WO2004038378A3 - Phthalocyanine dyes - Google Patents

Phthalocyanine dyes Download PDF

Info

Publication number
WO2004038378A3
WO2004038378A3 PCT/US2003/033995 US0333995W WO2004038378A3 WO 2004038378 A3 WO2004038378 A3 WO 2004038378A3 US 0333995 W US0333995 W US 0333995W WO 2004038378 A3 WO2004038378 A3 WO 2004038378A3
Authority
WO
WIPO (PCT)
Prior art keywords
phthalocyanine dyes
useful
disclosed
dyes
bioassays
Prior art date
Application number
PCT/US2003/033995
Other languages
French (fr)
Other versions
WO2004038378A2 (en
Inventor
Xinzhan Peng
Daniel R Draney
Jiyan Chen
Original Assignee
Li Cor Inc
Xinzhan Peng
Daniel R Draney
Jiyan Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Li Cor Inc, Xinzhan Peng, Daniel R Draney, Jiyan Chen filed Critical Li Cor Inc
Priority to AU2003284169A priority Critical patent/AU2003284169A1/en
Publication of WO2004038378A2 publication Critical patent/WO2004038378A2/en
Publication of WO2004038378A3 publication Critical patent/WO2004038378A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00Porphines; Azaporphines
    • C09B47/04Phthalocyanines abbreviation: Pc
    • C09B47/32Cationic phthalocyanine dyes
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00Dyes not provided for by a single group of this subclass
    • C09B69/008Dyes containing a substituent, which contains a silicium atom

Abstract

Fluorescent dyes are disclosed which are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes disclosed are preferably water soluble, isomericly pure, possess high quantum yield, and are useful in bioassays.
PCT/US2003/033995 2002-10-25 2003-10-24 Phthalocyanine dyes WO2004038378A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003284169A AU2003284169A1 (en) 2002-10-25 2003-10-24 Phthalocyanine dyes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42128702P 2002-10-25 2002-10-25
US60/421,287 2002-10-25
US10/693,300 2003-10-23
US10/693,300 US7005518B2 (en) 2002-10-25 2003-10-23 Phthalocyanine dyes

Publications (2)

Publication Number Publication Date
WO2004038378A2 WO2004038378A2 (en) 2004-05-06
WO2004038378A3 true WO2004038378A3 (en) 2006-05-18

Family

ID=32912026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033995 WO2004038378A2 (en) 2002-10-25 2003-10-24 Phthalocyanine dyes

Country Status (3)

