WO2004008939B1 - Method and apparatus for increasing spatial resolution of a pet scanner - Google Patents

Method and apparatus for increasing spatial resolution of a pet scanner

Info

Publication number
WO2004008939B1
WO2004008939B1 PCT/US2003/021303 US0321303W WO2004008939B1 WO 2004008939 B1 WO2004008939 B1 WO 2004008939B1 US 0321303 W US0321303 W US 0321303W WO 2004008939 B1 WO2004008939 B1 WO 2004008939B1
Authority
WO
WIPO (PCT)
Prior art keywords
detector
detector array
set forth
scanner
emission tomography
Prior art date
Application number
PCT/US2003/021303
Other languages
French (fr)
Other versions
WO2004008939A8 (en
WO2004008939A2 (en
WO2004008939A3 (en
Inventor
Yuan-Chuan Tai
Original Assignee
Univ Washington
Yuan-Chuan Tai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Yuan-Chuan Tai filed Critical Univ Washington
Priority to EP03765500A priority Critical patent/EP1540376A2/en
Priority to CA002491683A priority patent/CA2491683A1/en
Priority to JP2004523076A priority patent/JP2005532571A/en
Priority to AU2003278699A priority patent/AU2003278699A1/en
Publication of WO2004008939A2 publication Critical patent/WO2004008939A2/en
Publication of WO2004008939A3 publication Critical patent/WO2004008939A3/en
Publication of WO2004008939B1 publication Critical patent/WO2004008939B1/en
Publication of WO2004008939A8 publication Critical patent/WO2004008939A8/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01TMEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/29Measurement performed on radiation beams, e.g. position or section of the beam; Measurement of spatial distribution of radiation
    • G01T1/2914Measurement of spatial distribution of radiation
    • G01T1/2985In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis)

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine (AREA)

Abstract

A method and apparatus for increasing the resolution of Positron Emission Tomography scanner (20). The method and apparatus comprise elements and acts for centering a region of interest of an object (24) at a point (36) between first and second detector arrays (26,28) which is at least about ten percent closer to the first detector array (26) than to the second detector array (28).

Claims

AMENDED CLAIMS
[Received by the International Bureau on 28 July 2004 (28.07.04): original claims 2-5, 17-20, 27, 30-33, 40, 43-45, 47-48 are unchanged. Original claims 6,
9, 12, 21, 22, 25, 34, 35, 38 are cancelled. Original claims 1, 7, 8, 10, 11, 13-16, 23, 24, 26,
28, 29, 36, 37, 39, 41, 42, 46 replaced with amended claims bearing the same numbers.
Original claims 49-103 are replaced with new and amended claims 49-109. New claims
49, 50, 58, 59, 67, 68, 110-133 are added. (24 pages)]
WHAT IS CLAIMED IS:
1. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by a distance, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about ten percent closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating said scanned object relative to said first and second detector arrays; and scanning the rotated object with the scanner.
2. A method as set forth in claim 1 wherein the point is at least about thirty-three percent closer to said first detector array than to said second detector array.
3. A method as set forth in claim 2 wherein the point is at least about sixty-seven percent closer to said first detector array than to said second detector array.
4. A method as set forth in claim 3 wherein the point is about eighty-two percent closer to said first detector array than to said second detector array.
5. A method as set forth in claim 1 wherein the point is no more than about ninety-eight percent closer to said first detector array than to said second detector array.
43
6. (Cancelled) .
7. A method as set forth in claim 1 wherein the object is rescanned after being rotated.
8. A method as set forth in claim 1 wherein the object is rescanned while being rotated.
9. (Cancelled) .
10. A method as set forth in claim 1 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
11. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by a distance, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about ten percent closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating at least one of said first and second detector arrays about an axis; and scanning the object with the scanner.
12. (Cancelled) .
13. A method as set forth in claim 11 wherein the axis is closer to the first array than to said second array.
44
14. A method as set forth in claim 13 wherein the axis extends through the region of interest of the object.
15. A method as set forth in claim 11 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
16. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about twenty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about one centimeter closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating said scanned object relative to said first and second detector arrays; and scanning the rotated object with the scanner.
17. A method as set forth in claim 16 wherein the point is at least about five centimeters closer to said first detector array than to said second detector array.
18. A method as set forth in claim 17 wherein the point is at least about ten centimeters closer to said first detector array than to said second detector array.
45
19. A method as set forth in claim 18 wherein the point is about fourteen centimeters closer to said first detector array than to said second detector array.
20. A method as set forth in claim 16 wherein the point is no closer than about one centimeter to said first detector array.
21-22. (Cancelled).
23. A method as set forth in claim 16 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
24. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about twenty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about one centimeter closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating at least one of said first and second detector arrays about an axis; and scanning the object with the scanner.
25. (Cancelled).
26. A method as set forth in claim 24 wherein the axis is closer to the first array than to said second array.
27. A method as set forth in claim 26 wherein the axis extends through the region of interest of the object.
28. A method as set forth in claim 24 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
29. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about eighty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about four centimeters closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating said scanned object relative to first and second detector arrays; and scanning the rotated object with the scanner.
30. A method as set forth in claim 29 wherein the point is at least about twenty centimeters closer to said first detector array than to said second detector array.
31. A method as set forth in claim 30 wherein the point is at least about forty centimeters closer to said first detector array than to said second detector array.
47
32. A method as set forth in claim 31 wherein the point is about fifty-six centimeters closer to said first detector array than to said second detector array.
33. A method as set forth in claim 29 wherein the point is no closer than about four centimeters to said first detector array.
34-35. (Cancelled) .
36. A method as set forth' in claim 29 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
37. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about eighty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about four centimeters closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating at least one of said first and second detector arrays about an axis; and scanning the object with the scanner.
38. (Cancelled).
39. A method as set forth in claim 37 wherein the axis is closer to the first array than to said second array.
47
40. A method as set forth in claim 39 wherein the axis extends through the region of interest of the object.
41. A method as set forth in claim 37 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
42. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by a distance; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays; wherein said point is located at least about ten percent closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are rotatable about an axis .
43. A positron emission tomography scanner as set forth in claim 42 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
48
44. A positron emission tomography scanner as set forth in claim 43 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
45. A positron emission tomography scanner as set forth in claim 42 wherein the point is located at least about thirty-three percent closer to said first detector array than to said second detector array.
46. A positron emission tomography scanner as set forth in claim 45 wherein the point is located at least about sixty-seven percent closer to said first detector array than to said second detector array.
47. A positron emission tomography scanner as set forth in claim 46 wherein the point is located about eighty-two percent closer to said first detector array than to said second detector array.
48. A positron emission tomography scanner as set forth in claim 42 wherein the point is located no more than about ninety-eight percent closer to said first detector array than to said second detector array.
49. A positron emission tomography scanner as set forth in claim 42 wherein said axis is closer to said first detector array than to said second detector array.
49
50. A positron emission tomography scanner as set forth in claim 49 wherein said axis extends through the region of interest of said object.
51. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about twenty centimeters; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about one centimeter closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are rotatable about an axis.
52. A positron emission tomography scanner as set forth in claim 51 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
53. A positron emission tomography scanner as set forth in claim 52 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
50
