WO2003035115A3 - Fibrin membrane and methods for its preparation- application to artificial skin - Google Patents

Fibrin membrane and methods for its preparation- application to artificial skin Download PDF

Info

Publication number
WO2003035115A3
WO2003035115A3 PCT/US2002/034408 US0234408W WO03035115A3 WO 2003035115 A3 WO2003035115 A3 WO 2003035115A3 US 0234408 W US0234408 W US 0234408W WO 03035115 A3 WO03035115 A3 WO 03035115A3
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
artificial skin
preparation
methods
application
Prior art date
Application number
PCT/US2002/034408
Other languages
French (fr)
Other versions
WO2003035115A2 (en
Inventor
Yves Delmotte
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Priority to AU2002356861A priority Critical patent/AU2002356861A1/en
Publication of WO2003035115A2 publication Critical patent/WO2003035115A2/en
Publication of WO2003035115A3 publication Critical patent/WO2003035115A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/046—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0078—Arrangements for separately storing several components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons

Abstract

A biopolymer membrane in its substantially dry form having a thickness less than about 75 microns, a solvent content less than about 5 % by weight of the membrane, a radius of curvature of less than about 5 centimeters, a density greater 5 than about 1 g/cm3, and a maximum pore size of about 20 microns. The biopolymer can be fibrin. The membrane is useful for making artificial skin.
PCT/US2002/034408 2001-10-26 2002-10-28 Fibrin membrane and methods for its preparation- application to artificial skin WO2003035115A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002356861A AU2002356861A1 (en) 2001-10-26 2002-10-28 Fibrin membrane and methods for its preparation- application to artificial skin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/004,257 2001-10-26
US10/004,257 US20020131933A1 (en) 1996-01-16 2001-10-26 Biopolymer membrane and methods for its preparation

Publications (2)

Publication Number Publication Date
WO2003035115A2 WO2003035115A2 (en) 2003-05-01
WO2003035115A3 true WO2003035115A3 (en) 2003-07-17

Family

ID=21709910

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/034408 WO2003035115A2 (en) 2001-10-26 2002-10-28 Fibrin membrane and methods for its preparation- application to artificial skin

Country Status (3)

