WO2001098348A3 - Regulation of cellproliferation and differentiation using topically applied peptides - Google Patents

Regulation of cellproliferation and differentiation using topically applied peptides Download PDF

Info

Publication number
WO2001098348A3
WO2001098348A3 PCT/US2001/019650 US0119650W WO0198348A3 WO 2001098348 A3 WO2001098348 A3 WO 2001098348A3 US 0119650 W US0119650 W US 0119650W WO 0198348 A3 WO0198348 A3 WO 0198348A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulation
differentiation
cellproliferation
topically applied
hair growth
Prior art date
Application number
PCT/US2001/019650
Other languages
French (fr)
Other versions
WO2001098348A2 (en
Inventor
Michael F Holick
Original Assignee
Michael F Holick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael F Holick filed Critical Michael F Holick
Priority to EP01946566A priority Critical patent/EP1349564A2/en
Priority to CA002413860A priority patent/CA2413860A1/en
Priority to US10/311,366 priority patent/US20040022838A1/en
Priority to AU2001268594A priority patent/AU2001268594A1/en
Publication of WO2001098348A2 publication Critical patent/WO2001098348A2/en
Publication of WO2001098348A3 publication Critical patent/WO2001098348A3/en
Priority to US11/639,238 priority patent/US20070128265A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth

Abstract

Methods are disclosed for the regulation of cell differentiation and proliferation, e.g., for treating hyperproliferative skin disorder, such as psoriasis, for enhancing wound healing, for stimulation hair growth and inhibiting hair growth, by topical administration of parathyroid hormone (PTH), parathyroid related peptide (PTHrP), or fragment, analog or derivative thereof, and salts thereof, encapsulated by particular liposomes.
PCT/US2001/019650 2000-06-22 2001-06-20 Regulation of cellproliferation and differentiation using topically applied peptides WO2001098348A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01946566A EP1349564A2 (en) 2000-06-22 2001-06-20 Regulation of cellproliferation and differentiation using topically applied peptides
CA002413860A CA2413860A1 (en) 2000-06-22 2001-06-20 Regulation of cellproliferation and differentiation using topically applied peptides
US10/311,366 US20040022838A1 (en) 2001-06-20 2001-06-20 Regulation of cell proliferation and differentiation using topically applied peptides
AU2001268594A AU2001268594A1 (en) 2000-06-22 2001-06-20 Regulation of cellproliferation and differentiation using topically applied peptides
US11/639,238 US20070128265A1 (en) 2000-06-22 2006-12-15 Regulation of cell proliferation and differentiation using topically applied peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21324700P 2000-06-22 2000-06-22
US60/213,247 2000-06-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/639,238 Continuation US20070128265A1 (en) 2000-06-22 2006-12-15 Regulation of cell proliferation and differentiation using topically applied peptides

Publications (2)

Publication Number Publication Date
WO2001098348A2 WO2001098348A2 (en) 2001-12-27
WO2001098348A3 true WO2001098348A3 (en) 2003-07-31

Family

ID=22794320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019650 WO2001098348A2 (en) 2000-06-22 2001-06-20 Regulation of cellproliferation and differentiation using topically applied peptides

Country Status (4)

Country Link
EP (1) EP1349564A2 (en)
AU (1) AU2001268594A1 (en)
CA (1) CA2413860A1 (en)
WO (1) WO2001098348A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2472472A1 (en) 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
CN1822853A (en) * 2003-07-15 2006-08-23 加拿大国家研究委员会 Cyclic analogs of human parathyroid hormone for the treatment of conditions characterized by hyperproliferative skin cells
FR2857667B1 (en) 2003-07-18 2007-07-13 Inst Europ Biolog Cellulaire NEW PEPTIDE CONJUGATES USEFUL IN THE PREVENTIVE AND CURATIVE TREATMENT OF ALOPECIA
FR2857597B1 (en) 2003-07-18 2008-01-25 Inst Europeen Biolog Cellulair USE OF PEPTIDE CONJUGATES FOR THE PREPARATION OF COMPOSITIONS FOR THE PREVENTIVE AND CURATIVE TREATMENT OF ALOPECIA.
CN109182250A (en) * 2018-09-30 2019-01-11 山东省立医院 A kind of Cochlea of Mouse hair cell cultural method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692433A (en) * 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
US5260065A (en) * 1991-09-17 1993-11-09 Micro Vesicular Systems, Inc. Blended lipid vesicles
US5744128A (en) * 1995-05-03 1998-04-28 Holick; Michael F. Use of emu oil for stimulating skin and hair growth
US5965157A (en) * 1993-04-02 1999-10-12 Anticancer Inc. Method to provide for production of hair coloring pigments in hair follicles
WO2000018735A1 (en) * 1998-09-30 2000-04-06 The Procter & Gamble Company 2-substituted heterocyclic sulfonamides
US6066618A (en) * 1987-10-20 2000-05-23 Holick; Michael F. Regulation of cell proliferation and differentiation using peptides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692433A (en) * 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
US6066618A (en) * 1987-10-20 2000-05-23 Holick; Michael F. Regulation of cell proliferation and differentiation using peptides
US5260065A (en) * 1991-09-17 1993-11-09 Micro Vesicular Systems, Inc. Blended lipid vesicles
US5965157A (en) * 1993-04-02 1999-10-12 Anticancer Inc. Method to provide for production of hair coloring pigments in hair follicles
US5744128A (en) * 1995-05-03 1998-04-28 Holick; Michael F. Use of emu oil for stimulating skin and hair growth
WO2000018735A1 (en) * 1998-09-30 2000-04-06 The Procter & Gamble Company 2-substituted heterocyclic sulfonamides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HOLICK MICHEL F ET AL: "A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 91, no. 17, 1994, 1994, pages 8014 - 8016, XP002213035, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
CA2413860A1 (en) 2001-12-27
WO2001098348A2 (en) 2001-12-27
EP1349564A2 (en) 2003-10-08
AU2001268594A1 (en) 2002-01-02

Similar Documents

Publication Publication Date Title
CA2192944A1 (en) Stimulation of Hair Growth by Peptide-Copper Complexes
WO2003018748A3 (en) Anti-cancer and wound healing compounds
CA2404810A1 (en) Topical composition having undifferentiated plant seed cells and method for using same
AU6554594A (en) Method for delivering beneficial compositions to hair follicles
AU3434697A (en) Compounds with growth hormone releasing properties
WO1996012498A3 (en) Dermatological compositions containing benzoyl peroxide and a compound reducing skin irritation
MXPA01005549A (en) Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds.
EP2158907A3 (en) Topical administration of arginine for pain treatment
ES2190093T3 (en) USE OF A NEURTURINE PROTEIN PRODUCT TO PREVENT AND TREAT THE HEARING LOSS.
WO2005034883A3 (en) A method of healing skin wounds in mammals and a composition therefor
CA2315246A1 (en) Topical compositions for enhancing glutathione production
WO2000063246A3 (en) Compounds and methods for modulating beta-catenin mediated gene expression
DE69907577D1 (en) Anti-inflammatory composition
PL370795A1 (en) Composition based on etyllinoleate and triethylcitrate for the treatment of seborrhea and acne
WO2002028420A3 (en) Regulation of cell proliferation and differentiation using topically applied nucleic acid molecules
TW200407312A (en) Preparations for topical administration of substances having antiandrogenic activity
AU3902299A (en) Methods of treating microbial infection and therapeutic formulations therefor
CA2291144A1 (en) Topical treatment of psoriasis using neutralizing antibodies to il-8
CA2157836A1 (en) L-carnitine salt and cosmetic and pharmaceutical compositions containing same for treating dermatoses
WO2001098348A3 (en) Regulation of cellproliferation and differentiation using topically applied peptides
CA2267309A1 (en) Use of 1-hydroxy-2-pyridones for the treatment of skin infections
AU2002325710A1 (en) Effect of growth hormone and igf-1 on neural stem cells and therapeutic application
EP1281763A3 (en) Early growth response-1 (EGR-1) transcription factor
ES2137125A1 (en) Use of the zinc salt of glycyrrhetic acid in preparations against acne, and the compositions which contain said salt.
MXPA03011622A (en) Use of glycoprotein for the treatment and re-epithelialisation of wounds.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2413860

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001946566

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10311366

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001946566

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP