WO2002099397A3 - Light modulated microarray reader and methods relating thereto - Google Patents

Light modulated microarray reader and methods relating thereto Download PDF

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Publication number
WO2002099397A3
WO2002099397A3 PCT/US2002/017899 US0217899W WO02099397A3 WO 2002099397 A3 WO2002099397 A3 WO 2002099397A3 US 0217899 W US0217899 W US 0217899W WO 02099397 A3 WO02099397 A3 WO 02099397A3
Authority
WO
WIPO (PCT)
Prior art keywords
spots
microarray reader
microarray
light modulated
methods relating
Prior art date
Application number
PCT/US2002/017899
Other languages
French (fr)
Other versions
WO2002099397A2 (en
Inventor
Calum E Macaulay
Pierre M Lane
Original Assignee
Digital Optical Imaging Corp
Calum E Macaulay
Pierre M Lane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Digital Optical Imaging Corp, Calum E Macaulay, Pierre M Lane filed Critical Digital Optical Imaging Corp
Priority to EP02744238A priority Critical patent/EP1397668A2/en
Priority to CA002452693A priority patent/CA2452693A1/en
Publication of WO2002099397A2 publication Critical patent/WO2002099397A2/en
Publication of WO2002099397A3 publication Critical patent/WO2002099397A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/02—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/02—Viewing or reading apparatus
    • G02B27/021—Reading apparatus

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Microarray readers and methods that compensate for target spots that are too dim or too bright for the microarray reader to accurately measure. The readers adjust the amount of light directed at or received from specific non-acceptable target spots, such that dim spots receive more excitation light and overly bright spots receive less. This increases or decreases, respectively, their measured brightness, which in turn effectively increases the range over which a microarray reader can accurately measure the spots, and can improve the signal-to-noise ratio and other aspects of the measurements.
PCT/US2002/017899 2001-06-06 2002-06-06 Light modulated microarray reader and methods relating thereto WO2002099397A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02744238A EP1397668A2 (en) 2001-06-06 2002-06-06 Light modulated microarray reader and methods relating thereto
CA002452693A CA2452693A1 (en) 2001-06-06 2002-06-06 Light modulated microarray reader and methods relating thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29663501P 2001-06-06 2001-06-06
US60/296,635 2001-06-06

Publications (2)

Publication Number Publication Date
WO2002099397A2 WO2002099397A2 (en) 2002-12-12
WO2002099397A3 true WO2002099397A3 (en) 2003-03-20

Family

ID=23142861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/017899 WO2002099397A2 (en) 2001-06-06 2002-06-06 Light modulated microarray reader and methods relating thereto

Country Status (4)

Country Link
US (2) US6794658B2 (en)
EP (1) EP1397668A2 (en)
CA (1) CA2452693A1 (en)
WO (1) WO2002099397A2 (en)

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DE19914279C1 (en) * 1999-03-25 2000-09-07 Jena Optronik Gmbh Sensor for optical examination of stimulated sample pixels on e.g. nano-titration screening plates or bio-chips for gene analysis, employs e.g. a liquid crystal matrix shutter and fiber optics with photomultiplier detection

Also Published As

Publication number Publication date
WO2002099397A2 (en) 2002-12-12
EP1397668A2 (en) 2004-03-17
US20030002040A1 (en) 2003-01-02
US20040262534A1 (en) 2004-12-30
US6794658B2 (en) 2004-09-21
CA2452693A1 (en) 2002-12-12

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