WO2004091627A3 - Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs - Google Patents

Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs Download PDF

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Publication number
WO2004091627A3
WO2004091627A3 PCT/US2004/010969 US2004010969W WO2004091627A3 WO 2004091627 A3 WO2004091627 A3 WO 2004091627A3 US 2004010969 W US2004010969 W US 2004010969W WO 2004091627 A3 WO2004091627 A3 WO 2004091627A3
Authority
WO
WIPO (PCT)
Prior art keywords
dihydro
analogs
oxo
naphthpyridine
heterocyclic substituted
Prior art date
Application number
PCT/US2004/010969
Other languages
French (fr)
Other versions
WO2004091627A2 (en
Inventor
Jeffrey P Whitten
Michael K Schwaebe
Terrance Moran
Original Assignee
Cylene Pharmaceuticals Inc
Jeffrey P Whitten
Michael K Schwaebe
Terrance Moran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cylene Pharmaceuticals Inc, Jeffrey P Whitten, Michael K Schwaebe, Terrance Moran filed Critical Cylene Pharmaceuticals Inc
Priority to EP04759328A priority Critical patent/EP1610795A4/en
Publication of WO2004091627A2 publication Critical patent/WO2004091627A2/en
Publication of WO2004091627A3 publication Critical patent/WO2004091627A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention relates to 1,4-dihydro-4-oxo-1,8-napthpyridine analogs of the formula (1) and pharmaceutically acceptable salts, esters, and prodrugs thereof, wherein A, X, W and Y are substituents. The present invention also relates to methods for using such compounds.
PCT/US2004/010969 2003-04-07 2004-04-07 Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs WO2004091627A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04759328A EP1610795A4 (en) 2003-04-07 2004-04-07 Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46120503P 2003-04-07 2003-04-07
US60/461,205 2003-04-07
US51956903P 2003-11-12 2003-11-12
US60/519,569 2003-11-12

Publications (2)

Publication Number Publication Date
WO2004091627A2 WO2004091627A2 (en) 2004-10-28
WO2004091627A3 true WO2004091627A3 (en) 2004-11-25

Family

ID=33303039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010969 WO2004091627A2 (en) 2003-04-07 2004-04-07 Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs

Country Status (3)

Country Link
US (2) US7163948B2 (en)
EP (1) EP1610795A4 (en)
WO (1) WO2004091627A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354916B2 (en) 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
EP1610759A4 (en) 2003-04-07 2007-04-25 Cylene Pharmaceuticals Inc Substituted quinobenzoxazine analogs
US7507727B2 (en) 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
JP4858683B2 (en) * 2005-01-20 2012-01-18 アステラス製薬株式会社 Process for producing quinolone derivative or salt thereof
JP4853824B2 (en) * 2005-01-20 2012-01-11 アステラス製薬株式会社 Pharmaceutical composition comprising a quinolone derivative as an active ingredient
WO2006113509A2 (en) * 2005-04-15 2006-10-26 Cylene Pharmaceuticals, Inc. Quinobenzoxazine analogs and methods of using thereof
US20080119492A1 (en) * 2005-07-29 2008-05-22 Jean-Marie Lehn Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation
US8470817B2 (en) * 2009-10-26 2013-06-25 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
TW201722957A (en) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產（第二）有限公司 Chemical compounds

Citations (1)

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Publication number Priority date Publication date Assignee Title
US4324983A (en) * 1977-09-15 1982-04-13 Humiston Gerald F Binary vapor cycle method of electrical power generation

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US5318965A (en) 1990-08-24 1994-06-07 Abbott Laboratories Quinobenzoxazine, antineoplastic agents
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WO1999040093A2 (en) 1998-02-04 1999-08-12 Board Of Regents, The University Of Texas System Synthesis of quinobenzoxazine analogues with topoisomerase ii and quadruplex interactions for use as antineoplastic agents
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324983A (en) * 1977-09-15 1982-04-13 Humiston Gerald F Binary vapor cycle method of electrical power generation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SANTILLI A.A.: "Synthesis and antibacterial evaluation of 1,2,3,4-tetrahydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ester, carbonitriles and carboxamides", J. MED. CHEM., vol. 18, no. 10, April 1975 (1975-04-01), pages 1038 - 1041, XP002982920 *
See also references of EP1610795A4 *

Also Published As

Publication number Publication date
EP1610795A4 (en) 2007-10-24
US20050004160A1 (en) 2005-01-06
WO2004091627A2 (en) 2004-10-28
US20070010512A1 (en) 2007-01-11
EP1610795A2 (en) 2006-01-04
US7163948B2 (en) 2007-01-16

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