WO2002067188A3 - Image analysis of the golgi complex - Google Patents

Image analysis of the golgi complex Download PDF

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Publication number
WO2002067188A3
WO2002067188A3 PCT/US2002/004492 US0204492W WO02067188A3 WO 2002067188 A3 WO2002067188 A3 WO 2002067188A3 US 0204492 W US0204492 W US 0204492W WO 02067188 A3 WO02067188 A3 WO 02067188A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
golgi complex
golgi
complex
information
Prior art date
Application number
PCT/US2002/004492
Other languages
French (fr)
Other versions
WO2002067188A2 (en
WO2002067188A9 (en
Inventor
Ge Cong
Eugeni A Vaisberg
Hsien-Hsun Wu
Original Assignee
Cytokinetics Inc
Ge Cong
Eugeni A Vaisberg
Hsien-Hsun Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc, Ge Cong, Eugeni A Vaisberg, Hsien-Hsun Wu filed Critical Cytokinetics Inc
Priority to AU2002306501A priority Critical patent/AU2002306501A1/en
Publication of WO2002067188A2 publication Critical patent/WO2002067188A2/en
Publication of WO2002067188A3 publication Critical patent/WO2002067188A3/en
Publication of WO2002067188A9 publication Critical patent/WO2002067188A9/en

Links

Classifications

    • G01N15/1433—
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle with colour

Abstract

Methods, code and apparatus analyze cell images to automatically identify and characterize the Golgi complex in individual cells. This is accomplished by first locating the cells in the image and defining boundaries of those cells that subsume some or all of the Golgi complex of those cells. The Golgi complex in the images typically have intensity values corresponding to the concentration of a Golgi component in the cell (e.g. a polysaccharide associated with the Golgi complex). The method/system then analyzes the Golgi components of the image (typically on a pixel-by-pixel basis) to mathematically characterize the Golgi complex of individual cells. This mathematical characterization represents phenotypic information about the cells' Golgi complex and can be used to classify cells. From this information, mechanism of action and other important biological information can be deduced.
PCT/US2002/004492 2001-02-20 2002-02-14 Image analysis of the golgi complex WO2002067188A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002306501A AU2002306501A1 (en) 2001-02-20 2002-02-14 Image analysis of the golgi complex

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/792,012 US7151847B2 (en) 2001-02-20 2001-02-20 Image analysis of the golgi complex
US09/792,012 2001-02-20

Publications (3)

Publication Number Publication Date
WO2002067188A2 WO2002067188A2 (en) 2002-08-29
WO2002067188A3 true WO2002067188A3 (en) 2003-04-10
WO2002067188A9 WO2002067188A9 (en) 2004-04-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004492 WO2002067188A2 (en) 2001-02-20 2002-02-14 Image analysis of the golgi complex

Country Status (3)

Country Link
US (2) US7151847B2 (en)
AU (1) AU2002306501A1 (en)
WO (1) WO2002067188A2 (en)

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Also Published As

Publication number Publication date
AU2002306501A1 (en) 2002-09-04
WO2002067188A2 (en) 2002-08-29
US7151847B2 (en) 2006-12-19
WO2002067188A9 (en) 2004-04-01
US20020141631A1 (en) 2002-10-03
US20060228016A1 (en) 2006-10-12

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