cutting unit at the far end within a closure cap for minimum invasion
DE10049812B4 (en) 2000-10-09 2004-06-03 Universitätsklinikum Freiburg Device for filtering out macroscopic particles from the bloodstream during local removal of an aortic valve on the human or animal heart
DE10049815B4 (en) 2000-10-09 2005-10-13 Universitätsklinikum Freiburg Device for local ablation of an aortic valve on the human or animal heart
WO2002076281A2 (en) * 2000-11-07 2002-10-03 Artemis Medical Inc. Tissue separator assembly and method
US6482228B1 (en) 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
JP4328093B2 (en) 2000-11-21 2009-09-09 レックス メディカル リミテッド パートナーシップ Percutaneous aortic valve
US6494909B2 (en) 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
US20020072789A1 (en) 2000-12-12 2002-06-13 Hackett Steven S. Soc lubricant filler port
WO2002047539A2 (en) 2000-12-15 2002-06-20 Viacor, Inc. Apparatus and method for replacing aortic valve
ES2253325T3 (en) * 2000-12-15 2006-06-01 ANGIOMED GMBH & CO. MEDIZINTECHNIK KG ENDOVASCULAR PROTESIS WITH VALVE.
US6562058B2 (en) 2001-03-02 2003-05-13 Jacques Seguin Intravascular filter system
US6503272B2 (en) 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US7374571B2 (en) * 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US7556646B2 (en) * 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
DE10121210B4 (en) 2001-04-30 2005-11-17 Universitätsklinikum Freiburg Anchoring element for the intraluminal anchoring of a heart valve replacement and method for its production
US6682558B2 (en) 2001-05-10 2004-01-27 3F Therapeutics, Inc. Delivery system for a stentless valve bioprosthesis
US6663663B2 (en) 2001-05-14 2003-12-16 M.I. Tech Co., Ltd. Stent
US20030069635A1 (en) 2001-05-29 2003-04-10 Cartledge Richard G. Prosthetic heart valve
KR100393548B1 (en) 2001-06-05 2003-08-02 주식회사 엠아이텍 Stent
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US7201761B2 (en) * 2001-06-29 2007-04-10 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
FR2828091B1 (en) * 2001-07-31 2003-11-21 Seguin Jacques ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT
FR2828263B1 (en) * 2001-08-03 2007-05-11 Philipp Bonhoeffer DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE
US6896002B2 (en) * 2001-08-21 2005-05-24 Scimed Life Systems, Inc Pressure transducer protection valve
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20030065386A1 (en) * 2001-09-28 2003-04-03 Weadock Kevin Shaun Radially expandable endoprosthesis device with two-stage deployment
US6976974B2 (en) 2002-10-23 2005-12-20 Scimed Life Systems, Inc. Rotary manifold syringe
US7172572B2 (en) 2001-10-04 2007-02-06 Boston Scientific Scimed, Inc. Manifold system for a medical device
US20080021552A1 (en) * 2001-10-09 2008-01-24 Shlomo Gabbay Apparatus To Facilitate Implantation
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
GB0125925D0 (en) * 2001-10-29 2001-12-19 Univ Glasgow Mitral valve prosthesis
US6978176B2 (en) * 2001-12-08 2005-12-20 Lattouf Omar M Treatment for patient with congestive heart failure
US7189258B2 (en) 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
US20030130729A1 (en) 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US6730377B2 (en) 2002-01-23 2004-05-04 Scimed Life Systems, Inc. Balloons made from liquid crystal polymer blends
US6689144B2 (en) 2002-02-08 2004-02-10 Scimed Life Systems, Inc. Rapid exchange catheter and methods for delivery of vaso-occlusive devices
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US7125418B2 (en) 2002-04-16 2006-10-24 The International Heart Institute Of Montana Foundation Sigmoid valve and method for its percutaneous implantation
US20030199971A1 (en) 2002-04-23 2003-10-23 Numed, Inc. Biological replacement valve assembly
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US7141064B2 (en) 2002-05-08 2006-11-28 Edwards Lifesciences Corporation Compressed tissue for heart valve leaflets
US6830575B2 (en) 2002-05-08 2004-12-14 Scimed Life Systems, Inc. Method and device for providing full protection to a stent
