WO2001091826A2 - Cannula assembly for medical applications and method of manufacture - Google Patents

Cannula assembly for medical applications and method of manufacture Download PDF

Info

Publication number
WO2001091826A2
WO2001091826A2 PCT/US2001/017071 US0117071W WO0191826A2 WO 2001091826 A2 WO2001091826 A2 WO 2001091826A2 US 0117071 W US0117071 W US 0117071W WO 0191826 A2 WO0191826 A2 WO 0191826A2
Authority
WO
WIPO (PCT)
Prior art keywords
cannula
radius
roughened
bore
length
Prior art date
Application number
PCT/US2001/017071
Other languages
French (fr)
Other versions
WO2001091826A3 (en
Inventor
William E. Sagstetter
Original Assignee
Medical Safety Products, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Safety Products, Inc. filed Critical Medical Safety Products, Inc.
Priority to AU2001265005A priority Critical patent/AU2001265005B2/en
Priority to AU6500501A priority patent/AU6500501A/en
Priority to CA2409658A priority patent/CA2409658C/en
Priority to EP01939494.9A priority patent/EP1292353B1/en
Priority to JP2001587838A priority patent/JP2004525655A/en
Priority to MXPA02011657A priority patent/MXPA02011657A/en
Publication of WO2001091826A2 publication Critical patent/WO2001091826A2/en
Publication of WO2001091826A3 publication Critical patent/WO2001091826A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
    • B29C65/64—Joining a non-plastics element to a plastics element, e.g. by force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/343—Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/346—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub friction fit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
    • B21G—MAKING NEEDLES, PINS OR NAILS OF METAL
    • B21G1/00—Making needles used for performing operations
    • B21G1/08—Making needles used for performing operations of hollow needles or needles with hollow end, e.g. hypodermic needles, larding-needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/731—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the intensive physical properties of the material of the parts to be joined
    • B29C66/7316—Surface properties
    • B29C66/73161—Roughness or rugosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/74—Joining plastics material to non-plastics material
    • B29C66/742—Joining plastics material to non-plastics material to metals or their alloys
    • B29C66/7428—Transition metals or their alloys
    • B29C66/74283—Iron or alloys of iron, e.g. steel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2021/00—Use of unspecified rubbers as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/10—Polymers of propylene
    • B29K2023/12—PP, i.e. polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2025/00—Use of polymers of vinyl-aromatic compounds or derivatives thereof as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2027/00—Use of polyvinylhalogenides or derivatives thereof as moulding material
    • B29K2027/06—PVC, i.e. polyvinylchloride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2069/00—Use of PC, i.e. polycarbonates or derivatives thereof, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2305/00—Use of metals, their alloys or their compounds, as reinforcement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2305/00—Use of metals, their alloys or their compounds, as reinforcement
    • B29K2305/08—Transition metals
    • B29K2305/12—Iron
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7546—Surgical equipment
    • B29L2031/7548—Cannulas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining
    • Y10T29/49945—Assembling or joining by driven force fit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble
    • Y10T29/53313—Means to interrelatedly feed plural work parts from plural sources without manual intervention
    • Y10T29/53322—Means to assemble container
    • Y10T29/53339—Hypodermic syringe
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble
    • Y10T29/53313—Means to interrelatedly feed plural work parts from plural sources without manual intervention
    • Y10T29/53383—Means to interrelatedly feed plural work parts from plural sources without manual intervention and means to fasten work parts together
    • Y10T29/53396—Means to interrelatedly feed plural work parts from plural sources without manual intervention and means to fasten work parts together by friction fit

Definitions

  • the present application is directed generally to cannulas and specifically to the securement of the cannula to a hub member.
  • processes for manufacturing cannula assemblies must satisfy several requirements.
  • the process must have a low incidence of damaging the point of the cannula.
  • the process must have a low incidence of plugging the hollow passageway extending the length of the cannula.
  • the hub must hold onto the needle notwithstanding a film of lubricant such as silicone located on the needle.
  • the film of lubricant is placed on the needle to reduce the resistance of skin to puncture by the needle.
  • the process must provide a cannula assembly in which the minimum force required to push the cannula out of the hub is greater than forces associated with its intended use, thereby precluding disassociation of the cannula from the hub.
  • the standard manufacturing process for cannula assemblies to be used in medical applications typically includes numerous steps.
  • a first step the blunt end of the cannula is subjected to a grit blast to provide a roughened surface.
  • a suitable epoxy is applied to the roughened surface, and the roughened surface is then placed into a cylindrical passage in a hub.
  • the cylindrical passage has a number of peripherally disposed channels to contain the epoxy.
  • the narrower sections of the passage (disposed between the peripheral channels) typically have a radius larger than that of the roughened surface of the cannula.
  • the roughened surface permits the epoxy to form a strong bond between the peripherally disposed channels of the hub passage and the roughened end of the cannula.
  • the epoxy is than cured by a suitable process, such as by exposure to ultraviolet light, elevated temperatures (via radiant heating or induction heating), and the like.
  • a suitable process such as by exposure to ultraviolet light, elevated temperatures (via radiant heating or induction heating), and the like.
  • the epoxy can use a one stage curing process with air curing or a two stage curing process in which the epoxy is mixed with a hardener or other reactant to cause curing of the epoxy.
  • the hub is injection molded when the roughened surface is in the mold.
  • the present invention includes a cannula assembly having an interference fit between the cannula and a surface of a hub member.
  • the interference fit has sufficient strength that adhesives are not required to secure the cannula to the hub member.
  • the ability to manufacture a cannula assembly without using adhesives represents an -approximate 50% reduction in manufacturing costs and a significantly increased capacity for a given plant size compared to conventional manufacturing processes.
  • a method for manufacturing a cannula assembly including a hub member and a cannula includes the steps of:
  • a line-to-line fit refers to a relationship between the hub bore and adjacent portion of the cannula in which the outer diameter of the adjacent portion of the cannula is the same as or slightly less than the inner diameter of the bore
  • an interference fit refers to a relationship between the hub bore and adjacent portion of the cannula in which the outer diameter of the adjacent portion of the cannula is greater than the inner diameter of the hub bore.
  • the cannula and hub member can take on any number of configurations.
  • the cannula is typically elongated and can have any shape.
  • the cannula is typically formed from a metal such as a stainless steel.
  • the hub member can be in one or several pieces and can be of many differing shapes .
  • a preferred hub member configuration is shown in U. S . Patents 5 ,714, 125 and 5,910,289, which are incorporated herein fully by this reference.
  • the hub member is typically formed from a nontoxic plastic typically used for medical devices.
  • the forming step can be performed by any suitable process capable of roughening the outer surface of the cannula. Examples include (i) mechanical techniques such as grit blasting or contacting the outer surface with an abrasive medium; (ii) chemical techniques such as etching with an acid, and reacting the outer surface with an oxidant; and/or (iii) thermal techniques such as heating the outer surface to a softening temperature followed by deformation of the softened area to form a corrugated surface and the like.
  • mechanical techniques such as grit blasting or contacting the outer surface with an abrasive medium
  • chemical techniques such as etching with an acid, and reacting the outer surface with an oxidant
  • thermal techniques such as heating the outer surface to a softening temperature followed by deformation of the softened area to form a corrugated surface and the like.
  • the preferred depth of the grit blast creates an outer diameter of the grit blasted (roughened) portion of the cannula that is slightly greater than the inner diameter of the hub bore.
  • the outer diameter of the roughened portion is at least about 0.0001 inches, more typically at least about 0.0002 inches, and most typically at least about 0.0003 inches more than the smooth portion of the cannula.
  • the outer diameter of the roughened portion is typically no more than about .001 inches and more typically no more than about 0.0008 inches more than the smooth portion of the cannula.
  • the grit blasting is typically more circumferential than conventional grit blasting processes.
  • the roughened (enlarged) portion of the cannula extends at least about 320° around the circumference of the cannula.
  • the roughened portion of the cannula has a length and the cannula a total length.
  • the length of the roughened portion is from about 25 to about 50% of the total length.
  • the length of the roughened portion typically ranges from about 5 to about 50 mm and more typically from about 10 to about 25 mm.
  • the length of the smooth portion typically ranges from about 0.25 to about 0.75 inches.
  • the total length of the cannula typically ranges from about 0.5 to about 1 inches.
  • the tolerance between the radii of the roughened and smooth portions on the one hand and of the hub bore on the other is typically relatively small.
  • the radius of the smooth portion is at least about 5% and more typically at least about 10% less than the radius of the roughened portion
  • the radius of the hub bore ranges from about 75 to about 99% of the radius of the roughened portion and from about 100 to about 125% of the radius of the smooth portion.
  • the length of the roughened portion be substantially the same as the length of the hub bore.
  • the length of the interface between the hub bore and the roughened portion ranges from about 50 to about 100% of a length of the roughened portion.
  • the length of the roughened portion is preferably at least about 5 mm, more preferably at least about 7.5 mm, and even more preferably at least about 10 mm but not more than about 50 mm, more preferably not more than about 30 mm, and even more preferably not more than about 25 mm.
  • the hub in one configuration is made of an elastomeric material that elastically deforms (expands) when the roughened portion is forced into engagement with the inner wall of the bore.
  • the material has a flex modulus that is at least about 200,000 psi, more preferably at least about 225,000 psi, and even more preferably at least about 250,000 psi but no more than about 500,000 psi, more preferably no more than about 450,000 psi, and even more preferably no more than about 350,000 psi.
  • Particularly preferred materials include plastics such as polycarbonate, polystyrene, polypropylene, and poly(vinyl chloride).
  • the manufacturing process of the present invention is not only capable of producing cannula assemblies inexpensively and at a high throughput but also satisfies the above-noted requirements for medical applications.
  • the process can have a low incidence of damaging the point of the cannula due to the line-to-line engagement of the substantially smooth portion and the bore of the hub. Because the process does not utilize adhesives, the process cannot plug the hollow passageway extending the length of the cannula with adhesives.
  • the process can be effective in holding lubricant coated needles and can provide a cannula assembly in which the minimum force required to push the cannula out of the hub is five pounds or more. Surprisingly, it has been discovered that the roughened portion of the cannula, elastic wall of the hub bore, and lubricant act synergistically to provide a relatively high pushout force for the cannula assembly.
  • a medical device that includes:
  • a manufacturing method for a cannula assembly includes:
  • the insertion force required to bring the roughened portion into full engagement with the hub bore is at least about 5 pounds and more typically at least about 7.5 pounds.
  • Fig. 2 is a perspective view of a cannula after the grit blasting
  • Fig 3 is a rear view of the grit blasted cannula;
  • Fig 4 is a cross-sectional view taken along line 4-4 of Fig. 3;
  • Fig 5 is a perspective view of a hub member;
  • Fig 6 is a rear view of the hub member;
  • Fig 7 is a cross-sectional view taken along line 7-7 of Fig. 6;
  • Fig 8 is a view showing the cannula before insertion into the hub member bore, which is shown in the cross-sectional view of Fig. 7;
  • Fig. 9 is a view showing the substantially smooth portion of the cannula being inserted into the hub member bore, which is shown in the cross-sectional view of Fig. 7;
  • Fig. 10 is a view showing the roughened portion of the cannula being inserted into the hub member bore, which is shown in the cross-sectional view of Fig. 7;
  • Fig. 11 is a plan view of a hub member according to another embodiment of the present invention.
  • Fig. 12 is qross- sectional view of a hub member according to the embodiment of Fig. 11 with the cross-section being taken along line 12-12 of Fig. 11;
  • Fig. 13 is another cross-sectional view of the hub member of Fig. 11 with the cross- section being taken along line 13-13 of Fig. 11; and
  • Fig. 14 is an enlarged view of the portion of the hub member in Fig. 13 enclosed by the circle 14.
  • the cannula is formed by a suitable process. Such processes are conventional. Typically, the cannula is formed from a high strength, nontoxic material such as stainless steel. The cannula can be of any length or diameter, depending upon the application.
  • the proximal (nonpuncturing or unpointed or blunt) end of the cannula is grit blasted to form a roughened surface or roughened portion of the cannula.
  • the depth of the grit blast is sufficiently high to permit a strong (nonadhesive) bond to form between the hub member and the cannula.
  • the grit blast depth provides a radius for the roughened portion which creates an outer diameter greater than the inner diameter of the hub bore.
  • the outer diameter of the roughened portion preferably is a diameter permissive for insertion into the hub bore (e.g., with an insertion force of no more than about 25 pounds).
  • the roughened surface 28 of the cannula 32 has a slightly larger outer radius (R,) than the outer radius (R 2 ) of the substantially smooth portion 36 of the cannula.
  • the (average, mean, median, and/or mode) radius R j is larger than R 2 and more typically ranges from about 2.5 to about 30% more than R 2 , more typically from about 5 to about 30% more than R 2 , and even more typically ranges from about 10 to about 25% more than R 2 .
  • the radius R ⁇ will typically have slight fluctuations around the circumference of and along the length L GB of the roughened surface 28.
  • the length L GB of the roughened surface (Fig.2) (and of the interface between the hub bore and the roughened surface) must be sufficient for the cannula to be firmly positioned in the hub member bore.
  • the length L GB is from about 25 to about 75% and more typically from about 25 to about 50% of the total length L of the cannula.
  • the length L GB ranges from about 0.25 to about 1 inch and more typically from about 0.5 to about 1 inch.
  • the cannula includes a central bore 40 that is in communication with one or more inlets 44 for passing fluids, such as bodily fluids down the length L of the cannula.
  • the pointed end 48 is used to puncture a surface to permit fluids to pass through the inlet(s) 44, into the central bore 40, and through the outlet 52 into a collection vessel.
  • the cannula 32 is inserted in step
  • the cannula is inserted concentrically into the bore 60 at the rear 72 of the hub member 64 so that the substantially smooth portion 36 of the cannula 32 initially passes down the bore 60 in a line-to-line fit, and the roughened surface 28 subsequently engages the bore 60 in an interference (or friction) fit.
  • the close tolerances between the radii of the surfaces 28 and 36 on the one hand and the bore wall 60 on the other prevents the cannula from digging too much into the bore wall 60.
  • the insertion force required to insert the cannula into the bore 60 is typically no more than about 25 pounds and more typically ranges from about 5 to about 20 pounds. As will be appreciated, the use of too strong an insertion force can bend or deform the cannula.
  • the insertion force is typically less than the force required to dislodge the cannula from the cannula assembly.
  • the cylindrical outer surface of the portion 36 is substantially parallel to, concentric with, and in close tolerance with the cylindrical inner surface 76 of the bore 60.
  • the radius R H of the bore 60 is substantially the same as the radius R 2 of the cannula portion 36 and more typically ranges from about 100 to about 125% of the radius R 2 and even more typically ranges from about 100 to about 120% of the radius R 2 . h most applications, the radius R H ranges from about 0.5 to about 1.5 mm and even more typically from about 0.75 to about 1.25 mm.
  • the cylindrical outer surface of the surface 28 is also substantially parallel to, concentric with, and in close tolerance with the cylindrical inner surface 76 of the bore 60.
  • the radius R H of the bore 60 is substantially less than (average, mean, median, and/or mode) the radius R ⁇ of the cannula portion 28 and more typically ranges from about 75 to about 99% of the (average, mean, median, and/or mode) radius R j and even more typically ranges from about 90 to about 99% of the radius (average, mean, median, and/or
  • the length L GB is typically close to the length L H of the hub bore. More typically, the bore length Lg ranges from about 50 to about 150% of the length L GB and even more typically from about 75 to about 125% of the length 3B-
  • the final product 90 has many desirable characteristics.
  • the force required to remove the cannula from the hub member is typically more than required for functional use of the cannula assembly.
  • a hub member according to another embodiment is depicted in Figs. 11-14.
  • the hub member is of the type disclosed in U.S. Patents 5,714,125 and 5,910,289.
  • the hub member includes a number of inwardly facing ribs lOOa-h radiating from a center 104.
  • a hub bore 108 extends through a lower portion of the hub member body and opens into a drainage passage 112 located at a lower or proximal end of the hub member to facilitate drainage of fluids from the distal end of the hub member to the proximal end.
  • At least most of the roughened portion of the cannula engages the wall of the hub bore 108.
  • the pointed end 48 of the cannula extends into the distal end of the hub member while the blunt end of the cannula is positioned in the drainage passage in the proximal end of the cannula.
  • a flexible segment tube containing a bodily fluid such as blood is punctured by the pointed end of the cannula and the fluid in the tube flows through a passageway extending the length of the cannula and through the blunt end into a suitable receptacle.
  • the interference fit between the roughened section of the cannula and the bore 108 is sufficient to eliminate the use of an adhesive to hold the cannula in the hub member, even while the cannula is being inserted into the flexible segment tube.
  • the assembly is manufactured by inserting the pointed end 48 first into the drainage passage 112 and then into the bore 108 followed by the roughened portion until the roughened portion engages the bore wall.
  • the ribs 1 OOa-h restrict the lateral forces that are applied to the pointed end 48 of the cannula when a fluid-containing receptacle, such as a flexible segment tube containing a blood sample, is inserted into the distal end of the hub member for puncturing by the pointed end 48 and drainage through the drainage passage of the cannula.

Abstract

The present invention is directed to a process for inserting a cannula (32) into a hub member (64). The process uses an interference or frictional fit between the bore (60) of the hub member (64) and a roughened portion of the cannula's exterior surface (28). In this manner, adhesives are not required in the assembly of the two components.

Description

IMPROVED NEEDLE DESIGN AND MANUFACTURING METHOD FOR MEDICAL APPLICATIONS
FIELD OF THE INVENTION The present application is directed generally to cannulas and specifically to the securement of the cannula to a hub member.
BACKGROUND OF THE INVENTION To be acceptable, processes for manufacturing cannula assemblies, which include a hub and cannula, must satisfy several requirements. For example, the process must have a low incidence of damaging the point of the cannula. Second, the process must have a low incidence of plugging the hollow passageway extending the length of the cannula. Third, the hub must hold onto the needle notwithstanding a film of lubricant such as silicone located on the needle. As will be appreciated, the film of lubricant is placed on the needle to reduce the resistance of skin to puncture by the needle. Fourth, the process must provide a cannula assembly in which the minimum force required to push the cannula out of the hub is greater than forces associated with its intended use, thereby precluding disassociation of the cannula from the hub.
The standard manufacturing process for cannula assemblies to be used in medical applications typically includes numerous steps. In a first step, the blunt end of the cannula is subjected to a grit blast to provide a roughened surface. A suitable epoxy is applied to the roughened surface, and the roughened surface is then placed into a cylindrical passage in a hub. The cylindrical passage has a number of peripherally disposed channels to contain the epoxy. The narrower sections of the passage (disposed between the peripheral channels) typically have a radius larger than that of the roughened surface of the cannula. The roughened surface permits the epoxy to form a strong bond between the peripherally disposed channels of the hub passage and the roughened end of the cannula. The epoxy is than cured by a suitable process, such as by exposure to ultraviolet light, elevated temperatures (via radiant heating or induction heating), and the like. Alternatively, the epoxy can use a one stage curing process with air curing or a two stage curing process in which the epoxy is mixed with a hardener or other reactant to cause curing of the epoxy. In another process, the hub is injection molded when the roughened surface is in the mold. Further, detail on conventional manufacturing processes is contained in U.S. Patents 4,581,024; 4,655,764; 5,026,355; 5,215,621; and 5,207,853, each ofwhich is incorporated herein by this reference. These processes can have a number of drawbacks. First, there can be incompatability with the epoxies used to secure the cannula to the hub and the plastic material in the hub. Second, the need to cure some adhesives using ultraviolet curing requires a hub that is substantially transparent. This requirement imposes further substantial limitations on the types of plastics that can be used to form the hub. The use of a thermal cure of the adhesive can cause physical or chemical changes of the plastic which can undesirably alter the physical characteristics (e.g., strength) of the material. In addition, all the above processes require extra time in to manufacture a cannula assembly, which significantly increases costs.
SUMMARY OF THE INVENTION
These and other problems are addressed by the method and device configurations of the present invention. Generally, the present invention includes a cannula assembly having an interference fit between the cannula and a surface of a hub member. The interference fit has sufficient strength that adhesives are not required to secure the cannula to the hub member. In some cases, the ability to manufacture a cannula assembly without using adhesives represents an -approximate 50% reduction in manufacturing costs and a significantly increased capacity for a given plant size compared to conventional manufacturing processes.
In a first embodiment of the present invention, a method for manufacturing a cannula assembly including a hub member and a cannula is provided. The method includes the steps of:
(a) forming (e.g., by grit blasting) a roughened exterior surface on a portion of the cannula to yield a roughened portion of the cannula such that the roughened portion is adjacent to an unroughened or substantially smooth (e.g., non-grit blasted) portion of the exterior surface of the cannula; and
(b) inserting the roughened portion of the cannula into a central bore of a hub (typically after the smooth portion is inserted into the central bore), wherein a radius of the smooth portion is substantially the same as a radius of the hub bore to form a line-to-line fit between the wall of the bore and the adjacent surface of the smooth portion of the cannula and the radius of the roughened portion is slightly larger than the bore radius to form an interference fit between the wall of the bore and the adjacent, roughened portion of the cannula. As used herein, a line-to-line fit refers to a relationship between the hub bore and adjacent portion of the cannula in which the outer diameter of the adjacent portion of the cannula is the same as or slightly less than the inner diameter of the bore, and an interference fit refers to a relationship between the hub bore and adjacent portion of the cannula in which the outer diameter of the adjacent portion of the cannula is greater than the inner diameter of the hub bore.
The cannula and hub member can take on any number of configurations. The cannula is typically elongated and can have any shape. The cannula is typically formed from a metal such as a stainless steel. The hub member can be in one or several pieces and can be of many differing shapes . A preferred hub member configuration is shown in U. S . Patents 5 ,714, 125 and 5,910,289, which are incorporated herein fully by this reference. The hub member is typically formed from a nontoxic plastic typically used for medical devices.
The forming step can be performed by any suitable process capable of roughening the outer surface of the cannula. Examples include (i) mechanical techniques such as grit blasting or contacting the outer surface with an abrasive medium; (ii) chemical techniques such as etching with an acid, and reacting the outer surface with an oxidant; and/or (iii) thermal techniques such as heating the outer surface to a softening temperature followed by deformation of the softened area to form a corrugated surface and the like.
When grit blasting is employed to roughen the outer surface of the cannula, the preferred depth of the grit blast creates an outer diameter of the grit blasted (roughened) portion of the cannula that is slightly greater than the inner diameter of the hub bore. Typically, the outer diameter of the roughened portion is at least about 0.0001 inches, more typically at least about 0.0002 inches, and most typically at least about 0.0003 inches more than the smooth portion of the cannula. The outer diameter of the roughened portion is typically no more than about .001 inches and more typically no more than about 0.0008 inches more than the smooth portion of the cannula. The grit blasting is typically more circumferential than conventional grit blasting processes. Preferably, the roughened (enlarged) portion of the cannula extends at least about 320° around the circumference of the cannula. In one configuration, the roughened portion of the cannula has a length and the cannula a total length. The length of the roughened portion is from about 25 to about 50% of the total length. The length of the roughened portion typically ranges from about 5 to about 50 mm and more typically from about 10 to about 25 mm. The length of the smooth portion typically ranges from about 0.25 to about 0.75 inches. The total length of the cannula typically ranges from about 0.5 to about 1 inches. To provide a strong interference fit, the tolerance between the radii of the roughened and smooth portions on the one hand and of the hub bore on the other is typically relatively small. In one configuration, the radius of the smooth portion is at least about 5% and more typically at least about 10% less than the radius of the roughened portion, h yet another configuration, the radius of the hub bore ranges from about 75 to about 99% of the radius of the roughened portion and from about 100 to about 125% of the radius of the smooth portion.
It is preferred that the length of the roughened portion be substantially the same as the length of the hub bore. In one configuration, the length of the interface between the hub bore and the roughened portion ranges from about 50 to about 100% of a length of the roughened portion. In the configuration, the length of the roughened portion is preferably at least about 5 mm, more preferably at least about 7.5 mm, and even more preferably at least about 10 mm but not more than about 50 mm, more preferably not more than about 30 mm, and even more preferably not more than about 25 mm.
To further enhance the retention forces between the roughened portion and the adjoining hub bore, the hub in one configuration is made of an elastomeric material that elastically deforms (expands) when the roughened portion is forced into engagement with the inner wall of the bore. Preferably, the material has a flex modulus that is at least about 200,000 psi, more preferably at least about 225,000 psi, and even more preferably at least about 250,000 psi but no more than about 500,000 psi, more preferably no more than about 450,000 psi, and even more preferably no more than about 350,000 psi. Particularly preferred materials include plastics such as polycarbonate, polystyrene, polypropylene, and poly(vinyl chloride).
The manufacturing process of the present invention is not only capable of producing cannula assemblies inexpensively and at a high throughput but also satisfies the above-noted requirements for medical applications. The process can have a low incidence of damaging the point of the cannula due to the line-to-line engagement of the substantially smooth portion and the bore of the hub. Because the process does not utilize adhesives, the process cannot plug the hollow passageway extending the length of the cannula with adhesives. The process can be effective in holding lubricant coated needles and can provide a cannula assembly in which the minimum force required to push the cannula out of the hub is five pounds or more. Surprisingly, it has been discovered that the roughened portion of the cannula, elastic wall of the hub bore, and lubricant act synergistically to provide a relatively high pushout force for the cannula assembly.
In a second embodiment of the present invention, a medical device is provided that includes:
(a) a cannula having an exterior surface having a roughened portion and an unroughened portion; and
(b) a hub member having an elastic bore, at least the roughened portion of the cannula being received in the elastic bore, wherein the bore has a radius such that an interference fit exists between the roughened surface of the cannula located in the bore and the surface of the bore. In a third embodiment, a manufacturing method for a cannula assembly is provided that includes:
(a) grit blasting a portion of the cannula such that the grit blasted portion of the cannula's exterior surface is roughened relative to a non-grit blasted portion of the exterior surface that is substantially smooth; (b) inserting the substantially smooth portion of the cannula into a bore of a hub member;
(c) forcing the substantially smooth portion to pass through the bore;
(d) inserting the grit blasted portion of the cannula into the hub bore; and
(e) forcing at least most of the grit blasted portion of the cannula into an interference fit with the hub bore. In one configuration, the insertion force required to bring the roughened portion into full engagement with the hub bore is at least about 5 pounds and more typically at least about 7.5 pounds.
The foregoing list of embodiments is neither complete nor exhaustive. As will be obvious to one of ordinary skill in the art, a number of other embodiments are possible that include one or more of the above-noted features. Such embodiments are considered to be included within the scope of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a flow schematic of an embodiment of a process according to the present invention;
Fig. 2 is a perspective view of a cannula after the grit blasting;
Fig 3 is a rear view of the grit blasted cannula; Fig 4 is a cross-sectional view taken along line 4-4 of Fig. 3; Fig 5 is a perspective view of a hub member; Fig 6 is a rear view of the hub member; Fig 7 is a cross-sectional view taken along line 7-7 of Fig. 6; Fig 8 is a view showing the cannula before insertion into the hub member bore, which is shown in the cross-sectional view of Fig. 7;
Fig. 9 is a view showing the substantially smooth portion of the cannula being inserted into the hub member bore, which is shown in the cross-sectional view of Fig. 7;
Fig. 10 is a view showing the roughened portion of the cannula being inserted into the hub member bore, which is shown in the cross-sectional view of Fig. 7;
Fig. 11 is a plan view of a hub member according to another embodiment of the present invention;
Fig. 12 is qross- sectional view of a hub member according to the embodiment of Fig. 11 with the cross-section being taken along line 12-12 of Fig. 11; Fig. 13 is another cross-sectional view of the hub member of Fig. 11 with the cross- section being taken along line 13-13 of Fig. 11; and
Fig. 14 is an enlarged view of the portion of the hub member in Fig. 13 enclosed by the circle 14.
DETAILED DESCRIPTION
The manufacturing process of the present invention will be described with reference to Figure 1. In the first step 20, the cannula is formed by a suitable process. Such processes are conventional. Typically, the cannula is formed from a high strength, nontoxic material such as stainless steel. The cannula can be of any length or diameter, depending upon the application. In the second step 24, the proximal (nonpuncturing or unpointed or blunt) end of the cannula is grit blasted to form a roughened surface or roughened portion of the cannula.
The depth of the grit blast is sufficiently high to permit a strong (nonadhesive) bond to form between the hub member and the cannula. Typically, the grit blast depth provides a radius for the roughened portion which creates an outer diameter greater than the inner diameter of the hub bore. However, the outer diameter of the roughened portion preferably is a diameter permissive for insertion into the hub bore (e.g., with an insertion force of no more than about 25 pounds).
Referring to Figs. 2 through 4, the roughened surface 28 of the cannula 32 has a slightly larger outer radius (R,) than the outer radius (R2) of the substantially smooth portion 36 of the cannula. Typically, the (average, mean, median, and/or mode) radius Rj is larger than R2 and more typically ranges from about 2.5 to about 30% more than R2, more typically from about 5 to about 30% more than R2, and even more typically ranges from about 10 to about 25% more than R2. Because of the irregular nature of the roughened surface 28, the radius Rλ will typically have slight fluctuations around the circumference of and along the length LGB of the roughened surface 28.
The length LGB of the roughened surface (Fig.2) (and of the interface between the hub bore and the roughened surface) must be sufficient for the cannula to be firmly positioned in the hub member bore. Typically, the length LGB is from about 25 to about 75% and more typically from about 25 to about 50% of the total length L of the cannula. Typically, the length LGB ranges from about 0.25 to about 1 inch and more typically from about 0.5 to about 1 inch.
As will be appreciated, the cannula includes a central bore 40 that is in communication with one or more inlets 44 for passing fluids, such as bodily fluids down the length L of the cannula. The pointed end 48 is used to puncture a surface to permit fluids to pass through the inlet(s) 44, into the central bore 40, and through the outlet 52 into a collection vessel.
Referring again to Fig. 1 and to Figs. 5 through 10, the cannula 32 is inserted in step
56 into a bore 60 of the hub member 64 and passed in the direction shown through the length of the bore 60 such that the roughened surface 28 engages the interior wall 76 of the bore 60.
The cannula is inserted concentrically into the bore 60 at the rear 72 of the hub member 64 so that the substantially smooth portion 36 of the cannula 32 initially passes down the bore 60 in a line-to-line fit, and the roughened surface 28 subsequently engages the bore 60 in an interference (or friction) fit. The close tolerances between the radii of the surfaces 28 and 36 on the one hand and the bore wall 60 on the other prevents the cannula from digging too much into the bore wall 60. In this manner, the insertion force required to insert the cannula into the bore 60 is typically no more than about 25 pounds and more typically ranges from about 5 to about 20 pounds. As will be appreciated, the use of too strong an insertion force can bend or deform the cannula. The insertion force is typically less than the force required to dislodge the cannula from the cannula assembly. The cylindrical outer surface of the portion 36 is substantially parallel to, concentric with, and in close tolerance with the cylindrical inner surface 76 of the bore 60. Typically, the radius RH of the bore 60 is substantially the same as the radius R2 of the cannula portion 36 and more typically ranges from about 100 to about 125% of the radius R2 and even more typically ranges from about 100 to about 120% of the radius R2. h most applications, the radius RH ranges from about 0.5 to about 1.5 mm and even more typically from about 0.75 to about 1.25 mm.
The cylindrical outer surface of the surface 28 is also substantially parallel to, concentric with, and in close tolerance with the cylindrical inner surface 76 of the bore 60. Typically, the radius RH of the bore 60 is substantially less than (average, mean, median, and/or mode) the radius R{ of the cannula portion 28 and more typically ranges from about 75 to about 99% of the (average, mean, median, and/or mode) radius Rj and even more typically ranges from about 90 to about 99% of the radius (average, mean, median, and/or
To provide adequate contact surface to form a strong (nonadhesive or nonfrictional) bond between the hub member 64 and the cannula 32, the length LGB is typically close to the length LH of the hub bore. More typically, the bore length Lg ranges from about 50 to about 150% of the length LGB and even more typically from about 75 to about 125% of the length 3B-
Referring again to Fig. 1 , the final product 90 has many desirable characteristics. The force required to remove the cannula from the hub member is typically more than required for functional use of the cannula assembly. A hub member according to another embodiment is depicted in Figs. 11-14. The hub member is of the type disclosed in U.S. Patents 5,714,125 and 5,910,289. The hub member includes a number of inwardly facing ribs lOOa-h radiating from a center 104. A hub bore 108 extends through a lower portion of the hub member body and opens into a drainage passage 112 located at a lower or proximal end of the hub member to facilitate drainage of fluids from the distal end of the hub member to the proximal end. At least most of the roughened portion of the cannula (not shown) engages the wall of the hub bore 108. The pointed end 48 of the cannula extends into the distal end of the hub member while the blunt end of the cannula is positioned in the drainage passage in the proximal end of the cannula. A flexible segment tube containing a bodily fluid such as blood is punctured by the pointed end of the cannula and the fluid in the tube flows through a passageway extending the length of the cannula and through the blunt end into a suitable receptacle. As noted, the interference fit between the roughened section of the cannula and the bore 108 is sufficient to eliminate the use of an adhesive to hold the cannula in the hub member, even while the cannula is being inserted into the flexible segment tube. The assembly is manufactured by inserting the pointed end 48 first into the drainage passage 112 and then into the bore 108 followed by the roughened portion until the roughened portion engages the bore wall. The ribs 1 OOa-h restrict the lateral forces that are applied to the pointed end 48 of the cannula when a fluid-containing receptacle, such as a flexible segment tube containing a blood sample, is inserted into the distal end of the hub member for puncturing by the pointed end 48 and drainage through the drainage passage of the cannula.
The foregoing description of the present invention has been presented for purposes of illustration and description. Furthermore, the description is not intended to limit the invention to the form disclosed herein. Consequently, variations and modifications commensurate with the above teachings, in the skill or knowledge of the relevant art, are within the scope of the present invention. The embodiments described here and above are further intended to explain best modes for practicing the invention and to enable others skilled in the art to utilize the invention in such, or other, embodiments and with various modifications required by the particular applications or uses of the present invention. It is intended that the appended claims be construed to include alternative embodiments to the extent permitted by the prior art.

Claims

What is claimed is:
1. A method for manufacturing a cannula assembly including a hub member and a cannula, comprising the steps of: forming a roughened exterior surface on a portion of the cannula such that the roughened portion of the cannula is roughened and another portion of the exterior surface of the cannula is substantially smooth; and inserting the roughened portion of the cannula into a central bore of a hub, wherein a radius of the roughened portion is larger than a radius of the hub bore to form an interference fit therebetween.
2. The method of Claim 1, wherein the forming step includes grit blasting the portion of the cannula.
3. The method of Claim 2, wherein the roughened exterior surface extends substantially completely around a circumference of the cannula.
4. The method of Claim 1 , wherein the roughened portion has a length and the cannula a total length and the length of the roughened portion is from about 25 to about 50% of the total length.
5. The method of Claim 1, wherein the hub is formed from an elastic material such that the central bore expands elastically when the roughened portion engages the wall of the central bore.
6. The method of Claim 1 , wherein the roughened portion has a radius and the radius is from about 2.5 to about 30% more than the radius of the substantially smooth portion.
7. The method of Claim 1, wherein the hub member is formed from a material having a flex modulus ranging from about 200,000 psi to about 500,000 psi.
8. The method of Claim 1, wherein the radius of the hub bore is from about 75 to about 99% of the radius of the roughened portion of the cannula.
9. The method of Claim 1 , wherein the radius of the hub bore is from about 100 to about 125% of the radius of the substantially smooth portion of the cannula.
10. The method of Claim 1 , wherein the radius of the roughened portion is at least about 0.0001 inches more than the radius of the hub bore.
11. The method of Claim 1 , wherein a length of an interface between the hub bore and roughened portion ranges from about 5 to about 50 mm.
12. The method of Claim 1, wherein a length of the roughened portion ranges from about 5 to about 50 mm.
13. The method of Claim 1, wherein the bore has a length and the length of the bore is substantially the same as the length of the roughened portion.
14. A cannula assembly manufactured by the method of Claim 1.
15. The method of Claim 1, wherein the cannula has a pointed end to puncture a surface.
16. A medical device, comprising:
(a) a cannula having an exterior surface, with a roughened portion of the exterior surface being roughened and having a radius and a substantially smooth portion of the exterior surface being substantially smooth and having a radius; and
(b) a hub member having a bore, at least the roughened portion of the cannula being received in the bore, wherein the bore has a radius such that an interference fit exists between the exterior surface of the cannula located in the bore and the surface of the bore.
17. The device of Claim 15, wherein the roughened exterior surface extends substantially completely around a circumference of the cannula.
18. The device of Claim 15, wherein the roughened portion has a length and the cannula a total length and the length of the roughened portion is from about 25 to about 50% of the total length.
19. The device of Claim 15, wherein the hub is formed from an elastic material such that the central bore expands elastically when the roughened portion engages the wall of the central bore.
20. The device of Claim 15, wherein the roughened portion has a radius and the radius is from about 2.5 to about 30% more than the radius of the substantially smooth portion.
21. The device of Claim 15 , wherein the hub member is formed from a material having a flex modulus ranging from about 200,000 psi to about 500,000 psi.
22. The device of Claim 15, wherein the radius of the hub bore is from about 75 to about 99% of the second radius.
23. The device of Claim 15, wherein the radius of the hub bore is from about 100 to about 125% of the radius of the substantially smooth portion of the cannula.
24. The device of Claim 15, wherein the radius of the roughened portion is at least about 0.0001 inches more than the radius of the hub bore.
25. The device of Claim 15, wherein a length of aninterface between the hub bore and roughened portion ranges from about 5 to about 50 mm.
26. The device of Claim 15, wherein a length of the roughened portion ranges from about 5 to about 50 mm.
27. The device of Claim 15, wherein the roughened portion has a length that ranges from about 5 to about 50 mm.
28. The device of Claim 15, wherein the hub bore is substantially free of an adhesive.
29. The device of Claim 17, wherein the bore has a length and the length of the bore is substantially the same as the length of the roughened portion.
30. The device of Claim 15, wherein the hub member possess a plurality of ribs, said plurality of ribs extending from said hub bore such that said plurality of ribs lessen lateral forces applied to said cannula.
31. A method for manufacturing a cannula assembly including a hub member and a cannula, comprising the steps of: grit blasting a portion of the cannula such that the grit blasted portion of the cannula's exterior surface is roughened relative to a portion of the exterior surface that is substantially smooth; inserting the substantially smooth portion of the cannula into a bore of a hub member; forcing the substantially smooth portion to pass through the bore; inserting the grit blasted portion of the cannula into the hub bore; and forcing at least most of the grit blasted portion of the cannula into a frictional fit with the hub bore.
32. The method of Claim 31, wherein the roughened exterior surface extends substantially completely around a circumference of the cannula.
33. The method of Claim 31 , wherein the roughened portion has a length and the cannula a total length and the length of the roughened portion is from about 25 to about 50% of the total length.
34. The method of Claim 31 , wherein the hub is formed from an elastic material such that the central bore expands elastically when the roughened portion engages the wall of the central bore.
35. The method of Claim 31 , wherein the roughened portion has a radius and the radius is from about 2.5 to about 30% more than the radius of the substantially smooth portion.
36. The method of Claim 31 , wherein the hub member is formed from a material having a flex modulus ranging from about 200,000 psi to about 500,000 psi.
37. The method of Claim 31, wherein the radius of the hub bore is from about 75 to about 99% of the radius of the roughened portion of the cannula.
38. The method of Claim 31 , wherein the radius of the hub bore is from about 100 to about 125% of the radius of the substantially smooth portion of the cannula.
39. The method of Claim 31 , wherein the radius of the roughened portion is at least about 0.0001 inches more than the radius of the hub bore.
40. The method of Claim 31, wherein a length of an interface between the hub bore and roughened portion ranges from about 5 to about 50 mm.
41. The method of Claim 31 , wherein a length of the roughened portion ranges from about 5 to about 50 mm.
42. The method of Claim 31 , wherein the bore has a length and the length of the bore is substantially the same as the length of the roughened portion.
43. A medical device, comprising: (a) a cannula having an exterior surface, with a roughened portion of the exterior surface being roughened and having a radius and a substantially smooth portion of the exterior surface being substantially smooth and having a radius; and
(b) a hub member having a bore, at least the roughened portion of the cannula being received in the bore, wherein the bore is substantially free of adhesive.
44. A medical device according to claim 43, wherein the bore has a radius such that an interference fit exists between the exterior surface of the cannula located in the bore and the surface of the bore.
45. The device of Claim 43, wherein the roughened exterior surface extends substantially completely around a circumference of the cannula.
46. The device of Claim 43 , wherein the roughened portion has a length and the cannula a total length and the length of the roughened portion is from about 25 to about 50% of the total length.
47. The device of Claim 43, wherein the hub is formed from an elastic material such that the central bore expands elastically when the roughened portion engages the wall of the central bore.
48. The device of Claim 43 , wherein the roughened portion has a radius and the radius is from about 2.5 to about 30% more than the radius of the substantially smooth portion.
49. The device of Claim 43, wherein the hub member is formed from a material having a flex modulus ranging from about 200,000 psi to about 500,000 psi.
50. The device of Claim 43, wherein the radius of the hub bore is from about 75 to about 99% of the second radius.
51. The device of Claim 43 , wherein the radius of the hub bore is from about 100 to about 125% of the radius of the substantially smooth portion of the cannula.
52. The device of Claim 43, wherein the radius of the roughened portion is at least about 0.0001 inches more than the radius of the hub bore.
53. The device of Claim 43 , wherein a length of an interface between the hub bore and roughened portion ranges from about 5 to about 50 mm.
54. The device of Claim 43, wherein a length of the roughened portion ranges from about 5 to about 50 mm.
55. The device of Claim 43, wherein the roughened portion has a length that ranges from about 5 to about 50 mm.
56. The device of Claim 43, wherein the bore has a length and the length of the bore is substantially the same as the length of the roughened portion.
57. The device of Claim 43 , wherein the hub member possess a plurality of ribs, said plurality of ribs extending from said hub bore such that said plurality of ribs lessen lateral forces applied to said cannula.
58. A method of manufacturing a cannula assembly including a hub member and a cannula, comprising the steps of: a roughening means for roughening a first portion but not a second portion of an exterior surface of the cannula such that the first portion is roughened and the second portion is substantially smooth; an insertion means for inserting the roughened first portion of the cannula into a central bore of the hub member, wherein a radius of the roughened first portion is larger than a radius of the central bore to form an interference fit therebetween.
59. The method of Claim 58 , wherein the roughening means includes grit blasting means for grit blasting the first portion of the cannula.
60. The method of Claim 58, wherein the roughened first portion extends substantially completely around a circumference of the cannula.
61. The method of Claim 58, wherein the roughened first portion has a length and the cannula a total length and the length of the roughened first portion is from about 25 to about 50% of the total length.
62. The method of Claim 58, wherein the hub is formed from an elastic material such that the central bore expands elastically when the roughened first portion engages the wall of the central bore.
63. The method of Claim 58, wherein the roughened first portion has a radius and the radius is from about 2.5 to about 30% more than the radius of the substantially smooth second portion.
64. The method of Claim 58, wherein the hub member is formed from a material having a flex modulus ranging from about 200,000 psi to about 500,000 psi.
65. The method of Claim 58, wherein the radius of the hub bore is from about 75 to about 99% of the radius of the roughened first portion of the cannula.
66. The method of Claim 58, wherein the radius of the hub bore is from about 100 to about 125% of the radius of the substantially smooth second portion of the cannula.
67. The method of Claim 58, wherein the radius of the roughened first portion is at least about 0.0001 inches more than the radius of the hub bore.
68 The method of Claim 58, wherein a length of an interface between the hub bore and roughened first portion ranges from about 5 to about 50 mm.
69. The method of Claim 58, wherein a length of the roughened first portion ranges from about 5 to about 50 mm.
70. The method of Claim 58, wherein the bore is substantially free of adhesive.
PCT/US2001/017071 2000-05-26 2001-05-25 Cannula assembly for medical applications and method of manufacture WO2001091826A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2001265005A AU2001265005B2 (en) 2000-05-26 2001-05-25 Improved needle design and manufacturing method for medical applications
AU6500501A AU6500501A (en) 2000-05-26 2001-05-25 Improved needle design and manufacturing method for medical applications
CA2409658A CA2409658C (en) 2000-05-26 2001-05-25 Cannula assembly for medical applications and method of manufacture
EP01939494.9A EP1292353B1 (en) 2000-05-26 2001-05-25 Improved needle design and manufacturing method for medical applications
JP2001587838A JP2004525655A (en) 2000-05-26 2001-05-25 Cannula assembly and method of manufacture for medical applications
MXPA02011657A MXPA02011657A (en) 2000-05-26 2001-05-25 Cannula assembly for medical applications and method of manufacture.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20770900P 2000-05-26 2000-05-26
US60/207,709 2000-05-26

Publications (2)

Publication Number Publication Date
WO2001091826A2 true WO2001091826A2 (en) 2001-12-06
WO2001091826A3 WO2001091826A3 (en) 2002-04-04

Family

ID=22771673

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/017071 WO2001091826A2 (en) 2000-05-26 2001-05-25 Cannula assembly for medical applications and method of manufacture

Country Status (8)

Country Link
US (2) US6709428B2 (en)
EP (1) EP1292353B1 (en)
JP (1) JP2004525655A (en)
CN (1) CN1533289A (en)
AU (2) AU6500501A (en)
CA (1) CA2409658C (en)
MX (1) MXPA02011657A (en)
WO (1) WO2001091826A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3257535A1 (en) * 2016-06-17 2017-12-20 Terumo Europe NV Needle assembly and syringe containing the same

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047593A1 (en) * 1999-12-24 2001-07-05 Toray Industries, Inc. Catheter with balloon
ATE373992T1 (en) * 2003-07-07 2007-10-15 Coraflo Ltd Liab Co HIGH PERFORMANCE CANNULAES
ES2568494T3 (en) * 2004-07-20 2016-04-29 Becton Dickinson And Company Blood sampling set
GB0503083D0 (en) * 2005-02-15 2005-03-23 Engineering Business Ltd Launch and recovery apparatus and method
US20090062750A1 (en) * 2007-08-27 2009-03-05 Morteza Gharib Medical device for injecting a local anesthetic
US8118736B2 (en) * 2007-09-27 2012-02-21 Swan Valley Medical, Incorporated Method of accessing a bladder and associated apparatus therefor
WO2009067648A1 (en) * 2007-11-21 2009-05-28 Becton, Dickinson And Company Safety needle guard
EP2227281B1 (en) * 2007-11-21 2020-02-26 Becton, Dickinson and Company Needle safety device
US8721603B2 (en) 2008-01-15 2014-05-13 West Pharmaceutical Services, Inc. Syringe with co-molded hub and cannula
EP2484401A1 (en) * 2008-01-15 2012-08-08 West Pharmaceutical Services, Inc. A cannula with a syringe barrel
US8915890B2 (en) 2009-07-30 2014-12-23 Becton, Dickinson And Company Medical device assembly
US8568308B2 (en) 2009-08-14 2013-10-29 Alan M. Reznik Customizable, self holding, space retracting arthroscopic/endoscopic cannula system
EP2455117A1 (en) * 2010-11-19 2012-05-23 Sanofi-Aventis Deutschland GmbH Assembly device for injection needles
USD693002S1 (en) 2011-09-21 2013-11-05 West Pharmaceutical Services, Inc. Hub for medical container
USD689188S1 (en) 2012-07-19 2013-09-03 West Pharmaceutical Services, Inc. Syringe plunger rod
SE1350137A1 (en) * 2013-02-05 2014-08-06 Vigmed Ab needle device
EP2967648B1 (en) * 2013-03-15 2018-11-28 Applied Medical Resources Corporation Trocar cannula assembly with low profile insertion configuration and method of manufacture
WO2014155481A1 (en) * 2013-03-25 2014-10-02 テルモ株式会社 Syringe with injection needle, and manufacturing method of syringe with injection needle
CN103302855A (en) * 2013-06-13 2013-09-18 盐城金沃医疗科技有限公司 Thermal expansion device of medical disposable remaining needle plastic needle bed
AU2017345235A1 (en) * 2016-10-17 2019-03-07 Medical Components, Inc. Needle cannula-catheter bonding method and apparatus
KR200487150Y1 (en) * 2018-01-23 2018-08-13 코박메드 주식회사 Cannula

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581024A (en) 1984-12-10 1986-04-08 Becton, Dickinson And Company Needle assembly
US4655764A (en) 1983-03-11 1987-04-07 Terumo Corporation Medical needle assembly and medical device incorporating the same
US5026355A (en) 1990-01-23 1991-06-25 Becton Dickinson And Company Needle and hub assembly with needle contacting member
US5207853A (en) 1990-07-30 1993-05-04 Nissho Corporation Method of manufacturing injection needles
US5215621A (en) 1990-07-30 1993-06-01 Nissho Corporation Apparatus for manufacturing an injection needle
US5714125A (en) 1996-03-07 1998-02-03 Medical Safety Products, Inc. Device for collecting a blood sample from a plastic segment tube

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2665689A (en) * 1951-07-03 1954-01-12 Cutter Lab Needle assembly and method of producing said assembly
US2740192A (en) * 1951-07-09 1956-04-03 Robert W Ogle Method for imbedding a hollow needle in plastic material
US2868201A (en) * 1954-03-08 1959-01-13 Gabriel Daniel Aspirating needle hub
US3093134A (en) * 1959-01-19 1963-06-11 Brunswick Corp Needle with molded hub
US3076457A (en) * 1961-02-14 1963-02-05 Copen Simon Irving Hypodermic needle
US3470604A (en) * 1966-07-01 1969-10-07 American Hospital Supply Corp Method of making a hypodermic needle
GB1262780A (en) * 1968-12-30 1972-02-09 Injekta Klingenthal Veb Method of producing hypodermic needles with a plastics neck
US3509880A (en) * 1969-03-13 1970-05-05 Yolan R Guttman Intravenous needle hub construction
US3648684A (en) 1970-08-04 1972-03-14 Cleora W Barnwell Device for the direct transfer of blood from a human to culture bottles
US3782383A (en) * 1973-03-06 1974-01-01 Vicra Sterile Inc Winged infusion holding device with thermoplastic elastomeric body
US4003262A (en) 1974-12-16 1977-01-18 Becton, Dickinson And Company Apparatus for measuring precise micro quantities of fluid samples
US4176451A (en) 1978-09-14 1979-12-04 Mcmorrow John J Blood segment processor
US4295477A (en) 1979-08-15 1981-10-20 Becton, Dickinson And Company Multiple sampling device having molded valve and hub
US4263922A (en) 1979-08-31 1981-04-28 American Hospital Supply Corporation Method and device for collecting, transporting, and delivering micro samples of blood
US4367749A (en) 1979-09-17 1983-01-11 Becton, Dickinson & Company Nonthrombogenic articles and method of preparation
US4392497A (en) 1980-12-02 1983-07-12 Ghaussy Rahmat U Erythrocyte sedimentation rate apparatus and method
US4413992A (en) * 1981-12-02 1983-11-08 Baxter Travenol Laboratories, Inc. Cannula support assembly and its method of manufacture
ES266599Y (en) 1982-06-18 1983-11-16 "DEVICE APPLICABLE TO THE CONDUCT OF ANALYSIS".
US4585444A (en) * 1983-03-22 1986-04-29 Smith And Nephew Associated Companies Limited Intravenous needle assembly
US4886072A (en) 1983-12-16 1989-12-12 Becton, Dickinson And Company Multiple sample needle assembly with vein indicator
US4589871A (en) * 1985-03-29 1986-05-20 Becton, Dickinson And Company Syringe barrel
US4675007A (en) * 1985-10-03 1987-06-23 Concept, Inc. Coupling device for attachment to an end of a catheter
US4617012A (en) * 1985-10-29 1986-10-14 Manresa, Inc. Sterile connector with movable connection member
SE462464B (en) 1987-01-14 1990-07-02 Broden Bengt Inge EQUIPMENT FOR SAMPLING ON PATIENTS
FR2625810B1 (en) 1988-01-08 1990-12-21 Allflex Europ Sa DEVICE FOR TAKING LIQUIDS FOR SINGLE USE
US4950132A (en) * 1988-02-11 1990-08-21 Ford Motor Company Swashplate and sliding shoe assembly for an air conditioning compressor
US4840185A (en) 1988-02-17 1989-06-20 Manuel Hernandez Blood sampling device with shield
JPH0755498Y2 (en) 1988-07-13 1995-12-20 川澄化学工業株式会社 Blood collection device for blood transfusion and blood test
US5151231A (en) * 1990-03-19 1992-09-29 Becton, Dickinson And Company Method for making liquid crystalline tube having a point
SE469454B (en) 1990-07-11 1993-07-05 Radi Medical Systems FIBEROPTICAL CONNECTION AND APPLICATION THEREOF
JPH0774772B2 (en) 1990-12-31 1995-08-09 エイ． レビン ロバート Blood sampling assembly, target cell collection method and target component collection method
US5688246A (en) * 1991-04-19 1997-11-18 Biotime, Inc. Microcannula
US5286453A (en) 1992-04-02 1994-02-15 Pope Carolyn M Device for dispensing a biological fluid from a sealed vacuum tube
US5254312A (en) 1992-05-18 1993-10-19 Staebler Charles R Apparatus for collecting a blood sample from a sealed tube
US5380301A (en) * 1992-07-10 1995-01-10 Sherwood Medical Company Catheter/hub strain relief and method of manufacture thereof
US5921591A (en) * 1992-10-07 1999-07-13 Argent; Michael E. Pipe connecting assembly and method for joining two lengths of pipe by a press-fit connection
US5342325A (en) * 1992-12-07 1994-08-30 Dlp, Incorporated Introducer needle and catheter assembly
US5313969A (en) 1992-12-08 1994-05-24 Hsieh Ch Ing Lung Instant pressure-reducing process and device for a blood-gathering tube
AU682670B2 (en) * 1993-02-05 1997-10-16 Becton Dickinson & Company Syringe needle isolation device
EP0687203A4 (en) 1993-03-05 1996-09-25 William H Thompson Blood sample segment evacuation tool
US5376003A (en) * 1993-03-30 1994-12-27 Rizkalla; Adel J. Deflector shield for a dental air/water/spray syringe
US5257980A (en) * 1993-04-05 1993-11-02 Minimed Technologies, Ltd. Subcutaneous injection set with crimp-free soft cannula
US5385561A (en) * 1994-01-18 1995-01-31 Bard International, Inc. Apparatus and method for injecting a viscous material into the tissue of a patient
US5746733A (en) * 1994-05-19 1998-05-05 Becton, Dickinson And Company Syringe filling and delivery device
US6162236A (en) * 1994-07-11 2000-12-19 Terumo Kabushiki Kaisha Trocar needle and expandable trocar tube
US5639426A (en) * 1994-08-31 1997-06-17 Bayer Corporation Sample liquid aspiration and dispensing probe
US5579661A (en) * 1994-09-02 1996-12-03 Dana Corporation Noise and vibration dampening connector for a two-piece transmission shift lever assembly
US5807347A (en) * 1995-12-21 1998-09-15 Bonaldo; Jean M. Medical valve element
FR2759780B1 (en) 1997-02-19 1999-05-07 Central Labo Europ SINGLE USE SAFETY DEVICE FOR TRANSFERRING BLOOD
US6162203A (en) * 1999-01-11 2000-12-19 Haaga; John R. Cargo delivery needle
US6488668B1 (en) 2000-11-16 2002-12-03 Ideal Instruments, Inc. Detectable heavy duty needle

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4655764A (en) 1983-03-11 1987-04-07 Terumo Corporation Medical needle assembly and medical device incorporating the same
US4581024A (en) 1984-12-10 1986-04-08 Becton, Dickinson And Company Needle assembly
US5026355A (en) 1990-01-23 1991-06-25 Becton Dickinson And Company Needle and hub assembly with needle contacting member
US5207853A (en) 1990-07-30 1993-05-04 Nissho Corporation Method of manufacturing injection needles
US5215621A (en) 1990-07-30 1993-06-01 Nissho Corporation Apparatus for manufacturing an injection needle
US5714125A (en) 1996-03-07 1998-02-03 Medical Safety Products, Inc. Device for collecting a blood sample from a plastic segment tube
US5910289A (en) 1996-03-07 1999-06-08 Medical Safety Products, Inc. Device for collecting a blood sample from a plastic segment tube

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1292353A4

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3257535A1 (en) * 2016-06-17 2017-12-20 Terumo Europe NV Needle assembly and syringe containing the same
WO2017216315A1 (en) * 2016-06-17 2017-12-21 Terumo Europe Nv Needle assembly and syringe containing the same
US11285272B2 (en) 2016-06-17 2022-03-29 Terumo Europe Nv Needle assembly and syringe containing the same

Also Published As

Publication number Publication date
CN1533289A (en) 2004-09-29
US7024749B2 (en) 2006-04-11
AU6500501A (en) 2001-12-11
US20020010435A1 (en) 2002-01-24
WO2001091826A3 (en) 2002-04-04
CA2409658C (en) 2010-07-20
CA2409658A1 (en) 2001-12-06
EP1292353B1 (en) 2013-10-16
EP1292353A4 (en) 2009-11-25
MXPA02011657A (en) 2004-07-30
EP1292353A2 (en) 2003-03-19
JP2004525655A (en) 2004-08-26
AU2001265005B2 (en) 2005-11-03
US20030088234A1 (en) 2003-05-08
US6709428B2 (en) 2004-03-23

Similar Documents

Publication Publication Date Title
US6709428B2 (en) Needle design and manufacturing method for medical applications
AU2001265005A1 (en) Improved needle design and manufacturing method for medical applications
US9352118B2 (en) Modular introducer and exchange sheath
EP1466644B1 (en) Indwelling catheter set
EP3381495B1 (en) Iv catheter and needle assembly and method
US5257980A (en) Subcutaneous injection set with crimp-free soft cannula
JP4404642B2 (en) Catheter and catheter manufacturing method
US8414560B2 (en) Luer connector assembly
CA1239072A (en) Self-sealing check valve
AU745421B2 (en) Self-sealing septa
AU2022271462A1 (en) Septum housing for a catheter
EP3698839A1 (en) Intermittent catheter
EP1242141A1 (en) Splittable medical valve
AU2002259265A1 (en) Luer connector assembly
US20100078031A1 (en) Medical Device Tube having a Flange with Opposing Support Ears for Improved Alignment and Retention of an Inner Cannula in an Outer Cannula
CN101827620A (en) Flexible cannula or medical device conduit
WO2009003175A1 (en) Tracheostomy tube connector key system
EP3398646B1 (en) Medical device with hemostatic valve
US11896775B2 (en) Catheter and process for manufacturing a catheter
EP0499368A1 (en) Intravenous needle assemblies
GB2037919A (en) Tube & Connector Assembly
JPH01256974A (en) Tubular member and tubular member assembly unit and their manufacture

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 2001265005

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2409658

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001939494

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 018204996

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/011657

Country of ref document: MX

WWP Wipo information: published in national office

Ref document number: 2001939494

Country of ref document: EP

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWG Wipo information: grant in national office

Ref document number: 2001265005

Country of ref document: AU