WO2002053139A3 - Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders - Google Patents

Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders Download PDF

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Publication number
WO2002053139A3
WO2002053139A3 PCT/US2001/045863 US0145863W WO02053139A3 WO 2002053139 A3 WO2002053139 A3 WO 2002053139A3 US 0145863 W US0145863 W US 0145863W WO 02053139 A3 WO02053139 A3 WO 02053139A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor antagonist
treatment
amino acid
excitatory amino
neurological disorders
Prior art date
Application number
PCT/US2001/045863
Other languages
French (fr)
Other versions
WO2002053139A2 (en
WO2002053139A8 (en
Inventor
Kirk Willis Johnson
Original Assignee
Lilly Co Eli
Kirk Willis Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Kirk Willis Johnson filed Critical Lilly Co Eli
Priority to AU2002241565A priority Critical patent/AU2002241565A1/en
Publication of WO2002053139A2 publication Critical patent/WO2002053139A2/en
Publication of WO2002053139A3 publication Critical patent/WO2002053139A3/en
Publication of WO2002053139A8 publication Critical patent/WO2002053139A8/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a method of treating a neurological disorder, particularly migraine, comprising administering to a patient an effective amount of an excitatory amino receptor antagonist in combination with a 5HT1f agonist.
PCT/US2001/045863 2001-01-05 2001-12-20 Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders WO2002053139A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002241565A AU2002241565A1 (en) 2001-01-05 2001-12-20 Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25992301P 2001-01-05 2001-01-05
US60/259,923 2001-01-05

Publications (3)

Publication Number Publication Date
WO2002053139A2 WO2002053139A2 (en) 2002-07-11
WO2002053139A3 true WO2002053139A3 (en) 2002-08-22
WO2002053139A8 WO2002053139A8 (en) 2003-11-13

Family

ID=22987001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045863 WO2002053139A2 (en) 2001-01-05 2001-12-20 Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders

Country Status (2)

Country Link
AU (1) AU2002241565A1 (en)
WO (1) WO2002053139A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101825972B1 (en) 2010-10-15 2018-02-06 콘테라 파르마 에이피에스 Combinations of serotonin receptor agonists for treatment of movement disorders
PT2838517T (en) 2012-04-18 2018-01-04 Contera Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721252A (en) * 1994-10-05 1998-02-24 Eli Lilly And Company 5HT1F agonists for the treatment of migraine
WO1998045270A1 (en) * 1997-04-07 1998-10-15 Eli Lilly And Company Pharmacological agents
WO2001001972A2 (en) * 1999-07-06 2001-01-11 Eli Lilly And Company SELECTIVE iGluR5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721252A (en) * 1994-10-05 1998-02-24 Eli Lilly And Company 5HT1F agonists for the treatment of migraine
WO1998045270A1 (en) * 1997-04-07 1998-10-15 Eli Lilly And Company Pharmacological agents
WO2001001972A2 (en) * 1999-07-06 2001-01-11 Eli Lilly And Company SELECTIVE iGluR5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE

Also Published As

Publication number Publication date
WO2002053139A2 (en) 2002-07-11
WO2002053139A8 (en) 2003-11-13
AU2002241565A1 (en) 2002-07-16

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