WO2001040257A3 - Modified il-12 subunits and nucleic acids encoding them - Google Patents

Modified il-12 subunits and nucleic acids encoding them Download PDF

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Publication number
WO2001040257A3
WO2001040257A3 PCT/US2000/032664 US0032664W WO0140257A3 WO 2001040257 A3 WO2001040257 A3 WO 2001040257A3 US 0032664 W US0032664 W US 0032664W WO 0140257 A3 WO0140257 A3 WO 0140257A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
polypeptides
subunits
modified
acids encoding
Prior art date
Application number
PCT/US2000/032664
Other languages
French (fr)
Other versions
WO2001040257A2 (en
Inventor
Steven R Leong
Juha Punnonen
Original Assignee
Maxygen Inc
Steven R Leong
Juha Punnonen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen