AMENDED CLAIMS
[Received by the International Bureau on 28 July 2004 (28.07.04): original claims 2-5, 17-20, 27, 30-33, 40, 43-45, 47-48 are unchanged. Original claims 6,
9, 12, 21, 22, 25, 34, 35, 38 are cancelled. Original claims 1, 7, 8, 10, 11, 13-16, 23, 24, 26,
28, 29, 36, 37, 39, 41, 42, 46 replaced with amended claims bearing the same numbers.
Original claims 49-103 are replaced with new and amended claims 49-109. New claims
49, 50, 58, 59, 67, 68, 110-133 are added. (24 pages)]
WHAT IS CLAIMED IS:
1. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by a distance, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about ten percent closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating said scanned object relative to said first and second detector arrays; and scanning the rotated object with the scanner.
2. A method as set forth in claim 1 wherein the point is at least about thirty-three percent closer to said first detector array than to said second detector array.
3. A method as set forth in claim 2 wherein the point is at least about sixty-seven percent closer to said first detector array than to said second detector array.
4. A method as set forth in claim 3 wherein the point is about eighty-two percent closer to said first detector array than to said second detector array.
5. A method as set forth in claim 1 wherein the point is no more than about ninety-eight percent closer to said first detector array than to said second detector array.
43
6. (Cancelled) .
7. A method as set forth in claim 1 wherein the object is rescanned after being rotated.
8. A method as set forth in claim 1 wherein the object is rescanned while being rotated.
9. (Cancelled) .
10. A method as set forth in claim 1 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
11. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by a distance, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about ten percent closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating at least one of said first and second detector arrays about an axis; and scanning the object with the scanner.
12. (Cancelled) .
13. A method as set forth in claim 11 wherein the axis is closer to the first array than to said second array.
44
14. A method as set forth in claim 13 wherein the axis extends through the region of interest of the object.
15. A method as set forth in claim 11 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
16. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about twenty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about one centimeter closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating said scanned object relative to said first and second detector arrays; and scanning the rotated object with the scanner.
17. A method as set forth in claim 16 wherein the point is at least about five centimeters closer to said first detector array than to said second detector array.
18. A method as set forth in claim 17 wherein the point is at least about ten centimeters closer to said first detector array than to said second detector array.
45
19. A method as set forth in claim 18 wherein the point is about fourteen centimeters closer to said first detector array than to said second detector array.
20. A method as set forth in claim 16 wherein the point is no closer than about one centimeter to said first detector array.
21-22. (Cancelled).
23. A method as set forth in claim 16 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
24. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about twenty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about one centimeter closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating at least one of said first and second detector arrays about an axis; and scanning the object with the scanner.
25. (Cancelled).
26. A method as set forth in claim 24 wherein the axis is closer to the first array than to said second array.
27. A method as set forth in claim 26 wherein the axis extends through the region of interest of the object.
28. A method as set forth in claim 24 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
29. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about eighty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about four centimeters closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating said scanned object relative to first and second detector arrays; and scanning the rotated object with the scanner.
30. A method as set forth in claim 29 wherein the point is at least about twenty centimeters closer to said first detector array than to said second detector array.
31. A method as set forth in claim 30 wherein the point is at least about forty centimeters closer to said first detector array than to said second detector array.
47
32. A method as set forth in claim 31 wherein the point is about fifty-six centimeters closer to said first detector array than to said second detector array.
33. A method as set forth in claim 29 wherein the point is no closer than about four centimeters to said first detector array.
34-35. (Cancelled) .
36. A method as set forth' in claim 29 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
37. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about eighty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about four centimeters closer to said first detector array than to said second detector array; scanning the object with the scanner; rotating at least one of said first and second detector arrays about an axis; and scanning the object with the scanner.
38. (Cancelled).
39. A method as set forth in claim 37 wherein the axis is closer to the first array than to said second array.
47
40. A method as set forth in claim 39 wherein the axis extends through the region of interest of the object.
41. A method as set forth in claim 37 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
42. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by a distance; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays; wherein said point is located at least about ten percent closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are rotatable about an axis .
43. A positron emission tomography scanner as set forth in claim 42 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
48
44. A positron emission tomography scanner as set forth in claim 43 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
45. A positron emission tomography scanner as set forth in claim 42 wherein the point is located at least about thirty-three percent closer to said first detector array than to said second detector array.
46. A positron emission tomography scanner as set forth in claim 45 wherein the point is located at least about sixty-seven percent closer to said first detector array than to said second detector array.
47. A positron emission tomography scanner as set forth in claim 46 wherein the point is located about eighty-two percent closer to said first detector array than to said second detector array.
48. A positron emission tomography scanner as set forth in claim 42 wherein the point is located no more than about ninety-eight percent closer to said first detector array than to said second detector array.
49. A positron emission tomography scanner as set forth in claim 42 wherein said axis is closer to said first detector array than to said second detector array.
49
50. A positron emission tomography scanner as set forth in claim 49 wherein said axis extends through the region of interest of said object.
51. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about twenty centimeters; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about one centimeter closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are rotatable about an axis.
52. A positron emission tomography scanner as set forth in claim 51 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
53. A positron emission tomography scanner as set forth in claim 52 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
50
54. A positron emission tomography scanner as set forth in claim 51 wherein said point is located at least about five centimeters closer to said first detector array than to said second detector array.
55. A positron emission tomography scanner as set forth in claim 54 wherein said point is located at least about ten centimeters closer to said first detector array than to said second detector array.
56. A position emission tomography scanner as set forth in claim 55 wherein the point is located about fourteen centimeters closer to said first detector array than to said second detector array.
57. A positron emission tomography scanner as set forth in claim 51 wherein said point no closer than about one centimeter to said first detector array.
58. A positron emission tomography scanner as set forth in claim 51 wherein said axis is closer to said first detector array than to said second detector array.
59. A positron emission tomography scanner as set forth in claim 58 wherein said axis extends through the region of interest of said object.
60. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about eighty centimeters/
51
a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about four centimeters closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are rotatable about an axis.
61. A positron emission tomography scanner as set forth in claim 60 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
62. A positron emission tomography scanner as set forth in claim 61 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
63. A positron emission tomography scanner as set forth in claim 60 wherein said point is located at least about twenty centimeters closer to said first detector array than to said second detector array.
64. A positron emission tomography scanner as set forth in claim 63 wherein said point is located at least about forty centimeters closer to said first detector array than to said second detector array.
52
65. A positron emission tomography scanner as set forth in claim 64 wherein the point is located about fifty-six centimeters closer to said first detector array than to said second detector array.
66. A positron emission tomography scanner as set forth in claim 60 wherein said point is located no closer than about four centimeters to said first detector array.
67. A positron emission tomography scanner as set forth in claim 60 wherein said axis is closer to said first detector array than to said second detector array.
68. A positron emission tomography scanner as set forth in claim 67 wherein said axis extends through the region of interest of said object.
69. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays, each of said first and second detector arrays being formed as an arc of a circle; and a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about ten percent closer to said first detector array than to said second detector array.
53
70. A positron emission tomography scanner as set forth in claim 69 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
71. A positron emission tomography scanner as set forth in claim 70 wherein the intrinsic spatial resolution of each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
72. A positron emission tomography scanner as set forth in claim 69 wherein each of said first and second detector arrays are formed as a half circle.
73. A positron emission tomography scanner as set forth in claim 69 wherein the arc of the first detector array and the arc of the second detector array are centered about a common axis.
74. A positron emission tomography scanner as set forth in claim 69 wherein the point is at least about thirty- three percent closer to said first detector array than to said second detector array.
75. A positron emission tomography scanner as set forth in claim 74 wherein the point is at least about sixty- seven percent closer to said first detector array than to said second detector array.
54
76. A positron emission tomography scanner as set forth in claim 75 wherein the point is about eighty-two percent closer to said first detector array than to said second detector array.
77. A positron emission tomography scanner as set forth in claim 69 wherein the point is no more than about ninety-eight percent closer to said first detector array than to said second detector array.
78. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays, said first and second detector arrays each being formed as an arc of a circle: centering the region of interest of the object at a point between the first and second detector arrays which is at least about ten percent closer to said first detector array than to said second detector array; and scanning the object with the scanner.
