WO2003060078A8 - Heterocyclic modulators of nuclear receptors - Google Patents

Heterocyclic modulators of nuclear receptors

Info

Publication number
WO2003060078A8
WO2003060078A8 PCT/US2002/041224 US0241224W WO03060078A8 WO 2003060078 A8 WO2003060078 A8 WO 2003060078A8 US 0241224 W US0241224 W US 0241224W WO 03060078 A8 WO03060078 A8 WO 03060078A8
Authority
WO
WIPO (PCT)
Prior art keywords
nuclear receptors
heterocyclic modulators
compounds
heterocyclic
modulating
Prior art date
Application number
PCT/US2002/041224
Other languages
French (fr)
Other versions
WO2003060078A3 (en
WO2003060078A2 (en
WO2003060078A9 (en
Inventor
Richard Martin
Brenton Todd Flatt
Tie-Lin Wang
Jeffery Dean Kahl
Original Assignee
X Ceptor Therapeutics Inc
Richard Martin
Brenton Todd Flatt
Tie-Lin Wang
Jeffery Dean Kahl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by X Ceptor Therapeutics Inc, Richard Martin, Brenton Todd Flatt, Tie-Lin Wang, Jeffery Dean Kahl filed Critical X Ceptor Therapeutics Inc
Priority to AT02806505T priority Critical patent/ATE521599T1/en
Priority to EP02806505A priority patent/EP1465882B1/en
Priority to AU2002367060A priority patent/AU2002367060A1/en
Publication of WO2003060078A2 publication Critical patent/WO2003060078A2/en
Publication of WO2003060078A9 publication Critical patent/WO2003060078A9/en
Publication of WO2003060078A8 publication Critical patent/WO2003060078A8/en
Publication of WO2003060078A3 publication Critical patent/WO2003060078A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.
PCT/US2002/041224 2001-12-21 2002-12-20 Heterocyclic modulators of nuclear receptors WO2003060078A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT02806505T ATE521599T1 (en) 2001-12-21 2002-12-20 HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS
EP02806505A EP1465882B1 (en) 2001-12-21 2002-12-20 Hetrocyclic modulators of nuclear receptors
AU2002367060A AU2002367060A1 (en) 2001-12-21 2002-12-20 Heterocyclic modulators of nuclear receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34272001P 2001-12-21 2001-12-21
US60/342,720 2001-12-21

Publications (4)

Publication Number Publication Date
WO2003060078A2 WO2003060078A2 (en) 2003-07-24
WO2003060078A9 WO2003060078A9 (en) 2004-02-19
WO2003060078A8 true WO2003060078A8 (en) 2004-04-29
WO2003060078A3 WO2003060078A3 (en) 2004-06-24

Family

ID=23342988

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041224 WO2003060078A2 (en) 2001-12-21 2002-12-20 Heterocyclic modulators of nuclear receptors

Country Status (6)

Country Link
US (2) US6696473B2 (en)
EP (1) EP1465882B1 (en)
AT (1) ATE521599T1 (en)
AU (1) AU2002367060A1 (en)
ES (1) ES2367539T3 (en)
WO (1) WO2003060078A2 (en)

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Also Published As

Publication number Publication date
US20040180942A1 (en) 2004-09-16
AU2002367060A1 (en) 2003-07-30
EP1465882A2 (en) 2004-10-13
ATE521599T1 (en) 2011-09-15
WO2003060078A3 (en) 2004-06-24
US20030212111A1 (en) 2003-11-13
AU2002367060A8 (en) 2003-07-30
EP1465882B1 (en) 2011-08-24
US7115640B2 (en) 2006-10-03
WO2003060078A2 (en) 2003-07-24
WO2003060078A9 (en) 2004-02-19
ES2367539T3 (en) 2011-11-04
EP1465882A4 (en) 2005-04-06
US6696473B2 (en) 2004-02-24

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