WO2004002419A3 - Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment - Google Patents
Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment Download PDFInfo
- Publication number
- WO2004002419A3 WO2004002419A3 PCT/US2003/020408 US0320408W WO2004002419A3 WO 2004002419 A3 WO2004002419 A3 WO 2004002419A3 US 0320408 W US0320408 W US 0320408W WO 2004002419 A3 WO2004002419 A3 WO 2004002419A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solvates
- methods
- carvedilol
- compositions
- correspondinq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03762176A EP1534270A4 (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment |
EA200500091A EA008384B1 (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, compositions and methods to treat hypertension, congestive heart failur and angina |
AU2003248746A AU2003248746B2 (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
KR1020137008295A KR101468827B1 (en) | 2002-06-27 | 2003-06-27 | Carvedilol Phosphate Salts and(or) Solvates Thereof, Corresponding Compositions, and(or) Methods of Treatment |
KR1020137033808A KR20140006111A (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and(or) solvates thereof, corresponding compositions, and(or) methods of treatment |
CA2492060A CA2492060C (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
NZ537161A NZ537161A (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
MXPA04012923A MXPA04012923A (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment. |
US10/518,654 US7268156B2 (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions and/or methods of treatment |
BRPI0312102-0A BR0312102A (en) | 2002-06-27 | 2003-06-27 | carvedilol phosphate salts and / or their solvates, corresponding compositions, and / or treatment methods |
JP2004518025A JP2005533823A (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate and / or solvates thereof, corresponding compositions and / or methods of treatment |
IL165814A IL165814A (en) | 2002-06-27 | 2004-12-16 | Carvedilol phosphate salts or solvates thereof, corresponding compositions and uses thereof in the preparation of medicaments for treating hypertension, congestive heart failure or angina |
NO20050427A NO329710B1 (en) | 2002-06-27 | 2005-01-25 | Carvedilol phosphate salts and / or solvates thereof, and pharmaceutical compositions comprising these |
US11/767,578 US7893100B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,566 US20070259940A1 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,581 US7759384B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,586 US7902378B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,573 US7626041B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39217502P | 2002-06-27 | 2002-06-27 | |
US60/392,175 | 2002-06-27 |
Related Child Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10518654 A-371-Of-International | 2003-06-27 | ||
US11/767,566 Continuation US20070259940A1 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,578 Division US7893100B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,581 Division US7759384B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,573 Division US7626041B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
US11/767,586 Division US7902378B2 (en) | 2002-06-27 | 2007-06-25 | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004002419A2 WO2004002419A2 (en) | 2004-01-08 |
WO2004002419A3 true WO2004002419A3 (en) | 2004-06-03 |
Family
ID=30000823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/020408 WO2004002419A2 (en) | 2002-06-27 | 2003-06-27 | Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment |
Country Status (15)
Country | Link |
---|---|
US (6) | US7268156B2 (en) |
EP (1) | EP1534270A4 (en) |
JP (3) | JP2005533823A (en) |
KR (3) | KR20140006111A (en) |
CN (6) | CN103254114A (en) |
AU (1) | AU2003248746B2 (en) |
BR (1) | BR0312102A (en) |
CA (1) | CA2492060C (en) |
EA (1) | EA008384B1 (en) |
IL (1) | IL165814A (en) |
MX (1) | MXPA04012923A (en) |
NO (1) | NO329710B1 (en) |
NZ (1) | NZ537161A (en) |
WO (1) | WO2004002419A2 (en) |
ZA (1) | ZA200410011B (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20080064908A (en) * | 2000-06-28 | 2008-07-09 | 테바 파마슈티컬 인더스트리즈 리미티드 | Carvedilol |
US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
EP1474133A4 (en) * | 2002-01-15 | 2006-02-01 | Teva Pharma | Crystalline solids of carvedilol and processes for their preparation |
AU2003231283A1 (en) * | 2002-04-30 | 2003-11-17 | Sb Pharmco Puerto Rico Inc. | Carvedilol monocitrate monohydrate |
WO2004002472A1 (en) | 2002-06-27 | 2004-01-08 | Sb Pharmco Puerto Rico Inc. | Carvedilol hydrobromide |
MXPA04012923A (en) * | 2002-06-27 | 2005-03-31 | Sb Pharmco Inc | Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment. |
CN1694959B (en) | 2002-09-13 | 2013-09-18 | 雷普利瑟公司 | Non-sequence complementary antiviral oligonucleotides |
WO2005051325A2 (en) * | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Carvedilol compositions methods of treatment and delivery |
US8734850B2 (en) * | 2003-11-25 | 2014-05-27 | Flamel Technologies | Oral medicinal product with modified release of at least one active principle in multimicrocapsular form |
EP1686986A4 (en) * | 2003-11-25 | 2009-05-27 | Sb Pharmco Inc | Carvedilol salts, corresponding compositions, methods of delivery and/or treatment |
US20070043099A1 (en) * | 2005-06-09 | 2007-02-22 | Igor Lifshitz | Crystalline forms of carvedilol and processes for their preparation |
WO2007144900A2 (en) * | 2006-06-14 | 2007-12-21 | Matrix Laboratories Limited | Carvedilol phosphate sesquihydrate |
EP1991527A2 (en) * | 2006-06-28 | 2008-11-19 | Teva Pharmaceutical Industries Ltd | Polymorphous forms of carvedilol phosphate |
US20090028935A1 (en) * | 2006-12-01 | 2009-01-29 | Kristin Arnold | Carvedilol forms, compositions, and methods of preparation thereof |
WO2008070072A2 (en) * | 2006-12-01 | 2008-06-12 | Mutual Pharmaceutical Company, Inc. | Carvedilol forms, compositions, and methods of preparation thereof |
WO2008084494A1 (en) * | 2007-01-08 | 2008-07-17 | Matrix Laboratories Limited | Novel polymorphic forms of carvedilol dihydrogen phosphate and process for preparing the same |
US20080207726A1 (en) * | 2007-02-26 | 2008-08-28 | Santiago Ini | Process for the purification of carvedilol or its salts thereof |
WO2008104990A1 (en) * | 2007-02-27 | 2008-09-04 | Lupin Limited | Amorphous carvedilol dihydrogen phosphate |
US20080249317A1 (en) * | 2007-04-04 | 2008-10-09 | Apotex Inc. | Novel amorphous form of carvedilol phosphate and processes for the preparation thereof |
WO2008142703A1 (en) * | 2007-05-17 | 2008-11-27 | Wanbury Limited | A novel cost effective process for production of carvedilol phosphate |
EP2014649A1 (en) * | 2007-06-27 | 2009-01-14 | Inke, S.A. | Novel amorphous carvedilol dihydrogen phosphate |
WO2009008009A1 (en) * | 2007-07-11 | 2009-01-15 | Lupin Limited | Novel crystalline form b of carvedilol dihydrogen phosphate |
US20100076047A1 (en) * | 2007-08-20 | 2010-03-25 | Sankar Reddy Budidet | Amorphous 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol phosphate salt |
US8278461B2 (en) | 2007-08-21 | 2012-10-02 | Lupin Limited | Stable amorphous form of carvedilol dihydrogen phosphate with stabilizer |
US20090076283A1 (en) * | 2007-09-07 | 2009-03-19 | Scinopharm Taiwan Ltd. | Method of crystallizing carvedilol phosphate and the product thereof |
US20090111998A1 (en) * | 2007-10-25 | 2009-04-30 | Srinivas Reddy Gade | Process for the preparation of carvedilol dihydrogen phosphate hemihydrate and pharmaceutical compositions thereof |