US20040117004A1 (en) 2002-05-16 2004-06-17 Osborne Thomas A. Stent and method of forming a stent with integral barbs
EP1513440A2 (en) * 2002-05-30 2005-03-16 The Board of Trustees of The Leland Stanford Junior University Apparatus and method for coronary sinus access
US8287555B2 (en) * 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
DE10362367B3 (en) 2002-08-13 2022-02-24 Jenavalve Technology Inc. Device for anchoring and aligning prosthetic heart valves
US7041132B2 (en) * 2002-08-16 2006-05-09 3F Therapeutics, Inc, Percutaneously delivered heart valve and delivery means thereof
CA2503258C (en) 2002-08-28 2011-08-16 Heart Leaflet Technologies, Inc. Method and device for treating diseased valve
US6875231B2 (en) 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
US7105013B2 (en) * 2002-09-30 2006-09-12 Advanced Cardiovascular Systems, Inc. Protective sleeve assembly for a balloon catheter
AU2003277115A1 (en) * 2002-10-01 2004-04-23 Ample Medical, Inc. Device and method for repairing a native heart valve leaflet
JP2006503654A (en) 2002-10-24 2006-02-02 ボストン サイエンティフィック リミテッド Venous valve device and method
EP1567087B1 (en) 2002-11-08 2009-04-01 Jacques Seguin Endoprosthesis for vascular bifurcation
US7255706B2 (en) 2002-11-13 2007-08-14 Rosengart Todd K Apparatus and method for cutting a heart valve
US6887266B2 (en) 2002-11-14 2005-05-03 Synecor, Llc Endoprostheses and methods of manufacture
FR2847155B1 (en) 2002-11-20 2005-08-05 Younes Boudjemline METHOD FOR MANUFACTURING A MEDICAL IMPLANT WITH ADJUSTED STRUCTURE AND IMPLANT OBTAINED THEREBY
WO2004050137A2 (en) 2002-11-29 2004-06-17 Mindguard Ltd. Braided intraluminal device for stroke prevention
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6830585B1 (en) 2003-01-14 2004-12-14 3F Therapeutics, Inc. Percutaneously deliverable heart valve and methods of implantation
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
WO2004089250A1 (en) 2003-03-30 2004-10-21 Fidel Realyvasquez Apparatus and methods for valve repair
US20050107871A1 (en) 2003-03-30 2005-05-19 Fidel Realyvasquez Apparatus and methods for valve repair
WO2004089253A1 (en) * 2003-04-01 2004-10-21 Cook Incorporated Percutaneously deployed vascular valves
US7175656B2 (en) * 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US20040210240A1 (en) 2003-04-21 2004-10-21 Sean Saint Method and repair device for treating mitral valve insufficiency
US8388628B2 (en) 2003-04-24 2013-03-05 Medtronic, Inc. Expandable sheath for delivering instruments and agents into a body lumen and methods for use
US7591832B2 (en) 2003-04-24 2009-09-22 Medtronic, Inc. Expandable guide sheath and apparatus with distal protection and methods for use
EP1472996B1 (en) * 2003-04-30 2009-09-30 Medtronic Vascular, Inc. Percutaneously delivered temporary valve
US20040267357A1 (en) 2003-04-30 2004-12-30 Allen Jeffrey W. Cardiac valve modification method and device
EP1631218B1 (en) 2003-05-28 2010-09-15 Cook Incorporated Prosthetic valve with vessel engaging member
WO2005004753A1 (en) 2003-06-09 2005-01-20 3F Therapeutics, Inc. Atrioventricular heart valve and minimally invasive delivery systems thereof
US20040260394A1 (en) 2003-06-20 2004-12-23 Medtronic Vascular, Inc. Cardiac valve annulus compressor system
US20070255396A1 (en) 2003-06-20 2007-11-01 Medtronic Vascular, Inc. Chrodae Tendinae Girdle
EP1648346A4 (en) 2003-06-20 2006-10-18 Medtronic Vascular Inc Valve annulus reduction system
WO2004112652A2 (en) * 2003-06-20 2004-12-29 Medtronic Vascular, Inc. Device, system, and method for contracting tissue in a mammalian body
US7316706B2 (en) * 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
US7201772B2 (en) * 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
EP1648339B2 (en) 2003-07-08 2020-06-17 Ventor Technologies Ltd. Implantable prosthetic devices particularly for transarterial delivery in the treatment of aortic stenosis, and methods of implanting such devices
WO2005018507A2 (en) * 2003-07-18 2005-03-03 Ev3 Santa Rosa, Inc. Remotely activated mitral annuloplasty system and methods
US7621948B2 (en) * 2003-07-21 2009-11-24 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
WO2005011535A2 (en) * 2003-07-31 2005-02-10 Cook Incorporated Prosthetic valve for implantation in a body vessel
EP1659992B1 (en) 2003-07-31 2013-03-27 Cook Medical Technologies LLC Prosthetic valve devices and methods of making such devices
DE10340265A1 (en) * 2003-08-29 2005-04-07 Sievers, Hans-Hinrich, Prof. Dr.med. Prosthesis for the replacement of the aortic and / or mitral valve of the heart
US20050049692A1 (en) * 2003-09-02 2005-03-03 Numamoto Michael J. Medical device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US8535344B2 (en) 2003-09-12 2013-09-17 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection and removing embolic material
WO2005032421A2 (en) 2003-09-15 2005-04-14 Medtronic Vascular, Inc. Apparatus and method for elongation of a papillary muscle
EG24012A (en) 2003-09-24 2008-03-23 Wael Mohamed Nabil Lotfy Valved balloon stent
US10219899B2 (en) 2004-04-23 2019-03-05 Medtronic 3F Therapeutics, Inc. Cardiac valve replacement systems
US7604650B2 (en) 2003-10-06 2009-10-20 3F Therapeutics, Inc. Method and assembly for distal embolic protection
US7101396B2 (en) * 2003-10-06 2006-09-05 3F Therapeutics, Inc. Minimally invasive valve replacement system
US20060259137A1 (en) 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
ATE464864T1 (en) 2003-10-15 2010-05-15 Cook Inc HOLDING DEVICE FOR A PROSTHESIS STORAGE SYSTEM
US7419498B2 (en) 2003-10-21 2008-09-02 Nmt Medical, Inc. Quick release knot attachment system
US7347869B2 (en) 2003-10-31 2008-03-25 Cordis Corporation Implantable valvular prosthesis
US7070616B2 (en) 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
WO2005046531A2 (en) 2003-11-12 2005-05-26 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve regurgitation
US7955384B2 (en) * 2003-11-12 2011-06-07 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve regurgitation
WO2005046488A2 (en) * 2003-11-12 2005-05-26 Medtronic Vascular, Inc. Cardiac valve annulus reduction system
WO2005048883A1 (en) 2003-11-13 2005-06-02 Fidel Realyvasquez Methods and apparatus for valve repair
US7186265B2 (en) 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US7261732B2 (en) * 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
WO2005069850A2 (en) 2004-01-15 2005-08-04 Macoviak John A Trestle heart valve replacement
US7597711B2 (en) * 2004-01-26 2009-10-06 Arbor Surgical Technologies, Inc. Heart valve assembly with slidable coupling connections
CA2556077C (en) 2004-02-05 2012-05-01 Children's Medical Center Corporation Transcatheter delivery of a replacement heart valve
FR2865926B1 (en) * 2004-02-11 2006-05-12 Perouse Laboratoires TUBULAR PROSTHESIS.
US20050203549A1 (en) 2004-03-09 2005-09-15 Fidel Realyvasquez Methods and apparatus for off pump aortic valve replacement with a valve prosthesis
WO2005089674A1 (en) 2004-03-15 2005-09-29 Medtronic Vascular Inc. Radially crush-resistant stent
US7131936B2 (en) 2004-03-17 2006-11-07 Schlosser Frank J Apparatus for training a body part of a person and method for using same
CA2561188A1 (en) 2004-03-31 2005-10-20 Med Institute, Inc. Endoluminal graft with a prosthetic valve
US7462191B2 (en) * 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
FR2874812B1 (en) * 2004-09-07 2007-06-15 Perouse Soc Par Actions Simpli INTERCHANGEABLE PROTHETIC VALVE
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
US6951571B1 (en) 2004-09-30 2005-10-04 Rohit Srivastava Valve implanting device
US20060089711A1 (en) * 2004-10-27 2006-04-27 Medtronic Vascular, Inc. Multifilament anchor for reducing a compass of a lumen or structure in mammalian body
WO2006054107A2 (en) * 2004-11-19 2006-05-26 Medtronic Inc. Method and apparatus for treatment of cardiac valves
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
US7955385B2 (en) 2005-02-28 2011-06-07 Medtronic Vascular, Inc. Device, system, and method for aiding valve annuloplasty
US7780723B2 (en) * 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US20070027533A1 (en) * 2005-07-28 2007-02-01 Medtronic Vascular, Inc. Cardiac valve annulus restraining device
AU2006295080A1 (en) * 2005-09-21 2007-04-05 Medtronic, Inc. Composite heart valve apparatus manufactured using techniques involving laser machining of tissue
WO2007038540A1 (en) * 2005-09-26 2007-04-05 Medtronic, Inc. Prosthetic cardiac and venous valves
US7482899B2 (en) * 2005-10-02 2009-01-27 Jun Shen Electromechanical latching relay and method of operating same
US8167932B2 (en) * 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US20070100439A1 (en) 2005-10-31 2007-05-03 Medtronic Vascular, Inc. Chordae tendinae restraining ring
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
US20070203391A1 (en) 2006-02-24 2007-08-30 Medtronic Vascular, Inc. System for Treating Mitral Valve Regurgitation
US20070225681A1 (en) 2006-03-21 2007-09-27 Medtronic Vascular Catheter Having a Selectively Formable Distal Section
US20070238979A1 (en) 2006-03-23 2007-10-11 Medtronic Vascular, Inc. Reference Devices for Placement in Heart Structures for Visualization During Heart Valve Procedures
WO2007123658A1 (en) 2006-03-28 2007-11-01 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US20070233238A1 (en) 2006-03-31 2007-10-04 Medtronic Vascular, Inc. Devices for Imaging and Navigation During Minimally Invasive Non-Bypass Cardiac Procedures
EP2004053A2 (en) 2006-03-31 2008-12-24 Medtronic Vascular Inc. Telescoping catheter with electromagnetic coils for imaging and navigation during cardiac procedures
US7625403B2 (en) 2006-04-04 2009-12-01 Medtronic Vascular, Inc. Valved conduit designed for subsequent catheter delivered valve therapy
US7740655B2 (en) 2006-04-06 2010-06-22 Medtronic Vascular, Inc. Reinforced surgical conduit for implantation of a stented valve therein
US7524331B2 (en) 2006-04-06 2009-04-28 Medtronic Vascular, Inc. Catheter delivered valve having a barrier to provide an enhanced seal
US7591848B2 (en) 2006-04-06 2009-09-22 Medtronic Vascular, Inc. Riveted stent valve for percutaneous use
US20070239269A1 (en) 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
US7699892B2 (en) 2006-04-12 2010-04-20 Medtronic Vascular, Inc. Minimally invasive procedure for implanting an annuloplasty device
US20070244555A1 (en) 2006-04-12 2007-10-18 Medtronic Vascular, Inc. Annuloplasty Device Having a Helical Anchor and Methods for its Use
EP2010102B1 (en) 2006-04-12 2019-06-12 Medtronic Vascular, Inc. Annuloplasty device having a helical anchor
US20070244544A1 (en) 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US20070244545A1 (en) 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Prosthetic Conduit With Radiopaque Symmetry Indicators
US20070244546A1 (en) 2006-04-18 2007-10-18 Medtronic Vascular, Inc. Stent Foundation for Placement of a Stented Valve
US20070288000A1 (en) 2006-04-19 2007-12-13 Medtronic Vascular, Inc. Method for Aiding Valve Annuloplasty
US7442207B2 (en) 2006-04-21 2008-10-28 Medtronic Vascular, Inc. Device, system, and method for treating cardiac valve regurgitation
CN101442958B (en) 2006-04-28 2012-09-05 麦德托尼克公司 Apparatus for cardiac valve replacement
EP2111190B1 (en) 2007-01-19 2013-10-09 Medtronic, Inc. Stented heart valve devices for atrioventricular valve replacement
EP2124826B2 (en) 2007-02-15 2020-09-23 Medtronic, Inc. Multi-layered stents
EP2129332B1 (en) 2007-02-16 2019-01-23 Medtronic, Inc. Replacement prosthetic heart valves

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4892541A (en) 1982-11-29 1990-01-09 Tascon Medical Technology Corporation Heart valve prosthesis
US4680031A (en) 1982-11-29 1987-07-14 Tascon Medical Technology Corporation Heart valve prosthesis
US5156621A (en) 1988-03-22 1992-10-20 Navia Jose A Stentless bioprosthetic cardiac valve
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US6168614B1 (en) * 1990-05-18 2001-01-02 Heartport, Inc. Valve prosthesis for implantation in the body
US5197979A (en) 1990-09-07 1993-03-30 Baxter International Inc. Stentless heart valve and holder
US5336258A (en) 1990-09-07 1994-08-09 Baxter International Inc. Stentless heart valve and holder
US5509930A (en) 1993-12-17 1996-04-23 Autogenics Stentless heart valve
US20050251251A1 (en) * 1996-12-31 2005-11-10 Alain Cribier Valve prosthesis for implantation in body channels
US6254436B1 (en) 1997-12-10 2001-07-03 Koito Manufacturing Co., Ltd. Electrical connector for automotive lamp
US6001126A (en) 1997-12-24 1999-12-14 Baxter International Inc. Stentless bioprosthetic heart valve with coronary protuberances and related methods for surgical repair of defective heart valves
US6342070B1 (en) 1997-12-24 2002-01-29 Edwards Lifesciences Corp. Stentless bioprosthetic heart valve with patent coronary protuberances and method of surgical use thereof
US6558417B2 (en) 1998-06-26 2003-05-06 St. Jude Medical, Inc. Single suture biological tissue aortic stentless valve
US6364905B1 (en) 1999-01-27 2002-04-02 Sulzer Carbomedics Inc. Tri-composite, full root, stentless valve
FR2826863A1 (en) * 2001-07-04 2003-01-10 Jacques Seguin ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT
WO2005013860A2 (en) * 2003-07-29 2005-02-17 PFM PRODUKTE FüR DIE MEDIZIN AKTIENGESELLSCHAFT Implantable device as organ valve replacement

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BONHOEFFER, P. ET AL.: "Percutaneous Insertion of the Pulmonary Valve", JAM COLL CARDIOL, vol. 39, 2002, pages 1664 - 1669
H. SAFI, D. ILIOPOULOS, D. DUFF: "Repeat replacement of aortic valve bioprosthesis", ANN. THORAC. SURG., vol. 59, 1995, pages 1217 - 1219, XP008058625 *
P. BONHOEFFER: "Percutaneous insertion of the pulmonary valve", JOURNAL OF AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION, vol. 39, no. 10, 2002, pages 1664 - 1669
P.BONHOEFFER: "Percutaneous insertion of the pulmonarry valve", JOURNAL OF AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION, vol. 39, no. 10, 2002, pages 1664 - 1669, XP008058618 *

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9301843B2 (en) 2003-12-19 2016-04-05 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8932349B2 (en) 2004-09-02 2015-01-13 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US9918834B2 (en) 2004-09-02 2018-03-20 Boston Scientific Scimed, Inc. Cardiac valve, system and method
US9622859B2 (en) 2005-02-01 2017-04-18 Boston Scientific Scimed, Inc. Filter system and method
US9808341B2 (en) 2005-02-23 2017-11-07 Boston Scientific Scimed Inc. Valve apparatus, system and method
US9370419B2 (en) 2005-02-23 2016-06-21 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9861473B2 (en) 2005-04-15 2018-01-09 Boston Scientific Scimed Inc. Valve apparatus, system and method
EP1883375B1 (en) * 2005-05-24 2016-12-07 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US10130468B2 (en) 2005-05-24 2018-11-20 Edwards Lifesciences Corporation Replacement prosthetic heart valves
US11284998B2 (en) 2005-05-24 2022-03-29 Edwards Lifesciences Corporation Surgical methods of replacing prosthetic heart valves
US10456251B2 (en) 2005-05-24 2019-10-29 Edwards Lifesciences Corporation Surgical methods of replacing prosthetic heart valves
US9554903B2 (en) 2005-05-24 2017-01-31 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
US11337812B2 (en) 2005-06-10 2022-05-24 Boston Scientific Scimed, Inc. Venous valve, system and method
US9028542B2 (en) 2005-06-10 2015-05-12 Boston Scientific Scimed, Inc. Venous valve, system, and method
US9474609B2 (en) 2005-09-21 2016-10-25 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8460365B2 (en) 2005-09-21 2013-06-11 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US10548734B2 (en) 2005-09-21 2020-02-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8672997B2 (en) 2005-09-21 2014-03-18 Boston Scientific Scimed, Inc. Valve with sinus
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US8348999B2 (en) 2007-01-08 2013-01-08 California Institute Of Technology In-situ formation of a valve
US10226344B2 (en) 2007-02-05 2019-03-12 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US11504239B2 (en) 2007-02-05 2022-11-22 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US9421083B2 (en) 2007-02-05 2016-08-23 Boston Scientific Scimed Inc. Percutaneous valve, system and method
US8470023B2 (en) 2007-02-05 2013-06-25 Boston Scientific Scimed, Inc. Percutaneous valve, system, and method
US8414641B2 (en) 2007-12-21 2013-04-09 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
EP3050541B1 (en) 2008-05-01 2019-08-14 Edwards Lifesciences Corporation Prosthetic mitral valve assembly
US10952846B2 (en) 2008-05-01 2021-03-23 Edwards Lifesciences Corporation Method of replacing mitral valve
EP3549555B1 (en) 2008-05-01 2021-06-16 Edwards Lifesciences Corporation Prosthetic mitral valve assembly
US11717401B2 (en) 2008-05-01 2023-08-08 Edwards Lifesciences Corporation Prosthetic heart valve assembly
EP2358307B1 (en) 2008-09-15 2021-12-15 Medtronic Ventor Technologies Ltd. Prosthetic heart valve having identifiers for aiding in radiographic positioning
EP2861186B1 (en) 2012-06-19 2019-07-24 Boston Scientific Scimed, Inc. Replacement heart valve
US11786366B2 (en) 2018-04-04 2023-10-17 Vdyne, Inc. Devices and methods for anchoring transcatheter heart valve
US10595994B1 (en) 2018-09-20 2020-03-24 Vdyne, Llc Side-delivered transcatheter heart valve replacement
US11273033B2 (en) 2018-09-20 2022-03-15 Vdyne, Inc. Side-delivered transcatheter heart valve replacement
US11344413B2 (en) 2018-09-20 2022-05-31 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US11071627B2 (en) 2018-10-18 2021-07-27 Vdyne, Inc. Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis
US11109969B2 (en) 2018-10-22 2021-09-07 Vdyne, Inc. Guidewire delivery of transcatheter heart valve
US11278437B2 (en) 2018-12-08 2022-03-22 Vdyne, Inc. Compression capable annular frames for side delivery of transcatheter heart valve replacement
US11253359B2 (en) 2018-12-20 2022-02-22 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valves and methods of delivery
US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
US11185409B2 (en) 2019-01-26 2021-11-30 Vdyne, Inc. Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis
US11298227B2 (en) 2019-03-05 2022-04-12 Vdyne, Inc. Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
US11076956B2 (en) 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
US11202706B2 (en) 2019-05-04 2021-12-21 Vdyne, Inc. Cinch device and method for deployment of a side-delivered prosthetic heart valve in a native annulus
US11166814B2 (en) 2019-08-20 2021-11-09 Vdyne, Inc. Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
US11179239B2 (en) 2019-08-20 2021-11-23 Vdyne, Inc. Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
US11331186B2 (en) 2019-08-26 2022-05-17 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
US11234813B2 (en) 2020-01-17 2022-02-01 Vdyne, Inc. Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery

Also Published As

Publication number Publication date
ES2708934T3 (en) 2019-04-12
EP3466373B1 (en) 2022-10-26
US20080161911A1 (en) 2008-07-03
US20210007845A1 (en) 2021-01-14
EP2455042B1 (en) 2018-10-31
EP2455042A2 (en) 2012-05-23
US8591570B2 (en) 2013-11-26
US11253355B2 (en) 2022-02-22
EP2455042A3 (en) 2013-09-11
US20140052242A1 (en) 2014-02-20
US20170020666A1 (en) 2017-01-26
EP1804726A1 (en) 2007-07-11
US20080161910A1 (en) 2008-07-03
EP3466373A1 (en) 2019-04-10
ES2933685T3 (en) 2023-02-13
US20060052867A1 (en) 2006-03-09
EP1804726B1 (en) 2016-03-23
US9480556B2 (en) 2016-11-01

Similar Documents

Publication Publication Date Title
US20210007845A1 (en) Replacement prosthetic heart valve, system and method of implant
US20200405478A1 (en) Stented prosthetic heart valves
US10172709B2 (en) Delivery systems and methods of implantation for replacement prosthetic heart valve
EP1883375B1 (en) Rapid deployment prosthetic heart valve
JP5687070B2 (en) Stent for prosthetic heart valve

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005801202

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2005801202

Country of ref document: EP