WO2004000379A8 - Stent coatings with sustained drug release rate - Google Patents

Stent coatings with sustained drug release rate

Info

Publication number
WO2004000379A8
WO2004000379A8 PCT/US2003/015347 US0315347W WO2004000379A8 WO 2004000379 A8 WO2004000379 A8 WO 2004000379A8 US 0315347 W US0315347 W US 0315347W WO 2004000379 A8 WO2004000379 A8 WO 2004000379A8
Authority
WO
WIPO (PCT)
Prior art keywords
release rate
drug release
sustained drug
stent coatings
coating
Prior art date
Application number
PCT/US2003/015347
Other languages
French (fr)
Other versions
WO2004000379A1 (en
Inventor
Syed F A Hossainy
Gordon Stewart
Original Assignee
Advanced Cardiovascular System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cardiovascular System filed Critical Advanced Cardiovascular System
Priority to AU2003245282A priority Critical patent/AU2003245282A1/en
Priority to AT03738920T priority patent/ATE448812T1/en
Priority to JP2004515686A priority patent/JP2005530551A/en
Priority to DE60330144T priority patent/DE60330144D1/en
Priority to EP03738920A priority patent/EP1517713B1/en
Publication of WO2004000379A1 publication Critical patent/WO2004000379A1/en
Publication of WO2004000379A8 publication Critical patent/WO2004000379A8/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00Materials or methods for coatings medical devices
    • A61L2420/08Coatings comprising two or more layers

Abstract

Coating and methods of forming coating for implantable medical devices, such as stents, are described. The coating are used for the sustained release of a therapeutic agent or drug.
PCT/US2003/015347 2002-06-21 2003-05-14 Stent coatings with sustained drug release rate WO2004000379A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003245282A AU2003245282A1 (en) 2002-06-21 2003-05-14 Stent coatings with sustained drug release rate
AT03738920T ATE448812T1 (en) 2002-06-21 2003-05-14 COATING OF STENTS WITH DELAYED RELEASE
JP2004515686A JP2005530551A (en) 2002-06-21 2003-05-14 Stent coating with sustained drug release rate
DE60330144T DE60330144D1 (en) 2002-06-21 2003-05-14 COATING OF STENTS WITH DELAYED ACTIVE INGREDIENT EXTRACTION
EP03738920A EP1517713B1 (en) 2002-06-21 2003-05-14 Stent coatings with sustained drug release rate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/177,154 2002-06-21
US10/177,154 US7396539B1 (en) 2002-06-21 2002-06-21 Stent coatings with engineered drug release rate

Publications (2)

Publication Number Publication Date
WO2004000379A1 WO2004000379A1 (en) 2003-12-31
WO2004000379A8 true WO2004000379A8 (en) 2004-08-26

Family

ID=29999084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/015347 WO2004000379A1 (en) 2002-06-21 2003-05-14 Stent coatings with sustained drug release rate

Country Status (7)

Country Link
US (2) US7396539B1 (en)
EP (1) EP1517713B1 (en)
JP (1) JP2005530551A (en)
AT (1) ATE448812T1 (en)
AU (1) AU2003245282A1 (en)
DE (1) DE60330144D1 (en)
WO (1) WO2004000379A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8915952B2 (en) 2004-03-31 2014-12-23 Merlin Md Pte Ltd. Method for treating aneurysms
US8920430B2 (en) 2004-03-31 2014-12-30 Merlin Md Pte. Ltd. Medical device

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
GB0100761D0 (en) * 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US6656506B1 (en) * 2001-05-09 2003-12-02 Advanced Cardiovascular Systems, Inc. Microparticle coated medical device
WO2004026361A1 (en) * 2002-09-18 2004-04-01 Medtronic Vascular, Inc. Controllable drug releasing gradient coatings for medical devices
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US20090093875A1 (en) 2007-05-01 2009-04-09 Abbott Laboratories Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
US8313759B2 (en) * 2003-03-06 2012-11-20 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent
US20040215335A1 (en) * 2003-04-25 2004-10-28 Brin David S. Methods and apparatus for treatment of aneurysmal tissue
DE10329260A1 (en) * 2003-06-23 2005-01-13 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Stent with a coating system
US20050033417A1 (en) * 2003-07-31 2005-02-10 John Borges Coating for controlled release of a therapeutic agent
US7166099B2 (en) * 2003-08-21 2007-01-23 Boston Scientific Scimed, Inc. Multilayer medical devices
DE10357281A1 (en) * 2003-12-05 2005-07-14 Hassel, Thomas, Dipl.-Ing. Degradable stent for blood vessel support made of magnesium material, comprises degradation-inhibiting biocompatible coating
DE10361940A1 (en) * 2003-12-24 2005-07-28 Restate Patent Ag Degradation control of biodegradable implants by coating
US8137397B2 (en) * 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US20070027523A1 (en) * 2004-03-19 2007-02-01 Toner John L Method of treating vascular disease at a bifurcated vessel using coated balloon
US8431145B2 (en) 2004-03-19 2013-04-30 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
US20050208093A1 (en) 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
US9011831B2 (en) 2004-09-30 2015-04-21 Advanced Cardiovascular Systems, Inc. Methacrylate copolymers for medical devices
CA2509083A1 (en) * 2004-12-22 2006-06-22 Merlin Md Pte Ltd A medical device
KR100511618B1 (en) * 2005-01-17 2005-08-31 이경범 Multi-layer coating of drug release controllable coronary stent and method for manufacturing the same
CN101141948B (en) * 2005-03-14 2011-08-24 佰威控股有限公司 Drug delivery compositions and related methods
US7700659B2 (en) * 2005-03-24 2010-04-20 Advanced Cardiovascular Systems, Inc. Implantable devices formed of non-fouling methacrylate or acrylate polymers
US9381279B2 (en) 2005-03-24 2016-07-05 Abbott Cardiovascular Systems Inc. Implantable devices formed on non-fouling methacrylate or acrylate polymers
JP5082058B2 (en) * 2005-04-05 2012-11-28 テルモ株式会社 Medical instruments
US20070050009A1 (en) * 2005-08-30 2007-03-01 Aiden Flanagan Bioabsorbable stent
US20070055352A1 (en) * 2005-09-07 2007-03-08 Wendy Naimark Stent with pockets for containing a therapeutic agent
US8069814B2 (en) 2006-05-04 2011-12-06 Advanced Cardiovascular Systems, Inc. Stent support devices
US20080095918A1 (en) * 2006-06-14 2008-04-24 Kleiner Lothar W Coating construct with enhanced interfacial compatibility
US7713541B1 (en) 2006-11-21 2010-05-11 Abbott Cardiovascular Systems Inc. Zwitterionic terpolymers, method of making and use on medical devices
EP2097119A4 (en) * 2006-11-21 2012-10-17 Abbott Lab Use of a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride in drug eluting coatings
US20080118541A1 (en) * 2006-11-21 2008-05-22 Abbott Laboratories Use of a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride in drug eluting coatings on medical devices
US8017141B2 (en) 2006-12-15 2011-09-13 Advanced Cardiovascular Systems, Inc. Coatings of acrylamide-based copolymers
US8221496B2 (en) 2007-02-01 2012-07-17 Cordis Corporation Antithrombotic and anti-restenotic drug eluting stent
US20080286332A1 (en) 2007-05-14 2008-11-20 Pacetti Stephen D Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
US8367150B2 (en) 2007-06-15 2013-02-05 Abbott Cardiovascular Systems Inc. Methods and apparatus for coating stents
US9737638B2 (en) 2007-06-20 2017-08-22 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
DE102007034364A1 (en) * 2007-07-24 2009-01-29 Biotronik Vi Patent Ag Degradable metal stent with active ingredient-containing coating
US8409272B2 (en) 2007-09-04 2013-04-02 Japan Stent Technology Co., Ltd. Sustained drug-releasing stent
US8128983B2 (en) * 2008-04-11 2012-03-06 Abbott Cardiovascular Systems Inc. Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network
US20090297584A1 (en) * 2008-04-18 2009-12-03 Florencia Lim Biosoluble coating with linear over time mass loss
US20090285873A1 (en) * 2008-04-18 2009-11-19 Abbott Cardiovascular Systems Inc. Implantable medical devices and coatings therefor comprising block copolymers of poly(ethylene glycol) and a poly(lactide-glycolide)
US8916188B2 (en) * 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
US8697113B2 (en) * 2008-05-21 2014-04-15 Abbott Cardiovascular Systems Inc. Coating comprising a terpolymer comprising caprolactone and glycolide
US8709040B2 (en) 2008-06-26 2014-04-29 Vitasynergies, Llc Suture anchor, guide for locating a hole in a bone, and suture anchor delivery tool
DE102008040356A1 (en) * 2008-07-11 2010-01-14 Biotronik Vi Patent Ag Stent with biodegradable stent struts and drug depots
US20100106242A1 (en) * 2008-10-23 2010-04-29 Abbott Cardiovascular Systems Inc. Stent and method for making a stent
DE102008043277A1 (en) * 2008-10-29 2010-05-06 Biotronik Vi Patent Ag Implant made of a biocorrodible iron or magnesium alloy
WO2010101072A1 (en) 2009-03-02 2010-09-10 株式会社日本ステントテクノロジー Drug releasing stent
US8183337B1 (en) 2009-04-29 2012-05-22 Abbott Cardiovascular Systems Inc. Method of purifying ethylene vinyl alcohol copolymers for use with implantable medical devices
US8697110B2 (en) * 2009-05-14 2014-04-15 Abbott Cardiovascular Systems Inc. Polymers comprising amorphous terpolymers and semicrystalline blocks
US8911766B2 (en) 2009-06-26 2014-12-16 Abbott Cardiovascular Systems Inc. Drug delivery compositions including nanoshells for triggered drug release
US8951595B2 (en) * 2009-12-11 2015-02-10 Abbott Cardiovascular Systems Inc. Coatings with tunable molecular architecture for drug-coated balloon
US8480620B2 (en) * 2009-12-11 2013-07-09 Abbott Cardiovascular Systems Inc. Coatings with tunable solubility profile for drug-coated balloon
US20110144577A1 (en) * 2009-12-11 2011-06-16 John Stankus Hydrophilic coatings with tunable composition for drug coated balloon
EP2338534A2 (en) * 2009-12-21 2011-06-29 Biotronik VI Patent AG Medical implant, coating method and implantation method
EP2833837B1 (en) 2012-04-06 2023-03-29 Merlin MD PTE Ltd. Devices for treating an aneurysm
US10238513B2 (en) * 2017-07-19 2019-03-26 Abbott Cardiovascular Systems Inc. Intravascular stent

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1078329B (en) 1955-04-27 1960-03-24 Du Pont Process for the production of an elastic copolymer from vinylidene fluoride and another fluoroolefin
US2968649A (en) 1958-12-04 1961-01-17 Du Pont Elastomeric terpolymers
US3178399A (en) 1961-08-10 1965-04-13 Minnesota Mining & Mfg Fluorine-containing polymers and preparation thereof
US3324069A (en) 1964-10-23 1967-06-06 Pennsalt Chemicals Corp Vinylidene fluoride polymer dispersions
US3856827A (en) 1970-12-28 1974-12-24 Jefferson Chem Co Inc Silicon containing molybdenum catalysts
US3779805A (en) 1971-05-19 1973-12-18 Bell Telephone Labor Inc Method of making waveguide mode filter
US4076929A (en) 1975-10-30 1978-02-28 Pennwalt Corporation Vinylidene fluoride polymer having improved melt flow properties
US4197380A (en) 1978-03-01 1980-04-08 Raychem Corporation Hot melt adhesive comprising fluorocarbon elastomer, ethylene copolymer and tackifier
US4346710A (en) 1978-06-16 1982-08-31 Pennwalt Corporation Article for storage and transport of biogenic fluids
US4353960A (en) 1978-09-21 1982-10-12 Kureha Kagaku Kogyo Kabushiki Kaisha Composite and conjugate filaments
JPS6037733B2 (en) 1978-10-12 1985-08-28 住友電気工業株式会社 Tubular organ prosthesis material and its manufacturing method
US4423183A (en) 1980-09-16 1983-12-27 David Hudson, Inc. Fluoroelastomer film compositions and solutions containing fatty polyamide curatives
JPS57144756A (en) 1981-03-04 1982-09-07 Koken Kk Impermeable laminated film
US4935477A (en) 1981-08-20 1990-06-19 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4977026A (en) 1981-08-20 1990-12-11 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4530569A (en) 1981-08-20 1985-07-23 E. I. Du Pont De Nemours And Company Optical fibers comprising cores clad with amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4973142A (en) 1981-08-20 1990-11-27 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4977008A (en) 1981-08-20 1990-12-11 E. I Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4985308A (en) 1981-08-20 1991-01-15 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4948851A (en) 1981-08-20 1990-08-14 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4977025A (en) 1981-08-20 1990-12-11 E. I Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US5006382A (en) 1981-08-20 1991-04-09 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4999248A (en) 1981-08-20 1991-03-12 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4982056A (en) 1981-08-20 1991-01-01 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxide
US4754009A (en) 1981-08-20 1988-06-28 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US5000547A (en) 1981-08-20 1991-03-19 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4975505A (en) 1981-08-20 1990-12-04 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4977297A (en) 1981-08-20 1990-12-11 E. I. Du Pont De Nemours And Company Amorphous copolymers of perfluoro-2,2-dimethyl-1,3-dioxole
US4485250A (en) 1981-11-19 1984-11-27 E. I. Du Pont De Nemours And Company Perfluorodioxole and its polymers
US4399264A (en) 1981-11-19 1983-08-16 E. I. Du Pont De Nemours & Co. Perfluorodioxole and its polymers
US5051978A (en) 1982-11-30 1991-09-24 Burroughs Corporation Coated media for optical recording
US4636346A (en) 1984-03-08 1987-01-13 Cordis Corporation Preparing guiding catheter
US4564013A (en) 1984-05-24 1986-01-14 Ethicon, Inc. Surgical filaments from vinylidene fluoride copolymers
US4569978A (en) 1984-07-25 1986-02-11 Pennwalt Corporation Emulsion polymerization of vinylidene fluoride polymers in the presence of trichlorofluoromethane as chain transfer agent
US4632842A (en) 1985-06-20 1986-12-30 Atrium Medical Corporation Glow discharge process for producing implantable devices
US4718907A (en) 1985-06-20 1988-01-12 Atrium Medical Corporation Vascular prosthesis having fluorinated coating with varying F/C ratio
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4871357A (en) 1986-01-21 1989-10-03 Baxter International Inc. Ionic heparin coating
US4749585A (en) 1986-04-11 1988-06-07 University Of Medicine And Dentistry Of New Jersey Antibiotic bonded prosthesis and process for producing same
GB2194539B (en) 1986-09-01 1990-08-01 Labofina Sa Pvdf-based powder coatings
JPS6389138A (en) 1986-10-03 1988-04-20 オリンパス光学工業株式会社 Cover of curved pipe for endoscope
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4876109A (en) 1987-04-13 1989-10-24 Cardiac Pacemakers, Inc. Soluble covering for cardiac pacing electrode
US4897457A (en) 1987-08-14 1990-01-30 Asahi Glass Company Ltd. Novel fluorine-containing cyclic polymer
US5047020A (en) 1987-09-14 1991-09-10 Baxter International Inc. Ionic heparin coating
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US5185408A (en) 1987-12-17 1993-02-09 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5076659A (en) 1988-05-27 1991-12-31 E. I. Du Pont De Nemours And Company Process for the stabilization of fluoropolymers
US4931287A (en) 1988-06-14 1990-06-05 University Of Utah Heterogeneous interpenetrating polymer networks for the controlled release of drugs
US4908404A (en) 1988-08-22 1990-03-13 Biopolymers, Inc. Synthetic amino acid-and/or peptide-containing graft copolymers
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US5053048A (en) 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US5030394A (en) 1988-11-08 1991-07-09 Labofina, S.A. PVdF-based powder coatings
US4977901A (en) 1988-11-23 1990-12-18 Minnesota Mining And Manufacturing Company Article having non-crosslinked crystallized polymer coatings
JP3027606B2 (en) 1989-06-15 2000-04-04 デユポン・カナダ・インコーポレーテツド Perfluorodioxole membrane
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5107852A (en) 1990-04-02 1992-04-28 W. L. Gore & Associates, Inc. Catheter guidewire device having a covering of fluoropolymer tape
US5093427A (en) 1990-05-10 1992-03-03 Atochem North America, Inc. Copolymers of vinylidene fluoride and hexafluoropropylene and process for preparing the same
US5395311A (en) 1990-05-14 1995-03-07 Andrews; Winston A. Atherectomy catheter
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5112457A (en) 1990-07-23 1992-05-12 Case Western Reserve University Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants
US5455040A (en) 1990-07-26 1995-10-03 Case Western Reserve University Anticoagulant plasma polymer-modified substrate
US5302385A (en) 1990-08-20 1994-04-12 Becton, Dickinson And Company Polyurethane-polyvinylpyrrolidone block copolymer and iodine carrier therefrom
US5632776A (en) 1990-11-22 1997-05-27 Toray Industries, Inc. Implantation materials
US5246451A (en) 1991-04-30 1993-09-21 Medtronic, Inc. Vascular prosthesis and method
DE69223033T2 (en) 1991-08-27 1998-03-26 Daikin Ind Ltd FLUORED RUBBER COATING COMPOSITION
US5176972A (en) 1991-09-11 1993-01-05 Polaroid Corporation Imaging medium with low refractive index layer
WO1993005825A1 (en) 1991-09-20 1993-04-01 Baxter International Inc. Processes for reducing the thrombogenicity of biomaterials
JPH05307137A (en) * 1992-01-07 1993-11-19 Olympus Optical Co Ltd Lens barrel
US5296283A (en) 1992-01-13 1994-03-22 E. I. Du Pont De Nemours And Company Protective coating for machine-readable markings
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5591224A (en) 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5368566A (en) 1992-04-29 1994-11-29 Cardiovascular Dynamics, Inc. Delivery and temporary stent catheter having a reinforced perfusion lumen
US5276121A (en) 1992-05-05 1994-01-04 E. I. Du Pont De Nemours And Company Amorphous copolymers of two fluorinated ring monomers
US5383928A (en) 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5383853A (en) 1992-11-12 1995-01-24 Medtronic, Inc. Rapid exchange catheter
US5342348A (en) 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5336518A (en) 1992-12-11 1994-08-09 Cordis Corporation Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents
US5443458A (en) 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5861168A (en) * 1993-06-11 1999-01-19 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
JPH0767895A (en) 1993-06-25 1995-03-14 Sumitomo Electric Ind Ltd Antimicrobial artificial blood vessel and suture yarn for antimicrobial operation
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
DE69330132T2 (en) 1993-07-23 2001-11-15 Cook Inc FLEXIBLE STENT WITH A CONFIGURATION MOLDED FROM A MATERIAL SHEET
PT1118325E (en) 1993-07-29 2006-05-31 Us Health USES OF PACLITAXEL AND ITS DERIVATIVES IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF RESTENOSE
US5380299A (en) 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5310838A (en) 1993-09-07 1994-05-10 E. I. Du Pont De Nemours And Company Functional fluoropolymers
DE4337613A1 (en) 1993-11-04 1995-05-11 Fichtel & Sachs Ag Friction clutch with automatic wear compensation and play generator
CA2176826C (en) * 1993-12-10 2000-09-26 Nusayr Azam Guiding catheter
US5403341A (en) 1994-01-24 1995-04-04 Solar; Ronald J. Parallel flow endovascular stent and deployment apparatus therefore
US5408020A (en) 1994-05-09 1995-04-18 E. I. Du Pont De Nemours And Company Copolymers of perhalo-2,2-di-loweralkyl-1,3-dioxole, and perfluoro-2-methylene-4-methyl-1,3-dioxolane
US5578073A (en) 1994-09-16 1996-11-26 Ramot Of Tel Aviv University Thromboresistant surface treatment for biomaterials
US5649977A (en) * 1994-09-22 1997-07-22 Advanced Cardiovascular Systems, Inc. Metal reinforced polymer stent
WO1996011671A1 (en) * 1994-10-12 1996-04-25 Focal, Inc. Targeted delivery via biodegradable polymers
US5575818A (en) 1995-02-14 1996-11-19 Corvita Corporation Endovascular stent with locking ring
US6179817B1 (en) * 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
US5869127A (en) * 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
US6147168A (en) * 1995-03-06 2000-11-14 Ethicon, Inc. Copolymers of absorbable polyoxaesters
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5900425A (en) * 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
US5628728A (en) 1995-05-31 1997-05-13 Ekos Corporation Medicine applying tool
US5562734A (en) 1995-05-31 1996-10-08 Zimmer, Inc. Method for reducing gamma radiation sterilization induced discoloration
US5750234A (en) * 1996-06-07 1998-05-12 Avery Dennison Corporation Interior automotive laminate with thermoplastic low gloss coating
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5820917A (en) * 1995-06-07 1998-10-13 Medtronic, Inc. Blood-contacting medical device and method
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
WO1997022371A1 (en) * 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
JP3941128B2 (en) * 1995-12-18 2007-07-04 ダイキン工業株式会社 Powder coating composition
US5713949A (en) * 1996-08-06 1998-02-03 Jayaraman; Swaminathan Microporous covered stents and method of coating
US5874165A (en) * 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
US6060534A (en) * 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6033724A (en) * 1996-11-27 2000-03-07 Spalding Sports Worldwide, Inc. Golf ball mold preparation technique and coating system
KR100526913B1 (en) * 1997-02-20 2005-11-09 쿡 인코포레이티드 Coated implantable medical device
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
US5879697A (en) * 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US6056993A (en) * 1997-05-30 2000-05-02 Schneider (Usa) Inc. Porous protheses and methods for making the same wherein the protheses are formed by spraying water soluble and water insoluble fibers onto a rotating mandrel
DE69839077T2 (en) * 1997-06-18 2009-01-22 Boston Scientific Ltd., St. Michael POLYCARBONATE POLYURETHANE DISPERSION AS A DUST-RESISTANT COATING
US5897911A (en) * 1997-08-11 1999-04-27 Advanced Cardiovascular Systems, Inc. Polymer-coated stent structure
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
DE69918607T2 (en) * 1998-03-05 2005-07-21 Solvay Solexis, Inc., Wilmington Weather resistant coating compositions of polyvinylidene fluoride containing polymethylmethacrylate
DE69926017T2 (en) * 1998-04-27 2005-12-22 SurModics, Inc., Eden Prairie Bioactive agents releasing coatings
EP1076534B1 (en) * 1998-05-05 2007-04-04 Boston Scientific Limited Stent with smooth ends
US6187024B1 (en) * 1998-11-10 2001-02-13 Target Therapeutics, Inc. Bioactive coating for vaso-occlusive devices
US6503556B2 (en) * 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6790228B2 (en) * 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6203551B1 (en) * 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US6610087B1 (en) * 1999-11-16 2003-08-26 Scimed Life Systems, Inc. Endoluminal stent having a matched stiffness region and/or a stiffness gradient and methods for providing stent kink resistance
JP4789302B2 (en) * 2000-04-19 2011-10-12 ホーユー株式会社 Hair dye storage container
US6716444B1 (en) * 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US6783793B1 (en) * 2000-10-26 2004-08-31 Advanced Cardiovascular Systems, Inc. Selective coating of medical devices
US6545097B2 (en) * 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6824559B2 (en) * 2000-12-22 2004-11-30 Advanced Cardiovascular Systems, Inc. Ethylene-carboxyl copolymers as drug delivery matrices
NZ528994A (en) * 2001-04-26 2006-02-24 Control Delivery Sys Inc Sustained release drug delivery system containing codrugs
US6585755B2 (en) * 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US20030073961A1 (en) * 2001-09-28 2003-04-17 Happ Dorrie M. Medical device containing light-protected therapeutic agent and a method for fabricating thereof
US20030077312A1 (en) * 2001-10-22 2003-04-24 Ascher Schmulewicz Coated intraluminal stents and reduction of restenosis using same
US7217426B1 (en) * 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7005137B1 (en) * 2002-06-21 2006-02-28 Advanceed Cardiovascular Systems, Inc. Coating for implantable medical devices
US20040063805A1 (en) * 2002-09-19 2004-04-01 Pacetti Stephen D. Coatings for implantable medical devices and methods for fabrication thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8915952B2 (en) 2004-03-31 2014-12-23 Merlin Md Pte Ltd. Method for treating aneurysms
US8920430B2 (en) 2004-03-31 2014-12-30 Merlin Md Pte. Ltd. Medical device
US9585668B2 (en) 2004-03-31 2017-03-07 Merlin Md Pte Ltd Medical device
US9844433B2 (en) 2004-03-31 2017-12-19 Merlin Md Pte. Ltd. Medical device

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EP1517713B1 (en) 2009-11-18
EP1517713A1 (en) 2005-03-30
AU2003245282A1 (en) 2004-01-06
US20090005861A1 (en) 2009-01-01
US7396539B1 (en) 2008-07-08
DE60330144D1 (en) 2009-12-31
WO2004000379A1 (en) 2003-12-31
ATE448812T1 (en) 2009-12-15

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