WO2002034111A3 - In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics - Google Patents

In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics Download PDF

Info

Publication number
WO2002034111A3
WO2002034111A3 PCT/US2001/032632 US0132632W WO0234111A3 WO 2002034111 A3 WO2002034111 A3 WO 2002034111A3 US 0132632 W US0132632 W US 0132632W WO 0234111 A3 WO0234111 A3 WO 0234111A3
Authority
WO
WIPO (PCT)
Prior art keywords
cavity
bioprosthetic
situ
biopolymer
vertebral disc
Prior art date
Application number
PCT/US2001/032632
Other languages
French (fr)
Other versions
WO2002034111A2 (en
Inventor
K Umit Yuksel
Steven P Walsh
Kirby S Black
Original Assignee
Cryolife Inc
K Umit Yuksel
Steven P Walsh
Kirby S Black
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryolife Inc, K Umit Yuksel, Steven P Walsh, Kirby S Black filed Critical Cryolife Inc
Priority to CA002422884A priority Critical patent/CA2422884C/en
Priority to AT01984004T priority patent/ATE494014T1/en
Priority to AU1538702A priority patent/AU1538702A/en
Priority to DE60143804T priority patent/DE60143804D1/en
Priority to EP01984004A priority patent/EP1328220B1/en
Priority to JP2002537171A priority patent/JP4202749B2/en
Priority to AU2002215387A priority patent/AU2002215387B2/en
Publication of WO2002034111A2 publication Critical patent/WO2002034111A2/en
Publication of WO2002034111A3 publication Critical patent/WO2002034111A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A61L27/3658—Intervertebral discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/4445—Means for culturing intervertebral disc tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/445—Intervertebral disc tissue harvest sites

Abstract

Bioprosthetic devices (10) include an exterior biological tissue member (10-1) which at least partly defines a cavity, and a proteinaceous biopolymer (10-2) which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device (10) is a bioprosthetic vertebral disc, having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer (10-2). Preferably, the proteinaceous biopolymer (10-2) is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.
PCT/US2001/032632 2000-10-24 2001-10-24 In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics WO2002034111A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002422884A CA2422884C (en) 2000-10-24 2001-10-24 In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
AT01984004T ATE494014T1 (en) 2000-10-24 2001-10-24 BIOPROSTHETIC FILLERS AND METHODS, IN PARTICULAR FOR THE FORMATION OF INTERVERTAL DISC BIOPROStheses IN SITU
AU1538702A AU1538702A (en) 2000-10-24 2001-10-24 In situ bioprosthetic filler and methods, particularly for the in situ formationof vertebral disc bioprosthetics
DE60143804T DE60143804D1 (en) 2000-10-24 2001-10-24 BIOPROTHETIC FILLER AND METHODS, ESPECIALLY FOR THE FORMATION OF BANCH BIOPROTHESIS IN SITU
EP01984004A EP1328220B1 (en) 2000-10-24 2001-10-24 Bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
JP2002537171A JP4202749B2 (en) 2000-10-24 2001-10-24 In-situ bioartificial filler and method for in-situ formation of bioartificial intervertebral disc in particular
AU2002215387A AU2002215387B2 (en) 2000-10-24 2001-10-24 In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24245700P 2000-10-24 2000-10-24
US60/242,457 2000-10-24

Publications (2)

Publication Number Publication Date
WO2002034111A2 WO2002034111A2 (en) 2002-05-02
WO2002034111A3 true WO2002034111A3 (en) 2003-01-16

Family

ID=22914850

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/032632 WO2002034111A2 (en) 2000-10-24 2001-10-24 In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics

Country Status (9)

