WO2002017881A3 - Transdermal pharmaceutical delivery composition - Google Patents

Transdermal pharmaceutical delivery composition Download PDF

Info

Publication number
WO2002017881A3
WO2002017881A3 PCT/GB2001/003863 GB0103863W WO0217881A3 WO 2002017881 A3 WO2002017881 A3 WO 2002017881A3 GB 0103863 W GB0103863 W GB 0103863W WO 0217881 A3 WO0217881 A3 WO 0217881A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
delivery composition
pharmaceutical delivery
transdermal pharmaceutical
pharmaceutically
Prior art date
Application number
PCT/GB2001/003863
Other languages
French (fr)
Other versions
WO2002017881A2 (en
Inventor
Arthur Tudor Tucker
Nigel Benjamin
Original Assignee
Queen Mary & Westfield College
Arthur Tudor Tucker
Nigel Benjamin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queen Mary & Westfield College, Arthur Tudor Tucker, Nigel Benjamin filed Critical Queen Mary & Westfield College
Priority to US10/363,439 priority Critical patent/US8128964B2/en
Priority to JP2002522855A priority patent/JP4869540B2/en
Priority to EP01963158A priority patent/EP1328252B1/en
Priority to AU2001284191A priority patent/AU2001284191B2/en
Priority to AU8419101A priority patent/AU8419101A/en
Priority to DE60125217T priority patent/DE60125217T2/en
Publication of WO2002017881A2 publication Critical patent/WO2002017881A2/en
Publication of WO2002017881A3 publication Critical patent/WO2002017881A3/en
Priority to US12/231,555 priority patent/US8114442B2/en
Priority to US13/360,601 priority patent/US20120183595A1/en
Priority to US13/935,070 priority patent/US20140187481A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.
PCT/GB2001/003863 2000-08-30 2001-08-30 Transdermal pharmaceutical delivery composition WO2002017881A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US10/363,439 US8128964B2 (en) 2000-08-30 2001-08-30 Transdermal pharmaceutical delivery composition
JP2002522855A JP4869540B2 (en) 2000-08-30 2001-08-30 Composition for transdermal drug delivery
EP01963158A EP1328252B1 (en) 2000-08-30 2001-08-30 Transdermal pharmaceutical delivery composition
AU2001284191A AU2001284191B2 (en) 2000-08-30 2001-08-30 Transdermal pharmaceutical delivery composition
AU8419101A AU8419101A (en) 2000-08-30 2001-08-30 Transdermal pharmaceutical delivery composition
DE60125217T DE60125217T2 (en) 2000-08-30 2001-08-30 TRANSDERMALE PHARMACEUTICAL COMPOSITION FOR THE ADMINISTRATIVE ADMINISTRATION
US12/231,555 US8114442B2 (en) 2000-08-30 2008-09-03 Transdermal pharmaceutical delivery compositions
US13/360,601 US20120183595A1 (en) 2000-08-30 2012-01-27 Transdermal Pharmaceutical Delivery Composition
US13/935,070 US20140187481A1 (en) 2000-08-30 2013-07-03 Transdermal Pharmaceutical Delivery Composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0021317.3 2000-08-30
GBGB0021317.3A GB0021317D0 (en) 2000-08-30 2000-08-30 Transdermal pharmaceutical delivery composition

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/363,439 A-371-Of-International US8128964B2 (en) 2000-08-30 2001-08-30 Transdermal pharmaceutical delivery composition
US12/231,555 Division US8114442B2 (en) 2000-08-30 2008-09-03 Transdermal pharmaceutical delivery compositions
US13/360,601 Division US20120183595A1 (en) 2000-08-30 2012-01-27 Transdermal Pharmaceutical Delivery Composition

Publications (2)

Publication Number Publication Date
WO2002017881A2 WO2002017881A2 (en) 2002-03-07
WO2002017881A3 true WO2002017881A3 (en) 2003-04-17

Family

ID=9898548

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/003863 WO2002017881A2 (en) 2000-08-30 2001-08-30 Transdermal pharmaceutical delivery composition

Country Status (9)

Country Link
US (4) US8128964B2 (en)
EP (1) EP1328252B1 (en)
JP (1) JP4869540B2 (en)
AT (1) ATE347879T1 (en)
AU (2) AU2001284191B2 (en)
DE (1) DE60125217T2 (en)
ES (1) ES2275716T3 (en)
GB (1) GB0021317D0 (en)
WO (1) WO2002017881A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102369004A (en) * 2009-01-29 2012-03-07 香榭有限公司 Treatment of psoriasis
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8927030B2 (en) 2003-07-09 2015-01-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same

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GB0021317D0 (en) * 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
EP1846009A2 (en) * 2005-02-11 2007-10-24 NOLabs AB Improved device for application of medicaments, manufacturing method therefor, and method of treatment
WO2006125123A2 (en) * 2005-05-19 2006-11-23 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
GB0607402D0 (en) 2006-04-12 2006-05-24 Barts & London Nhs Trust Therapeutic composition and use
US8445018B2 (en) * 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US8221690B2 (en) 2007-10-30 2012-07-17 The Invention Science Fund I, Llc Systems and devices that utilize photolyzable nitric oxide donors
US8642093B2 (en) 2007-10-30 2014-02-04 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US20090110933A1 (en) * 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices related to nitric oxide releasing materials
US20090112197A1 (en) 2007-10-30 2009-04-30 Searete Llc Devices configured to facilitate release of nitric oxide
US7862598B2 (en) * 2007-10-30 2011-01-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US20110190604A1 (en) * 2006-12-22 2011-08-04 Hyde Roderick A Nitric oxide sensors and systems
WO2009055008A1 (en) * 2007-10-24 2009-04-30 Wharton Innovative Products, Llc Two part lotion for the delivery of nitrite ions to the skin
US8877508B2 (en) * 2007-10-30 2014-11-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US8980332B2 (en) 2007-10-30 2015-03-17 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US10080823B2 (en) 2007-10-30 2018-09-25 Gearbox Llc Substrates for nitric oxide releasing devices
US7897399B2 (en) 2007-10-30 2011-03-01 The Invention Science Fund I, Llc Nitric oxide sensors and systems
US8349262B2 (en) 2007-10-30 2013-01-08 The Invention Science Fund I, Llc Nitric oxide permeable housings
US8303995B1 (en) * 2008-06-13 2012-11-06 Board Of Regents, The University Of Texas System Nitrite formulations and their use as nitric oxide prodrugs
ES2400210T3 (en) * 2008-10-02 2013-04-08 Mylan Inc. Method for preparing a multilayer adhesive laminate
US20100098733A1 (en) * 2008-10-16 2010-04-22 Novan, Inc. Nitric oxide releasing particles for oral care applications
WO2011022680A2 (en) 2009-08-21 2011-02-24 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
US20110086234A1 (en) * 2009-10-13 2011-04-14 Nathan Stasko Nitric oxide-releasing coatings
RU2445918C1 (en) * 2010-07-15 2012-03-27 Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет Noninvasive diagnostic technique for abnormal lymphatic and venous vessels of lower extremities
EP2533773B1 (en) 2010-10-21 2015-08-19 Kipax Ab Topical dermal delivery device for nitric oxide delivery
WO2012131412A2 (en) 2011-03-31 2012-10-04 Szabo Laszlo Gabor Pharmaceutical composition containing no, process for the preparation and use thereof
BR112014003414B1 (en) * 2011-08-17 2021-09-21 Board Of Regents, The University Of Texas System COMPOSITION AND ORAL DELIVERY SYSTEM FOR INCREASE PHYSIOLOGICAL AND THERAPEUTIC LEVELS OF NITRIC OXIDE
PT2782584T (en) 2011-11-23 2021-09-02 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10517817B2 (en) * 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
GB201309091D0 (en) 2013-05-20 2013-07-03 Edixomed Ltd Dressing system
GB201309092D0 (en) 2013-05-20 2013-07-03 Edixomed Ltd Transdermal delivery system
US11406769B2 (en) * 2014-01-31 2022-08-09 Galderma Holding SA Lubrication of an injection needle
AR100562A1 (en) 2014-05-22 2016-10-12 Therapeuticsmd Inc PHARMACEUTICAL COMPOSITION OF ESTRADIOL AND PROGESTERONE FOR HORMONAL REPLACEMENT THERAPY
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
ES2807200T3 (en) 2014-07-11 2021-02-22 Novan Inc Topical antiviral compositions and procedures for their use
US10925689B2 (en) 2014-07-14 2021-02-23 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
GB201420761D0 (en) 2014-11-21 2015-01-07 Edixomed Ltd And First Water Ltd Dressing system
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10849864B2 (en) 2015-07-28 2020-12-01 Novan, Inc. Combinations and methods for the treatment and/or prevention of fungal infections
GB201520990D0 (en) 2015-11-27 2016-01-13 Edixomed Ltd Dressing system
CA3020153A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
US10413505B1 (en) 2017-02-07 2019-09-17 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
US10149843B1 (en) 2017-02-07 2018-12-11 Gneus Lifescineces Inc. Pharmaceutical compositions and methods of using the same
US10231961B1 (en) 2017-02-07 2019-03-19 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
BR112021023832A8 (en) 2019-06-04 2023-02-28 Thirty Holdings Ltd METHODS AND COMPOSITIONS FOR THE GENERATION OF NITRIC OXIDE AND USES THEREOF
JP2023510662A (en) 2019-06-04 2023-03-15 サーティー レスピラトリー リミテッド Methods and compositions for producing nitric oxides and their use for delivering nitric oxides through the respiratory tract
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927030B2 (en) 2003-07-09 2015-01-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US9387224B2 (en) 2003-07-09 2016-07-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Treatment of specific cardiovascular conditions with nitrite
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8956658B2 (en) 2005-05-27 2015-02-17 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8962029B2 (en) 2005-05-27 2015-02-24 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9403851B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9403852B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
CN102369004A (en) * 2009-01-29 2012-03-07 香榭有限公司 Treatment of psoriasis
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same

Also Published As

Publication number Publication date
US20090036491A1 (en) 2009-02-05
AU2001284191B2 (en) 2006-02-16
US8128964B2 (en) 2012-03-06
EP1328252B1 (en) 2006-12-13
DE60125217D1 (en) 2007-01-25
DE60125217T2 (en) 2007-10-25
ES2275716T3 (en) 2007-06-16
JP4869540B2 (en) 2012-02-08
US8114442B2 (en) 2012-02-14
GB0021317D0 (en) 2000-10-18
AU2001284191C1 (en) 2002-03-13
ATE347879T1 (en) 2007-01-15
WO2002017881A2 (en) 2002-03-07
US20120183595A1 (en) 2012-07-19
AU8419101A (en) 2002-03-13
US20040013747A1 (en) 2004-01-22
EP1328252A2 (en) 2003-07-23
JP2004507486A (en) 2004-03-11
US20140187481A1 (en) 2014-07-03

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