US20110015247A1 (en) * | 2008-04-04 | 2011-01-20 | Shodhana Laboratories Limited | Novel crystalline form of carvedilol dihydrogen phosphate and related processes |
US7763645B2 (en) * | 2008-05-23 | 2010-07-27 | Wanbury Limited | Carvedilol dihydrogen phosphate monohydrate |
CN101891671B (en) * | 2010-07-26 | 2012-06-27 | 天津大学 | Crystals of carvidilol dihydric phosphate and preparation method thereof |
US8492426B1 (en) * | 2012-07-12 | 2013-07-23 | Anis Ahmad | Use of carvedilol for treatment of diabetes mellitus |
CN106892858A (en) * | 2015-12-21 | 2017-06-27 | 上海科胜药物研发有限公司 | A kind of carvidilol dihydric phosphate novel crystal forms |
US10357476B1 (en) | 2018-10-30 | 2019-07-23 | Anis Ahmad | Method for treating coronary artery disease |
CN110279662A (en) * | 2019-06-05 | 2019-09-27 | 合肥合源药业有限公司 | A kind of solid dispersions and preparation method and application of insoluble drug Carvedilol |
US10772869B1 (en) | 2019-07-24 | 2020-09-15 | ECI Pharmaceuticals, LLC | Pharmaceutical compositions including carvedilol and methods of using the same |
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-
2003
- 2003-06-27 MX MXPA04012923A patent/MXPA04012923A/en active IP Right Grant
- 2003-06-27 AU AU2003248746A patent/AU2003248746B2/en not_active Expired
- 2003-06-27 KR KR1020137033808A patent/KR20140006111A/en not_active Application Discontinuation
- 2003-06-27 KR KR1020137008295A patent/KR101468827B1/en active IP Right Grant
- 2003-06-27 KR KR1020117028711A patent/KR20110134952A/en not_active Application Discontinuation
- 2003-06-27 CN CN2013100984294A patent/CN103254114A/en active Pending
- 2003-06-27 US US10/518,654 patent/US7268156B2/en not_active Expired - Lifetime
- 2003-06-27 NZ NZ537161A patent/NZ537161A/en not_active IP Right Cessation
- 2003-06-27 CN CN2013100984947A patent/CN103288714A/en active Pending
- 2003-06-27 BR BRPI0312102-0A patent/BR0312102A/en not_active Application Discontinuation
- 2003-06-27 CN CN201010152481XA patent/CN101898995B/en not_active Expired - Lifetime
- 2003-06-27 CN CN2013100984468A patent/CN103333099A/en active Pending
- 2003-06-27 EA EA200500091A patent/EA008384B1/en not_active IP Right Cessation
- 2003-06-27 CA CA2492060A patent/CA2492060C/en not_active Expired - Lifetime
- 2003-06-27 WO PCT/US2003/020408 patent/WO2004002419A2/en active Application Filing
- 2003-06-27 JP JP2004518025A patent/JP2005533823A/en not_active Withdrawn
- 2003-06-27 CN CNA038202301A patent/CN1678305A/en active Pending
- 2003-06-27 CN CN2013100986020A patent/CN103288715A/en active Pending
- 2003-06-27 EP EP03762176A patent/EP1534270A4/en not_active Ceased
-
2004
- 2004-12-10 ZA ZA200410011A patent/ZA200410011B/en unknown
- 2004-12-16 IL IL165814A patent/IL165814A/en not_active IP Right Cessation
-
2005
- 2005-01-25 NO NO20050427A patent/NO329710B1/en not_active IP Right Cessation
-
2007
- 2007-06-25 US US11/767,586 patent/US7902378B2/en not_active Expired - Lifetime
- 2007-06-25 US US11/767,578 patent/US7893100B2/en active Active
- 2007-06-25 US US11/767,581 patent/US7759384B2/en not_active Expired - Lifetime
- 2007-06-25 US US11/767,566 patent/US20070259940A1/en not_active Abandoned
- 2007-06-25 US US11/767,573 patent/US7626041B2/en not_active Expired - Lifetime
-
2010
- 2010-12-17 JP JP2010282048A patent/JP5422545B2/en not_active Expired - Lifetime
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2013
- 2013-08-02 JP JP2013161656A patent/JP2013241450A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2001087837A1 (en) * | 2000-05-18 | 2001-11-22 | A/S Gea Farmaceutisk Fabrik | Process and intermediates for the preparation of 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol or acid addition salts thereof |
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