79. A positron emission tomography scanner as set forth in claim 78 wherein each of said first and second detector arrays has at least one detector having an intrinsic spatial resolution, and wherein the intrinsic spatial resolution of at least one. of the detectors of said first detector array is at least as great as the intrinsic spatial resolution of at least one of the detectors of said second detector array.
80. A positron emission tomography scanner as set forth in claim 79 wherein the intrinsic spatial resolution of
55
each detector of the first detector array is greater than the intrinsic spatial resolution of each detector of the second detector array.
81. A method as set forth in claim 78 wherein the point is at least about thirty-three percent closer to said first detector array than to said second detector array.
82. A method as set forth in claim 81 wherein the point is at least about sixty-seven percent closer to said first detector array than to said second detector array.
83. A method as set forth in claim 82 wherein the point is about eighty-two percent closer to said first detector array than to said second detector array.
84. A method as set forth in claim 78 wherein the point is no more than about ninety-eight percent closer to said first detector array than to said second detector array.
85. A method as set forth in claim 78 further comprising the steps of: moving said object relative to said first and second detector arrays; and scanning the moved object with the scanner.
86. A method as set forth in claim 85 wherein the object is scanned after being moved.
87. A method as set forth in claim 85 wherein the object is scanned while being moved.
56
88. A method as set forth in claim 85 wherein the object is rotated relative to said first and second' -detector arrays.
89. A method as set forth in claim 88 wherein the object is rotated through an angle of between about zero degrees and about 360 degrees.
90. A method as set forth in claim 78 further comprising the steps of: moving at least one of said first and second detector arrays relative to said object; and scanning the object with the scanner.
91. A method as set forth in claim 90 wherein the step of moving the arrays comprises rotating said first and second detector arrays about an axis.
92. A method as set forth in claim 91 wherein the axis is closer to the first array than to said second array.
93. A method as set forth in claim 92 wherein the axis extends through the region of interest of the object.
94. A method as set forth in claim 91 wherein said first and second arrays are rotated through an angle of between about zero degrees and about 360 degrees.
95. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: a first circular detector array;
57
a second circular detector array concentric with said first detector array; and a stage for holding the object inside said first and second detector arrays; wherein said first detector array is at least about ten percent smaller than said second detector array.
96. A positron emission tomography scanner as set forth in claim 95 first detector array is at least about thirty- three percent smaller than said second detector array.
97. A positron emission tomography scanner as set forth in claim 96 first detector array is at least about sixty- seven percent smaller than said second detector array.
98. A positron emission tomography scanner as set forth in claim 95 wherein said stage is located to center the region of interest of the object at a point concentric with the first and second detector arrays.
99. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising first and second circular concentric detector arrays, said first detector array being at least about ten percent smaller than said second detector array, said method comprising the steps of: centering the region of interest of the object at a point inside the first and second detector arrays; and scanning the object with the scanner.
100. In a positron emission tomography scanner having a primary positron emission tomography scanner for providing an
58
image of a region of an object, said primary scanner having opposing detector arrays spaced by a distance, each of said detector arrays including at least one detector having an intrinsic spatial resolution, an improvement comprising a secondary positron emission tomography scanner for providing an image of a region of an object said secondary scanner comprising an accessory detector array including at least one accessory detector having an intrinsic spatial resolution at least as great as the intrinsic spatial resolution of said primary scanner detector, said accessory detector array of said secondary positron emission tomography scanner being positioned inside an outer boundary defined by said opposing detector arrays of the primary scanner.
101. An improvement as set forth in claim 100 wherein said accessory detector has a width less than a width of said primary scanner detectors.
102. An improvement as set forth in claim 101 wherein said accessory detector has a length less than a length of said primary scanner detectors.
103. An improvement as set forth in claim 100 wherein said accessory detector has a length less than a length of said primary scanner detectors.
104. In a positron emission tomography scanner having a primary positron emission tomography scanner for providing an image of a region of an object, said primary scanner having a primary detector array including a plurality of detectors defining an outer boundary, each of said detectors having an intrinsic spatial resolution, the improvement comprising a
59
secondary positron emission tomography scanner for providing an image of a region of an object, said secondary scanner comprising an accessory detector array including a plurality of detectors, at least one detector of said accessory detector array having an intrinsic spatial resolution at least as great as the intrinsic spatial resolution of each of said primary scanner detectors, said accessory detector array being positioned inside the outer boundary of said primary detector array.
105. An improvement as set forth in claim 104 wherein said accessory detector has a width less than a width of said primary scanner detectors.
106. An improvement as set forth in claim 105 wherein said accessory detector has a length less than a length of said primary scanner detectors.
107. An improvement as set forth in claim 104 wherein said accessory detector has a length less than a length of said primary scanner detectors.
108. An improvement as set forth in claim 104 wherein said accessory detector array is semi-cylindrical.
109. An improvement as set forth in claim 104 wherein said accessory detector array is cylindrical.
110. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second
60
detector arrays spaced by a distance, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is closer to said first detector array than to said second detector array; scanning the object with the scanner; orbiting at least one of said object and first and second detector arrays relative to an axis after scanning the object; and scanning the object with the scanner.
111. A method as set forth in claim 110 wherein said axis is closer to said first detector array than to said second detector array.
112. A method as set forth in claim 111 wherein said axis extends through said region of interest of said object.
113. A method as set forth in claim 110 wherein the object is rescanned after being orbited.
114. A method as set forth in claim 110 wherein the object is rescanned while being orbited.
115. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about twenty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at
61
least about one centimeter closer to said first detector array than to said second detector array; scanning the object with the scanner; orbiting at least one of said object and first and second detector arrays relative to an axis; and rescanning the object with the scanner.
116. A method as set forth in claim 115 wherein said axis is closer to said first detector array than to said second detector array.
117. A method as set forth in claim 116 wherein said axis extends through said region of interest of said object.
118. A method as set forth in claim 115 wherein the object is rescanned after being orbited.
119. A method as set forth in claim 115 wherein the object is rescanned while being orbited.
120. A method of increasing resolution of an image of a region of interest of an object provided by a positron emission tomography scanner comprising opposing first and second detector arrays spaced by no more than about eighty centimeters, said method comprising the steps of: centering the region of interest of the object at a point between the first and second detector arrays which is at least about four centimeters closer to said first detector array than to said second detector array; scanning the object with the scanner; orbiting at least one of said object and first and second detector arrays relative to an axis; and
62
rescanning the object with the scanner.
121. A method as set forth in claim 120 wherein said axis is closer to said first detector array than to said second detector array.
122. A method as set forth in claim 121 wherein said axis extends through said region of interest of said object.
123. A method as set forth in claim 120 wherein the object is rescanned after being orbited.
124. A method as set forth in claim 120 wherein the object is rescanned while being orbited.
125. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by a distance; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector' arrays; wherein said point is located at least about ten percent closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are capable of orbiting about an axis.
63
126. A positron emission tomography scanner as set forth in claim 125 wherein said axis is closer to said first detector array than to said second detector array.
127. A positron emission tomography scanner as set forth in claim 126 wherein said axis extends through the region of interest of said object.
128. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about twenty centimeters; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about one centimeter closer to said first detector array than to said second detector array; and wherein at least one of said object and first and second detector arrays are capable of orbiting about an axis,
.129. A positron emission tomography scanner as set forth in claim 128 wherein said axis is closer to said first detector array than to said second detector array.
130. A positron emission tomography scanner as set forth in claim 129 wherein said axis extends through the region of interest of said object.
64
131. A positron emission tomography scanner for providing an image of a region of interest of an object, said scanner comprising: opposing first and second detector arrays spaced by no more than about eighty centimeters; a stage for holding the object between said first and second detector arrays, said stage being located to center the region of interest of the object at a point between the first and second detector arrays, said point being at least about four centimeters closer to said first detector array than to said second detector array; and wherein at' least one of said object and first and second detector arrays are capable of orbiting about an axis.
132. A positron emission tomography scanner as set forth in claim 131 wherein said axis is closer to said first detector array than to said second detector array.
133. A positron emission tomography scanner as set forth in claim 132 wherein said axis extends through the region of interest of said object.
65