WO2002079751A3 - Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same - Google Patents

Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same Download PDF

Info

Publication number
WO2002079751A3
WO2002079751A3 PCT/US2001/044451 US0144451W WO02079751A3 WO 2002079751 A3 WO2002079751 A3 WO 2002079751A3 US 0144451 W US0144451 W US 0144451W WO 02079751 A3 WO02079751 A3 WO 02079751A3
Authority
WO
WIPO (PCT)
Prior art keywords
probe
workstation
capability
liquid flow
methods
Prior art date
Application number
PCT/US2001/044451
Other languages
French (fr)
Other versions
WO2002079751A2 (en
Inventor
Vaughn A Audain
Charles Amich Buckner Iii
Hendrick Mario Geysen
James R Ormand
Original Assignee
Glaxo Group Ltd
Vaughn A Audain
Charles Amich Buckner Iii
Hendrick Mario Geysen
James R Ormand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Vaughn A Audain, Charles Amich Buckner Iii, Hendrick Mario Geysen, James R Ormand filed Critical Glaxo Group Ltd
Priority to EP01273634A priority Critical patent/EP1365855A2/en
Priority to AU2001297745A priority patent/AU2001297745A1/en
Priority to US10/399,927 priority patent/US20040054286A1/en
Publication of WO2002079751A2 publication Critical patent/WO2002079751A2/en
Publication of WO2002079751A3 publication Critical patent/WO2002079751A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G01N2035/00554—Mixing by a special element, e.g. stirrer using ultrasound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1058—General features of the devices using the transfer device for another function for mixing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/18—Injection using a septum or microsyringe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

A hollow probe cooperates with an ultrasonic transducing device designed with liquid flow-through capability. The probe and transducing device are combined into a probe assembly, which can be integrated into an automated liquid handling workstation. As a functional component of the workstation, the probe can be connected to and manipulated by a robotic arm of the workstation, and thus programmed to move in three-dimensional space to and from various locations of the sampling apparatus. In particular, the probe can be inserted into the individual wells or test tubes of a plate or rack utilized to contain sample substances. The probe can be used to conduct a variety of liquid handling tasks and additionally can be used to ultrasonically excite sample substances contained in the individual wells of the plate, thereby improving dilution of such sample substances and increasing throughput of any given sample preparation procedure. A liquid level detection device can be connected to the probe assembly.
PCT/US2001/044451 2000-11-09 2001-11-05 Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same WO2002079751A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01273634A EP1365855A2 (en) 2000-11-09 2001-11-05 Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same
AU2001297745A AU2001297745A1 (en) 2000-11-09 2001-11-05 Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same
US10/399,927 US20040054286A1 (en) 2001-11-05 2001-11-05 Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24757200P 2000-11-09 2000-11-09
US60/247,572 2000-11-09

Publications (2)

Publication Number Publication Date
WO2002079751A2 WO2002079751A2 (en) 2002-10-10
WO2002079751A3 true WO2002079751A3 (en) 2003-09-18

Family

ID=22935411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044451 WO2002079751A2 (en) 2000-11-09 2001-11-05 Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same

Country Status (3)

Country Link
EP (1) EP1365855A2 (en)
AU (1) AU2001297745A1 (en)
WO (1) WO2002079751A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102967676A (en) * 2012-10-25 2013-03-13 宁波大学 Elution device for inspecting sampling process of polychlorinated biphenyl pollutant by using gas chromatography-mass spectrometer

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7258480B2 (en) * 2005-01-10 2007-08-21 Dade Behring Inc. Apparatus for mixing liquid samples using a two dimensional stirring pattern
GB201000527D0 (en) 2010-01-13 2010-03-03 Pera Innovation Ltd Sonication apparatus and method
CN101881706B (en) * 2010-07-05 2014-04-02 深圳迈瑞生物医疗电子股份有限公司 Sampling device and method
CA2809251C (en) * 2012-09-27 2014-09-02 Cinrg Systems Inc. System and method for automated dilution and delivery of liquid samples to an optical particle counter
CN102967677A (en) * 2012-10-25 2013-03-13 宁波大学 PCBs (Polychlorinated Biphenyls) elution device for intensifying target object desorption and mass transfer based on physical assistance
PT109563B (en) 2016-08-02 2020-09-23 Hovione Farmaciencia Sa METHOD FOR IMPROVING THE DEVELOPMENT AND VALIDATION OF ANALYTICAL AND SAMPLE PREPARATION METHODS FOR ACCURATE AND REPRODUCTIVE MEASUREMENT OF PARTICLE SIZE
JP6876650B2 (en) * 2018-03-30 2021-05-26 日本電子株式会社 Automatic analyzer and automatic analysis method
CN110408535B (en) * 2019-08-15 2022-11-04 淮阴师范学院 Can improve breeding device of beta-glucosidase activity

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4930898A (en) * 1988-06-27 1990-06-05 The United States Of America As Represented By The Secretary Of Agriculture Process and apparatus for direct ultrasonic mixing prior to analysis
US5026167A (en) * 1989-10-19 1991-06-25 Heat Systems Incorporated Ultrasonic fluid processing system
US5365783A (en) * 1993-04-30 1994-11-22 Packard Instrument Company, Inc. Capacitive sensing system and technique
EP0801309A2 (en) * 1996-04-08 1997-10-15 SANYO ELECTRIC Co., Ltd. Pipetting apparatus
WO1999032038A1 (en) * 1997-12-23 1999-07-01 Fibrasonics Inc. Ultrasonic probe with isolated outer cannula
JPH11230970A (en) * 1998-02-09 1999-08-27 Hitachi Ltd Method for dispensing sample and automatic analyzer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4930898A (en) * 1988-06-27 1990-06-05 The United States Of America As Represented By The Secretary Of Agriculture Process and apparatus for direct ultrasonic mixing prior to analysis
US5026167A (en) * 1989-10-19 1991-06-25 Heat Systems Incorporated Ultrasonic fluid processing system
US5365783A (en) * 1993-04-30 1994-11-22 Packard Instrument Company, Inc. Capacitive sensing system and technique
EP0801309A2 (en) * 1996-04-08 1997-10-15 SANYO ELECTRIC Co., Ltd. Pipetting apparatus
WO1999032038A1 (en) * 1997-12-23 1999-07-01 Fibrasonics Inc. Ultrasonic probe with isolated outer cannula
JPH11230970A (en) * 1998-02-09 1999-08-27 Hitachi Ltd Method for dispensing sample and automatic analyzer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Misonix_Sonicator_Brochure (pdf download)", MISONIX, NY 11735, US, 13 March 2003 (2003-03-13), XP002234571, Retrieved from the Internet <URL:http://www.misonix.com/Products/index.cfm?fuseaction=viewproduct&prod=44&div=11&cat=21> [retrieved on 20030313] *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 13 30 November 1999 (1999-11-30) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102967676A (en) * 2012-10-25 2013-03-13 宁波大学 Elution device for inspecting sampling process of polychlorinated biphenyl pollutant by using gas chromatography-mass spectrometer

Also Published As

Publication number Publication date
WO2002079751A2 (en) 2002-10-10
AU2001297745A1 (en) 2002-10-15
EP1365855A2 (en) 2003-12-03

Similar Documents

Publication Publication Date Title
CN206975048U (en) Prepare for identifying the automated system with single sample suspensions liquid of antibiotic susceptibility test
JP5301610B2 (en) Apparatus and method for handling fluid for analysis
JP4948539B2 (en) Automatic solid phase microextraction (SPME) sampling device
JP6786116B2 (en) Electrical measuring device for target chemical substances and its method
JP2009529675A (en) Specimen high-speed feeder
JP2018529942A (en) Modular liquid handling system
WO2004036214A3 (en) Automated kinetci solubility assay apparatus and method
EP1876451A3 (en) Handling method of body fluid sample and analysis apparatus using the same
WO2003048389A3 (en) Test apparatus
MXPA06003765A (en) Diagnostic test device and method of using same.
CA2457930A1 (en) Diagnostic testing process and apparatus
WO2002057753A3 (en) Rapid test for biological substances using ftir
JP4644657B2 (en) Method and apparatus for manipulating individual small objects
CA2713206A1 (en) Apparatus and method for analyte detection
JP2011513737A (en) Apparatus and method for cleaning fluid processing probes
JPH04503568A (en) Liquid sample analysis device and liquid sample analysis method using a new and improved liquid sample aspiration and dispensing probe
WO2002079751A3 (en) Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same
JP2010502988A (en) Micro sample cup rack adapter
CN107966522B (en) Titration module of biochip and titration test equipment thereof
CN109520993A (en) Foodstuff surface residue micro-fluidic detection device and method based on Raman spectrum
CA2266472A1 (en) Aliquoting method for automatic sample examination and measurement instrument
CA2174438A1 (en) Cleaning solution for automatic analyzers
EP1640701A3 (en) Method and apparatus for analyte concentration free of intermediate transfer
US20230045244A1 (en) Injection device, semiconductor testing system and its testing method
DE50309876D1 (en) Test element analysis system

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 10399927

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2001273634

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2001273634

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2001273634

Country of ref document: EP