54. A positron emission tomography scanner as set forth in claim 51 wherein said point is located at least about five centimeters closer to said first detector array than to said second detector array.
55. A positron emission tomography scanner as set forth in claim 54 wherein said point is located at least about ten centimeters closer to said first detector array than to said second detector array.
56. A position emission tomography scanner as set forth in claim 55 wherein the point is located about fourteen centimeters closer to said first detector array than to said second detector array.
57. A positron emission tomography scanner as set forth in claim 51 wherein said point no closer than about one centimeter to said first detector array.
58. A positron emission tomography scanner as set forth in claim 51 wherein said axis is closer to said first detector array than to said second detector array.
59. A positron emission tomography scanner as set forth in claim 58 wherein said axis extends through the region of interest of said object.
60. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about eighty centimeters/
51 a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about four centimeters closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are rotatable about an axis.
61. A positron emission tomography scanner as set forth in claim 60 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
62. A positron emission tomography scanner as set forth in claim 61 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
63. A positron emission tomography scanner as set forth in claim 60 wherein said point is located at least about twenty centimeters closer to said first detector array than to said second detector array.
64. A positron emission tomography scanner as set forth in claim 63 wherein said point is located at least about forty centimeters closer to said first detector array than to said second detector array.
52
65. A positron emission tomography scanner as set forth in claim 64 wherein the point is located about fifty-six centimeters closer to said first detector array than to said second detector array.
66. A positron emission tomography scanner as set forth in claim 60 wherein said point is located no closer than about four centimeters to said first detector array.
67. A positron emission tomography scanner as set forth in claim 60 wherein said axis is closer to said first detector array than to said second detector array.
68. A positron emission tomography scanner as set forth in claim 67 wherein said axis extends through the region of interest of said object.
69. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays, each of said first and second detector arrays being formed as an arc of a circle; and a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about ten percent closer to said first detector array than to said second detector array.
53
70. A positron emission tomography scanner as set forth in claim 69 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
71. A positron emission tomography scanner as set forth in claim 70 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
72. A positron emission tomography scanner as set forth in claim 69 wherein each of said first and second detector arrays are formed as a half circle.
73. A positron emission tomography scanner as set forth in claim 69 wherein the arc of the first detector array and the arc of the second detector array are centered about a common axis.
74. A positron emission tomography scanner as set forth in claim 69 wherein the point is at least about thirty- three percent closer to said first detector array than to said second detector array.
75. A positron emission tomography scanner as set forth in claim 74 wherein the point is at least about sixty- seven percent closer to said first detector array than to said second detector array.
54
76. A positron emission tomography scanner as set forth in claim 75 wherein the point is about eighty-two percent closer to said first detector array than to said second detector array.
77. A positron emission tomography scanner as set forth in claim 69 wherein the point is no more than about ninety-eight percent closer to said first detector array than to said second detector array.
78. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays, said first and second detector arrays each being formed as an arc of a circle: centering the region of interest of the object at a point between the first and second detector arrays which is at least about ten percent closer to said first detector array than to said second detector array; and scanning the object with the scanner.
79. A positron emission tomography scanner as set forth in claim 78 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one. of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
80. A positron emission tomography scanner as set forth in claim 79 wherein the intrinsic spatial resolution of
55 each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
81. A method as set forth in claim 78 wherein the point is at least about thirty-three percent closer to said first detector array than to said second detector array.
82. A method as set forth in claim 81 wherein the point is at least about sixty-seven percent closer to said first detector array than to said second detector array.
83. A method as set forth in claim 82 wherein the point is about eighty-two percent closer to said first detector array than to said second detector array.
84. A method as set forth in claim 78 wherein the point is no more than about ninety-eight percent closer to said first detector array than to said second detector array.
85. A method as set forth in claim 78 further comprising the steps of: moving said object relative to said first and second detector arrays; and scanning the moved object with the scanner.
86. A method as set forth in claim 85 wherein the object is scanned after being moved.
87. A method as set forth in claim 85 wherein the object is scanned while being moved.
56
88. A method as set forth in claim 85 wherein the object is rotated relative to said first and second' -detector arrays.
89. A method as set forth in claim 88 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
90. A method as set forth in claim 78 further comprising the steps of: moving at least one of said first and second detector arrays relative to said object; and scanning the object with the scanner.
91. A method as set forth in claim 90 wherein the step of moving the arrays comprises rotating said first and second detector arrays about an axis.
92. A method as set forth in claim 91 wherein the axis is closer to the first array than to said second array.
93. A method as set forth in claim 92 wherein the axis extends through the region of interest of the object.
94. A method as set forth in claim 91 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
95. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: a first circular detector array;
57 a second circular detector array concentric with said first detector array; and a stage for holding the object inside said first and second detector arrays; wherein said first detector array is at least about ten percent smaller than said second detector array.
96. A positron emission tomography scanner as set forth in claim 95 first detector array is at least about thirty- three percent smaller than said second detector array.
97. A positron emission tomography scanner as set forth in claim 96 first detector array is at least about sixty- seven percent smaller than said second detector array.
98. A positron emission tomography scanner as set forth in claim 95 wherein said stage is located to center the region of interest of the object at a point concentric with the first and second detector arrays.
99. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising first and second circular concentric detector arrays, said first detector array being at least about ten percent smaller than said second detector array, said method comprising the steps of: centering the region of interest of the object at a point inside the first and second detector arrays; and scanning the object with the scanner.
100. In a positron emission tomography scanner having a primary positron emission tomography scanner for providing an
58 image of a region of an object, said primary scanner having opposing detector arrays spaced by a distance, each of said detector arrays including at least one detector having an intrinsic spatial resolution, an improvement comprising a secondary positron emission tomography scanner for providing an image of a region of an object said secondary scanner comprising an accessory detector array including at least one accessory detector having an intrinsic spatial resolution at least as great as the intrinsic spatial resolution of said primary scanner detector, said accessory detector array of said secondary positron emission tomography scanner being positioned inside an outer boundary defined by said opposing detector arrays of the primary scanner.
101. An improvement as set forth in claim 100 wherein said accessory detector has a width less than a width of said primary scanner detectors.
102. An improvement as set forth in claim 101 wherein said accessory detector has a length less than a length of said primary scanner detectors.
103. An improvement as set forth in claim 100 wherein said accessory detector has a length less than a length of said primary scanner detectors.
104. In a positron emission tomography scanner having a primary positron emission tomography scanner for providing an image of a region of an object, said primary scanner having a primary detector array including a plurality of detectors defining an outer boundary, each of said detectors having an intrinsic spatial resolution, the improvement comprising a
59 secondary positron emission tomography scanner for providing an image of a region of an object, said secondary scanner comprising an accessory detector array including a plurality of detectors, at least one detector of said accessory detector array having an intrinsic spatial resolution at least as great as the intrinsic spatial resolution of each of said primary scanner detectors, said accessory detector array being positioned inside the outer boundary of said primary detector array.
105. An improvement as set forth in claim 104 wherein said accessory detector has a width less than a width of said primary scanner detectors.
106. An improvement as set forth in claim 105 wherein said accessory detector has a length less than a length of said primary scanner detectors.
107. An improvement as set forth in claim 104 wherein said accessory detector has a length less than a length of said primary scanner detectors.
108. An improvement as set forth in claim 104 wherein said accessory detector array is semi-cylindrical.
109. An improvement as set forth in claim 104 wherein said accessory detector array is cylindrical.
110. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second
60 detector arrays spaced by a distance, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is closer to said first detector array than to said second detector array; scanning the object with the scanner; orbiting at least one of said object and first and second detector arrays relative to an axis after scanning the object; and scanning the object with the scanner.
111. A method as set forth in claim 110 wherein said axis is closer to said first detector array than to said second detector array.
112. A method as set forth in claim 111 wherein said axis extends through said region of interest of said object.
113. A method as set forth in claim 110 wherein the object is rescanned after being orbited.
114. A method as set forth in claim 110 wherein the object is rescanned while being orbited.
115. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about twenty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at
61 least about one centimeter closer to said first detector array than to said second detector array; scanning the object with the scanner; orbiting at least one of said object and first and second detector arrays relative to an axis; and rescanning the object with the scanner.
116. A method as set forth in claim 115 wherein said axis is closer to said first detector array than to said second detector array.
117. A method as set forth in claim 116 wherein said axis extends through said region of interest of said object.
118. A method as set forth in claim 115 wherein the object is rescanned after being orbited.
119. A method as set forth in claim 115 wherein the object is rescanned while being orbited.
120. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about eighty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about four centimeters closer to said first detector array than to said second detector array; scanning the object with the scanner; orbiting at least one of said object and first and second detector arrays relative to an axis; and
62 rescanning the object with the scanner.
121. A method as set forth in claim 120 wherein said axis is closer to said first detector array than to said second detector array.
122. A method as set forth in claim 121 wherein said axis extends through said region of interest of said object.
123. A method as set forth in claim 120 wherein the object is rescanned after being orbited.
124. A method as set forth in claim 120 wherein the object is rescanned while being orbited.
125. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by a distance; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector' arrays; wherein said point is located at least about ten percent closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are capable of orbiting about an axis.
63
126. A positron emission tomography scanner as set forth in claim 125 wherein said axis is closer to said first detector array than to said second detector array.
127. A positron emission tomography scanner as set forth in claim 126 wherein said axis extends through the region of interest of said object.
128. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about twenty centimeters; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about one centimeter closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are capable of orbiting about an axis,
.129. A positron emission tomography scanner as set forth in claim 128 wherein said axis is closer to said first detector array than to said second detector array.
130. A positron emission tomography scanner as set forth in claim 129 wherein said axis extends through the region of interest of said object.
64
131. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about eighty centimeters; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about four centimeters closer to said first detector array than to said second detector array; and wherein at' least one of said object and first and second detector arrays are capable of orbiting about an axis.
132. A positron emission tomography scanner as set forth in claim 131 wherein said axis is closer to said first detector array than to said second detector array.
133. A positron emission tomography scanner as set forth in claim 132 wherein said axis extends through the region of interest of said object.
65
PCT/US2003/021303 2002-07-05 2003-07-03 Method and apparatus for increasing spatial resolution of a pet scanner WO2004008939A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03765500A EP1540376A2 (en) 2002-07-05 2003-07-03 Method and apparatus for increasing spatial resolution of a pet scanner
CA002491683A CA2491683A1 (en) 2002-07-05 2003-07-03 Method and apparatus for increasing spatial resolution of a pet scanner
JP2004523076A JP2005532571A (en) 2002-07-05 2003-07-03 Method and apparatus for increasing the spatial resolution of a PET scanner
AU2003278699A AU2003278699A1 (en) 2002-07-05 2003-07-03 Method and apparatus for increasing spatial resolution of a pet scanner

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39413502P 2002-07-05 2002-07-05
US60/394,135 2002-07-05
US10/439,697 US6946658B2 (en) 2002-07-05 2003-05-16 Method and apparatus for increasing spatial resolution of a pet scanner
US10/439,697 2003-05-16

Publications (4)

Publication Number Publication Date
WO2004008939A2 WO2004008939A2 (en) 2004-01-29
WO2004008939A3 WO2004008939A3 (en) 2004-07-29
WO2004008939B1 true WO2004008939B1 (en) 2004-09-16
WO2004008939A8 WO2004008939A8 (en) 2005-04-07

Family

ID=30003346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/021303 WO2004008939A2 (en) 2002-07-05 2003-07-03 Method and apparatus for increasing spatial resolution of a pet scanner

Country Status (6)

Country Link
US (2) US6946658B2 (en)
EP (1) EP1540376A2 (en)
JP (1) JP2005532571A (en)
AU (1) AU2003278699A1 (en)
CA (1) CA2491683A1 (en)
WO (1) WO2004008939A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946658B2 (en) * 2002-07-05 2005-09-20 The Washington University Method and apparatus for increasing spatial resolution of a pet scanner
US6992295B2 (en) * 2003-10-27 2006-01-31 Photodetection Systems, Inc. PET scanner with structured optical element
JP2005257335A (en) * 2004-03-09 2005-09-22 Sumitomo Heavy Ind Ltd Pet diagnostic system, detector, data processor, and pet diagnostic program for user terminal
US7038212B2 (en) * 2004-04-30 2006-05-02 General Electric Company Method and system for normalization of a positron emission tomography system
EP1780676A1 (en) * 2005-10-25 2007-05-02 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Imaging method and device with dual reading scanner
JP2007145676A (en) * 2005-11-30 2007-06-14 Toshiba Ceramics Co Ltd Method for improving surface purity of lutetium silicate crystal
CN101490581A (en) * 2006-07-21 2009-07-22 皇家飞利浦电子股份有限公司 Method and system for improved TOF PET reconstruction
US8243127B2 (en) * 2006-10-27 2012-08-14 Zecotek Display Systems Pte. Ltd. Switchable optical imaging system and related 3D/2D image switchable apparatus
US8188736B2 (en) * 2007-01-11 2012-05-29 Koninklijke Philips Electronics N.V. PET/MR scanners for simultaneous PET and MR imaging
WO2009125309A2 (en) * 2008-04-10 2009-10-15 Koninklijke Philips Electronics, N.V. Modular multi-geometry pet system
US7732774B2 (en) * 2008-09-19 2010-06-08 Jefferson Science Associates, Llc High resolution PET breast imager with improved detection efficiency
EP2438468B1 (en) 2009-06-01 2019-04-17 Koninklijke Philips N.V. Pet detector system with improved capabilities for quantification
US20120056095A1 (en) * 2010-09-03 2012-03-08 Scott Metzler Collimation apparatus for high resolution imaging
US8502154B2 (en) * 2011-04-21 2013-08-06 Kabushiki Kaisha Toshiba Method and system for organ specific PET imaging
US9207333B2 (en) 2011-04-21 2015-12-08 Kabushiki Kaisha Toshiba Geometry for PET imaging
US9322929B2 (en) * 2011-04-21 2016-04-26 Kabushiki Kaisha Toshiba PET imaging system including detector elements of different design and performance
US9591989B2 (en) 2011-04-22 2017-03-14 Washington University Insert device for enhancing PET and MRI images
KR101190795B1 (en) * 2012-04-27 2012-10-12 경북대학교 산학협력단 Method and apparatus of detecting real size of ordan or lesion in medical image
US9980686B2 (en) 2013-07-23 2018-05-29 Koninklijke Philips N.V. Hybrid (spectral/non-spectral) imaging detector array and corresponding processing electronics
US9182606B2 (en) 2014-01-29 2015-11-10 Emine Goulanian Rear-projection autostereoscopic 3D display system
US9182605B2 (en) 2014-01-29 2015-11-10 Emine Goulanian Front-projection autostereoscopic 3D display system
GB2524470B (en) * 2014-02-16 2019-04-17 Wang Wei An apparatus and method for "high-resolution" electrical impedance imaging
CN103800023B (en) * 2014-02-19 2015-12-09 中国科学院高能物理研究所 A kind of two flatbed imaging device based on continuous crystal
WO2016077554A1 (en) * 2014-11-12 2016-05-19 Washington University Systems and methods for point-of-care positron emission tomography
KR101693986B1 (en) * 2015-05-11 2017-01-06 현대자동차주식회사 Wireless recharge apparatus for mobile phone
WO2017091697A1 (en) * 2015-11-23 2017-06-01 Berr Stuart S Positron emission tomography systems and methods
WO2021042712A1 (en) * 2019-08-27 2021-03-11 上海鹏钼医疗科技有限公司 Pet detection apparatus
US20230072303A1 (en) * 2020-01-29 2023-03-09 University Of Cincinnati Contrast enhancement method for the objects with intrinsic partial volume effect
US11445995B2 (en) 2020-06-26 2022-09-20 Raytheon Company Gradient index scintillator for improved resolution

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473749A (en) 1982-01-29 1984-09-25 The United States Of America As Represented By The United States Department Of Energy Clamshell tomograph
US4559597A (en) * 1982-07-07 1985-12-17 Clayton Foundation For Research Three-dimensional time-of-flight positron emission camera system
US4743764A (en) 1984-12-04 1988-05-10 Computer Technology And Imaging, Inc. Two dimensional photon counting position encoder system and process
US4647779A (en) 1985-05-13 1987-03-03 Clayton Foundation For Research Multiple layer positron emission tomography camera
US4833327A (en) * 1987-04-29 1989-05-23 Hiram Hart High-resolution radioisotopic imaging system
CA1303256C (en) 1988-12-14 1992-06-09 Royal Institution For The Advancement Of Learning (The) Scintillation crystals for positron emission tomography having a non reflecting band
JPH084586B2 (en) * 1989-02-07 1996-01-24 浜松ホトニクス株式会社 CT device
US4980552A (en) * 1989-06-20 1990-12-25 The Regents Of The University Of California High resolution PET scanner using rotating ring array of enlarged detectors having successively offset collimation apertures
US5103098A (en) * 1989-11-09 1992-04-07 Board Of Regents, The University Of Texas System High resolution gamma ray detectors for positron emission tomography (pet) and single photon emission computed tomography (spect)
US5965891A (en) 1992-01-22 1999-10-12 Frederick M. Mako Dedicated apparatus and method for emission mammography
US6229145B1 (en) 1992-01-22 2001-05-08 Pem Technologies, Inc. Dedicated apparatus and method emission mammography
US5665971A (en) * 1993-04-12 1997-09-09 Massachusetts Institute Of Technology Radiation detection and tomography
JPH06347555A (en) 1993-06-10 1994-12-22 Hamamatsu Photonics Kk Position imaging device
US5567944A (en) 1995-04-28 1996-10-22 University Of Cincinnati Compton camera for in vivo medical imaging of radiopharmaceuticals
US5719400A (en) 1995-08-07 1998-02-17 The Regents Of The University Of California High resolution detector array for gamma-ray imaging
AU7440496A (en) * 1995-10-12 1997-04-30 Adac Laboratories Resolution enhancement for dual head gamma camera
EP0862749B1 (en) * 1995-11-22 2001-07-04 Picker International, Inc. Real time pet imaging method for a single photon gamma camera
US5825031A (en) * 1996-10-11 1998-10-20 Board Of Regents The University Of Texas System Tomographic pet camera with adjustable diameter detector ring
IL122357A0 (en) * 1997-11-27 1998-04-05 Elgems Ltd Calibration of pet cameras
US6459085B1 (en) 1999-10-26 2002-10-01 Rush Presbyterian-St. Luke's Medical Center Depth of interaction system in nuclear imaging
US6388244B1 (en) * 2000-03-20 2002-05-14 Philips Medical Systems (Cleveland), Inc. Virtual contouring for transmission scanning in spect and pet studies
US6603125B1 (en) 2000-06-02 2003-08-05 Koninklijke Philips Electronics, N.V. Event localization and fall-off correction by distance-dependent weighting
US7105824B2 (en) * 2002-05-09 2006-09-12 Neurologica, Corp. High resolution photon emission computed tomographic imaging tool
US6484051B1 (en) 2001-05-15 2002-11-19 James Daniel Coincident multiple compton scatter nuclear medical imager
US6727502B1 (en) * 2001-06-27 2004-04-27 Koninklijke Philips Electronics, N.V. Calibration technique for coincidence imaging systems
US6946658B2 (en) * 2002-07-05 2005-09-20 The Washington University Method and apparatus for increasing spatial resolution of a pet scanner
US7078699B2 (en) * 2002-10-04 2006-07-18 Varian Medical Systems Technologies, Inc. Imaging apparatus and method with event sensitive photon detection

Also Published As

Publication number Publication date
WO2004008939A8 (en) 2005-04-07
WO2004008939A2 (en) 2004-01-29
US20040004188A1 (en) 2004-01-08
US7485866B2 (en) 2009-02-03
US6946658B2 (en) 2005-09-20
EP1540376A2 (en) 2005-06-15
WO2004008939A3 (en) 2004-07-29
JP2005532571A (en) 2005-10-27
US20060027755A1 (en) 2006-02-09
AU2003278699A1 (en) 2004-02-09
CA2491683A1 (en) 2004-01-29

Similar Documents

Publication Publication Date Title
WO2004008939B1 (en) Method and apparatus for increasing spatial resolution of a pet scanner
EP0579033B2 (en) X-ray tomography apparatus
EP0917657B1 (en) Multi-slice detector array
EP2076792B1 (en) Acquisition and reconstruction of projection data using a stationary ct geometry
CA1160763A (en) Emission computed tomograph
Genna et al. The development of ASPECT, an annular single crystal brain camera for high efficiency SPECT
CN1672039A (en) Anti-scattering X-ray shielding for CT scanners
CN1284651A (en) Image regeneration device and method in computer X-ray tomography system camera system
US5054049A (en) Patient support means for x-ray absorption compensation in computer tomography system
CN1593344A (en) Radiation tomography apparatus
JP2002530140A (en) Method and apparatus for correcting motion of an x-ray beam
CN1290513A (en) Reproducing method and device for stereo image in chromatographic X-ray photographic system of screw conic beam scanning computer
US6170358B1 (en) Indexing mechanism
US7217038B2 (en) Fixing structure for rolling bearing
US6118840A (en) Methods and apparatus to desensitize incident angle errors on a multi-slice computed tomograph detector
JP4275064B2 (en) Cone beam CT scanner with reduced scan length
WO2007055501A1 (en) Multi purpose x-ray micro ct scanner
US5974109A (en) Methods and apparatus for cell ganging in a multislice computed tomography system
US20060256913A1 (en) Method and apparatus to facilitate computerized tomography of relatively large objects
Moore et al. Improve Performance from Modifications to the Multidetector SPECT Brain Scanner
US6438198B1 (en) Computed tomography method
US6271517B1 (en) Pet scanner point source locator
US5777331A (en) Tomographic emission scanner having offset high detection efficiency area
Farquhar et al. An evaluation of exact and approximate 3-D reconstruction algorithms for a high-resolution, small-animal PET scanner
JPH04343309A (en) Cam mechanism for lens barrel

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
B Later publication of amended claims

Effective date: 20040728

WWE Wipo information: entry into national phase

Ref document number: 2491683

Country of ref document: CA

Ref document number: 2003278699

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2004523076

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2003765500

Country of ref document: EP

CFP Corrected version of a pamphlet front page

Free format text: UNDER (54) PUBLISHED TITLE REPLACED BY CORRECT TITLE

WWP Wipo information: published in national office

Ref document number: 2003765500

Country of ref document: EP