Country Link
US (1) US7005518B2 (en)
AU (1) AU2003284169A1 (en)
WO (1) WO2004038378A2 (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172866A1 (en) * 2000-07-07 2007-07-26 Susan Hardin Methods for sequence determination using depolymerizing agent
DE60131194T2 (en) * 2000-07-07 2008-08-07 Visigen Biotechnologies, Inc., Bellaire SEQUENCE PROVISION IN REAL TIME
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US20090186343A1 (en) * 2003-01-28 2009-07-23 Visigen Biotechnologies, Inc. Methods for preparing modified biomolecules, modified biomolecules and methods for using same
CA2618443A1 (en) * 2005-08-10 2007-02-15 Novadaq Technologies, Inc. Intra-operative head & neck nerve mapping
US20070122344A1 (en) * 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US20070208331A1 (en) * 2006-03-02 2007-09-06 Chu Michael S Systems and methods of treatment within a gastrointestinal lumen
US20080241951A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Method and apparatus for moving stage detection of single molecular events
US20080241938A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Automated synthesis or sequencing apparatus and method for making and using same
US20080091005A1 (en) * 2006-07-20 2008-04-17 Visigen Biotechnologies, Inc. Modified nucleotides, methods for making and using same
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
WO2008076524A2 (en) 2006-10-27 2008-06-26 Life Technologies Corporation Fluorogenic ph sensitive dyes and their method of use
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US20110168543A1 (en) * 2008-04-01 2011-07-14 New Jersey Institute Of Technology Microwave-Assisted Synthesis of Perfluorophthalocyanine Molecules
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP2274017B1 (en) 2008-04-30 2016-04-13 Ben Gurion University Of The Negev Research And Development Authority E-selectin specific vascular delivery systems
WO2009135178A2 (en) 2008-05-02 2009-11-05 Flower Robert W Methods for production and use of substance-loaded erythrocytes (s-les) for observation and treatment of microvascular hemodynamics
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
WO2011025501A1 (en) 2009-08-31 2011-03-03 Hewlett-Packard Development Company, L.P. Naphthalocyanine dye and ink containing the same
US8202358B2 (en) * 2009-10-02 2012-06-19 Hewlett-Packard Development Company, L.P. Phthalocyanine, naphthalocyanine, and bridged phthalocyanine/naphthalocyanine dyes and inks containing the same
US8226757B2 (en) * 2009-10-22 2012-07-24 Hewlett-Packard Development Company, L.P. Phthalocyanine dye and ink containing the same
WO2011146595A2 (en) 2010-05-21 2011-11-24 Siemens Healthcare Diagnostics Inc. Zwitterionic reagents
WO2011151814A2 (en) 2010-05-29 2011-12-08 Ben-Gurion University Of The Negev Research And Development Authority Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications
US8524239B2 (en) 2010-07-09 2013-09-03 The United States of America as represented by the Secrectary, Department of Health and Human Services Photosensitizing antibody-fluorophore conjugates
WO2013190391A2 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
JP6141145B2 (en) * 2012-08-22 2017-06-07 キヤノン株式会社 DYE COMPOUND, INK CONTAINING THE DYE COMPOUND, COLOR FILTER RESIST COMPOSITION, AND THERMAL TRANSFER RECORDING INK SHEET
WO2015187677A1 (en) 2014-06-02 2015-12-10 Li-Cor, Inc. Phthalocyanine probes and uses thereof
AU2015300915B2 (en) 2014-08-08 2020-09-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Photo-controlled removal of targets in vitro and in vivo
US10557855B2 (en) * 2014-08-19 2020-02-11 Board Of Regents, The University Of Texas System Silicon quantum dot optical probes
US9663554B2 (en) 2014-09-19 2017-05-30 Li-Cor, Inc. Multifunctional protein molecular weight ladders
UA109751C2 (en) * 2014-09-26 2015-09-25 METHOD OF DETERMINATION OF HYDROGEL IN BIOLOGICAL FABRICS
CA2963987A1 (en) 2014-09-29 2016-04-07 Novadaq Technologies Inc. Imaging a target fluorophore in a biological material in the presence of autofluorescence
EP3203902B1 (en) 2014-10-09 2021-07-07 Novadaq Technologies ULC Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
CA2994822C (en) 2015-08-07 2023-01-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (nir-pit) of suppressor cells to treat cancer
CN108136039A (en) 2015-08-18 2018-06-08 阿斯皮利安治疗学股份有限公司 For the composition of photoimmunotherapy, combination and correlation technique
JP7055742B6 (en) 2015-08-18 2022-06-07 ラクテン・メディカル,インコーポレイテッド Phthalocyanine pigment conjugate and its preservation method
US11140305B2 (en) 2017-02-10 2021-10-05 Stryker European Operations Limited Open-field handheld fluorescence imaging systems and methods
CN106866721B (en) * 2017-03-10 2019-03-26 江苏省原子医学研究所 A kind of silicon phthalocyanine derivative and its application for preparing biotin acceptor targeting silicon phthalocyanine photosensitizer
WO2019036249A1 (en) 2017-08-18 2019-02-21 Li-Cor, Inc. Sonodynamic therapy
CA3100981A1 (en) 2018-06-01 2019-12-05 Rakuten Medical, Inc. Phthalocyanine dye conjugate compositions
US20220016245A1 (en) 2018-08-08 2022-01-20 The University Of Tokyo Conjugate of biotin-modified dimer and phthalocyanine dye
US20220073641A1 (en) 2018-12-28 2022-03-10 The University Of Tokyo Fusion protein of antibody that recognizes cancer cells and mutant streptavidin
CN115943306A (en) 2019-03-29 2023-04-07 乐天医药生技股份有限公司 Methods and related biomarkers for photoimmunotherapy
CA3136294A1 (en) 2019-04-10 2020-10-15 Coralluma Llc. Ir700 nanocompositions for cardiac therapies and applications
EP4010023A1 (en) 2019-08-07 2022-06-15 Rakuten Medical, Inc. Cetuximab-ir700 conjugate compositions
WO2021207742A1 (en) * 2020-04-10 2021-10-14 Mi2 Holdings LLC Nanoparticles for use in photodynamic therapies and methods of making, evaluating and using the same
MX2022012721A (en) 2020-04-10 2023-01-16 Rakuten Medical Inc Phthalocyanine dye compounds, conjugates and methods of use thereof.
EP4212179A1 (en) 2020-09-11 2023-07-19 JSR Corporation Complex and photoimmunotherapy
JP7440725B2 (en) 2020-12-16 2024-02-29 国立大学法人北海道大学 Compound decomposition method and compound
JP2024516546A (en) * 2021-04-09 2024-04-16 ラクテン・メディカル,インコーポレイテッド Phthalocyanine dye compounds, conjugates and methods of use thereof
JP7384195B2 (en) 2021-10-05 2023-11-21 東洋インキScホールディングス株式会社 Fluorescent labeling dyes and fluorescent labeling agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484778A (en) * 1990-07-17 1996-01-16 University Hospitals Of Cleveland Phthalocyanine photosensitizers for photodynamic therapy and methods for their use

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3094536A (en) * 1961-01-03 1963-06-18 Malcolm E Kenney Silicon phthalocyanines
US5171534A (en) * 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5135717A (en) 1986-12-24 1992-08-04 British Technology Group Usa Inc. Tetrabenztriazaporphyrin reagents and kits containing the same
US5346670A (en) * 1986-12-24 1994-09-13 British Technology Group U.S.A. Inc. Phthalocyanine and tetrabenztriazaporphyrin reagents
SE8801070D0 (en) 1988-03-23 1988-03-23 Pharmacia Ab METHOD FOR IMMOBILIZING A DNA SEQUENCE ON A SOLID SUPPORT
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5136717A (en) * 1988-11-23 1992-08-04 Flavors Technology Inc. Realtime systolic, multiple-instruction, single-data parallel computer system
WO1991011533A1 (en) 1990-01-26 1991-08-08 E.I. Du Pont De Nemours And Company Method for isolating primer extension products from template-directed dna polymerase reactions
ATE206395T1 (en) * 1990-05-15 2001-10-15 Hyperion Inc FLUORESCENT PORPHYRIN AND FLUORESCENT PHTHALOCYANINE-POLYETHYLENE GLYCOL, POLYOL AND SACCHARIDE DERIVATIVES AS FLUORESCENT PROBE
US5846703A (en) * 1990-05-15 1998-12-08 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US6060598A (en) * 1990-05-15 2000-05-09 Hyperion, Inc. Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
ATE206124T1 (en) 1990-05-15 2001-10-15 Diatron Corp DETECTFULLY LABELED MARKER COMPOUND WITH A FLUOROPHORE RESIDUE, A FLUORESCENCE SAMPLE WITH THE MARKER COMPOUND AND USES THEREOF.
US5166197A (en) * 1990-07-17 1992-11-24 Kenney Malcolm E Phthalocyanine photosensitizers for photodynamic therapy
GB9017788D0 (en) 1990-08-14 1990-09-26 Medical Res Council Method for preparing,isolating and sequencing polynucleotides
EP0658167B1 (en) 1992-09-03 1999-04-14 The Perkin-Elmer Corporation 4,7-dichlorofluorescein dyes as molecular probes
US6027709A (en) * 1997-01-10 2000-02-22 Li-Cor Inc. Fluorescent cyanine dyes
US5872248A (en) * 1997-03-28 1999-02-16 Case Western Reserve University Methods for inserting silicon into phthalocyanines and naphthalocyanines
DE60010956T2 (en) 1999-03-25 2005-06-16 Nisshinbo Industries, Inc. Carbodiimide compounds containing a fluorescent group, their precursors and processes for their preparation
US6323186B1 (en) * 1999-09-17 2001-11-27 Molecular Probes, Inc. Phosphate-bound polyazaindacene derivatives of nucleotides
DE60116510T2 (en) 2000-09-19 2006-07-13 Li-Cor, Inc., Lincoln cyanine
DE60126297T2 (en) * 2000-09-29 2007-11-15 Molecular Probes, Inc., Eugene MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES
WO2002096913A1 (en) 2001-05-25 2002-12-05 Gentian As Substituted di(hydroxy/alkoxy)silicon phthalocyanines and their uses
US20050249668A1 (en) 2002-03-29 2005-11-10 Ralph Weissleder Nir-fluorescent cyanine dyes, their synthesis and biological use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484778A (en) * 1990-07-17 1996-01-16 University Hospitals Of Cleveland Phthalocyanine photosensitizers for photodynamic therapy and methods for their use
US5484778C1 (en) * 1990-07-17 2001-05-08 Univ Cleveland Hospitals Phthalocynine photosensitizers for photodynamic therapy and methods for their use

Also Published As

Publication number Publication date
WO2004038378A2 (en) 2004-05-06
US20040171827A1 (en) 2004-09-02
US7005518B2 (en) 2006-02-28
AU2003284169A8 (en) 2004-05-13
AU2003284169A1 (en) 2004-05-13

Similar Documents

Publication Publication Date Title
WO2004038378A3 (en) Phthalocyanine dyes
WO2007024898A3 (en) Displays with integrated photovoltaic cells
AU2003235181A1 (en) Organic semiconductor composition, organic semiconductor element, and process for producing the same
WO2006020947A9 (en) Phosphonate fluorescent dyes and conjugates
WO1998030992A3 (en) Fluorescent cyanine dyes
WO2004070772A3 (en) Conjugated polymers and blends containing carbazole, representation and use thereof
WO1999064047A8 (en) Novel antiviral compounds
AU2003222069A1 (en) Mammalian cdr mimetibodies, compositions, methods and uses
EP1572079A3 (en) Mammalian cdr mimetibodies, compositions, methods and uses
WO2005050171A3 (en) Methods and compositions relating to single reactive center reagents
WO2001034835A3 (en) Method for the production of biopolymers with modified properties
MXPA05007668A (en) Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis.
AU2003290794A1 (en) Curable epoxy compositions, methods and articles made therefrom
MXPA03009001A (en) Antifreeze concentrate containing the colorant c.i. reactive violet 5.
AU2003266364A1 (en) 9-cyano-substituted perylene-3,4-dicarboxylic acid monoimides as dyestuffs
AU2002249531A1 (en) Immunotherapy based on dendritic cells
WO2003042344A3 (en) Apo2 ligand/trail formulations
BR0317593A (en) Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor
AU2003300522A1 (en) 4-phenyl-pyrimido (4,5-b) indole derivatives
WO2004055117A3 (en) Carboxamide-substituted dyes for analytical applications
WO2004003510A3 (en) Fluorescent dyes, energy transfer couples and methods
WO2004022029A3 (en) Branched alcohol-based personal care compositions
AU2002334884A1 (en) Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
AU2003281693A1 (en) Functional fluorescent dyes
AU2003234198A8 (en) Novel genes, compositions, and methods for modulating the unfolded protein response

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP