WO2002103051A3 - Nucleic acid triplex and quadruplex formation - Google Patents

Nucleic acid triplex and quadruplex formation Download PDF

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Publication number
WO2002103051A3
WO2002103051A3 PCT/IB2002/001972 IB0201972W WO02103051A3 WO 2002103051 A3 WO2002103051 A3 WO 2002103051A3 IB 0201972 W IB0201972 W IB 0201972W WO 02103051 A3 WO02103051 A3 WO 02103051A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
quadruplex formation
acid triplex
triplex
intercalators
Prior art date
Application number
PCT/IB2002/001972
Other languages
French (fr)
Other versions
WO2002103051A2 (en
Inventor
Glen H Erikson
Jasmine I Daksis
Ivana Kandic
Pierre Picard
Original Assignee
Ingeneus Corp
Glen H Erikson
Jasmine I Daksis
Ivana Kandic
Pierre Picard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ingeneus Corp, Glen H Erikson, Jasmine I Daksis, Ivana Kandic, Pierre Picard filed Critical Ingeneus Corp
Priority to BR0210544-6A priority Critical patent/BR0210544A/en
Priority to AU2002304318A priority patent/AU2002304318B2/en
Priority to KR1020037016650A priority patent/KR100699960B1/en
Priority to EP02733104A priority patent/EP1436415B1/en
Priority to CA002450831A priority patent/CA2450831A1/en
Priority to JP2003505372A priority patent/JP2004534541A/en
Priority to IL15930902A priority patent/IL159309A0/en
Priority to MXPA03012071A priority patent/MXPA03012071A/en
Publication of WO2002103051A2 publication Critical patent/WO2002103051A2/en
Publication of WO2002103051A3 publication Critical patent/WO2002103051A3/en
Priority to HK05100061.9A priority patent/HK1067666A1/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6839Triple helix formation or other higher order conformations in hybridisation assays

Abstract

Heteropolymeric triplexes and quadruplexes and methods for making them; the use of accelerator agents such as cations to create them; the use of fluorescent intercalators and fluorescent probe-bound non-intercalators to detect them.
PCT/IB2002/001972 2001-06-20 2002-05-31 Nucleic acid triplex and quadruplex formation WO2002103051A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BR0210544-6A BR0210544A (en) 2001-06-20 2002-05-31 Nucleic Acid Multiplex Formation
AU2002304318A AU2002304318B2 (en) 2001-06-20 2002-05-31 Nucleic acid triplex and quadruplex formation
KR1020037016650A KR100699960B1 (en) 2001-06-20 2002-05-31 Nucleic Acid Triplex And Quadruplex Formation
EP02733104A EP1436415B1 (en) 2001-06-20 2002-05-31 Nucleic acid triplex and quadruplex formation
CA002450831A CA2450831A1 (en) 2001-06-20 2002-05-31 Nucleic acid multiplex formation
JP2003505372A JP2004534541A (en) 2001-06-20 2002-05-31 Formation of multiple nucleic acid strands
IL15930902A IL159309A0 (en) 2001-06-20 2002-05-31 Nucleic acid multiplex formation
MXPA03012071A MXPA03012071A (en) 2001-06-20 2002-05-31 Nucleic acid multiplex formation.
HK05100061.9A HK1067666A1 (en) 2001-06-20 2005-01-05 Nucleic acid triplex and quadruplex formation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/885,731 2001-06-20
US09/885,731 US6927027B2 (en) 1999-12-21 2001-06-20 Nucleic acid multiplex formation

Publications (2)

Publication Number Publication Date
WO2002103051A2 WO2002103051A2 (en) 2002-12-27
WO2002103051A3 true WO2002103051A3 (en) 2004-04-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/001972 WO2002103051A2 (en) 2001-06-20 2002-05-31 Nucleic acid triplex and quadruplex formation

Country Status (16)

Country Link
US (1) US6927027B2 (en)
EP (1) EP1436415B1 (en)
JP (1) JP2004534541A (en)
KR (1) KR100699960B1 (en)
CN (1) CN1533441A (en)
AU (1) AU2002304318B2 (en)
BR (1) BR0210544A (en)
CA (1) CA2450831A1 (en)
CO (1) CO5550493A2 (en)
HK (1) HK1067666A1 (en)
IL (1) IL159309A0 (en)
MX (1) MXPA03012071A (en)
NZ (1) NZ530647A (en)
RU (1) RU2304168C2 (en)
WO (1) WO2002103051A2 (en)
ZA (1) ZA200400372B (en)

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US7052844B2 (en) * 1999-12-21 2006-05-30 Ingeneus, Inc. Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
JP4616988B2 (en) * 2000-12-20 2011-01-19 株式会社アイシン・コスモス研究所 DNA polymorphism detection method applying triple-stranded DNA formation technology
EP1558762B1 (en) * 2002-10-23 2013-09-11 University of Utah Research Foundation Amplicon melting analysis with saturation dyes
US20040142329A1 (en) * 2003-01-17 2004-07-22 Ingeneus Corporation Probe conjugation to increase multiplex binding motif preference
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US20050249669A1 (en) * 2003-10-22 2005-11-10 Academia Sinica Quadruplex stabilizer
BRPI0508100A (en) * 2004-02-28 2007-07-17 Chang Ning J Wang nucleic acid complexes as well as detection process and multiphase system
US9657347B2 (en) 2004-04-20 2017-05-23 University of Utah Research Foundation and BioFire Defense, LLC Nucleic acid melting analysis with saturation dyes
RU2464320C2 (en) 2004-09-24 2012-10-20 Инджиниес Инк. Genome analysis
EP1880019A1 (en) * 2005-05-12 2008-01-23 Arizona Board Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University Self-assembled nucleic acid nanoarrays and uses therefor
WO2007084380A2 (en) * 2006-01-13 2007-07-26 California Institute Of Technology Compounds and methods for nucleic acid mismatch detection
HUE025701T2 (en) 2007-05-11 2016-04-28 Adynxx Inc Gene expression and pain
CN101587066B (en) * 2008-05-23 2011-03-30 中国科学院化学研究所 Novel use of cyanine dye in detection of G-quadruplex DNA
RU2429293C1 (en) * 2009-12-15 2011-09-20 Общество С Ограниченной Ответственностью "Апто-Фарм" Thrombin inhibiting dna-aptamers and method of structure stabilisation
JP6251247B2 (en) 2012-05-10 2017-12-20 エーダイニクス インコーポレイテッド Formulation for active ingredient delivery
PT3180434T (en) 2014-08-15 2019-10-29 Adynxx Inc Oligonucleotide decoys for the treatment of pain
US10780051B2 (en) 2014-10-09 2020-09-22 Albert Einstein College Of Medicine Programmed cargo release using nucleic acid-stabilized micelles
CN105861682B (en) * 2016-05-05 2020-06-26 厦门多维生物医药科技有限公司 Guanine detecting probe
CN110951836B (en) * 2019-12-03 2023-05-23 华东师范大学 Method for regulating and controlling nucleic acid molecule strand displacement dynamics based on photochemistry
CN114539422A (en) * 2020-11-25 2022-05-27 安升(上海)医药科技有限公司 Construction method and application of multivalent protein drug and vaccine mediated by nucleic acid polymerization
CN113862337B (en) * 2021-10-15 2023-09-19 华东师范大学 Regulation and control method for improving DNA strand displacement reaction rate based on freeze thawing cycle

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Also Published As

Publication number Publication date
MXPA03012071A (en) 2004-06-03
CA2450831A1 (en) 2002-12-27
IL159309A0 (en) 2004-06-01
ZA200400372B (en) 2004-08-23
US20030113716A1 (en) 2003-06-19
RU2004101294A (en) 2005-02-27
RU2304168C2 (en) 2007-08-10
KR100699960B1 (en) 2007-03-27
CO5550493A2 (en) 2005-08-31
EP1436415B1 (en) 2012-08-22
KR20040019312A (en) 2004-03-05
JP2004534541A (en) 2004-11-18
US6927027B2 (en) 2005-08-09
EP1436415A2 (en) 2004-07-14
AU2002304318B2 (en) 2007-07-26
NZ530647A (en) 2005-12-23
WO2002103051A2 (en) 2002-12-27
HK1067666A1 (en) 2005-04-15
BR0210544A (en) 2005-05-31
CN1533441A (en) 2004-09-29

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