WO2005009258B1 - Method and device for delivering medicine to bone - Google Patents

Method and device for delivering medicine to bone

Info

Publication number
WO2005009258B1
WO2005009258B1 PCT/US2004/022884 US2004022884W WO2005009258B1 WO 2005009258 B1 WO2005009258 B1 WO 2005009258B1 US 2004022884 W US2004022884 W US 2004022884W WO 2005009258 B1 WO2005009258 B1 WO 2005009258B1
Authority
WO
WIPO (PCT)
Prior art keywords
bone
insert
screw
alloys
substance
Prior art date
Application number
PCT/US2004/022884
Other languages
French (fr)
Other versions
WO2005009258A1 (en
Inventor
Patrick J Sweeney
Original Assignee
Patrick J Sweeney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34108876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005009258(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/620,287 external-priority patent/US7575572B2/en
Priority claimed from US10/682,307 external-priority patent/US7608062B2/en
Application filed by Patrick J Sweeney filed Critical Patrick J Sweeney
Priority to AT04757057T priority Critical patent/ATE512632T1/en
Priority to EP04757057A priority patent/EP1653869B1/en
Publication of WO2005009258A1 publication Critical patent/WO2005009258A1/en
Publication of WO2005009258B1 publication Critical patent/WO2005009258B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7061—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/72—Intramedullary pins, nails or other devices
    • A61B17/7233—Intramedullary pins, nails or other devices with special means of locking the nail to the bone
    • A61B17/7258—Intramedullary pins, nails or other devices with special means of locking the nail to the bone with laterally expanding parts, e.g. for gripping the bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8685—Pins or screws or threaded wires; nuts therefor comprising multiple separate parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3472—Trocars; Puncturing needles for bones, e.g. intraosseus injections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/72—Intramedullary pins, nails or other devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/74—Devices for the head or neck or trochanter of the femur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/74—Devices for the head or neck or trochanter of the femur
    • A61B17/742—Devices for the head or neck or trochanter of the femur having one or more longitudinal elements oriented along or parallel to the axis of the neck
    • A61B17/744—Devices for the head or neck or trochanter of the femur having one or more longitudinal elements oriented along or parallel to the axis of the neck the longitudinal elements coupled to an intramedullary nail
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Bone screws (100) and inserts (300) disposed therein or thereon are provided for the delivery of medicants to bone. The bone screws (100) provide a method to strengthen or repair damaged bones, or to promote bony fusion, and in conjunction with the inserts, provide a method of delivering a continuous or regulated amount of medicant to a desired location within the bone such as a fracture interface. In one embodiment, the inserts (300) are customized in size, shape, or configuration after the bone screw (100) has been inserted into the patient.

Claims

AMENDED CLAIMS [received by the International Bureau on 09 February 2005 (09.02.05); original claims 1-43 replaced by new claims 1-43 (6 Pages)]
WHAT IS CLAIMED IS: 1. A device for delivering a substance to a bone, the device comprising: (a) a bone screw comprising two ends connected by a shaft, wherein the shaft is threaded along at least a portion of its exterior and caπnulated along at least a portion of its length; (b) one or more bone-screw fenestrations disposed along the cannulated portion of the bone-screw shaft; (c) an insert disposed inside the bone-screw cannulation, wherein the insert is cannulated along at least a portion of its length; and (d) one or more insert fenestrations disposed along the cannulated portion of the insert.
2. The device of claim 1 wherein the insert blocks at least one bone-screw fenestration.
3. The device of claim 1 wherein the bone screw compήses a material selected from the group consisting of titanium and its alloys, tantalum and its alloys, nickel-cadmium and its alloys, steel and its alloys., plastics, absorbable materials, resorbable materials, polyamino acids, polylactide, polyglycolide, hydroxylapatite, and tricalciumphosphate.
4. The device of claim 1 wherein the insert comprises a material selected from the group consisting of titanium and its alloys, tantalum and its alloys, nickel-cadmium and its alloys, steel and its alloys, plastics, absorbable materials, resorbable materials, polyamino acids, polylactide, polyglycolide, hydroxylapatite, and tricalciumphosphate.
5. The device of claim 1 further comprising a substance reservoir attached to at least one end of the bone screw or insert,
6. The device of claim 5 wherein the reservoir is implanted subcutaneously,
29
7. The device of claim 1 further comprising a pump attached to at least one end of the bone screw or insert.
8. The device of claim 7 wherein the pump is implanted subcutaneously.
9. The device of claim 1 wherein the bone screw further comprises an internal substance reservoir.
10. The device of claim 1 wherein the insert further comprises an internal substance reservoir.
11. A method of administering a substance to a bone, the method comprising introducing the device of claim 1 into a bone and introducing the substance into the insert cannulation.
12. The method of claim 11 comprising: (a) disposing the insert inside the bone-screw cannulation in a first alignment such that the insert blocks one or ore bone-screw fenestrations; (b) introducing the device into a bone; and (c) subsequently realigning ihe insert such that one or more of the blocked bone-screw fenestrations become unblocked.
13. The method of claim 11 comprising: (a) introducing the bone screw into a bone; (b) subsequently mtroducing the insert into the bone-screw cannulation.
14. A device for delivering a substance to a bone, the device comprising: (a) a bone screw comprising two ends connected by a shaft, wherein the shaft is cannulated along at least a portion of its length; b) one or more bone-screw fenestrations disposed along the cannulated portion of the bone-screw shaft; and
30 (c) an insert disposed inside the bone-screw cannulation, wherein the insert is cannulated along at least a portion of its length, and further wherein at least a portion of the insert comprises a porous material that is permeable to the substance to be delivered to the bone.
15. The device of claim 14 wherein the bone screw comprises a material selected from the group consisting of titanium and its alloys, tantalum and its alloys, nickel-cadmium and its alloys, steel and its alloys, plastics, absorbable materials, resorbable materials, polyamino acids, polylactide, polyglycolide, hydroxylapatite, and tricalciumphosphate.
16. The device of claim 14 wherein the insert comprises a material selected from the group consisting of titanium and its alloys, tantalum and its alloys, nickel-cadmium and its alloys, steel and its alloys, plastics, absorbable materials, resorbable materials, polyamino acids, polylaclide, polyglycolide, hydroxylapatite, and tricalciumphosphate.
17. The device of claim 14 further comprising a substance reservoir attached to at least one end of the bone screw or insert.
18. The device of claim 17 wherein the reservoir is implanted subcutaneously.
19. The device of claim 1 further comprising a pump attached to at least one end of the bone screw or insert.
20. The device of claim 1 wherein the pump is implanted subcutaneously.
21. The device of claim 1 wherein, the bone screw further comprises an internal substance reservoir.
22. The device of claim 14 wherein the insert further comprises an internal substance reservoir.
23. A method of administering a substance to a bone, the method comprising introducing the device of claim 14 into a bone and introducing the substance into tire insert cannulation.
24. A device for delivering a substance to a bone, the device comprising: (a) a bone screw comprising two ends connected by a shaft, wherein the shaft is cannulated along at least a portion of its length; (b) one or more bone-screw fenestrations disposed along the cannulated portion of the bone-screw shaft; (c) an insert disposed inside the bone-screw cannulation, wherein the insert is cannulated along at least a portion of its length; and (d) at least one expandable balloon disposed around a portion of the insert.
25. The device of claim 24, comprising a first balloon disposed around a first portion of the insert, a second balloon disposed around a second portion of the insert and at least one insert fenestration disposed between the first and second balloons.
26. The device of claim 24 wherein the bone screw comprises a material selected from the group consistmg of titanium and its alloys, tantalum and its alloys, nickel-cadmium and its alloys, steel and its alloys, plastics, absorbable materials, resorbable materials, polyamino acids, polylactide, polyglycolide, hydroxylapatite, and tricalciumphosphate.
27. The device of claim 24 wherein the insert comprises a material selected from the group consisting of titanium and its alloys, tantalum and its alloys, nickel-cadmium and its alloys, steel and its alloys, plastics, absorbable materials, resorbable materials, polyamino acids, polylactide, polyglycolide, hydroxylapatite, and tricalciumphosphate.
32
28. The device of claim 24 further comprising a substance reservoir attached to at least one end of the bone screw or insert.
29. The device of claim 28 wherein the reservoir is implanted subcutaneously.
30. The device of claim 24 further comprising a pump attached to at least one end of the bone screw or insert.
31. The device of claim 30 wherein the pump is implanted subcutaneously.
32. The device of claim 24 wherein the bone screw further comprises an internal substance reservoir.
33. The device of claim 24 wherein the insert further comprises an internal substance reservoir.
34. A method of administering a substance to a bone, the method comprising introducing the device of claim 24 into a bone and introducing the substance into the insert cannulation.
35. The method of claim 34 comprising: (a) introducing the device into a bone with the at least one balloon in a deflated state; and (b) subsequently inflating the at least one balloon.
36. The method of claim 34 comprising: (a) introducing the bone screw into a bone; (b) subsequently introducing the insert into the bone-screw cannulation.
37. A device for delivering a substance to a bone, the device comprising:
33 (a) a bone screw comprising two ends connected by a shaft, the shaft comprising a thread around at least a portion of its exterior surface; and (b) an insert comprising a cannulation along at least a portion of its length, the insert attached along the exterior surface of the bone screw.
38. The device of claim 37 wherein the external surface defines a groove i tming along at least a portion of its length and the insert is adapted to fit into the groove.
39. The device of claim 37 wherein the insert comprises one or more insert fenestrations disposed along the cannulated portion of the insert.
40. The device of claim 37 wherein the insert is permeable lo the substance to be delivered to the bone.
41. The device of claim 37 lurther comprising a substance reservoir attached to at least one end of the insert.
42. The device of claim 37 wherein the insert further comprises an internal substance reservoir.
4 . A method of administering a substance to a bone, the method comprising introducing the device of claim 37 into a bone and introducing the substance into the insert cannulation.
34
PCT/US2004/022884 2003-07-15 2004-07-15 Method and device for delivering medicine to bone WO2005009258A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT04757057T ATE512632T1 (en) 2003-07-15 2004-07-15 DEVICE FOR DELIVERING A MEDICATION TO A BONE
EP04757057A EP1653869B1 (en) 2003-07-15 2004-07-15 Device for delivering medicine to bone

