WO2004022593A8 - Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules - Google Patents
Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid moleculesInfo
- Publication number
- WO2004022593A8 WO2004022593A8 PCT/IB2003/004347 IB0304347W WO2004022593A8 WO 2004022593 A8 WO2004022593 A8 WO 2004022593A8 IB 0304347 W IB0304347 W IB 0304347W WO 2004022593 A8 WO2004022593 A8 WO 2004022593A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cytokines
- nucleic acid
- acid molecules
- encoding nucleic
- higher stability
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002498319A CA2498319A1 (en) | 2002-09-09 | 2003-09-08 | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
AU2003263552A AU2003263552A1 (en) | 2002-09-09 | 2003-09-08 | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
EP03794017A EP1539960B1 (en) | 2002-09-09 | 2003-09-08 | Protease-resistant modified interferon alpha polypeptides |
AT03794017T ATE466085T1 (en) | 2002-09-09 | 2003-09-08 | PROTEASE-RESISTANT MODIFIED INTERFERON ALPHA POLYPEPTIDES |
DE60332358T DE60332358D1 (en) | 2002-09-09 | 2003-09-08 | PROTEASE-RESISTANT MODIFIED INTERFERON ALPHA POLYPEPTIDE |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40989802P | 2002-09-09 | 2002-09-09 | |
US60/409,898 | 2002-09-09 | ||
US45713503P | 2003-03-21 | 2003-03-21 | |
US60/457,135 | 2003-03-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2004022593A2 WO2004022593A2 (en) | 2004-03-18 |
WO2004022593A3 WO2004022593A3 (en) | 2004-07-15 |
WO2004022593A8 true WO2004022593A8 (en) | 2007-05-18 |
Family
ID=31981642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/004347 WO2004022593A2 (en) | 2002-09-09 | 2003-09-08 | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
Country Status (8)
Country | Link |
---|---|
US (12) | US7611700B2 (en) |
EP (1) | EP1539960B1 (en) |
AT (1) | ATE466085T1 (en) |
AU (1) | AU2003263552A1 (en) |
CA (1) | CA2498319A1 (en) |
DE (1) | DE60332358D1 (en) |
ES (1) | ES2343518T3 (en) |
WO (1) | WO2004022593A2 (en) |
Cited By (4)
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US7884073B2 (en) | 2004-11-04 | 2011-02-08 | Hanall Biopharma Co., Ltd. | Modified growth hormone |
US8052964B2 (en) | 2002-09-09 | 2011-11-08 | Hanall Biopharma Co., Ltd. | Interferon-β mutants with increased anti-proliferative activity |
US8252743B2 (en) | 2006-11-28 | 2012-08-28 | Hanall Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
JP7050007B2 (en) | 2016-06-08 | 2022-04-07 | ヤンセン バイオテツク,インコーポレーテツド | GM-CSF mutant and usage |
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US7647184B2 (en) * | 2001-08-27 | 2010-01-12 | Hanall Pharmaceuticals, Co. Ltd | High throughput directed evolution by rational mutagenesis |
CA2491567A1 (en) * | 2002-07-01 | 2004-01-08 | The Kenneth S. Warren Institute, Inc. | Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs |
US20050202438A1 (en) * | 2002-09-09 | 2005-09-15 | Rene Gantier | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
US20060020396A1 (en) * | 2002-09-09 | 2006-01-26 | Rene Gantier | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
US20040137581A1 (en) * | 2002-10-01 | 2004-07-15 | Xencor | Interferon variants with improved properties |
US20050054053A1 (en) * | 2002-10-01 | 2005-03-10 | Xencor, Inc. | Interferon variants with improved properties |
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-
2003
- 2003-09-08 CA CA002498319A patent/CA2498319A1/en not_active Abandoned
- 2003-09-08 DE DE60332358T patent/DE60332358D1/en not_active Expired - Lifetime
- 2003-09-08 AT AT03794017T patent/ATE466085T1/en not_active IP Right Cessation
- 2003-09-08 ES ES03794017T patent/ES2343518T3/en not_active Expired - Lifetime
- 2003-09-08 US US10/658,834 patent/US7611700B2/en active Active
- 2003-09-08 EP EP03794017A patent/EP1539960B1/en not_active Expired - Lifetime
- 2003-09-08 WO PCT/IB2003/004347 patent/WO2004022593A2/en not_active Application Discontinuation
- 2003-09-08 AU AU2003263552A patent/AU2003263552A1/en not_active Abandoned
-
2005
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-
2007
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-
2008
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- 2008-06-06 US US12/157,150 patent/US8114839B2/en not_active Expired - Fee Related
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2011
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Cited By (7)
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US8052964B2 (en) | 2002-09-09 | 2011-11-08 | Hanall Biopharma Co., Ltd. | Interferon-β mutants with increased anti-proliferative activity |
US8057787B2 (en) | 2002-09-09 | 2011-11-15 | Hanall Biopharma Co., Ltd. | Protease resistant modified interferon-beta polypeptides |
US8105573B2 (en) | 2002-09-09 | 2012-01-31 | Hanall Biopharma Co., Ltd. | Protease resistant modified IFN beta polypeptides and their use in treating diseases |
US8114839B2 (en) | 2002-09-09 | 2012-02-14 | Hanall Biopharma Co., Ltd. | Protease resistant modified erythropoietin polypeptides |
US7884073B2 (en) | 2004-11-04 | 2011-02-08 | Hanall Biopharma Co., Ltd. | Modified growth hormone |
US8252743B2 (en) | 2006-11-28 | 2012-08-28 | Hanall Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
JP7050007B2 (en) | 2016-06-08 | 2022-04-07 | ヤンセン バイオテツク,インコーポレーテツド | GM-CSF mutant and usage |
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US20040132977A1 (en) | 2004-07-08 |
US20090131318A1 (en) | 2009-05-21 |
US7998469B2 (en) | 2011-08-16 |
US20080274081A9 (en) | 2008-11-06 |
US8057787B2 (en) | 2011-11-15 |
ATE466085T1 (en) | 2010-05-15 |
US20090123974A1 (en) | 2009-05-14 |
WO2004022593A3 (en) | 2004-07-15 |
US20070172459A1 (en) | 2007-07-26 |
US20080075672A1 (en) | 2008-03-27 |
ES2343518T3 (en) | 2010-08-03 |
US20110142801A1 (en) | 2011-06-16 |
US20060020116A1 (en) | 2006-01-26 |
WO2004022593A2 (en) | 2004-03-18 |
US8052964B2 (en) | 2011-11-08 |
US7611700B2 (en) | 2009-11-03 |
US20090053147A1 (en) | 2009-02-26 |
US7650243B2 (en) | 2010-01-19 |
AU2003263552A8 (en) | 2004-03-29 |
US8114839B2 (en) | 2012-02-14 |
EP1539960A2 (en) | 2005-06-15 |
US20070224665A1 (en) | 2007-09-27 |
DE60332358D1 (en) | 2010-06-10 |
EP1539960B1 (en) | 2010-04-28 |
US20070254838A1 (en) | 2007-11-01 |
US20080159977A1 (en) | 2008-07-03 |
US8105573B2 (en) | 2012-01-31 |
AU2003263552A1 (en) | 2004-03-29 |
US20080194477A1 (en) | 2008-08-14 |
CA2498319A1 (en) | 2004-03-18 |
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