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Publication numberWO2004076473 A3
Publication typeApplication
Application numberPCT/US2004/003774
Publication date17 Mar 2005
Filing date10 Feb 2004
Priority date12 Feb 2003
Also published asWO2004076473A2
Publication numberPCT/2004/3774, PCT/US/2004/003774, PCT/US/2004/03774, PCT/US/4/003774, PCT/US/4/03774, PCT/US2004/003774, PCT/US2004/03774, PCT/US2004003774, PCT/US200403774, PCT/US4/003774, PCT/US4/03774, PCT/US4003774, PCT/US403774, WO 2004/076473 A3, WO 2004076473 A3, WO 2004076473A3, WO-A3-2004076473, WO2004/076473A3, WO2004076473 A3, WO2004076473A3
InventorsBenjamin M Buehrer, Thomas R Barnett
ApplicantKarobio Ab, Benjamin M Buehrer, Thomas R Barnett
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Androgen receptor interacting peptides
WO 2004076473 A3
Abstract
The present invention is directed to a polypeptide that binds to the androgen receptor, the polypeptide comprising the amino acid sequence Ar-X-X-Z-Ar, or Ser-β-Ar- X-Δ-Ψ-Ar; or Ser-β-Ar-Δ-X-Ψ-Ar; or Ser-X-Ar-X-X-Ψ-Ar; wherein Ar is an aromatic amino acid; X is any amino acid; and Z is a hydrophobic amino acid (Ψ) or an aromatic amino acid (Ar), β is a basic amino acid; and A is an acidic amino acid. The present invention is also directed to methods of analyzing the surface conformation of a protein using one or more of the above polypeptide sequences; methods of identifying modulators of protein function using one or more of the above polypeptide sequences; and pharmaceutical compositions comprising a pharmaceutically acceptable carrier and one or more of the above polypeptide sequences.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US5942430 *16 Feb 199624 Aug 1999Diversa CorporationEsterases
US20030045680 *12 Mar 20026 Mar 2003Praecis Pharmaceuticals Inc.Peptidic modulators of the androgen receptor
Non-Patent Citations
Reference
1 *DOHERTY ET AL.: "Structure-activity relationships of C-terminal endothelin hexapeptide antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 18, 3 September 1993 (1993-09-03), pages 2585 - 2594, XP002983399
2 *HE ET AL.: "The FXXLF motif mediates androgen receptor-specific interactions with coregulators", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 12, 22 March 2002 (2002-03-22), pages 10226 - 10235, XP002983400
Classifications
International ClassificationC07K, A61K38/03, C07K7/06, G01N33/68, A61K38/10, C07K7/08, G01N33/574
Cooperative ClassificationG01N33/57434, A61K38/00, G01N2333/723, C07K7/08
European ClassificationC07K7/08, G01N33/574C14
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5 Apr 2006122Ep: pct application non-entry in european phase