WO2003011122A3 - Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light - Google Patents

Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light Download PDF

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Publication number
WO2003011122A3
WO2003011122A3 PCT/US2002/024254 US0224254W WO03011122A3 WO 2003011122 A3 WO2003011122 A3 WO 2003011122A3 US 0224254 W US0224254 W US 0224254W WO 03011122 A3 WO03011122 A3 WO 03011122A3
Authority
WO
WIPO (PCT)
Prior art keywords
scattered light
methods
imaging apparatus
multiply
directly
Prior art date
Application number
PCT/US2002/024254
Other languages
French (fr)
Other versions
WO2003011122A2 (en
Inventor
Ann E Elsner
Stephen A Burns
Andreas W Dreher
Robert H Webb
Original Assignee
Schepens Eye Res Inst
Ann E Elsner
Stephen A Burns
Andreas W Dreher
Robert H Webb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schepens Eye Res Inst, Ann E Elsner, Stephen A Burns, Andreas W Dreher, Robert H Webb filed Critical Schepens Eye Res Inst
Publication of WO2003011122A2 publication Critical patent/WO2003011122A2/en
Publication of WO2003011122A3 publication Critical patent/WO2003011122A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4795Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

Abstract

An apparatus and a method are disclosed for separating light remitted by a target into a directly scattered light component and at least one multiply scattered light component, detecting the components at least substantially simultaneously, and forming independent sets of image information from each component. The apparatus and the method can be employed in conjunction with techniques such as scanning and tomograghy to attain precise imaging of biological tissue, including the retina of the eye.
PCT/US2002/024254 2001-07-31 2002-07-31 Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light WO2003011122A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/919,498 US6640124B2 (en) 1998-01-30 2001-07-31 Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light
US09/919,498 2001-07-31

Publications (2)

Publication Number Publication Date
WO2003011122A2 WO2003011122A2 (en) 2003-02-13
WO2003011122A3 true WO2003011122A3 (en) 2003-07-10

Family

ID=25442194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024254 WO2003011122A2 (en) 2001-07-31 2002-07-31 Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light

Country Status (2)

Country Link
US (1) US6640124B2 (en)
WO (1) WO2003011122A2 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2426576T3 (en) * 2001-10-16 2013-10-24 Indiana University Research And Technology Corporation Imaging device to capture an image of a focal plane of a target in the eye through the pupil of the eye
FR2849218B1 (en) * 2002-12-20 2005-03-04 Mauna Kea Technologies CONFOCAL OPTICAL HEAD, IN PARTICULAR MINIATURE, INTEGRATED SCANNING AND CONFOCAL IMAGING SYSTEM IMPLEMENTING SAID HEAD
US9173562B2 (en) * 2003-01-23 2015-11-03 The Board Of Regents Of The University Of Texas System Method and apparatus for diagnosing neovascularized tissues
US7668350B2 (en) 2003-04-04 2010-02-23 Lumidigm, Inc. Comparative texture analysis of tissue for biometric spoof detection
KR20060002923A (en) 2003-04-04 2006-01-09 루미다임 인크. Multispectral biometric sensor
US7545963B2 (en) * 2003-04-04 2009-06-09 Lumidigm, Inc. Texture-biometrics sensor
US7460696B2 (en) 2004-06-01 2008-12-02 Lumidigm, Inc. Multispectral imaging biometrics
US7627151B2 (en) * 2003-04-04 2009-12-01 Lumidigm, Inc. Systems and methods for improved biometric feature definition
US7751594B2 (en) 2003-04-04 2010-07-06 Lumidigm, Inc. White-light spectral biometric sensors
US7599732B2 (en) * 2003-06-20 2009-10-06 The Texas A&M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
US7319522B2 (en) * 2004-05-27 2008-01-15 Finesse Solutions Llc. Systems and methods for in situ spectroscopic measurements
US8229185B2 (en) 2004-06-01 2012-07-24 Lumidigm, Inc. Hygienic biometric sensors
US8787630B2 (en) * 2004-08-11 2014-07-22 Lumidigm, Inc. Multispectral barcode imaging
US8057083B2 (en) * 2005-01-21 2011-11-15 Optiscan Pty, Ltd. Fibre bundle confocal endomicroscope
US7801338B2 (en) * 2005-04-27 2010-09-21 Lumidigm, Inc. Multispectral biometric sensors
JP2007029726A (en) * 2005-07-22 2007-02-08 Carl Zeiss Meditec Ag Ring light fundus camera
JP5030415B2 (en) * 2005-11-16 2012-09-19 オリンパス株式会社 Endoscope device
US7942526B2 (en) 2006-01-23 2011-05-17 Zeavision, Llc. Diagnostic, prescriptive, and data-gathering system and method for macular pigment deficits and other eye disorders
US20070232907A1 (en) * 2006-04-03 2007-10-04 Laurent Pelissier Methods and systems for configuring ultrasound systems for ultrasound examinations
US8488895B2 (en) * 2006-05-31 2013-07-16 Indiana University Research And Technology Corp. Laser scanning digital camera with pupil periphery illumination and potential for multiply scattered light imaging
US8355545B2 (en) 2007-04-10 2013-01-15 Lumidigm, Inc. Biometric detection using spatial, temporal, and/or spectral techniques
CN103336941A (en) 2006-07-19 2013-10-02 光谱辨识公司 Multibiometric multispectral imager
US8175346B2 (en) 2006-07-19 2012-05-08 Lumidigm, Inc. Whole-hand multispectral biometric imaging
US7995808B2 (en) 2006-07-19 2011-08-09 Lumidigm, Inc. Contactless multispectral biometric capture
US7804984B2 (en) * 2006-07-31 2010-09-28 Lumidigm, Inc. Spatial-spectral fingerprint spoof detection
US7801339B2 (en) * 2006-07-31 2010-09-21 Lumidigm, Inc. Biometrics with spatiospectral spoof detection
JP2008052029A (en) * 2006-08-24 2008-03-06 Takata Corp Photographing system, vehicle crew detection system, operation device controlling system, and vehicle
US20080221416A1 (en) * 2007-03-09 2008-09-11 Nellcor Puritan Bennett Llc System and method for detection of macular degeneration using spectrophotometry
WO2008134135A2 (en) 2007-03-21 2008-11-06 Lumidigm, Inc. Biometrics based on locally consistent features
EP1992277A1 (en) * 2007-05-14 2008-11-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Optical device and method for acquiring images of eye structures
GB0714341D0 (en) * 2007-07-23 2007-09-05 Molecular Vision Ltd A detection apparatus and method
MY162937A (en) * 2007-10-09 2017-07-31 Sicpa Holding Sa Security marking authentication device
CA2705859A1 (en) * 2007-10-15 2009-04-23 John P. Stokes Convergent well irradiating plaque for choroidal melanoma
CA3194784A1 (en) 2008-05-20 2009-11-26 University Health Network Device and method for fluorescence-based imaging and monitoring
WO2010085348A1 (en) * 2009-01-23 2010-07-29 Perelman Lev T Endoscopic polarized multispectral light scattering scanning method
EP2471023A1 (en) 2009-08-26 2012-07-04 Lumidigm, Inc. Multiplexed biometric imaging and dual-imager biometric sensor
WO2011091804A1 (en) * 2010-01-29 2011-08-04 Tartu Ülikool (University Of Tartu) An apparatus for quantitative cataract diagnostics
US8570149B2 (en) 2010-03-16 2013-10-29 Lumidigm, Inc. Biometric imaging using an optical adaptive interface
KR102028199B1 (en) * 2012-08-28 2019-10-04 한국전자통신연구원 Medical diagnosis device and method for controlling the device
JP2014161439A (en) * 2013-02-22 2014-09-08 Sony Corp Eyeground information acquisition device and method, and program
US9456746B2 (en) 2013-03-15 2016-10-04 Carl Zeiss Meditec, Inc. Systems and methods for broad line fundus imaging
US11076760B2 (en) * 2013-05-08 2021-08-03 Legaline Ag Apparatus configurated to and a process to photoacousticall image and measure a structure at the human eye fundus
JP6464558B2 (en) * 2014-03-14 2019-02-06 株式会社リコー Optical sensor, optical inspection apparatus, and internal characteristic estimation method
EP3129956B1 (en) * 2014-04-07 2020-01-01 Mimo AG Method for the analysis of image data representing a three-dimensional volume of biological tissue
US9144379B1 (en) 2015-02-10 2015-09-29 Clinton Norton Sims Diagnostic method and system for detecting early age macular degeneration, maculopathies and cystoid macular edema post cataract surgery
JP6769949B2 (en) 2014-07-24 2020-10-14 ユニバーシティー ヘルス ネットワーク Data collection and analysis for diagnostic purposes
US9332905B1 (en) 2015-02-10 2016-05-10 Clinton Norton Sims Diagnostic method and system for detecting early age-related macular degeneration, maculopathies and cystoid macular edema post cataract surgery
JP6766449B2 (en) * 2016-05-26 2020-10-14 株式会社ニデック Medical devices and programs
EP3738500A1 (en) * 2019-05-13 2020-11-18 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO Confocal and multi-scatter ophthalmoscope

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5303709A (en) * 1991-12-16 1994-04-19 Dreher Andreas W Retinal eye disease diagnostic system
US6003993A (en) * 1997-05-02 1999-12-21 The General Hospital Corp. Scanning ophthalmoscope with spatial light modulators
US6236877B1 (en) * 1998-01-30 2001-05-22 The Schepens Eye Research Institute Apparatus for near simultaneous observation of directly scattered image field and multiply scattered image field
WO2002088818A1 (en) * 2001-04-30 2002-11-07 The Schepens Eye Research Institute Apparatus for near simultaneous observation of directly scattered light and multiply scattered light

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL68411A6 (en) 1969-05-26 1973-02-28
US4213678A (en) 1977-09-29 1980-07-22 Retina Foundation Scanning ophthalmoscope for examining the fundus of the eye
US4555179A (en) 1982-11-08 1985-11-26 John Langerholc Detection and imaging of objects in scattering media by light irradiation
DE3422144A1 (en) 1984-06-14 1985-12-19 Josef Prof. Dr. 6900 Heidelberg Bille DEVICE FOR DISPLAYING AREA AREAS OF THE HUMAN EYE
US4764005A (en) 1985-09-17 1988-08-16 Eye Research Institute Of Retina Foundation Double scanning optical apparatus
US4844617A (en) 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
US5137355A (en) 1988-06-08 1992-08-11 The Research Foundation Of State University Of New York Method of imaging a random medium
US5028802A (en) 1990-01-11 1991-07-02 Eye Research Institute Of Retina Foundation Imaging apparatus and methods utilizing scannable microlaser source
US6112114A (en) 1991-12-16 2000-08-29 Laser Diagnostic Technologies, Inc. Eye examination apparatus employing polarized light probe
US5870167A (en) 1993-07-14 1999-02-09 Knopp; Carl F. Apparatus and method for imaging anterior structures of the eye
DE4417639A1 (en) 1994-05-19 1995-11-23 Boehringer Mannheim Gmbh Analysis of concns. of substances in a biological sample
US5813987A (en) 1995-08-01 1998-09-29 Medispectra, Inc. Spectral volume microprobe for analysis of materials
US5973779A (en) 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
IT1286838B1 (en) 1996-09-25 1998-07-17 Consiglio Nazionale Ricerche METHOD FOR COLLECTING IMAGES IN CONFOCAL MICROSCOPY
US5760901A (en) 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
US5830147A (en) 1997-05-30 1998-11-03 Schepens Eye Research Institute, Inc. Method and apparatus for examining optic nerve head circulation
US6002480A (en) 1997-06-02 1999-12-14 Izatt; Joseph A. Depth-resolved spectroscopic optical coherence tomography
US5963300A (en) 1998-02-17 1999-10-05 Amt Technologies, Corp. Ocular biometer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5303709A (en) * 1991-12-16 1994-04-19 Dreher Andreas W Retinal eye disease diagnostic system
US6003993A (en) * 1997-05-02 1999-12-21 The General Hospital Corp. Scanning ophthalmoscope with spatial light modulators
US6236877B1 (en) * 1998-01-30 2001-05-22 The Schepens Eye Research Institute Apparatus for near simultaneous observation of directly scattered image field and multiply scattered image field
WO2002088818A1 (en) * 2001-04-30 2002-11-07 The Schepens Eye Research Institute Apparatus for near simultaneous observation of directly scattered light and multiply scattered light

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ELSNER A E ET AL: "Multiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration", OPTICS EXPRESS, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC,, US, vol. 7, no. 2, 10 July 2000 (2000-07-10), pages 95 - 106, XP002186422, ISSN: 1094-4087 *

Also Published As

Publication number Publication date
US20020101566A1 (en) 2002-08-01
WO2003011122A2 (en) 2003-02-13
US6640124B2 (en) 2003-10-28

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