WO2002055139A8 - Needleless syringe - Google Patents

Needleless syringe

Info

Publication number
WO2002055139A8
WO2002055139A8 PCT/GB2002/000114 GB0200114W WO02055139A8 WO 2002055139 A8 WO2002055139 A8 WO 2002055139A8 GB 0200114 W GB0200114 W GB 0200114W WO 02055139 A8 WO02055139 A8 WO 02055139A8
Authority
WO
WIPO (PCT)
Prior art keywords
gas
particles
convergence
chamber
flow path
Prior art date
Application number
PCT/GB2002/000114
Other languages
French (fr)
Other versions
WO2002055139A1 (en
Inventor
Colin David Sheldrake
George Costigan
Brian John Bellhouse
Original Assignee
Powderject Res Ltd
Colin David Sheldrake
George Costigan
Brian John Bellhouse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Powderject Res Ltd, Colin David Sheldrake, George Costigan, Brian John Bellhouse filed Critical Powderject Res Ltd
Priority to EP02729462A priority Critical patent/EP1365824B1/en
Priority to NZ527298A priority patent/NZ527298A/en
Priority to JP2002555870A priority patent/JP2004521677A/en
Priority to CA002433992A priority patent/CA2433992A1/en
Priority to US10/466,076 priority patent/US7547292B2/en
Priority to AU2002219368A priority patent/AU2002219368B2/en
Priority to US13/077,571 priority patent/USRE43824E1/en
Priority to DE60210063T priority patent/DE60210063T2/en
Publication of WO2002055139A1 publication Critical patent/WO2002055139A1/en
Publication of WO2002055139A8 publication Critical patent/WO2002055139A8/en
Priority to CY20061100738T priority patent/CY1106102T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A61M2005/005—Magazines with multiple ampoules directly inserted into an injection or infusion device, e.g. revolver-like magazines containing ampoules with or without needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3007—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules with specially designed jet passages at the injector's distal end

Abstract

There is disclosed a method of distributing particles in a flow of gas and a needleless syringe for use in the needleless injection of particles into the skin or mucosa of a vertebrate subject. The syringe has the advantage that no bursting membranes are required, reducing noise, and that the particles are substantially uniformly distributed in the gas stream. This is achieved by providing a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. An exit nozzle is provided to accelerate the particles so entrained. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle. This provides an advantageous flow regime suitable for the needleless injection of powders.
PCT/GB2002/000114 2001-01-11 2002-01-11 Needleless syringe WO2002055139A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP02729462A EP1365824B1 (en) 2001-01-11 2002-01-11 Needleless syringe
NZ527298A NZ527298A (en) 2001-01-11 2002-01-11 Needleless syringe
JP2002555870A JP2004521677A (en) 2001-01-11 2002-01-11 Needleless syringe
CA002433992A CA2433992A1 (en) 2001-01-11 2002-01-11 Needleless syringe
US10/466,076 US7547292B2 (en) 2001-01-11 2002-01-11 Needleless syringe
AU2002219368A AU2002219368B2 (en) 2001-01-11 2002-01-11 Needleless syringe
US13/077,571 USRE43824E1 (en) 2001-01-11 2002-01-11 Needleless syringe
DE60210063T DE60210063T2 (en) 2001-01-11 2002-01-11 NEEDLESS SYRINGE
CY20061100738T CY1106102T1 (en) 2001-01-11 2006-06-05 SYRINGE WITHOUT NEEDLE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0100756.6A GB0100756D0 (en) 2001-01-11 2001-01-11 Needleless syringe
GB0100756.6 2001-01-11

Publications (2)

Publication Number Publication Date
WO2002055139A1 WO2002055139A1 (en) 2002-07-18
WO2002055139A8 true WO2002055139A8 (en) 2002-11-21

Family

ID=9906669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/000114 WO2002055139A1 (en) 2001-01-11 2002-01-11 Needleless syringe

Country Status (14)

Country Link
US (2) US7547292B2 (en)
EP (1) EP1365824B1 (en)
JP (2) JP2004521677A (en)
AT (1) ATE320827T1 (en)
AU (1) AU2002219368B2 (en)
CA (1) CA2433992A1 (en)
CY (1) CY1106102T1 (en)
DE (1) DE60210063T2 (en)
DK (1) DK1365824T3 (en)
ES (1) ES2260433T3 (en)
GB (1) GB0100756D0 (en)
NZ (1) NZ527298A (en)
PT (1) PT1365824E (en)
WO (1) WO2002055139A1 (en)

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USRE43824E1 (en) 2001-01-11 2012-11-20 Powder Pharmaceuticals Inc. Needleless syringe
US9044546B2 (en) 2007-05-04 2015-06-02 Powder Pharmaceuticals Incorporated Particle cassettes and processes therefor

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US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8731842B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
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US20040215135A1 (en) 2004-10-28
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CA2433992A1 (en) 2002-07-18
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US7547292B2 (en) 2009-06-16
DE60210063D1 (en) 2006-05-11
GB0100756D0 (en) 2001-02-21
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WO2002055139A1 (en) 2002-07-18
CY1106102T1 (en) 2011-06-08
EP1365824B1 (en) 2006-03-22
EP1365824A1 (en) 2003-12-03
ATE320827T1 (en) 2006-04-15
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ES2260433T3 (en) 2006-11-01
AU2002219368B2 (en) 2006-07-27

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