WO2004038401A3 - Biosensor having hematocrit and oxygen biases - Google Patents

Biosensor having hematocrit and oxygen biases Download PDF

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Publication number
WO2004038401A3
WO2004038401A3 PCT/US2003/033532 US0333532W WO2004038401A3 WO 2004038401 A3 WO2004038401 A3 WO 2004038401A3 US 0333532 W US0333532 W US 0333532W WO 2004038401 A3 WO2004038401 A3 WO 2004038401A3
Authority
WO
WIPO (PCT)
Prior art keywords
hematocrit
oxygen
biosensor
biases
mediator
Prior art date
Application number
PCT/US2003/033532
Other languages
French (fr)
Other versions
WO2004038401A2 (en
Inventor
Shridhara A Karinka
James W Scott
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to CA002503086A priority Critical patent/CA2503086A1/en
Priority to AU2003286597A priority patent/AU2003286597A1/en
Priority to JP2004547049A priority patent/JP4695879B2/en
Priority to EP03777801A priority patent/EP1556689A2/en
Publication of WO2004038401A2 publication Critical patent/WO2004038401A2/en
Publication of WO2004038401A3 publication Critical patent/WO2004038401A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted

Abstract

A biosensor that utilizes a mediator, i.e., an isomer of phenanthroline quinone, 1,10-phenanthroline-5,6-dione, and a metal ion, such as manganese, with an enzyme dependent upon NAD(P)+, such as, for example, glucose dehydrogenase, for improving the hematocrit bias and oxygen bias of biosensors. The electrodes of the biosensors employing this mediator and a metal ion provide an accurate clinical response over a hematocrit range that ranges from about 20% to about 70% and over an oxygen tension range that ranges from about 1kPa to about 20kPa.
PCT/US2003/033532 2002-10-23 2003-10-22 Biosensor having hematocrit and oxygen biases WO2004038401A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002503086A CA2503086A1 (en) 2002-10-23 2003-10-22 Biosensor having hematocrit and oxygen biases
AU2003286597A AU2003286597A1 (en) 2002-10-23 2003-10-22 Biosensor having hematocrit and oxygen biases
JP2004547049A JP4695879B2 (en) 2002-10-23 2003-10-22 Biosensor with hematocrit and oxygen bias
EP03777801A EP1556689A2 (en) 2002-10-23 2003-10-22 Biosensor having hematocrit and oxygen biases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/278,657 US7501053B2 (en) 2002-10-23 2002-10-23 Biosensor having improved hematocrit and oxygen biases
US10/278,657 2002-10-23

Publications (2)

Publication Number Publication Date
WO2004038401A2 WO2004038401A2 (en) 2004-05-06
WO2004038401A3 true WO2004038401A3 (en) 2004-06-17

Family

ID=32106586

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033532 WO2004038401A2 (en) 2002-10-23 2003-10-22 Biosensor having hematocrit and oxygen biases

Country Status (6)

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US (4) US7501053B2 (en)
EP (1) EP1556689A2 (en)
JP (1) JP4695879B2 (en)
AU (1) AU2003286597A1 (en)
CA (1) CA2503086A1 (en)
WO (1) WO2004038401A2 (en)

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US7754093B2 (en) 2010-07-13
US20040079653A1 (en) 2004-04-29
JP2006504096A (en) 2006-02-02
US20130001101A1 (en) 2013-01-03
US20060201805A1 (en) 2006-09-14
EP1556689A2 (en) 2005-07-27
US7501053B2 (en) 2009-03-10
AU2003286597A1 (en) 2004-05-13
AU2003286597A8 (en) 2004-05-13
WO2004038401A2 (en) 2004-05-06
JP4695879B2 (en) 2011-06-08
US8163160B2 (en) 2012-04-24
CA2503086A1 (en) 2004-05-06
US20110031133A1 (en) 2011-02-10

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