WO2002100437A3 - Ophthalmic compositions comprising hyaluronic acid - Google Patents

Ophthalmic compositions comprising hyaluronic acid Download PDF

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Publication number
WO2002100437A3
WO2002100437A3 PCT/EP2002/006279 EP0206279W WO02100437A3 WO 2002100437 A3 WO2002100437 A3 WO 2002100437A3 EP 0206279 W EP0206279 W EP 0206279W WO 02100437 A3 WO02100437 A3 WO 02100437A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyaluronic acid
ophthalmic compositions
ophthalmic
compositions
ketotifen
Prior art date
Application number
PCT/EP2002/006279
Other languages
French (fr)
Other versions
WO2002100437A2 (en
Inventor
Saunier Maggy Babiole
Jean-Claude Bizec
Andrea Fetz
Christian Schoch
Original Assignee
Novartis Ag
Novartis Erfind Verwalt Gmbh
Saunier Maggy Babiole
Jean-Claude Bizec
Andrea Fetz
Christian Schoch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Erfind Verwalt Gmbh, Saunier Maggy Babiole, Jean-Claude Bizec, Andrea Fetz, Christian Schoch filed Critical Novartis Ag
Priority to BR0210139-4A priority Critical patent/BR0210139A/en
Priority to EP02740697A priority patent/EP1404370A2/en
Priority to AU2002314149A priority patent/AU2002314149A1/en
Priority to CA002449213A priority patent/CA2449213A1/en
Priority to JP2003503256A priority patent/JP2005508866A/en
Publication of WO2002100437A2 publication Critical patent/WO2002100437A2/en
Publication of WO2002100437A3 publication Critical patent/WO2002100437A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Ophthalmic compositions comprising an ophthalmic drug, e.g. ketotifen, and a linear polysaccharide compound, e.g. a hyaluronic acid compound, are useful for topical once-a-day administration to the eye.
PCT/EP2002/006279 2001-06-08 2002-06-07 Ophthalmic compositions comprising hyaluronic acid WO2002100437A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BR0210139-4A BR0210139A (en) 2001-06-08 2002-06-07 Pharmaceutical Compositions
EP02740697A EP1404370A2 (en) 2001-06-08 2002-06-07 Ophthalmic compositions comprising hyaluronic acid
AU2002314149A AU2002314149A1 (en) 2001-06-08 2002-06-07 Ophthalmic compositions comprising hyaluronic acid
CA002449213A CA2449213A1 (en) 2001-06-08 2002-06-07 Ophthalmic compositions comprising hyaluronic acid
JP2003503256A JP2005508866A (en) 2001-06-08 2002-06-07 Ophthalmic composition comprising hyaluronic acid

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP01113959.9 2001-06-08
EP01113958.1 2001-06-08
EP01113958 2001-06-08
EP01113959 2001-06-08
EP01115096.8 2001-06-21
EP01115097.6 2001-06-21
EP01115096 2001-06-21
EP01115097 2001-06-21

Publications (2)

Publication Number Publication Date
WO2002100437A2 WO2002100437A2 (en) 2002-12-19
WO2002100437A3 true WO2002100437A3 (en) 2003-04-24

Family

ID=27440131

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006279 WO2002100437A2 (en) 2001-06-08 2002-06-07 Ophthalmic compositions comprising hyaluronic acid

Country Status (9)

Country Link
EP (1) EP1404370A2 (en)
JP (1) JP2005508866A (en)
CN (1) CN1514735A (en)
AR (1) AR034371A1 (en)
AU (1) AU2002314149A1 (en)
BR (1) BR0210139A (en)
CA (1) CA2449213A1 (en)
PE (1) PE20030206A1 (en)
WO (1) WO2002100437A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846094B2 (en) 2003-11-12 2014-09-30 Allergan, Inc. Peripherally administered viscous formulations
US8962009B2 (en) 2004-04-30 2015-02-24 Allergan, Inc. Sustained release intraocular implants and related methods
US9265775B2 (en) 2003-11-12 2016-02-23 Allergan, Inc. Pharmaceutical compositions
US9572859B2 (en) 2004-01-20 2017-02-21 Allergan, Inc. Compositions and methods for localized therapy of the eye

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100436A2 (en) * 2001-06-08 2002-12-19 Novartis Ag Ophthalmic once-a-day composition
US8580851B2 (en) 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
JP2004143155A (en) * 2002-10-01 2004-05-20 Taisho Pharmaceut Co Ltd Ophthalmic solution
US20040137079A1 (en) * 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods
KR20120005052A (en) * 2003-08-21 2012-01-13 수캄포 아게 Ophthalmic composition
DE102005035986B4 (en) * 2005-07-28 2009-10-15 Bausch & Lomb Incorporated Sterile drippable multiphase emulsifier-free ophthalmic preparation
US20070077302A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for stabilizing ophthalmic compositions
CN100408046C (en) * 2005-12-22 2008-08-06 涂家生 Macrolide antibiotics sodium hyaluronate eye transfer system
US7767217B2 (en) * 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
BR112013008186A2 (en) * 2010-10-04 2016-06-21 Activbiotics Pharma Llc use of ripazil and analogues to treat eye problems
KR101412776B1 (en) 2013-03-11 2014-07-01 가톨릭대학교 산학협력단 Eye drop composition for treating keratoconjunctivitis and preparation method of the same
US10617763B2 (en) 2013-08-28 2020-04-14 Presbyopia Therapies, LLC Compositions and methods for the treatment of presbyopia
US9833441B2 (en) 2013-08-28 2017-12-05 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
US9089562B2 (en) 2013-08-28 2015-07-28 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
US10307408B2 (en) 2013-08-28 2019-06-04 Presbyopia Therapies, LLC Contact lens compositions and methods for the treatment of presbyopia
US9968594B2 (en) 2013-08-28 2018-05-15 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
US11179327B2 (en) 2013-08-28 2021-11-23 Lenz Therapeutics, Inc. Compositions and methods for the treatment of presbyopia
US9320709B2 (en) 2013-08-28 2016-04-26 Presbyopia Therapies Llc Storage stable compositions and methods for the treatment of refractive errors of the eye
US9314427B2 (en) 2013-08-28 2016-04-19 Presbyopia Therapies Llc Compositions and methods for the improvement of distance vision and the treatment of refractive errors of the eye
US10064818B2 (en) 2013-08-28 2018-09-04 Presbyopia Therapies, LLC Compositions and methods for the treatment of presbyopia
US9844537B2 (en) 2013-08-28 2017-12-19 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
PL3500255T3 (en) 2016-08-19 2023-03-13 Orasis Pharmaceuticals Ltd. Ophthalmic pharmaceutical compositions and uses relating thereto
US11648247B1 (en) 2021-12-16 2023-05-16 Lenz Therapeutics, Inc. Compositions and methods for the treatment of presbyopia

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0555898A2 (en) * 1985-04-05 1993-08-18 FIDIA S.p.A. Medicaments for non-topical use
RU2089191C1 (en) * 1994-01-28 1997-09-10 Научно-производственная фирма "Нарт" Method of prolongation of physiological effect of thymolol with respect to intraocular pressure decreasing
US5948401A (en) * 1995-12-22 1999-09-07 Union Carbide Chemicals & Plastics Technology Corporation Cationic therapeutic systems
EP0976407A1 (en) * 1997-05-20 2000-02-02 Senju Pharmaceutical Co., Ltd. Antiseptic composition
DE19923829A1 (en) * 1999-05-17 2000-11-23 Ulrich Kluegel Complex of hyaluronate, active ingredient and water, useful as topical pharmaceutical or cosmetic composition, is stable and has high content of active agent
WO2001007049A2 (en) * 1999-07-23 2001-02-01 Novartis Ag Ophthalmic composition comprising ketotifen

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0555898A2 (en) * 1985-04-05 1993-08-18 FIDIA S.p.A. Medicaments for non-topical use
RU2089191C1 (en) * 1994-01-28 1997-09-10 Научно-производственная фирма "Нарт" Method of prolongation of physiological effect of thymolol with respect to intraocular pressure decreasing
US5948401A (en) * 1995-12-22 1999-09-07 Union Carbide Chemicals & Plastics Technology Corporation Cationic therapeutic systems
EP0976407A1 (en) * 1997-05-20 2000-02-02 Senju Pharmaceutical Co., Ltd. Antiseptic composition
DE19923829A1 (en) * 1999-05-17 2000-11-23 Ulrich Kluegel Complex of hyaluronate, active ingredient and water, useful as topical pharmaceutical or cosmetic composition, is stable and has high content of active agent
WO2001007049A2 (en) * 1999-07-23 2001-02-01 Novartis Ag Ophthalmic composition comprising ketotifen

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BUCOLO C ET AL: "PHAMACOLOGICAL EVALUATION OF A NEW TIMOLOL/PILOCARPINE FORMULATION", OPHTHALMIC RESEARCH, BASEL, CH, vol. 30, no. 2, March 1998 (1998-03-01), pages 101 - 106, XP001021347 *
CAMBER O ET AL: "INFLUENCE OF SODIUM HYALURONATE ON THE MEIOTIC EFFECT OF PILOCARPINE IN RABBITS", CURRENT EYE RESEARCH, vol. 6, no. 6, 1987, pages 779 - 784, XP009001244, ISSN: 0271-3683 *
DATABASE WPI Section Ch Week 199818, Derwent World Patents Index; Class B03, AN 1998-205401, XP002221685 *
SAETTONE M F ET AL: "EVALUATION OF HIGH-MOLECULAR-WEIGHT AND LOW-MOLECULAR-WEIGHT FRACTIONS OF SODIUM HYALURONATE AND AN IONIC COMPLEX AS ADJUVANTS FOR TOPICAL OPHTHALMIC VEHICLES CONTAINING PILOCARPINE", INTERNATIONAL JOURNAL OF PHARMACEUTICS (AMSTERDAM), vol. 72, no. 2, 1991, pages 131 - 139, XP009001241, ISSN: 0378-5173 *
UVA M G ET AL: "A NEW ANTI-GLAUCOMA MUCOADHESIVE ASSOCIATION: 0.5% TIMOLOL - 2% PILOCARPINE IN SODIUM HYALURONATE VEHICLE AND ITS IOP LOWERING EFFECTS", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND, US, vol. 36, no. 4, 14 May 1995 (1995-05-14), pages S735, XP001021354, ISSN: 0146-0404 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846094B2 (en) 2003-11-12 2014-09-30 Allergan, Inc. Peripherally administered viscous formulations
US9265775B2 (en) 2003-11-12 2016-02-23 Allergan, Inc. Pharmaceutical compositions
US9572859B2 (en) 2004-01-20 2017-02-21 Allergan, Inc. Compositions and methods for localized therapy of the eye
US8962009B2 (en) 2004-04-30 2015-02-24 Allergan, Inc. Sustained release intraocular implants and related methods

Also Published As

Publication number Publication date
PE20030206A1 (en) 2003-04-09
WO2002100437A2 (en) 2002-12-19
AR034371A1 (en) 2004-02-18
CN1514735A (en) 2004-07-21
CA2449213A1 (en) 2002-12-19
BR0210139A (en) 2004-06-08
JP2005508866A (en) 2005-04-07
AU2002314149A1 (en) 2002-12-23
EP1404370A2 (en) 2004-04-07

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