WO2002103051A3 - Nucleic acid triplex and quadruplex formation - Google Patents
Nucleic acid triplex and quadruplex formation Download PDFInfo
- Publication number
- WO2002103051A3 WO2002103051A3 PCT/IB2002/001972 IB0201972W WO02103051A3 WO 2002103051 A3 WO2002103051 A3 WO 2002103051A3 IB 0201972 W IB0201972 W IB 0201972W WO 02103051 A3 WO02103051 A3 WO 02103051A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- quadruplex formation
- acid triplex
- triplex
- intercalators
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0210544-6A BR0210544A (en) | 2001-06-20 | 2002-05-31 | Nucleic Acid Multiplex Formation |
AU2002304318A AU2002304318B2 (en) | 2001-06-20 | 2002-05-31 | Nucleic acid triplex and quadruplex formation |
KR1020037016650A KR100699960B1 (en) | 2001-06-20 | 2002-05-31 | Nucleic Acid Triplex And Quadruplex Formation |
EP02733104A EP1436415B1 (en) | 2001-06-20 | 2002-05-31 | Nucleic acid triplex and quadruplex formation |
CA002450831A CA2450831A1 (en) | 2001-06-20 | 2002-05-31 | Nucleic acid multiplex formation |
JP2003505372A JP2004534541A (en) | 2001-06-20 | 2002-05-31 | Formation of multiple nucleic acid strands |
IL15930902A IL159309A0 (en) | 2001-06-20 | 2002-05-31 | Nucleic acid multiplex formation |
MXPA03012071A MXPA03012071A (en) | 2001-06-20 | 2002-05-31 | Nucleic acid multiplex formation. |
HK05100061.9A HK1067666A1 (en) | 2001-06-20 | 2005-01-05 | Nucleic acid triplex and quadruplex formation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/885,731 | 2001-06-20 | ||
US09/885,731 US6927027B2 (en) | 1999-12-21 | 2001-06-20 | Nucleic acid multiplex formation |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002103051A2 WO2002103051A2 (en) | 2002-12-27 |
WO2002103051A3 true WO2002103051A3 (en) | 2004-04-29 |
Family
ID=25387577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2002/001972 WO2002103051A2 (en) | 2001-06-20 | 2002-05-31 | Nucleic acid triplex and quadruplex formation |
Country Status (16)
Country | Link |
---|---|
US (1) | US6927027B2 (en) |
EP (1) | EP1436415B1 (en) |
JP (1) | JP2004534541A (en) |
KR (1) | KR100699960B1 (en) |
CN (1) | CN1533441A (en) |
AU (1) | AU2002304318B2 (en) |
BR (1) | BR0210544A (en) |
CA (1) | CA2450831A1 (en) |
CO (1) | CO5550493A2 (en) |
HK (1) | HK1067666A1 (en) |
IL (1) | IL159309A0 (en) |
MX (1) | MXPA03012071A (en) |
NZ (1) | NZ530647A (en) |
RU (1) | RU2304168C2 (en) |
WO (1) | WO2002103051A2 (en) |
ZA (1) | ZA200400372B (en) |
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US6656692B2 (en) * | 1999-12-21 | 2003-12-02 | Ingeneus Corporation | Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes |
US7052844B2 (en) * | 1999-12-21 | 2006-05-30 | Ingeneus, Inc. | Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism |
JP4616988B2 (en) * | 2000-12-20 | 2011-01-19 | 株式会社アイシン・コスモス研究所 | DNA polymorphism detection method applying triple-stranded DNA formation technology |
EP1558762B1 (en) * | 2002-10-23 | 2013-09-11 | University of Utah Research Foundation | Amplicon melting analysis with saturation dyes |
US20040142329A1 (en) * | 2003-01-17 | 2004-07-22 | Ingeneus Corporation | Probe conjugation to increase multiplex binding motif preference |
GB0310270D0 (en) * | 2003-05-03 | 2003-06-11 | Univ Edinburgh | Biomolecular devices |
US20050249669A1 (en) * | 2003-10-22 | 2005-11-10 | Academia Sinica | Quadruplex stabilizer |
BRPI0508100A (en) * | 2004-02-28 | 2007-07-17 | Chang Ning J Wang | nucleic acid complexes as well as detection process and multiphase system |
US9657347B2 (en) | 2004-04-20 | 2017-05-23 | University of Utah Research Foundation and BioFire Defense, LLC | Nucleic acid melting analysis with saturation dyes |
RU2464320C2 (en) | 2004-09-24 | 2012-10-20 | Инджиниес Инк. | Genome analysis |
EP1880019A1 (en) * | 2005-05-12 | 2008-01-23 | Arizona Board Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University | Self-assembled nucleic acid nanoarrays and uses therefor |
WO2007084380A2 (en) * | 2006-01-13 | 2007-07-26 | California Institute Of Technology | Compounds and methods for nucleic acid mismatch detection |
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CN101587066B (en) * | 2008-05-23 | 2011-03-30 | 中国科学院化学研究所 | Novel use of cyanine dye in detection of G-quadruplex DNA |
RU2429293C1 (en) * | 2009-12-15 | 2011-09-20 | Общество С Ограниченной Ответственностью "Апто-Фарм" | Thrombin inhibiting dna-aptamers and method of structure stabilisation |
JP6251247B2 (en) | 2012-05-10 | 2017-12-20 | エーダイニクス インコーポレイテッド | Formulation for active ingredient delivery |
PT3180434T (en) | 2014-08-15 | 2019-10-29 | Adynxx Inc | Oligonucleotide decoys for the treatment of pain |
US10780051B2 (en) | 2014-10-09 | 2020-09-22 | Albert Einstein College Of Medicine | Programmed cargo release using nucleic acid-stabilized micelles |
CN105861682B (en) * | 2016-05-05 | 2020-06-26 | 厦门多维生物医药科技有限公司 | Guanine detecting probe |
CN110951836B (en) * | 2019-12-03 | 2023-05-23 | 华东师范大学 | Method for regulating and controlling nucleic acid molecule strand displacement dynamics based on photochemistry |
CN114539422A (en) * | 2020-11-25 | 2022-05-27 | 安升(上海)医药科技有限公司 | Construction method and application of multivalent protein drug and vaccine mediated by nucleic acid polymerization |
CN113862337B (en) * | 2021-10-15 | 2023-09-19 | 华东师范大学 | Regulation and control method for improving DNA strand displacement reaction rate based on freeze thawing cycle |
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US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
WO1998029428A1 (en) * | 1997-01-02 | 1998-07-09 | Princeton University | Stabilization of triplexes by water structure-making substances |
US5888739A (en) * | 1996-08-27 | 1999-03-30 | Becton, Dickinson And Company | Detection of nucleic acids using G-quartets and I-tetraplexes |
US5928863A (en) * | 1986-11-26 | 1999-07-27 | Princeton University | Triple-stranded nucleic acids |
WO2000043543A1 (en) * | 1999-01-19 | 2000-07-27 | Dade Behring Inc. | Detection of differences between polynucleotides |
WO2001053526A2 (en) * | 2000-01-24 | 2001-07-26 | Ingeneus Corporation | Homogenous assay of duplex or triplex hybridization by means of multiple measurements under varied conditions |
WO2002004655A2 (en) * | 2000-07-10 | 2002-01-17 | Ingeneus Corporation | Cation mediated triplex hybridization assay |
US20020031775A1 (en) * | 1999-12-21 | 2002-03-14 | Erikson Glen H. | Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes |
WO2002024946A2 (en) * | 2000-09-19 | 2002-03-28 | Ingeneus Corporation | Quadruplex dna and duplex probe systems |
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-
2001
- 2001-06-20 US US09/885,731 patent/US6927027B2/en not_active Expired - Fee Related
-
2002
- 2002-05-31 KR KR1020037016650A patent/KR100699960B1/en not_active IP Right Cessation
- 2002-05-31 NZ NZ530647A patent/NZ530647A/en active IP Right Revival
- 2002-05-31 WO PCT/IB2002/001972 patent/WO2002103051A2/en active IP Right Grant
- 2002-05-31 MX MXPA03012071A patent/MXPA03012071A/en active IP Right Grant
- 2002-05-31 AU AU2002304318A patent/AU2002304318B2/en not_active Ceased
- 2002-05-31 BR BR0210544-6A patent/BR0210544A/en not_active IP Right Cessation
- 2002-05-31 RU RU2004101294/13A patent/RU2304168C2/en not_active IP Right Cessation
- 2002-05-31 JP JP2003505372A patent/JP2004534541A/en active Pending
- 2002-05-31 CA CA002450831A patent/CA2450831A1/en not_active Abandoned
- 2002-05-31 EP EP02733104A patent/EP1436415B1/en not_active Expired - Lifetime
- 2002-05-31 IL IL15930902A patent/IL159309A0/en unknown
- 2002-05-31 CN CNA028124103A patent/CN1533441A/en active Pending
-
2004
- 2004-01-19 ZA ZA200400372A patent/ZA200400372B/en unknown
- 2004-01-20 CO CO04003755A patent/CO5550493A2/en not_active Application Discontinuation
-
2005
- 2005-01-05 HK HK05100061.9A patent/HK1067666A1/en not_active IP Right Cessation
Patent Citations (9)
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US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5888739A (en) * | 1996-08-27 | 1999-03-30 | Becton, Dickinson And Company | Detection of nucleic acids using G-quartets and I-tetraplexes |
WO1998029428A1 (en) * | 1997-01-02 | 1998-07-09 | Princeton University | Stabilization of triplexes by water structure-making substances |
WO2000043543A1 (en) * | 1999-01-19 | 2000-07-27 | Dade Behring Inc. | Detection of differences between polynucleotides |
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WO2002024946A2 (en) * | 2000-09-19 | 2002-03-28 | Ingeneus Corporation | Quadruplex dna and duplex probe systems |
Non-Patent Citations (2)
Title |
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ZHURKIN V B ET AL: "A parallel DNA triplex as a model for the intermediate in homologous recombination.", JOURNAL OF MOLECULAR BIOLOGY, vol. 239, no. 2, 1994, pages 181 - 200, XP002244049, ISSN: 0022-2836 * |
Also Published As
Publication number | Publication date |
---|---|
MXPA03012071A (en) | 2004-06-03 |
CA2450831A1 (en) | 2002-12-27 |
IL159309A0 (en) | 2004-06-01 |
ZA200400372B (en) | 2004-08-23 |
US20030113716A1 (en) | 2003-06-19 |
RU2004101294A (en) | 2005-02-27 |
RU2304168C2 (en) | 2007-08-10 |
KR100699960B1 (en) | 2007-03-27 |
CO5550493A2 (en) | 2005-08-31 |
EP1436415B1 (en) | 2012-08-22 |
KR20040019312A (en) | 2004-03-05 |
JP2004534541A (en) | 2004-11-18 |
US6927027B2 (en) | 2005-08-09 |
EP1436415A2 (en) | 2004-07-14 |
AU2002304318B2 (en) | 2007-07-26 |
NZ530647A (en) | 2005-12-23 |
WO2002103051A2 (en) | 2002-12-27 |
HK1067666A1 (en) | 2005-04-15 |
BR0210544A (en) | 2005-05-31 |
CN1533441A (en) | 2004-09-29 |
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