WO2005045377A3 - Method and system for non-invasive measurements in a human body - Google Patents

Method and system for non-invasive measurements in a human body Download PDF

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Publication number
WO2005045377A3
WO2005045377A3 PCT/IL2004/001015 IL2004001015W WO2005045377A3 WO 2005045377 A3 WO2005045377 A3 WO 2005045377A3 IL 2004001015 W IL2004001015 W IL 2004001015W WO 2005045377 A3 WO2005045377 A3 WO 2005045377A3
Authority
WO
WIPO (PCT)
Prior art keywords
response
medium
condition
electromagnetic field
invasive measurements
Prior art date
Application number
PCT/IL2004/001015
Other languages
French (fr)
Other versions
WO2005045377A2 (en
Inventor
Ilya Fine
Alexander Finarov
Iosef Gandelman
Boris Fikhte
Original Assignee
Orsense Ltd
Ilya Fine
Alexander Finarov
Iosef Gandelman
Boris Fikhte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orsense Ltd, Ilya Fine, Alexander Finarov, Iosef Gandelman, Boris Fikhte filed Critical Orsense Ltd
Priority to JP2006539070A priority Critical patent/JP2007510492A/en
Priority to EP04799324A priority patent/EP1686889A4/en
Publication of WO2005045377A2 publication Critical patent/WO2005045377A2/en
Publication of WO2005045377A3 publication Critical patent/WO2005045377A3/en
Priority to IL175450A priority patent/IL175450A/en
Priority to US10/578,479 priority patent/US20070078312A1/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22Details, e.g. general constructional or apparatus details
    • G01N29/24Probes
    • G01N29/2418Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0053Detecting, measuring or recording by applying mechanical forces or stimuli by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00Indexing codes associated with group G01N29/00
    • G01N2291/02Indexing codes associated with the analysed material
    • G01N2291/024Mixtures
    • G01N2291/02466Biological material, e.g. blood

Abstract

A method and system are presented for use in non-invasive measurements in a patient's body. A condition of artificial blood kinetics is created at a measurement location in a patient's blood perfused fleshy medium, and this condition is maintained for a certain time period. An external electromagnetic field is applied to the measurement location while under the condition of artificial blood kinetics. A time variation of a response of the blood perfused fleshy medium to this external electromagnetic field is detected, and measured data indicative thereof is generated. The response of the medium can be a photo-acoustic signal obtained in response to incident light, and/or impedance of the medium in response to the applied ac electromagnetic field.
PCT/IL2004/001015 2003-11-06 2004-11-04 Method and system for non-invasive measurements in a human body WO2005045377A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2006539070A JP2007510492A (en) 2003-11-06 2004-11-04 Method and system for non-invasive measurement in the human body
EP04799324A EP1686889A4 (en) 2003-11-06 2004-11-04 Method and system for non-invasive measurements in a human body
IL175450A IL175450A (en) 2003-11-06 2006-05-04 Method and system for non-invasive measurements in a human body
US10/578,479 US20070078312A1 (en) 2003-11-06 2006-05-08 Method and system for non-invasive measurements in a human body

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/702,044 2003-11-06
US10/702,044 US7020506B2 (en) 2003-11-06 2003-11-06 Method and system for non-invasive determination of blood-related parameters

Publications (2)

Publication Number Publication Date
WO2005045377A2 WO2005045377A2 (en) 2005-05-19
WO2005045377A3 true WO2005045377A3 (en) 2005-10-27

Family

ID=34551580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/001015 WO2005045377A2 (en) 2003-11-06 2004-11-04 Method and system for non-invasive measurements in a human body

Country Status (4)

