WO2004093569A1

WO2004093569A1 - Topical composition on the basis of honey

Info

Publication number: WO2004093569A1
Application number: PCT/EG2004/000003
Authority: WO
Inventors: Osman Fathi Osman
Original assignee: Osman Fathi Osman
Priority date: 2003-04-21
Filing date: 2004-02-11
Publication date: 2004-11-04

Abstract

Honey compound is an invention made mainly of pure bee Honey with some additives to be used as Crearn for topical wound management. The additive augments the natural properties of the pure bee honey as an antimicrobial and wound healing promotion agent. Honey compound obviates the drawbacks of using pure bee honey for wounds, like the intense local pain, excessive fluid extravasa.tion through the wound and wound dressings dryness which may compromise the healing process. Bacteriological investigations, laboratory animals' studies confirmed the superior effects of the honey compound as an antibacterial and wound healing promotion agent in comparison to pure bee honey, and other topical wound agents. The components of the honey compound are stable to produce its long lasting beneficial effects over the wounds through out the dressing regimen.

Description

Honey Compound

Technical Fiel ;-

Honey Compound is an invention in the medical field made mainly of honey with some other additives to act as a potent and safe wound dressing agent with an antimicrobial and wound healing promotion effects, in an optimum wet wound atmosphere

Background Arts-

Honey was used in the treatment of wounds and bums by the ancient Egyptians and other civilizations thousands of years ago. Its use has continued in folk medicine until recent years. Many reports have recently been published demonstrating specific and detailed functions of its effective components as regards its antimicrobial and wound- healing promotion effects.

In spite of the high quality of pure bee honey as a topical wound agent, compared with other topical wound agents, its use is not without certain problems that may limit its optimal application, such as the intense local pain that the patient feels soon after its application. This may be intolerable, particularly in children, as also the excessive body fluid loss through the wound due to honey 's high osmolarity. This fluid loss has to be seriously considered because of its haemodynamic impact, especially in patients with major bums and in children.

Excessive fluid loss through the burn wound may also alter the beneficial properties of the applied bee, by causing its rapid dilution and accelerating its washout from the wound surface. It is also well known that within a few hours of application of honey dressing to the wound surface, the dressing will dry off because of evaporative water loss enlianced by body temperature, malcmg subsequent dressing changes difficult and possibly compromising the natural wound healing process.

There are also available other trials of honey formulas with many draw backs which make its use unsafe and difficult.

Disclosure of Invention :-

In this invention a compound made mainly of pure bee honey with some other additives to improve its properties and to augment its local and systemic beneficial effects obviating the draw backs of its use.

Honey compound consists of the following components in this ratio for preparation: -

* Fresh pure natural unprocessed bee honey 1000 gm * Fresh pure virgin olive oil 100-150 ml

* Fresh pure sesame oil 100-150 ml

* Fresh pure rice flour 140-180 gm

* Zinc oxide powder 60 gm

* Olive leaf extract 10% 10 gm

The honey compound is prepared by adding the olive oil and sesame oil to the honey with continuous shaking then rice flour and zinc oxide powder are added then olive leaf extract is added with continuous shaking until complete mixing of the compound without heating.

It was proved through the bacteriological examinations how potent is the antibacterial and antifungal effects of the honey compound in comparison to a known antibacterial and antifungal ointments and in comparison to the pure bee honey.

It was also proved throug the laboratory animal studies the potent effect of the honey compound to enhance wound healing in comparison to other topical wound agents and to pure bee honey without side effects. Best Mode for Carrying Out the Invention :-

This invention presents a new compound made mainly of honey with other additives for topical wound management in which all of the beneficial properties of honey were preserved and enlianced and the drawbacks of using honey were obviated through :-

1 - The oily content of the compound acts as a barrier preventing excessive loss of body fluids and decreasing evaporative wound water loss thus preventing wound desiccation and providing optimal wet atmosphere for wound healing. Olive oil contains polyphenolic compounds, which has an antibacterial effect to enhance wound healing.

Sesame oil has a local anaesthetic effect decreasing local wound pain.

2- Rice flour absorbs wound fluids thus keeping undiluted honey covering the wound for longer time.

3- Zinc Oxide improves the properties of the compound and supplies the wound with Zinc, which is very important trace element for wound healing process.

4- Olive leaf extract with its powerful antibacterial, antifungal and antiviral content augments the beneficial effects of the compound without any drawbacks. Medical Applicability:-

Honey compound is a powerful topical cream for bums and wound healing enhancement and it can be used as follows:

The cream is applied to the bum or wound smface in a 1 mm thickness layer then covered with dressings according to the wounds depth and extent. Wounds dressings are changed when it become soaked or when cream removed that is to keep the wound covered with the cream all the time until woimd healing.

Claims

- Pure bee honey 1000 gm

Characterized by

The bee honey should be pure fresh monofloral undiluted unprocessed. - Olive Oil 100 - 150 ml

Characterized by

Olive oil should be fresh pure virgin prepared without heating or any other chemical additives, amount adjusted according to the liquidity of honey. - Sesame Oil 100 - 150 ml

Characterized by

Sesame oil should be pure fresh prepared without chemical additives, amount adjusted according to the liquidity of honey. - Rice Flour 140 - 180 gm Rice flow should be fresh and ultrafme as a standard product for nutritional supplement, amount adjusted according to the liquidity of honey. - Zinc Oxide 60 gm

Characterized by Zinc oxide powder as a standard product of the pharmaceutical companies for medical use. - Olive leaf extracts 10%: 10 gm

Characterized by

Olive leaf extract 10% without added sugar, salt, wheat, com, yeast, soy derivatives, colourings, flavorings or preservatives.