Country Link
US (4) US20020049498A1 (en)
EP (1) EP1328220B1 (en)
JP (1) JP4202749B2 (en)
AT (1) ATE494014T1 (en)
AU (2) AU1538702A (en)
CA (1) CA2422884C (en)
DE (1) DE60143804D1 (en)
ES (1) ES2358498T3 (en)
WO (1) WO2002034111A2 (en)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1230902A1 (en) 1996-11-15 2002-08-14 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
EP1253854A4 (en) 1999-03-07 2010-01-06 Discure Ltd Method and apparatus for computerized surgery
US6821276B2 (en) * 1999-08-18 2004-11-23 Intrinsic Therapeutics, Inc. Intervertebral diagnostic and manipulation device
US7553329B2 (en) * 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
US7717961B2 (en) 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
US20040044412A1 (en) * 1999-08-18 2004-03-04 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
WO2004100841A1 (en) 1999-08-18 2004-11-25 Intrinsic Therapeutics, Inc. Devices and method for augmenting a vertebral disc nucleus
US7220281B2 (en) * 1999-08-18 2007-05-22 Intrinsic Therapeutics, Inc. Implant for reinforcing and annulus fibrosis
US20040010317A1 (en) * 1999-08-18 2004-01-15 Gregory Lambrecht Devices and method for augmenting a vertebral disc
WO2009033100A1 (en) 2007-09-07 2009-03-12 Intrinsic Therapeutics, Inc. Bone anchoring systems
JP4247519B2 (en) 1999-08-18 2009-04-02 イントリンジック セラピューティックス インコーポレイテッド Apparatus and method for nucleus augmentation and retention
US7998213B2 (en) 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
US6805695B2 (en) 2000-04-04 2004-10-19 Spinalabs, Llc Devices and methods for annular repair of intervertebral discs
US6723335B1 (en) * 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
WO2002034111A2 (en) * 2000-10-24 2002-05-02 Cryolife, Inc. In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
AU2001297782B2 (en) 2000-11-07 2006-03-02 Cryolife, Inc. Expandable foam-like biomaterials and methods
DE60207902T2 (en) * 2001-01-30 2006-06-14 Nissan Chemical Ind Ltd Isocyanurate compound and process for its preparation
US7144393B2 (en) * 2001-05-15 2006-12-05 Dipoto Gene P Structure for receiving surgical instruments
US20050209699A1 (en) * 2002-03-19 2005-09-22 Slivka Michael A Method for nonsurgical treatment of the nucleus pulposus of the intervertebral disc using genipin or proanthrocyanidin, and kit therefor
US6812211B2 (en) * 2002-03-19 2004-11-02 Michael Andrew Slivka Method for nonsurgical treatment of the intervertebral disc and kit therefor
US8388684B2 (en) * 2002-05-23 2013-03-05 Pioneer Signal Technology, Inc. Artificial disc device
US7001433B2 (en) * 2002-05-23 2006-02-21 Pioneer Laboratories, Inc. Artificial intervertebral disc device
US20040054414A1 (en) * 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
ATE462383T1 (en) * 2002-09-24 2010-04-15 Bogomir Gorensek STABILIZING DEVICE FOR INTERVERBAL DISCS AND METHOD THEREOF
US6932843B2 (en) 2002-09-25 2005-08-23 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
CA2504591C (en) * 2002-11-05 2011-09-13 Spineology Inc. A semi-biological intervertebral disc replacement system
JP2006515765A (en) * 2002-11-15 2006-06-08 エスディージーアイ・ホールディングス・インコーポレーテッド Collagen-based materials and methods for treating synovial joints
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
WO2004064673A2 (en) * 2003-01-17 2004-08-05 Psinergi Corporation Artificial nucleus pulposus and method of injecting same
US20070003525A1 (en) * 2003-01-31 2007-01-04 Moehlenbruck Jeffrey W Hydrogel compositions comprising nucleus pulposus tissue
FR2854801B1 (en) * 2003-05-12 2006-09-01 Khorionyx INJECTABLE GLOBINE INSOLUBLE IMPLANT
DK1638485T3 (en) * 2003-06-20 2011-05-02 Intrinsic Therapeutics Inc Device for delivery of an implant through an annular defect in an intervertebral disc
US20040260300A1 (en) * 2003-06-20 2004-12-23 Bogomir Gorensek Method of delivering an implant through an annular defect in an intervertebral disc
US20050071012A1 (en) * 2003-09-30 2005-03-31 Hassan Serhan Methods and devices to replace spinal disc nucleus pulposus
US7655012B2 (en) 2003-10-02 2010-02-02 Zimmer Spine, Inc. Methods and apparatuses for minimally invasive replacement of intervertebral discs
US20050116400A1 (en) * 2003-11-14 2005-06-02 White Moreno J. Non-linear fiber/matrix architecture
WO2005070071A2 (en) * 2004-01-08 2005-08-04 Spine Wave Inc. Apparatus and method for injecting fluent material at a distracted tissue site
EP1768617A4 (en) * 2004-06-29 2011-08-10 Spine Wave Inc Methods for treating defects and injuries of an intervertebral disc
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
JP4601051B2 (en) * 2004-12-20 2010-12-22 株式会社ユニバーサルエンターテインメント Gaming chips
CA2591921A1 (en) * 2005-02-23 2006-08-31 Zimmer Technology, Inc. Blend hydrogels and methods of making
US20070050034A1 (en) * 2005-05-24 2007-03-01 Schwardt Jeffrey D Low-compliance expandable medical device
US7442210B2 (en) * 2005-06-15 2008-10-28 Jerome Segal Mechanical apparatus and method for artificial disc replacement
US8197545B2 (en) 2005-10-27 2012-06-12 Depuy Spine, Inc. Nucleus augmentation delivery device and technique
AU2006321809A1 (en) * 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
DE602006017160D1 (en) 2005-12-22 2010-11-11 Zimmer Inc Perfluorocyclobutane crosslinked hydrogels
US7918889B2 (en) * 2006-02-27 2011-04-05 Warsaw Orthopedic, Inc. Expandable spinal prosthetic devices and associated methods
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US8282641B2 (en) 2006-03-28 2012-10-09 Depuy Spine, Inc. Methods and instrumentation for disc replacement
US20070233244A1 (en) * 2006-03-28 2007-10-04 Depuy Spine, Inc. Artificial Disc Replacement Using Posterior Approach
US8137404B2 (en) * 2006-03-28 2012-03-20 Depuy Spine, Inc. Artificial disc replacement using posterior approach
US20070233245A1 (en) * 2006-03-31 2007-10-04 Sdgi Holdings, Inc. Methods and instruments for delivering intervertebral devices
US8133279B2 (en) 2006-04-27 2012-03-13 Warsaw Orthopedic, Inc. Methods for treating an annulus defect of an intervertebral disc
US20070255406A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US20070255286A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for improved disc augmentation
US20070276491A1 (en) * 2006-05-24 2007-11-29 Disc Dynamics, Inc. Mold assembly for intervertebral prosthesis
US8092536B2 (en) * 2006-05-24 2012-01-10 Disc Dynamics, Inc. Retention structure for in situ formation of an intervertebral prosthesis
US20080004431A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic Inc Method of manufacturing an injectable collagen material
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US20080004703A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic, Inc. Method of treating a patient using a collagen material
US8118779B2 (en) * 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US20080082104A1 (en) 2006-07-27 2008-04-03 Lanx, Llc Methods and apparatuses for facilitating percutaneous fusion
US7758649B2 (en) * 2006-08-04 2010-07-20 Integrity Intellect Inc. Reversibly deformable implant
US8357168B2 (en) * 2006-09-08 2013-01-22 Spine Wave, Inc. Modular injection needle and seal assembly
US8715350B2 (en) 2006-09-15 2014-05-06 Pioneer Surgical Technology, Inc. Systems and methods for securing an implant in intervertebral space
EP2063817A4 (en) 2006-09-15 2012-04-18 Pioneer Surgical Technology Inc Joint arthroplasty devices having articulating members
US8715352B2 (en) * 2006-12-14 2014-05-06 Depuy Spine, Inc. Buckling disc replacement
US20080269897A1 (en) * 2007-04-26 2008-10-30 Abhijeet Joshi Implantable device and methods for repairing articulating joints for using the same
US20080268056A1 (en) * 2007-04-26 2008-10-30 Abhijeet Joshi Injectable copolymer hydrogel useful for repairing vertebral compression fractures
US8864801B2 (en) * 2007-04-30 2014-10-21 Warsaw Orthopedic, Inc. Method of deformity correction in a spine using injectable materials
DE102007034580B4 (en) * 2007-07-13 2012-11-08 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Biomaterial based on a hydrophilic polymeric carrier
US7731988B2 (en) * 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
WO2009046399A1 (en) * 2007-10-05 2009-04-09 Hynes Richard A Spinal stabilization treatment methods for maintaining axial spine height and sagital plane spine balance
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
DE102008008071A1 (en) * 2008-01-28 2009-08-06 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Injectable biocompatible composition
US20090222096A1 (en) * 2008-02-28 2009-09-03 Warsaw Orthopedic, Inc. Multi-compartment expandable devices and methods for intervertebral disc expansion and augmentation
US20090297603A1 (en) * 2008-05-29 2009-12-03 Abhijeet Joshi Interspinous dynamic stabilization system with anisotropic hydrogels
US7976578B2 (en) * 2008-06-04 2011-07-12 James Marvel Buffer for a human joint and method of arthroscopically inserting
NL1035724C2 (en) * 2008-07-18 2010-01-22 Univ Eindhoven Tech Prosthesis comprising a core of a gel material with a woven envelope and a method for the manufacture thereof and the application thereof.
US9132207B2 (en) * 2009-10-27 2015-09-15 Spine Wave, Inc. Radiopaque injectable nucleus hydrogel compositions
CN102740779A (en) * 2010-02-23 2012-10-17 克莱约生命公司 Applicator delivery tip extension
US9358122B2 (en) 2011-01-07 2016-06-07 K2M, Inc. Interbody spacer
WO2012131383A1 (en) 2011-03-31 2012-10-04 Isis Innovation Limited Intervertebral disc treatment apparatus
US20120276008A1 (en) * 2011-04-26 2012-11-01 Spine Wave, Inc. Radiopaque injectable nucleus hydrogel compositions
US9198769B2 (en) 2011-12-23 2015-12-01 Pioneer Surgical Technology, Inc. Bone anchor assembly, bone plate system, and method
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
US20140277467A1 (en) 2013-03-14 2014-09-18 Spinal Stabilization Technologies, Llc Prosthetic Spinal Disk Nucleus
WO2016073587A1 (en) 2014-11-04 2016-05-12 Spinal Stabilization Technologies Llc Percutaneous implantable nuclear prosthesis
CA2966748C (en) 2014-11-04 2023-03-21 Spinal Stabilization Technologies Llc Percutaneous implantable nuclear prosthesis
PL3344156T3 (en) 2015-09-01 2020-07-27 Spinal Stabilization Technologies Llc Implantable nuclear prosthesis
WO2017176973A1 (en) * 2016-04-07 2017-10-12 Rowan University Methods and compositions for inducing multi-targeted healing of intervertebral disc defects
JP2020533070A (en) 2017-09-08 2020-11-19 パイオニア サージカル テクノロジー インコーポレイテッド Intervertebral implants, instruments, and methods
USD907771S1 (en) 2017-10-09 2021-01-12 Pioneer Surgical Technology, Inc. Intervertebral implant
CA3111639A1 (en) 2018-09-04 2020-05-28 Spinal Stabilization Technologies, Llc Implantable nuclear prosthesis, kits, and related methods
US11931525B2 (en) * 2018-10-04 2024-03-19 Edwards Lifesciences Corporation Stabilizer for a delivery system
CN110680559B (en) * 2019-09-27 2022-02-15 长沙晟天新材料有限公司 Chest lock integrated piece and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258028A (en) * 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US6099565A (en) * 1995-06-07 2000-08-08 Sakura, Jr.; Chester Y. Prosthetic tissue implant and filler therefor

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309777A (en) 1980-11-13 1982-01-12 Patil Arun A Artificial intervertebral disc
US4472840A (en) * 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
DE3479402D1 (en) * 1984-06-12 1989-09-21 Oscobal Ag Method of producing a bone replacement material
US4620327A (en) * 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
EP0176728B1 (en) 1984-09-04 1989-07-26 Humboldt-Universität zu Berlin Intervertebral-disc prosthesis
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US6018030A (en) 1986-11-04 2000-01-25 Protein Polymer Technologies, Inc. Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
US4714469A (en) 1987-02-26 1987-12-22 Pfizer Hospital Products Group, Inc. Spinal implant
DE3734923C1 (en) 1987-10-15 1989-01-26 Biotest Pharma Gmbh Process for the preparation of a sterile plasma protein solution containing fibrinogen and coagulation factor XIII
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
CA1339083C (en) * 1987-11-13 1997-07-29 Steven R. Jefferies Bone repair material and delayed drug delivery system
US4911718A (en) 1988-06-10 1990-03-27 University Of Medicine & Dentistry Of N.J. Functional and biocompatible intervertebral disc spacer
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
CA1318469C (en) 1989-02-15 1993-06-01 Acromed Corporation Artificial disc
JP2817966B2 (en) 1989-10-13 1998-10-30 旭光学工業株式会社 Hard tissue replenishing kneaded material with reduced irritation to living body and method for producing the same
US5385606A (en) * 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
EP0621020A1 (en) * 1993-04-21 1994-10-26 SULZER Medizinaltechnik AG Intervertebral prosthesis and method of implanting such a prosthesis
US5373431A (en) 1993-08-31 1994-12-13 Cooper Industries, Inc. Ring/baffle element for a trim of a recessed lighting fixture
US5514180A (en) 1994-01-14 1996-05-07 Heggeness; Michael H. Prosthetic intervertebral devices
JP3127709B2 (en) 1994-04-25 2001-01-29 ブラザー工業株式会社 Recording device
US6140452A (en) * 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
AU2621295A (en) * 1994-05-24 1995-12-18 Smith & Nephew Plc Intervertebral disc implant
US5824093A (en) * 1994-10-17 1998-10-20 Raymedica, Inc. Prosthetic spinal disc nucleus
US5674296A (en) 1994-11-14 1997-10-07 Spinal Dynamics Corporation Human spinal disc prosthesis
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5817303A (en) 1995-05-05 1998-10-06 Protein Polymer Technologies, Inc. Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer
US5766584A (en) * 1995-06-02 1998-06-16 Massachusetts Institute Of Technology Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells
PT876165E (en) 1995-12-18 2006-10-31 Angiotech Biomaterials Corp COMPOSITIONS OF RETICULATED POLYMERS AND PROCESSES FOR THEIR USE
US5865845A (en) 1996-03-05 1999-02-02 Thalgott; John S. Prosthetic intervertebral disc
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US5895426A (en) 1996-09-06 1999-04-20 Osteotech, Inc. Fusion implant device and method of use
US5827328A (en) 1996-11-22 1998-10-27 Buttermann; Glenn R. Intervertebral prosthetic device
IT1291210B1 (en) 1997-03-18 1998-12-29 Bridgestone Firestone Tech ANTI-STATIC TIRE.
US5800549A (en) * 1997-04-30 1998-09-01 Howmedica Inc. Method and apparatus for injecting an elastic spinal implant
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6048346A (en) * 1997-08-13 2000-04-11 Kyphon Inc. Systems and methods for injecting flowable materials into bones
KR100563476B1 (en) 1998-07-03 2006-03-27 이진용 Bone regeneration material
JP3695511B2 (en) 1998-07-03 2005-09-14 ニプロ株式会社 Bone regeneration material
US6994686B2 (en) * 1998-08-26 2006-02-07 Neomend, Inc. Systems for applying cross-linked mechanical barriers
FR2787018B1 (en) * 1998-12-11 2001-03-02 Dimso Sa INTERVERTEBRAL DISC PROSTHESIS WITH LIQUID ENCLOSURE
WO2000045870A1 (en) 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Osteogenic paste compositions and uses thereof
GB9902976D0 (en) 1999-02-11 1999-03-31 Giltech Ltd Composite
US6264659B1 (en) * 1999-02-22 2001-07-24 Anthony C. Ross Method of treating an intervertebral disk
WO2000049978A1 (en) * 1999-02-22 2000-08-31 Guagliano Peter A Method of treating an intervertebral disk
US6206921B1 (en) 1999-02-22 2001-03-27 Peter A. Guagliano Method of replacing nucleus pulposus and repairing the intervertebral disk
US6436143B1 (en) * 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6805697B1 (en) * 1999-05-07 2004-10-19 University Of Virginia Patent Foundation Method and system for fusing a spinal region
US6921412B1 (en) * 1999-05-18 2005-07-26 Cryolife, Inc. Self-supporting, shaped, three-dimensional biopolymeric materials and methods
US6425919B1 (en) 1999-08-18 2002-07-30 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US6264695B1 (en) 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
US6332894B1 (en) * 2000-03-07 2001-12-25 Zimmer, Inc. Polymer filled spinal fusion cage
US6723335B1 (en) * 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
WO2002034111A2 (en) 2000-10-24 2002-05-02 Cryolife, Inc. In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
CA2429168C (en) * 2000-11-15 2010-06-08 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
US20060089721A1 (en) * 2001-01-17 2006-04-27 Muhanna Nabil L Intervertebral disc prosthesis and methods of implantation
US6936070B1 (en) * 2001-01-17 2005-08-30 Nabil L. Muhanna Intervertebral disc prosthesis and methods of implantation
US6488952B1 (en) * 2001-08-28 2002-12-03 John P. Kennedy Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system
AU2002336694A1 (en) * 2001-11-01 2003-05-12 Lawrence M. Boyd Devices and methods for the restoration of a spinal disc
WO2004064673A2 (en) * 2003-01-17 2004-08-05 Psinergi Corporation Artificial nucleus pulposus and method of injecting same
US7183369B1 (en) 2003-02-14 2007-02-27 Iowa State University Research Foundation, Inc. Injectible bodily prosthetics employing methacrylic copolymer gels
EP1626799B1 (en) * 2003-04-30 2010-04-14 Drexel University Thermogelling polymer blends for biomaterial applications

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258028A (en) * 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US6099565A (en) * 1995-06-07 2000-08-08 Sakura, Jr.; Chester Y. Prosthetic tissue implant and filler therefor

Also Published As

Publication number Publication date
DE60143804D1 (en) 2011-02-17
US7621959B2 (en) 2009-11-24
US7621954B2 (en) 2009-11-24
AU2002215387B2 (en) 2005-09-29
ES2358498T3 (en) 2011-05-11
EP1328220A4 (en) 2009-08-19
US20050102030A1 (en) 2005-05-12
JP2004532656A (en) 2004-10-28
US20080058942A1 (en) 2008-03-06
CA2422884C (en) 2009-05-19
WO2002034111A2 (en) 2002-05-02
ATE494014T1 (en) 2011-01-15
EP1328220A2 (en) 2003-07-23
EP1328220B1 (en) 2011-01-05
JP4202749B2 (en) 2008-12-24
US7896920B2 (en) 2011-03-01
US20070093902A1 (en) 2007-04-26
US20020049498A1 (en) 2002-04-25
CA2422884A1 (en) 2002-05-02
AU1538702A (en) 2002-05-06

Similar Documents

Publication Publication Date Title
WO2002034111A3 (en) In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
US8277828B2 (en) Delivery system for bone growth promoting material
US4950295A (en) Bone prosthesis anchoring method using a resorbable marrow cavity closure
US4344190A (en) Plugs for the medullary canal of a bone
WO2001006950A3 (en) Aneurysm embolization material and device
WO2002017794A9 (en) Tools and methods for creating cavities in bone
AU6614294A (en) Biodegradable implant precursor
WO2004026189A3 (en) Collagen-based materials and methods for augmenting intervertebral discs
CA2170753A1 (en) Improved soft tissue implant
WO2001037889A3 (en) Injectable bone-substitute material
BR9911998B1 (en) biocampatable diphtheric composition, method of preparing composition and filler, useful in restorative and plastic surgery
DE69930385D1 (en) EXPERIMENTAL IMPLANT FOR VASCULAR EMBOLIZATION, AND METHOD FOR THE PRODUCTION THEREOF
NZ513473A (en) Apparatus for treating fractured or diseased bone using expandable bodies and filling cavity with material
WO2003043503A3 (en) Tissue fastener
WO2002000142A3 (en) Intervertebral disc
ATE360398T1 (en) COMPRESSED TENDON TRANSPLANT AND DEVICE FOR PRODUCING IT
WO2003028782A1 (en) Composite material for tissue regeneration
AU4114897A (en) Biological material embedded in hydrogels, a process for the embedding thereof, and its use as artificial seed
KR900005944A (en) Bone regeneration material and artificial bone fixative
DE69401056T2 (en) METHOD FOR DELIVERING AN AIR-CONTAINING COMPOSITION
WO2003101334A3 (en) Method and device for moistening non-biological medical implant material
EP0321442A3 (en) Biologically absorbable implant material, and method for its preparation
AU2002220396A1 (en) Filler composition for soft tissue augmentation and reconstructive surgery
EP0914832A4 (en) Therapeutic material for periodontosis
AU649860B2 (en) A soft dog chew and the manufacturing method of said soft dog chew

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2422884

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001984004

Country of ref document: EP

Ref document number: 2002215387

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2002537171

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2001984004

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2002215387

Country of ref document: AU