WO2001048209A3 - Genes identified as required for proliferation of e. coli - Google Patents

Genes identified as required for proliferation of e. coli Download PDF

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Publication number
WO2001048209A3
WO2001048209A3 PCT/US2000/034419 US0034419W WO0148209A3 WO 2001048209 A3 WO2001048209 A3 WO 2001048209A3 US 0034419 W US0034419 W US 0034419W WO 0148209 A3 WO0148209 A3 WO 0148209A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
coli
proliferation
screen
proteins
Prior art date
Application number
PCT/US2000/034419
Other languages
French (fr)
Other versions
WO2001048209B1 (en
WO2001048209A2 (en
Inventor
R Allyn Forsyth
Kari L Ohlsen
Judith W Zyskind
Original Assignee
Elitra Pharmaceuticals Inc
R Allyn Forsyth
Kari L Ohlsen
Judith W Zyskind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elitra Pharmaceuticals Inc, R Allyn Forsyth, Kari L Ohlsen, Judith W Zyskind filed Critical Elitra Pharmaceuticals Inc
Priority to JP2001548722A priority Critical patent/JP2003518386A/en
Priority to CA002395335A priority patent/CA2395335A1/en
Priority to AU22774/01A priority patent/AU2277401A/en
Priority to EP00986553A priority patent/EP1244789A2/en
Publication of WO2001048209A2 publication Critical patent/WO2001048209A2/en
Publication of WO2001048209A3 publication Critical patent/WO2001048209A3/en
Publication of WO2001048209B1 publication Critical patent/WO2001048209B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The sequences of nucleic acids encoding proteins required for E. coli proliferation are disclosed. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than E. coli. The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids of the present invention can also be used in various assay systems to screen for antimicrobial agents.
PCT/US2000/034419 1999-12-23 2000-12-19 Genes identified as required for proliferation of e. coli WO2001048209A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001548722A JP2003518386A (en) 1999-12-23 2000-12-19 Genes identified as required for the growth of Escherichia coli
CA002395335A CA2395335A1 (en) 1999-12-23 2000-12-19 Genes identified as required for proliferation of e. coli
AU22774/01A AU2277401A (en) 1999-12-23 2000-12-19 Genes identified as required for proliferation of e. coli
EP00986553A EP1244789A2 (en) 1999-12-23 2000-12-19 Genes identified as required for proliferation of e. coli

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17300599P 1999-12-23 1999-12-23
US60/173,005 1999-12-23

Publications (3)

Publication Number Publication Date
WO2001048209A2 WO2001048209A2 (en) 2001-07-05
WO2001048209A3 true WO2001048209A3 (en) 2002-05-02
WO2001048209B1 WO2001048209B1 (en) 2002-06-06

Family

ID=22630109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/034419 WO2001048209A2 (en) 1999-12-23 2000-12-19 Genes identified as required for proliferation of e. coli

Country Status (7)

Country Link
US (1) US20020022718A1 (en)
EP (1) EP1244789A2 (en)
JP (1) JP2003518386A (en)
KR (1) KR20030003221A (en)
AU (1) AU2277401A (en)
CA (1) CA2395335A1 (en)
WO (1) WO2001048209A2 (en)

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AU2041901A (en) * 1999-11-09 2001-06-06 Elitra Pharmaceuticals, Inc. Genes essential for microbial proliferation and antisense thereto
JP2005532828A (en) * 2002-07-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド Methods for identifying cell growth inhibitors
US20050026189A1 (en) * 2003-05-29 2005-02-03 Liangsu Wang Microbial operons
GB0312972D0 (en) * 2003-06-05 2003-07-09 Norwegian Radium Hospital Res Screen for novel protein inhibitors
US7455840B2 (en) * 2003-11-19 2008-11-25 The Scripps Research Institute Compositions and methods to reduce mutagenesis
CN101243177B (en) * 2004-01-30 2012-12-05 味之素株式会社 L-amino acid-producing microorganism and method for producing L-amino acid
WO2006108075A2 (en) * 2005-04-05 2006-10-12 The Scripps Research Institute Compositions and methods for enhancing drug sensitivity and treating drug resistant infections an diseases
WO2008073444A2 (en) * 2006-12-12 2008-06-19 The Johns Hopkins University Phou (perf), a persistence switch involved in persister formation as a drug target for persister bacteria
CN101715490B (en) * 2007-04-06 2014-02-05 协和发酵生化株式会社 Method for production of glutathione or gamma-glutamylcysteine
JP2010154846A (en) * 2008-12-01 2010-07-15 Sony Corp Mutant gluconate dehydrogenase
US20140259212A1 (en) * 2009-11-18 2014-09-11 Basf Plant Science Company Gmbh Process for the Production of Fine Chemicals
WO2012090789A1 (en) * 2010-12-28 2012-07-05 国立大学法人広島大学 Polypeptide for distinguishing silicon oxide from silicon nitride, and use thereof
ITNA20120046A1 (en) * 2012-08-02 2014-02-03 No Self S R L USE OF NUCLEIC ACIDS OF PARASITIC BIOLOGICAL SYSTEMS, PATOGENES AND WEATHER FOR THE INHIBITION AND / OR CONTROL OF THE SAME SYSTEMS
US9416395B2 (en) * 2013-03-15 2016-08-16 City Of Hope Methods, compositions, and kits for detection of aspergillosis
US10227661B2 (en) * 2014-11-21 2019-03-12 GeneWeave Biosciences, Inc. Sequence-specific detection and phenotype determination
KR102124257B1 (en) * 2018-10-19 2020-06-26 대한민국(관리부서 질병관리본부장) Burkholderia pseudomallei diagnostic detection kit using rapid immunochromatography, its specific antibody and antibody-producing cell lines
US20220127624A1 (en) * 2019-02-05 2022-04-28 The Board Of Trustees Of The Leland Stanford Junior University Inducible Ammonia Production from a Symbiotic Diazotroph, Methods of Creation and Uses Thereof
NL2022581B1 (en) * 2019-02-14 2020-08-27 Koppert Bv Composition comprising a mixture of dna molecules, uses thereof as biological inhibitor and method for production
US11866728B2 (en) 2022-01-21 2024-01-09 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
WO2023192326A2 (en) * 2022-03-29 2023-10-05 Rutgers, The State University Of New Jersey Attenuated maturation-defective chlamydia vaccines

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WO1999002673A2 (en) * 1997-07-10 1999-01-21 Genesense Technologies, Inc. Antisense oligonucleotide sequences as inhibitors of microorganisms

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Also Published As

Publication number Publication date
EP1244789A2 (en) 2002-10-02
WO2001048209B1 (en) 2002-06-06
AU2277401A (en) 2001-07-09
KR20030003221A (en) 2003-01-09
CA2395335A1 (en) 2001-07-05
JP2003518386A (en) 2003-06-10
WO2001048209A2 (en) 2001-07-05
US20020022718A1 (en) 2002-02-21

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