Country Link
US (2) US7020506B2 (en)
EP (1) EP1686889A4 (en)
JP (1) JP2007510492A (en)
WO (1) WO2005045377A2 (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914613A (en) 1996-08-08 1999-06-22 Cascade Microtech, Inc. Membrane probing system with local contact scrub
US6256882B1 (en) 1998-07-14 2001-07-10 Cascade Microtech, Inc. Membrane probing system
US6965226B2 (en) 2000-09-05 2005-11-15 Cascade Microtech, Inc. Chuck for holding a device under test
US6914423B2 (en) 2000-09-05 2005-07-05 Cascade Microtech, Inc. Probe station
DE10143173A1 (en) 2000-12-04 2002-06-06 Cascade Microtech Inc Wafer probe has contact finger array with impedance matching network suitable for wide band
WO2003052435A1 (en) 2001-08-21 2003-06-26 Cascade Microtech, Inc. Membrane probing system
US7492172B2 (en) 2003-05-23 2009-02-17 Cascade Microtech, Inc. Chuck for holding a device under test
US7057404B2 (en) 2003-05-23 2006-06-06 Sharp Laboratories Of America, Inc. Shielded probe for testing a device under test
US7250626B2 (en) 2003-10-22 2007-07-31 Cascade Microtech, Inc. Probe testing structure
US7020506B2 (en) * 2003-11-06 2006-03-28 Orsense Ltd. Method and system for non-invasive determination of blood-related parameters
US7187188B2 (en) 2003-12-24 2007-03-06 Cascade Microtech, Inc. Chuck with integrated wafer support
US7427868B2 (en) 2003-12-24 2008-09-23 Cascade Microtech, Inc. Active wafer probe
CN1297229C (en) * 2004-07-27 2007-01-31 天津大学 Non-invasive detection device of pulse impedance spectrum blood sugar or other biood component and its detection method
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
US8036727B2 (en) 2004-08-11 2011-10-11 Glt Acquisition Corp. Methods for noninvasively measuring analyte levels in a subject
US7420381B2 (en) 2004-09-13 2008-09-02 Cascade Microtech, Inc. Double sided probing structures
US7656172B2 (en) 2005-01-31 2010-02-02 Cascade Microtech, Inc. System for testing semiconductors
US7535247B2 (en) 2005-01-31 2009-05-19 Cascade Microtech, Inc. Interface for testing semiconductors
JP2008537903A (en) 2005-04-13 2008-10-02 グルコライト・コーポレーシヨン Data processing and calibration method for blood glucose monitor based on OCT
US9713447B2 (en) * 2005-11-10 2017-07-25 Biovotion Ag Device for determining the glucose level in body tissue
US7758505B2 (en) 2006-04-03 2010-07-20 Elfi-Tech Ltd. Methods and apparatus for non-invasive determination of patient's blood conditions
US7723999B2 (en) 2006-06-12 2010-05-25 Cascade Microtech, Inc. Calibration structures for differential signal probing
US7764072B2 (en) 2006-06-12 2010-07-27 Cascade Microtech, Inc. Differential signal probing system
US7403028B2 (en) 2006-06-12 2008-07-22 Cascade Microtech, Inc. Test structure and probe for differential signals
US20080012578A1 (en) * 2006-07-14 2008-01-17 Cascade Microtech, Inc. System for detecting molecular structure and events
KR100871074B1 (en) * 2007-02-01 2008-11-28 삼성전자주식회사 Noninvasive apparatus and method for measuring blood glucose
WO2008124923A1 (en) * 2007-04-13 2008-10-23 Centre Hospitalier De L'universite De Montreal Method and system of ultrasound scatterer characterization
US7876114B2 (en) 2007-08-08 2011-01-25 Cascade Microtech, Inc. Differential waveguide probe
AU2008299938A1 (en) 2007-09-13 2009-03-19 The Curators Of The University Of Missouri Optical device components
AU2008307505B2 (en) 2007-10-04 2013-01-31 St. Louis Medical Devices, Inc. Optical device components
US7961305B2 (en) 2007-10-23 2011-06-14 The Curators Of The University Of Missouri Optical device components
US8571617B2 (en) 2008-03-04 2013-10-29 Glt Acquisition Corp. Flowometry in optical coherence tomography for analyte level estimation
WO2009120600A2 (en) 2008-03-25 2009-10-01 The Curators Of The University Of Missouri Method and system for non-invasive blood glucose detection utilizing spectral data of one or more components other than glucose
EP3222216B1 (en) 2008-05-22 2019-07-17 St. Louis Medical Devices, Inc. Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
US20090324033A1 (en) * 2008-06-30 2009-12-31 Nellcor Puritan Bennett Ireland Signal Processing Systems and Methods for Determining Slope Using an Origin Point
US8406865B2 (en) * 2008-09-30 2013-03-26 Covidien Lp Bioimpedance system and sensor and technique for using the same
US7888957B2 (en) 2008-10-06 2011-02-15 Cascade Microtech, Inc. Probing apparatus with impedance optimized interface
WO2010059247A2 (en) 2008-11-21 2010-05-27 Cascade Microtech, Inc. Replaceable coupon for a probing apparatus
US8319503B2 (en) 2008-11-24 2012-11-27 Cascade Microtech, Inc. Test apparatus for measuring a characteristic of a device under test
CN102438511B (en) 2009-04-01 2014-11-26 密苏里大学董事会 Optical spectroscopy device for non-invasive blood glucose detection and associated method of use
US8708907B2 (en) * 2009-05-06 2014-04-29 Elfi-Tech Method and apparatus for determining one or more blood parameters from analog electrical signals
US8798704B2 (en) * 2009-09-24 2014-08-05 Covidien Lp Photoacoustic spectroscopy method and system to discern sepsis from shock
US8235897B2 (en) 2010-04-27 2012-08-07 A.D. Integrity Applications Ltd. Device for non-invasively measuring glucose
JP5351848B2 (en) * 2010-07-22 2013-11-27 日本電信電話株式会社 Component concentration measuring method and apparatus
US8930145B2 (en) 2010-07-28 2015-01-06 Covidien Lp Light focusing continuous wave photoacoustic spectroscopy and its applications to patient monitoring
CN102274015A (en) * 2011-05-06 2011-12-14 天津大学 Method and device for wrist strap type pulse signal extraction based on optical fiber vibration period analysis
US8915852B2 (en) * 2012-07-06 2014-12-23 Centre Hospitalier De L'universite De Montreal System and method for ultrasound scatterer characterization
US9582705B2 (en) 2014-08-31 2017-02-28 Qualcomm Incorporated Layered filtering for biometric sensors
US9665763B2 (en) * 2014-08-31 2017-05-30 Qualcomm Incorporated Finger/non-finger determination for biometric sensors
US9195879B1 (en) 2014-08-31 2015-11-24 Qualcomm Incorporated Air/object determination for biometric sensors
KR102335739B1 (en) 2014-12-19 2021-12-06 삼성전자주식회사 Apparatus and method for measuring a blood glucose in a noninvasive manner
EP3278736B1 (en) * 2015-03-30 2019-06-19 Fujifilm Corporation Photoacoustic measurement device and system
WO2017072568A1 (en) 2015-11-01 2017-05-04 Elfi-Tech Ltd. Method and apparatus for hemodynamically characterizing a neurological or fitness state by dynamic light scattering (dls)
US11134901B2 (en) 2016-03-30 2021-10-05 Elfi-Tech Ltd. Method and apparatus for optically measuring blood pressure
US11350837B2 (en) 2016-03-30 2022-06-07 Elfi-Tech Ltd. Method and apparatus for optically measuring blood pressure
JP6795453B2 (en) * 2017-05-22 2020-12-02 日本電信電話株式会社 Measuring device and measuring method
JP2020101479A (en) * 2018-12-25 2020-07-02 日本電信電話株式会社 Component concentration measuring method and device
CN115135241A (en) * 2020-02-18 2022-09-30 朴英权 Non-invasive blood sugar detector
KR102164926B1 (en) * 2020-03-03 2020-10-13 박영권 Non-Invasive Glucose Sensor

