WO2002039948A3 - Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants - Google Patents

Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants Download PDF

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Publication number
WO2002039948A3
WO2002039948A3 PCT/IL2001/001050 IL0101050W WO0239948A3 WO 2002039948 A3 WO2002039948 A3 WO 2002039948A3 IL 0101050 W IL0101050 W IL 0101050W WO 0239948 A3 WO0239948 A3 WO 0239948A3
Authority
WO
WIPO (PCT)
Prior art keywords
cross
hyaluronic acid
gels
linked hyaluronic
cell culture
Prior art date
Application number
PCT/IL2001/001050
Other languages
French (fr)
Other versions
WO2002039948A2 (en
Inventor
Abraham Shahar
Zvi Nevo
Shimon Rochkind
Original Assignee
R Labs Bvi Nv
Abraham Shahar
Zvi Nevo
Shimon Rochkind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Labs Bvi Nv, Abraham Shahar, Zvi Nevo, Shimon Rochkind filed Critical R Labs Bvi Nv
Priority to AU2399502A priority Critical patent/AU2399502A/en
Priority to AU2002223995A priority patent/AU2002223995B2/en
Priority to JP2002542323A priority patent/JP2004535836A/en
Priority to EP01996348A priority patent/EP1339349A4/en
Priority to CA002428748A priority patent/CA2428748A1/en
Publication of WO2002039948A2 publication Critical patent/WO2002039948A2/en
Publication of WO2002039948A3 publication Critical patent/WO2002039948A3/en
Priority to IL155918A priority patent/IL155918A0/en
Priority to US10/669,476 priority patent/US20050260753A1/en
Priority to US11/223,465 priority patent/US20060024373A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00—Characterised by the use of proteins; Derivatives thereof

Abstract

The present invention concerns universal biocompatible matrices comprising cross-linked hyaluronic acid-laminin gels useful for clinical applications including as implants, for tissue engineering as well as in biotechnology. The gel matrices according to the present invention may be used clinically either per se or as a cell bearing implant- The gels are particularly useful for use for transplantation to the nervous system or as a coating or a scaffold for use on medical devices including stents.
PCT/IL2001/001050 2000-11-14 2001-11-13 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants WO2002039948A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2399502A AU2399502A (en) 2000-11-14 2001-11-13 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
AU2002223995A AU2002223995B2 (en) 2000-11-14 2001-11-13 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
JP2002542323A JP2004535836A (en) 2000-11-14 2001-11-13 Crosslinked hyaluronic acid-laminin gels and their use in cell culture and medical implants
EP01996348A EP1339349A4 (en) 2000-11-14 2001-11-13 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
CA002428748A CA2428748A1 (en) 2000-11-14 2001-11-13 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
IL155918A IL155918A0 (en) 2000-11-14 2003-05-14 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
US10/669,476 US20050260753A1 (en) 2000-11-14 2003-09-23 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
US11/223,465 US20060024373A1 (en) 2000-11-14 2005-09-09 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24844700P 2000-11-14 2000-11-14
US60/248,447 2000-11-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US43766303A Continuation 2000-11-14 2003-05-13

Publications (2)

Publication Number Publication Date
WO2002039948A2 WO2002039948A2 (en) 2002-05-23
WO2002039948A3 true WO2002039948A3 (en) 2002-08-15

Family

ID=22939170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/001050 WO2002039948A2 (en) 2000-11-14 2001-11-13 Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants

Country Status (6)

Country Link
US (2) US20050260753A1 (en)
EP (1) EP1339349A4 (en)
JP (1) JP2004535836A (en)
AU (2) AU2002223995B2 (en)
CA (1) CA2428748A1 (en)
WO (1) WO2002039948A2 (en)

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US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
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US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
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EP1750769B1 (en) * 2004-05-20 2013-01-23 Mentor Worldwide LLC Methods for making injectable polymer hydrogels
CA2572804C (en) * 2004-07-09 2013-04-02 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
AU2005286097A1 (en) * 2004-09-21 2006-03-30 Nvr Labs. Ltd. Compositions and methods for stem cell expansion and differentiation
WO2006091675A2 (en) * 2005-02-23 2006-08-31 Surmodics, Inc. Implantable medical articles having laminin coatings and methods of use
WO2007002664A2 (en) * 2005-06-22 2007-01-04 Massachusetts Institute Of Technology Propagation of undifferentiated embryonic stem cells in hyaluronic acid hydrogel
EP1916964A4 (en) 2005-08-26 2015-11-04 Zimmer Inc Implants and methods for repair, replacement and treatment of joint disease
EP1764117A1 (en) * 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
US20080097620A1 (en) * 2006-05-26 2008-04-24 Nanyang Technological University Implantable article, method of forming same and method for reducing thrombogenicity
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Also Published As

Publication number Publication date
EP1339349A4 (en) 2007-07-04
US20060024373A1 (en) 2006-02-02
EP1339349A2 (en) 2003-09-03
JP2004535836A (en) 2004-12-02
AU2399502A (en) 2002-05-27
AU2002223995B2 (en) 2006-05-11
US20050260753A1 (en) 2005-11-24
WO2002039948A2 (en) 2002-05-23
CA2428748A1 (en) 2002-05-23

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