WO2001074793A3 - Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 - Google Patents

Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 Download PDF

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Publication number
WO2001074793A3
WO2001074793A3 PCT/US2001/010307 US0110307W WO0174793A3 WO 2001074793 A3 WO2001074793 A3 WO 2001074793A3 US 0110307 W US0110307 W US 0110307W WO 0174793 A3 WO0174793 A3 WO 0174793A3
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WO
WIPO (PCT)
Prior art keywords
inhibitors
pai
plasminogen activator
activator inhibitor
compounds
Prior art date
Application number
PCT/US2001/010307
Other languages
French (fr)
Other versions
WO2001074793A2 (en
Inventor
Dale S Dhanoa
Declan E Ryan
Ingrid Deckman
Anthony Sapienza
Original Assignee
Dimensional Pharm Inc
Dale S Dhanoa
Declan E Ryan
Ingrid Deckman
Anthony Sapienza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Dimensional Pharm Inc, Dale S Dhanoa, Declan E Ryan, Ingrid Deckman, Anthony Sapienza filed Critical Dimensional Pharm Inc
Priority to AU2001249670A priority Critical patent/AU2001249670A1/en
Publication of WO2001074793A2 publication Critical patent/WO2001074793A2/en
Publication of WO2001074793A3 publication Critical patent/WO2001074793A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Abstract

The present invention relates to the use of aminothiazole derivatives of Formula (I) of as inhibitors of PAI-1, and to novel classes of aminothiazole derivatives, their synthesis and their use as inhibitors of PAI-1. It has been discovered that compounds of Formula (I): or a solvate, hydrate or a pharmaceutically acceptable salt thereof, wherein Y, Ar?1, Ar2, R1, R2¿, Z, m and n are described in the specification, inhibit plasminogen activator inhibitor-1 (PAI-1). These compounds can be used in the prophylaxis or for the treatment of thrombosis, angina pectoris, cerebral infarction, myocardial infarction, pulmonary infarction, intra-atrial thrombus in atrial fibrillation, deep venous thrombus, disseminated intravascular coagulation syndrome, diabetic complications, restenosis and stroke.
PCT/US2001/010307 2000-04-03 2001-04-02 Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 WO2001074793A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001249670A AU2001249670A1 (en) 2000-04-03 2001-04-02 Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19450500P 2000-04-03 2000-04-03
US60/194,505 2000-04-03

Publications (2)

Publication Number Publication Date
WO2001074793A2 WO2001074793A2 (en) 2001-10-11
WO2001074793A3 true WO2001074793A3 (en) 2002-05-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010307 WO2001074793A2 (en) 2000-04-03 2001-04-02 Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1

Country Status (3)

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US (2) US6586453B2 (en)
AU (1) AU2001249670A1 (en)
WO (1) WO2001074793A2 (en)

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CN101096363B (en) 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-three-substituted thiazole compound, preparation method, medicament composition and pharmacy use thereof
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AU2001249670A1 (en) 2001-10-15
WO2001074793A2 (en) 2001-10-11
US6586453B2 (en) 2003-07-01
US20010044545A1 (en) 2001-11-22
US20030220380A1 (en) 2003-11-27

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