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5111817A (en) * 1988-12-29 1992-05-12 Medical Physics, Inc. Noninvasive system and method for enhanced arterial oxygen saturation determination and arterial blood pressure monitoring
US5582179A (en) * 1993-05-17 1996-12-10 Omron Corporation Device to measure vascular function
US5642734A (en) * 1990-10-04 1997-07-01 Microcor, Inc. Method and apparatus for noninvasively determining hematocrit
US5827181A (en) * 1995-09-07 1998-10-27 Hewlett-Packard Co. Noninvasive blood chemistry measurement method and system
US6285894B1 (en) * 1997-03-25 2001-09-04 Siemens Aktiengesellschaft Method and device for non-invasive in vivo determination of blood constituents
US6309884B1 (en) * 1997-02-26 2001-10-30 Diasense, Inc. Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose
US6400972B1 (en) * 1998-06-17 2002-06-04 Orsense Ltd. Non-invasive method and system of optical measurements for determining the concentration of a substance in blood
US6587704B1 (en) * 1999-06-16 2003-07-01 Orsense Ltd. Method for non-invasive optical measurements of blood parameters

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO880891L (en) 1987-03-03 1988-09-05 Elizabeth May Dowling PROCEDURE AND APPARATUS FOR MEASURING OR DETECTING THE CONCENTRATION OF A SUBSTANCE.
US4975581A (en) * 1989-06-21 1990-12-04 University Of New Mexico Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids
US5348002A (en) * 1992-04-23 1994-09-20 Sirraya, Inc. Method and apparatus for material analysis
US5792668A (en) * 1993-08-06 1998-08-11 Solid State Farms, Inc. Radio frequency spectral analysis for in-vitro or in-vivo environments
GB2322941B (en) * 1997-03-07 2001-07-25 Optel Instr Ltd Biological measurement system
US5941821A (en) * 1997-11-25 1999-08-24 Trw Inc. Method and apparatus for noninvasive measurement of blood glucose by photoacoustics
GB9901304D0 (en) 1999-01-22 1999-03-10 Univ Liverpool Apparatus and method for determining dielectric properties of an electrically conductive fluid
EP1251772B1 (en) 1999-12-22 2012-11-14 Orsense Ltd. A method of optical measurements for determining various parameters of the patient's blood
US6466806B1 (en) * 2000-05-17 2002-10-15 Card Guard Scientific Survival Ltd. Photoacoustic material analysis
IL136673A0 (en) 2000-06-11 2001-06-14 Orsense Ltd A method and device for measuring the concentration of glucose or other substance in blood
CN1471373A (en) * 2001-02-05 2004-01-28 ��³��ɭ˹��˾ Methods of determining concentration of glucose in blood
CZ20032650A3 (en) 2001-03-06 2004-04-14 Pendragon Medical Ltd. Method and apparatus for determining concentration of a substance in a body fluid
US7020506B2 (en) * 2003-11-06 2006-03-28 Orsense Ltd. Method and system for non-invasive determination of blood-related parameters

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5111817A (en) * 1988-12-29 1992-05-12 Medical Physics, Inc. Noninvasive system and method for enhanced arterial oxygen saturation determination and arterial blood pressure monitoring
US5642734A (en) * 1990-10-04 1997-07-01 Microcor, Inc. Method and apparatus for noninvasively determining hematocrit
US5582179A (en) * 1993-05-17 1996-12-10 Omron Corporation Device to measure vascular function
US5827181A (en) * 1995-09-07 1998-10-27 Hewlett-Packard Co. Noninvasive blood chemistry measurement method and system
US6309884B1 (en) * 1997-02-26 2001-10-30 Diasense, Inc. Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose
US6285894B1 (en) * 1997-03-25 2001-09-04 Siemens Aktiengesellschaft Method and device for non-invasive in vivo determination of blood constituents
US6400972B1 (en) * 1998-06-17 2002-06-04 Orsense Ltd. Non-invasive method and system of optical measurements for determining the concentration of a substance in blood
US6587704B1 (en) * 1999-06-16 2003-07-01 Orsense Ltd. Method for non-invasive optical measurements of blood parameters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1686889A4 *

Also Published As

Publication number Publication date
US20070078312A1 (en) 2007-04-05
EP1686889A4 (en) 2012-11-28
JP2007510492A (en) 2007-04-26
US20050101846A1 (en) 2005-05-12
WO2005045377A2 (en) 2005-05-19
EP1686889A2 (en) 2006-08-09
US7020506B2 (en) 2006-03-28

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