Country Link
US (2) US20020131933A1 (en)
AU (1) AU2002356861A1 (en)
WO (1) WO2003035115A2 (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444222B1 (en) * 2001-05-08 2002-09-03 Verigen Transplantation Services International Ag Reinforced matrices
US20030118560A1 (en) * 2001-12-20 2003-06-26 Kelly Sheila J. Composite biocompatible matrices
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
ITMI20022501A1 (en) * 2002-11-26 2004-05-27 Dorin Olimpiu Petrescu ORGANIC CICATRIZING AND HEMOSTATIC DRESSING.
US20050032205A1 (en) * 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container
US20050113849A1 (en) * 2003-11-26 2005-05-26 Nicholas Popadiuk Prosthetic repair device
US20110097402A1 (en) * 2004-09-30 2011-04-28 Covalon Technologies Inc. Non-adhesive elastic gelatin matrices
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
WO2007033082A2 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (dmso)
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
JP5399072B2 (en) 2005-09-12 2014-01-29 アベラ ファーマスーティカルズ インコーポレイテッド System for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated therewith
US8273372B2 (en) * 2006-06-16 2012-09-25 Restoration Of Appearance & Function Trust Extracellular matrix composition
US8623842B2 (en) * 2006-09-27 2014-01-07 Hemostasis, Llc Hemostatic agent and method
US9485917B2 (en) 2006-12-15 2016-11-08 Ecovative Design, LLC Method for producing grown materials and products made thereby
US20100070020A1 (en) 2008-06-11 2010-03-18 Nanovasc, Inc. Implantable Medical Device
US20080311177A1 (en) 2007-06-14 2008-12-18 Massachusetts Institute Of Technology Self Assembled Films for Protein and Drug Delivery Applications
US8206632B2 (en) * 2007-12-18 2012-06-26 Ethicon, Inc. Methods of making composite prosthetic devices having improved bond strength
CA2991162A1 (en) * 2007-12-21 2009-07-02 Aptevo Biotherapeutics Llc Stabilized factor ix formulations containing trehalose
US8668863B2 (en) * 2008-02-26 2014-03-11 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
US9061087B2 (en) * 2008-03-04 2015-06-23 Hemostasis, Llc Method of making a hemostatic sponge wound dressing comprising subjecting the sponge to water vapor
ITFI20080070A1 (en) * 2008-04-04 2009-10-05 Azienda Ospedaliero Universitaria Careggi EXTRACELLULAR MATRIX INCLUDING FLAT FACTORS.
WO2009139904A1 (en) * 2008-05-14 2009-11-19 Proteonomix, Inc. Methods and devices for isolating embryonic stem cells
BRPI0921494A2 (en) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd method of planning a underground forming sampling operation, method of controlling a underground forming sampling operation, method of controlling a drilling operation for an underground formation, and method of sampling during the drilling operation.
EP2405891B1 (en) * 2009-03-11 2019-07-03 Exogenesis Corporation Method for modifying the wettability and/or other biocompatibility characteristics of a surface of a biological material by the application of gas cluster ion beam technology and biological materials made thereby
US8828050B2 (en) * 2009-05-04 2014-09-09 Oregon Biomedical Engineering Institute Hemorrhage control devices and methods
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US20110052663A1 (en) * 2009-09-01 2011-03-03 Hemostasis, Llc Hemostatic Sponge with Enzyme and Method of Manufacture
US20110091604A1 (en) * 2009-10-21 2011-04-21 Seth Adrian Miller Synthetic meat
WO2011053874A1 (en) 2009-10-30 2011-05-05 Tandem Abela Development Group Llc Dimethyl sulfoxide (dmso) and methylsulfonylmethane (msm) formulations to treat osteoarthritis
WO2012048283A1 (en) 2010-10-08 2012-04-12 Board Of Regents, The University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
EP2624874A4 (en) 2010-10-08 2014-04-02 Univ Texas Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
US20120209232A1 (en) * 2011-02-16 2012-08-16 Andrew Barofsky Wound stasis dressing for large surface wounds
US9623223B2 (en) 2011-02-16 2017-04-18 Revmedx, Inc. Wound dressings comprising a plurality of liquid-expandable articles
WO2012149494A2 (en) * 2011-04-27 2012-11-01 Massachusetts Institute Of Technology Coating compositions, methods and coated devices
US9114195B2 (en) 2011-08-22 2015-08-25 Exogenesis Corporation Method for modifying the wettability and other biocompatibility characteristics of a surface of a biological material by the application of beam technology and biological materials made thereby
JP2015511214A (en) * 2011-12-22 2015-04-16 アジェンタ・バイオテクノロジーズ，インコーポレイテッド Composition, preparation and use of high density chitosan membrane material
EP2841056A4 (en) 2012-04-23 2015-09-16 Massachusetts Inst Technology Stable layer-by-layer coated particles
US10086110B2 (en) * 2012-10-30 2018-10-02 The Cleveland Clinic Foundation Multipurpose membranes, methods for forming, and applications thereof
US11565027B2 (en) 2012-12-11 2023-01-31 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
CN103272264A (en) * 2013-05-27 2013-09-04 杭州电子科技大学 Sulfated polysaccharide calcium salt and chitosan organic acid calcium composite porous stent and preparation method thereof
CN103386150B (en) * 2013-07-04 2014-12-03 暨南大学 Preparation method and application of glucomannan/chitosan composite membrane for conducting tissue regeneration
US11277979B2 (en) 2013-07-31 2022-03-22 Ecovative Design Llc Mycological biopolymers grown in void space tooling
US20150101509A1 (en) 2013-10-14 2015-04-16 Gavin R. McIntyre Method of Manufacturing a Stiff Engineered Composite
TWI547529B (en) * 2014-02-14 2016-09-01 瀚醫生技股份有限公司 Method for forming dual layer composite material and dual layer composite material thereby
CN104027834B (en) * 2014-06-24 2015-06-10 浙江大学 Method for preparing thrombin/tannic acid multilayer film compound chitosan hemostatic sponge
EP3000489B1 (en) 2014-09-24 2017-04-05 Sofradim Production Method for preparing an anti-adhesion barrier film
CN107427601B (en) 2015-03-27 2021-08-31 3M创新有限公司 Fibrin compositions, methods and articles for wounds
CN107921172A (en) * 2015-04-27 2018-04-17 马克西姆·卡尔波夫 Hemostatic composition and device
DE102015111126A1 (en) * 2015-07-09 2017-01-12 Medizinische Hochschule Hannover A method for producing a bioartificial, primary acellular fibrin-based construct and this construct itself
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
EP3901246A1 (en) 2016-03-01 2021-10-27 The Fynder Group, Inc. Filamentous fungal biomats, methods of their production and methods of their use
CA3224181A1 (en) * 2016-05-31 2017-12-07 Octapharma Ag Plasma-based films and methods for making and using the same
US10940233B2 (en) 2016-10-05 2021-03-09 3M Innovative Properties Company Fibrinogen composition, method and wound articles
US11827754B2 (en) 2016-10-05 2023-11-28 3M Innovative Properties Company Fibrin composition comprising carrier material, method and wound articles
BR112019020132B1 (en) * 2017-03-31 2023-12-05 Ecovative Design, LLC Processed mycological biopolymer material and respective preparation method
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
US11266085B2 (en) 2017-11-14 2022-03-08 Ecovative Design Llc Increased homogeneity of mycological biopolymer grown into void space
US11920126B2 (en) 2018-03-28 2024-03-05 Ecovative Design Llc Bio-manufacturing process
US11293005B2 (en) 2018-05-07 2022-04-05 Ecovative Design Llc Process for making mineralized mycelium scaffolding and product made thereby
US20190359931A1 (en) 2018-05-24 2019-11-28 Ecovative Design Llc Process and Apparatus for Producing Mycelium Biomaterial
US11359174B2 (en) 2018-10-02 2022-06-14 Ecovative Design Llc Bioreactor paradigm for the production of secondary extra-particle hyphal matrices
CN109276759B (en) * 2018-11-27 2020-11-24 北京航空航天大学 Bionic antibacterial abdominal wall repair material
EP4137075A1 (en) * 2021-08-18 2023-02-22 Anecova S.A. Recoverable intra-uterine device

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941584A (en) * 1972-08-31 1974-04-18
EP0344924A2 (en) * 1988-06-02 1989-12-06 Organogenesis Inc. Fibrin-Collagen Tissue Equivalents and methods of preparation thereof
EP0485210A2 (en) * 1990-11-08 1992-05-13 Otogen Corporation Fibrin/collagen membrane material for biomedical use
WO1999015209A2 (en) * 1997-09-19 1999-04-01 Baxter Aktiengesellschaft Fibrin sponge
ES2132027A1 (en) * 1997-07-04 1999-08-01 Comunitario De Transfusion Del Development of an artificial skin by means of keratinocyte culture on a base of fibrin and human fibroblasts, and method for preparing this skin for transplantation
WO2000025838A1 (en) * 1998-11-04 2000-05-11 Baxter International Inc. Element provided with a fibrin layer, preparation and use thereof
WO2000071153A2 (en) * 1999-05-19 2000-11-30 Bio & Bio Licensing Sa Medicament for localised application, containing fibrinogen, thrombin, transglutaminases and proteinase inhibitors
WO2001085225A2 (en) * 2000-05-08 2001-11-15 Baxter International Inc. Fibrin porous structure
EP1184040A1 (en) * 2000-08-23 2002-03-06 Surface Care GmbH Skin matrix for covering and regeneration of injured skin parts and process for making the same
WO2002058750A2 (en) * 2001-01-25 2002-08-01 Nycomed Pharma As A suspension comprising fibrinogen, thrombin and alcohol and a method of coating a carrier with the same
WO2002070795A1 (en) * 2001-03-06 2002-09-12 Baxter Healthcare S.A. Elongated biopolymer structure containing fibrin
WO2002089868A1 (en) * 2001-05-09 2002-11-14 Baxter International Inc. Fibrin material and method for producing and using the same

