WO2003047493A3 - Stabilized reverse micelle compositions and uses thereof - Google Patents

Stabilized reverse micelle compositions and uses thereof Download PDF

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Publication number
WO2003047493A3
WO2003047493A3 PCT/US2002/038473 US0238473W WO03047493A3 WO 2003047493 A3 WO2003047493 A3 WO 2003047493A3 US 0238473 W US0238473 W US 0238473W WO 03047493 A3 WO03047493 A3 WO 03047493A3
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WO
WIPO (PCT)
Prior art keywords
mucosal
compositions
micelles
water
drugs
Prior art date
Application number
PCT/US2002/038473
Other languages
French (fr)
Other versions
WO2003047493A2 (en
Inventor
Panos P Constantinides
Likan Liang
Eun-Hyun Jang
Original Assignee
Dor Biopharma Inc
Panos P Constantinides
Likan Liang
Eun-Hyun Jang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dor Biopharma Inc, Panos P Constantinides, Likan Liang, Eun-Hyun Jang filed Critical Dor Biopharma Inc
Priority to US10/497,775 priority Critical patent/US8535650B2/en
Priority to AU2002362039A priority patent/AU2002362039B2/en
Priority to CA2468845A priority patent/CA2468845C/en
Priority to DE60231549T priority patent/DE60231549D1/en
Priority to JP2003548757A priority patent/JP2005515197A/en
Priority to EP02797165A priority patent/EP1460992B1/en
Priority to DK02797165T priority patent/DK1460992T3/en
Publication of WO2003047493A2 publication Critical patent/WO2003047493A2/en
Publication of WO2003047493A3 publication Critical patent/WO2003047493A3/en
Priority to HK05101122.4A priority patent/HK1071054A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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Abstract

The invention relates to compositions and methods for drug delivery suitable for promoting the transmucosal absorption of drugs, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and other polar solvents to form reverse micelles tha are physiclally stabilized in the presence of gastrointestinal fluid, water, and other hydrophilic solvents. Such stable reverse micelles are formed by suitable mixtures of polymeric or non-polymeric compounds with amphiphiles. Micelles made using these methods undergo phase transformation more slowly resulting in delayed drug release profiles and sustained absorption. When administered as a pharmaceutical to mucosal surfaces following oral ingestion or intranasal administration, therapeutic molecules principally solubilized in the aqueous phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions may comprise mono-, di-glycerides and/or their transesterifed products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrohilic moieties.
PCT/US2002/038473 2001-12-03 2002-12-03 Stabilized reverse micelle compositions and uses thereof WO2003047493A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US10/497,775 US8535650B2 (en) 2001-12-03 2002-12-03 Stabilized reverse micelle compositions and uses thereof
AU2002362039A AU2002362039B2 (en) 2001-12-03 2002-12-03 Stabilized reverse micelle compositions and uses thereof
CA2468845A CA2468845C (en) 2001-12-03 2002-12-03 Stabilized reverse micelle compositions and uses thereof
DE60231549T DE60231549D1 (en) 2001-12-03 2002-12-03 STABILIZED REVERSE MICRO-COMPOSITIONS AND THEIR USE
JP2003548757A JP2005515197A (en) 2001-12-03 2002-12-03 Stabilized reverse micelle composition and use thereof
EP02797165A EP1460992B1 (en) 2001-12-03 2002-12-03 Stabilized reverse micelle compositions and uses thereof
DK02797165T DK1460992T3 (en) 2001-12-03 2002-12-03 Stabilized reverse micelle compositions and applications thereof
HK05101122.4A HK1071054A1 (en) 2001-12-03 2005-02-12 Stabilized reverse micelle compositions and uses thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US33687301P 2001-12-03 2001-12-03
US60/336,873 2001-12-03
US35477402P 2002-02-05 2002-02-05
US60/354,774 2002-02-05
US37769102P 2002-05-03 2002-05-03
US60/377,691 2002-05-03

Publications (2)

Publication Number Publication Date
WO2003047493A2 WO2003047493A2 (en) 2003-06-12
WO2003047493A3 true WO2003047493A3 (en) 2003-10-16

Family

ID=27407158

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038473 WO2003047493A2 (en) 2001-12-03 2002-12-03 Stabilized reverse micelle compositions and uses thereof

Country Status (10)

Country Link
US (1) US8535650B2 (en)
EP (1) EP1460992B1 (en)
JP (2) JP2005515197A (en)
AT (1) ATE424815T1 (en)
AU (1) AU2002362039B2 (en)
CA (1) CA2468845C (en)
DE (1) DE60231549D1 (en)
DK (1) DK1460992T3 (en)
HK (1) HK1071054A1 (en)
WO (1) WO2003047493A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119159B2 (en) 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US7083920B2 (en) * 2001-05-18 2006-08-01 Nagaoka & Co. Ltd. Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto
US20050019901A1 (en) * 2002-01-31 2005-01-27 Evgenia Matveeva Methods for synthesis of bio-active nanoparticles and nanocapsules for use in optical bio-disc assays and disc assembly including same
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US20090148929A1 (en) * 2005-10-19 2009-06-11 Unirem, Inc. Biostimulation agent for bioremediation and methods therefor
US8236333B2 (en) * 2005-10-19 2012-08-07 Unirem, Inc. Active agent delivery and/or odor retentive composition and methods of use thereof
AU2007235251B2 (en) 2006-04-07 2013-02-07 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
PL2074141T3 (en) 2006-09-22 2017-02-28 Novo Nordisk A/S Protease resistant insulin analogues
EP1961412A1 (en) * 2006-12-27 2008-08-27 LEK Pharmaceuticals D.D. Self-microemulsifying drug delivery systems
GB0713672D0 (en) * 2007-07-13 2007-08-22 Imp Innovations Ltd Method for cell manipulation
US9260502B2 (en) 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
US8691759B2 (en) 2008-03-18 2014-04-08 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
AU2009244799B2 (en) 2008-05-07 2014-11-20 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
CA2638240C (en) * 2008-08-29 2010-02-02 Alexander Macgregor Method of treating dysglycemia and glucose excursions
US10098857B2 (en) * 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
US20100310660A1 (en) * 2009-06-08 2010-12-09 Taipei Medical University Dry powder microparticles for pulmonary delivery
US8258250B2 (en) * 2009-10-07 2012-09-04 Johnson & Johnson Consumer Companies, Inc. Compositions comprising superhydrophilic amphiphilic copolymers and methods of use thereof
US11173106B2 (en) * 2009-10-07 2021-11-16 Johnson & Johnson Consumer Inc. Compositions comprising a superhydrophilic amphiphilic copolymer and a micellar thickener
US8399590B2 (en) 2009-10-07 2013-03-19 Akzo Nobel Chemicals International B.V. Superhydrophilic amphiphilic copolymers and processes for making the same
WO2011108930A1 (en) 2010-03-04 2011-09-09 Interna Technologies Bv A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
ES2614115T3 (en) 2010-03-24 2017-05-29 Medesis Pharma Inverse micelle system comprising nucleic acids and their use
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
CA2804599C (en) 2010-07-06 2023-01-31 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
MX354750B (en) 2010-11-05 2018-03-20 Novavax Inc RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs).
AU2012204213A1 (en) 2011-01-07 2013-06-13 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
CN103338750A (en) * 2011-01-31 2013-10-02 丸宝株式会社 Dermal composition comprising polymeric reversed micelle, and method for producing same
AR086913A1 (en) * 2011-06-14 2014-01-29 Novartis Ag 4-METIL-3 - [[4- (3-PIRIDINIL) -2-PIRIMIDINIL] -AMINO] -N- [5- (4-METHYL-1H-IMIDAZOL-1-IL) -3- (TRIFLUORO-METIL) -FENIL] -BENZAMIDA AMORFA, FORM OF DOSAGE THAT CONTAINS AND METHOD TO PREPARE
KR101904824B1 (en) * 2011-09-06 2018-11-29 리쿠아비스타 비.브이. Surfactant and method of manufacturing electrowetting display devices uisng the same
US20140336147A1 (en) * 2011-12-12 2014-11-13 Agratech International, Inc. Hemostatic agents and methods of use
EP2794881B1 (en) 2011-12-22 2018-06-27 InteRNA Technologies B.V. Mirna for treating head and neck cancer
BR112014025132A2 (en) 2012-04-11 2017-07-11 Novo Nordisk As insulin formulations
KR102152751B1 (en) * 2012-09-28 2020-09-07 (주)아모레퍼시픽 Microcapsule containing glycoprotein of plant origin
WO2014072357A1 (en) 2012-11-06 2014-05-15 Interna Technologies B.V. Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
DK3055325T3 (en) 2013-10-07 2018-04-16 Novo Nordisk As New derivative of an insulin analogue
US10500289B2 (en) * 2014-03-26 2019-12-10 D. R. NANO Co., Ltd. Method of using methylene blue nanoparticle for detecting cancer by bioimaging
US10034834B1 (en) * 2014-10-24 2018-07-31 Aqua Regenerative Therapies Llc Compositions and methods for treating skin conditions
WO2016092569A1 (en) 2014-12-10 2016-06-16 Council Of Scientific & Industrial Research A discontinuous reverse micellar composition in cubic fd3m phase for sustained release of therapeutic drugs
US10058490B2 (en) * 2014-12-24 2018-08-28 L'oreal Acoustically-activated cosmetic hydrogels
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
WO2016161200A1 (en) 2015-03-31 2016-10-06 Uop Llc Halometallate ionic liquid micro-emulsions
CN110087674B (en) 2016-12-16 2023-01-03 诺和诺德股份有限公司 Pharmaceutical composition containing insulin
CA3079524A1 (en) 2017-11-03 2019-05-09 Interna Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
KR20210151187A (en) 2019-04-11 2021-12-13 알.피.쉐러 테크놀러지즈 엘엘씨 Formulations for Oral Delivery of Impermeable Proteins, Peptides and Small Molecules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485706B1 (en) * 1999-06-04 2002-11-26 Delrx Pharmaceutical Corp. Formulations comprising dehydrated particles of pharma-ceutical agents and process for preparing the same

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61185332A (en) * 1985-02-12 1986-08-19 Morinaga Milk Ind Co Ltd Stable water in oil type emulsion and its preparation
DE3682257D1 (en) 1985-11-22 1991-12-05 Takeda Chemical Industries Ltd LIPOSOME COMPOSITION.
US5811128A (en) * 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
CA2015291C (en) * 1989-04-27 1996-04-30 Etsuo Hasegawa Macromolecular endoplasmic reticulum
FR2659554B1 (en) * 1990-03-16 1994-09-30 Oreal COMPOSITION FOR THE COSMETIC AND / OR PHARMACEUTICAL TREATMENT OF THE TOP LAYERS OF THE EPIDERMIS BY TOPICAL APPLICATION TO THE SKIN AND PREPARATION METHOD THEREOF.
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5292499A (en) * 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
DK0580778T3 (en) * 1991-04-19 2000-01-31 Lds Technologies Inc Convertible microemulsion formulations
WO1993000160A1 (en) * 1991-06-27 1993-01-07 Emory University Multiple emulsions and methods of preparation
MX9204379A (en) 1991-07-26 1993-02-01 Smithkline Beecham Corp PHARMACEUTICALLY ACCEPTABLE, STABLE, SELF-EMULSIFIABLE OIL WATER MICROEMULSIONS.
JPH05194253A (en) * 1992-01-16 1993-08-03 Kirin Brewery Co Ltd Sustained release particulate pharmaceutical containing water-soluble polypeptide hormone and its production
GB9300875D0 (en) * 1993-01-18 1993-03-10 Ucb Sa Nanocapsule containing pharmaceutical compositions
US6191105B1 (en) * 1993-05-10 2001-02-20 Protein Delivery, Inc. Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
ATE317397T1 (en) * 1993-11-17 2006-02-15 Athena Neurosciences Inc TRANSPARENT LIQUID FOR ADMINISTRATION OF ENCAPSULATED MEDICATIONS
US5451569A (en) * 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
SE518619C2 (en) * 1994-12-09 2002-10-29 Gs Dev Ab Controlled release composition containing monocaproin
US5693516A (en) * 1995-11-27 1997-12-02 Novo Nordisk Biotech, Inc. Method for solubilizing proteins in organic solvents
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
CA2219698C (en) * 1996-10-31 2007-09-04 Takeda Chemical Industries, Ltd. Sustained-release preparation
US6417171B1 (en) * 1997-01-23 2002-07-09 Collaborative Laboratories, Inc. Preparation of polymers by interfacial derivatization
IS4518A (en) * 1997-07-09 1999-01-10 Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group New vaccine formulation
US6187335B1 (en) * 1997-12-31 2001-02-13 Orasomal Technologies, Inc. Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
ATE327735T1 (en) * 1998-04-01 2006-06-15 Jagotec Ag TAXAN MICROEMULSIONS
US20010025046A1 (en) * 1999-06-24 2001-09-27 Rong(Ron) Liu Self-emulsifying systems containing anticancer medicament
US6673612B2 (en) * 1999-07-16 2004-01-06 Mirus Corporation Micellar systems
US6193997B1 (en) * 1998-09-27 2001-02-27 Generex Pharmaceuticals Inc. Proteinic drug delivery system using membrane mimetics
US20030059376A1 (en) * 1999-06-04 2003-03-27 Libbey Miles A. Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
GB0001928D0 (en) * 2000-01-27 2000-03-22 Novartis Ag Organic compounds
EP1138310A1 (en) * 2000-03-28 2001-10-04 Primacare S.A. Proliposomes
CN1981873A (en) 2000-06-09 2007-06-20 莱古伦公司 Method of manufacturing micro colloidal particle and use of the same
US20030113366A1 (en) * 2001-12-14 2003-06-19 Macgregor Alexander Reverse-micellar delivery system for controlled transportation and enhanced absorption of agents
JP5194253B2 (en) * 2007-03-30 2013-05-08 国立大学法人弘前大学 Novel pharmacological use of proteoglycan contained in salmon cartilage

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485706B1 (en) * 1999-06-04 2002-11-26 Delrx Pharmaceutical Corp. Formulations comprising dehydrated particles of pharma-ceutical agents and process for preparing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein

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