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/620,287 2003-07-15
US10/620,287 US7575572B2 (en) 2003-07-15 2003-07-15 Method and device for delivering medicine to bone
US10/682,307 US7608062B2 (en) 2003-07-15 2003-10-09 Method and device for delivering medicine to bone
US10/682,307 2003-10-09
US10/704,526 US7527611B2 (en) 2003-07-15 2003-11-07 Method and device for delivering medicine to bone
US10/704,526 2003-11-07

Publications (2)

Publication Number Publication Date
WO2005009258A1 WO2005009258A1 (en) 2005-02-03
WO2005009258B1 true WO2005009258B1 (en) 2005-03-24

Family

ID=34108876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/022884 WO2005009258A1 (en) 2003-07-15 2004-07-15 Method and device for delivering medicine to bone

Country Status (4)

Country Link
US (2) US7527611B2 (en)
EP (1) EP1653869B1 (en)
AT (1) ATE512632T1 (en)
WO (1) WO2005009258A1 (en)

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EP1653869A4 (en) 2009-12-30
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WO2005009258A1 (en) 2005-02-03
EP1653869B1 (en) 2011-06-15
US7527611B2 (en) 2009-05-05
US20050015061A1 (en) 2005-01-20
US8808337B2 (en) 2014-08-19
US20090204158A1 (en) 2009-08-13

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