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2533004A (en) * 1943-10-27 1950-12-05 John D Ferry Fibrin clots and methods for preparing the same
US2576006A (en) * 1947-11-29 1951-11-20 Research Corp Methods of forming shaped fibrin products
US3523807A (en) * 1966-11-25 1970-08-11 Mihaly Gerendas Method of making a cross-linked fibrin prosthesis
US3641240A (en) * 1968-09-27 1972-02-08 Wyandotte Chemicals Corp Method for the treatment of an embolus or thrombus
US3723244A (en) * 1971-01-18 1973-03-27 Atomic Energy Commission Fibrous fibrin sheet and method for producing same
SE452109B (en) * 1973-01-29 1987-11-16 Pharmacia Ab SCIENTIFIC CLEANER EXTENDED SARYTOR
US4537767A (en) * 1973-01-29 1985-08-27 Pharmacia Aktiebolag Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method
US3919414A (en) * 1973-08-29 1975-11-11 Abbott Lab Accelerating the lysis of blood clots
US4233360A (en) * 1975-10-22 1980-11-11 Collagen Corporation Non-antigenic collagen and articles of manufacture
US4016877A (en) * 1976-02-23 1977-04-12 Avicon, Inc. Fibrous collagen derived web having hemostatic and wound sealing properties
US4148664A (en) * 1976-05-10 1979-04-10 Avicon, Inc. Preparation of fibrous collagen product having hemostatic and wound sealing properties
US4066083A (en) * 1976-06-03 1978-01-03 Pentapharm A.G. Sterile surgical collagen product
US4116898A (en) * 1977-01-31 1978-09-26 Becton, Dickinson And Company Non-thrombogenic articles
US4238480A (en) * 1978-05-19 1980-12-09 Sawyer Philip Nicholas Method for preparing an improved hemostatic agent and method of employing the same
EP0023787B1 (en) * 1979-07-25 1983-07-20 University Of Exeter Plugs for the medullary canal of a bone
US4675361A (en) * 1980-02-29 1987-06-23 Thoratec Laboratories Corp. Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
AT366916B (en) * 1980-04-02 1982-05-25 Immuno Ag DEVICE FOR APPLICATING A TISSUE ADHESIVE BASED ON HUMAN OR ANIMAL PROTEINS
US4442655A (en) * 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
SE430218B (en) * 1981-12-30 1983-10-31 Blombaeck E G B FILTER AND SET TO MAKE A SADANT
US4578067A (en) * 1982-04-12 1986-03-25 Alcon (Puerto Rico) Inc. Hemostatic-adhesive, collagen dressing for severed biological surfaces
JPS58180162A (en) * 1982-04-19 1983-10-21 株式会社高研 Anti-thrombosis medical material
DE3214337C2 (en) * 1982-04-19 1984-04-26 Serapharm - Michael Stroetmann, 4400 Münster Resorbable flat material for sealing and healing wounds and processes for their manufacture
DE3248188A1 (en) * 1982-12-27 1984-06-28 Behringwerke Ag, 3550 Marburg METHOD FOR PRODUCING A COLLAGEN FLEECE
US4548736A (en) * 1983-08-29 1985-10-22 Wisconsin Alumni Research Foundation Preparation of protein films
US4600574A (en) * 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
AT379311B (en) * 1984-03-29 1985-12-27 Immuno Ag DEVICE FOR APPLICATING A TISSUE ADHESIVE
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
WO1986007541A1 (en) * 1985-06-19 1986-12-31 Yasushi Zyo Composition which can impart antithrombotic ability and medical apparatus to be in contact with blood
US4690684A (en) * 1985-07-12 1987-09-01 C. R. Bard, Inc. Meltable stent for anastomosis
JPS6229532A (en) * 1985-07-31 1987-02-07 Koken:Kk Antithrombogenetic medical material and production thereof
US5049393A (en) * 1986-01-07 1991-09-17 Baylor College Of Medicine Anti-thrombogenic elastomer and objects and prostheses made therefrom
US4720512A (en) * 1986-03-24 1988-01-19 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
US4786556A (en) * 1986-03-24 1988-11-22 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
US4760131A (en) * 1986-04-23 1988-07-26 Collagen Corporation Wound-healing composition
DE3722904A1 (en) * 1987-01-09 1988-07-21 Harald Maslanka INJECTION DEVICE WITH DOUBLE CANNULA FOR AN ENDOSCOPE
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US4882148A (en) * 1987-06-18 1989-11-21 Corvita Corporation Crack prevention and improved thrombogenicity of implanted prostheses by sulfonation
US4978336A (en) * 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
AT397203B (en) * 1988-05-31 1994-02-25 Immuno Ag FABRIC ADHESIVE
US4874368A (en) * 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US4948540A (en) * 1988-08-01 1990-08-14 Semex Medical, Inc. Method of preparing collagen dressing sheet material
US5019393A (en) * 1988-08-03 1991-05-28 New England Deaconess Hospital Corporation Biocompatible substance with thromboresistance
US5053048A (en) * 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
DK223389D0 (en) * 1989-05-05 1989-05-05 Ferrosan As SAUCE FUNGI
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5185001A (en) * 1990-01-18 1993-02-09 The Research Foundation Of State University Of New York Method of preparing autologous plasma fibrin and application apparatus therefor
US5071644A (en) * 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
AU1971195A (en) * 1994-03-08 1995-09-25 Merocel Corporation Twisted polymeric sponge device
US5674488A (en) * 1994-10-07 1997-10-07 Reich; John J. Method for prevention and treatment of hyperchlolesterolemia by in vivo hydrogenation of cholesterol
US6074663A (en) * 1995-01-16 2000-06-13 Baxter International Inc. Method of using cross-linked fibrin material
US5833651A (en) * 1996-11-08 1998-11-10 Medtronic, Inc. Therapeutic intraluminal stents

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941584A (en) * 1972-08-31 1974-04-18
EP0344924A2 (en) * 1988-06-02 1989-12-06 Organogenesis Inc. Fibrin-Collagen Tissue Equivalents and methods of preparation thereof
EP0485210A2 (en) * 1990-11-08 1992-05-13 Otogen Corporation Fibrin/collagen membrane material for biomedical use
ES2132027A1 (en) * 1997-07-04 1999-08-01 Comunitario De Transfusion Del Development of an artificial skin by means of keratinocyte culture on a base of fibrin and human fibroblasts, and method for preparing this skin for transplantation
WO1999015209A2 (en) * 1997-09-19 1999-04-01 Baxter Aktiengesellschaft Fibrin sponge
WO2000025838A1 (en) * 1998-11-04 2000-05-11 Baxter International Inc. Element provided with a fibrin layer, preparation and use thereof
WO2000071153A2 (en) * 1999-05-19 2000-11-30 Bio & Bio Licensing Sa Medicament for localised application, containing fibrinogen, thrombin, transglutaminases and proteinase inhibitors
WO2001085225A2 (en) * 2000-05-08 2001-11-15 Baxter International Inc. Fibrin porous structure
EP1184040A1 (en) * 2000-08-23 2002-03-06 Surface Care GmbH Skin matrix for covering and regeneration of injured skin parts and process for making the same
WO2002058750A2 (en) * 2001-01-25 2002-08-01 Nycomed Pharma As A suspension comprising fibrinogen, thrombin and alcohol and a method of coating a carrier with the same
WO2002070795A1 (en) * 2001-03-06 2002-09-12 Baxter Healthcare S.A. Elongated biopolymer structure containing fibrin
WO2002089868A1 (en) * 2001-05-09 2002-11-14 Baxter International Inc. Fibrin material and method for producing and using the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 197434, Derwent World Patents Index; Class B04, AN 1974-60587V, XP002236499 *
DATABASE WPI Section Ch Week 199940, Derwent World Patents Index; Class B04, AN 1999-471189, XP002236500 *

Also Published As

Publication number Publication date
US20020131933A1 (en) 2002-09-19
WO2003035115A2 (en) 2003-05-01
AU2002356861A1 (en) 2003-05-06
US20070148161A1 (en) 2007-06-28

Similar Documents

Publication Publication Date Title
WO2003035115A3 (en) Fibrin membrane and methods for its preparation- application to artificial skin
WO1995012632A3 (en) Low density materials having good compression strength and articles formed therefrom
WO2004084828A3 (en) Keratinocyte-fibrocyte concomitant grafting for wound healing
WO2004006808A8 (en) Soft tissue implants and methods for making same
WO2002026939A3 (en) Microfabrication of membranes for the growth of cells
WO2000047129A3 (en) Microfabricated membranes and matrices
EP1273312A3 (en) Implant for cartilage tissue regeneration
JP2004517472A5 (en)
CA2252758A1 (en) Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
EP2302035A3 (en) A method of producing a cultured skin device
WO2000024437A8 (en) Textured and porous silicone rubber
CA2288793A1 (en) Poly(vinyl alcohol) cryogel
AU2002221033A1 (en) Cells to be used in producing virus vector, process for producing the same and process for producing virus vector with the use of the cells
WO1994020995A3 (en) Battery separators
AU2002224394A1 (en) Method for producing catalyst structures
EP1153961A3 (en) Polyvinyl alcohol polymer film, method of producing the same and polarization film
WO2001092477A3 (en) Three-dimensional skin model
WO2007003324A3 (en) Cell-free graft consisting of a matrix and a serum
WO2005085424A3 (en) Endothelial progenitor cells and methods of use thereof
AU3844599A (en) Biostable polyether polyurethane product
AU2000276877A1 (en) Process for producing gel sheet for application to living body, gel sheet for application to living body obtained by the production process, and method of skin care with the same
CA2332532A1 (en) Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
WO2004046322A3 (en) Replication of biological tiussue
CA2301025A1 (en) Cryoprotectant removal method and apparatus
ATE189120T1 (en) PRODUCTION OF MATRICES

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP