WO2003058199A3 - Arrays of microparticles and methods of preparation thereof - Google Patents

Arrays of microparticles and methods of preparation thereof Download PDF

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Publication number
WO2003058199A3
WO2003058199A3 PCT/US2002/041623 US0241623W WO03058199A3 WO 2003058199 A3 WO2003058199 A3 WO 2003058199A3 US 0241623 W US0241623 W US 0241623W WO 03058199 A3 WO03058199 A3 WO 03058199A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
microparticles
methods
preparation
chemical
Prior art date
Application number
PCT/US2002/041623
Other languages
French (fr)
Other versions
WO2003058199A2 (en
Inventor
Michael Seul
Chiu Wo Chau
Hui Huang
Sukanta Banerjee
Ye Hong
Jiacheng Yang
Original Assignee
Bioarray Solutions Ltd
Michael Seul
Chiu Wo Chau
Hui Huang
Sukanta Banerjee
Ye Hong
Jiacheng Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2002364034A priority Critical patent/AU2002364034B2/en
Priority to JP2003558459A priority patent/JP2005535868A/en
Priority to EP02798611A priority patent/EP1488236B1/en
Priority to KR1020047010315A priority patent/KR100966683B1/en
Priority to IL16273702A priority patent/IL162737A0/en
Priority to NZ533752A priority patent/NZ533752A/en
Application filed by Bioarray Solutions Ltd, Michael Seul, Chiu Wo Chau, Hui Huang, Sukanta Banerjee, Ye Hong, Jiacheng Yang filed Critical Bioarray Solutions Ltd
Priority to ES02798611T priority patent/ES2398194T3/en
Priority to CA2471693A priority patent/CA2471693C/en
Publication of WO2003058199A2 publication Critical patent/WO2003058199A2/en
Publication of WO2003058199A3 publication Critical patent/WO2003058199A3/en
Priority to IL162737A priority patent/IL162737A/en
Priority to HK05108808A priority patent/HK1074881A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00466—Beads in a slurry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00545—Colours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B01J2219/00662—Two-dimensional arrays within two-dimensional arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/149—Particles, e.g. beads

Abstract

This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays acccording to the methods described herein. The chip and/or multichip arrays of this invention are useful for chemical and biological assays.
PCT/US2002/041623 2001-12-28 2002-12-27 Arrays of microparticles and methods of preparation thereof WO2003058199A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2003558459A JP2005535868A (en) 2001-12-28 2002-12-27 Microparticle array and method for producing the same
EP02798611A EP1488236B1 (en) 2001-12-28 2002-12-27 Methods for preparing arrays of microparticles
KR1020047010315A KR100966683B1 (en) 2001-12-28 2002-12-27 Method for producing biochips
IL16273702A IL162737A0 (en) 2001-12-28 2002-12-27 Arrays of microparticles and methods of preparation
NZ533752A NZ533752A (en) 2001-12-28 2002-12-27 Arrays of microparticles and methods of preparation thereof
AU2002364034A AU2002364034B2 (en) 2001-12-28 2002-12-27 Arrays of microparticles and methods of preparation thereof
ES02798611T ES2398194T3 (en) 2001-12-28 2002-12-27 Matrices of microparticles and their preparation procedures
CA2471693A CA2471693C (en) 2001-12-28 2002-12-27 Arrays of microparticles and methods of preparation thereof
IL162737A IL162737A (en) 2001-12-28 2004-06-24 Arrays of microparticles and methods of preparation thereof
HK05108808A HK1074881A1 (en) 2001-12-28 2005-10-05 Arrays of microparticles and methods of preparation thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34362101P 2001-12-28 2001-12-28
US60/343,621 2001-12-28
US10/192,352 2002-07-09
US10/192,352 US7335153B2 (en) 2001-12-28 2002-07-09 Arrays of microparticles and methods of preparation thereof

Publications (2)

Publication Number Publication Date
WO2003058199A2 WO2003058199A2 (en) 2003-07-17
WO2003058199A3 true WO2003058199A3 (en) 2004-06-17

Family

ID=26888007

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041623 WO2003058199A2 (en) 2001-12-28 2002-12-27 Arrays of microparticles and methods of preparation thereof

Country Status (13)

Country Link
US (7) US7335153B2 (en)
EP (3) EP2565648B1 (en)
JP (2) JP2005535868A (en)
KR (1) KR100966683B1 (en)
CN (1) CN1299117C (en)
AU (1) AU2002364034B2 (en)
CA (1) CA2471693C (en)
ES (2) ES2398194T3 (en)
HK (1) HK1074881A1 (en)
IL (2) IL162737A0 (en)
NZ (1) NZ533752A (en)
PT (1) PT1488236E (en)
WO (1) WO2003058199A2 (en)

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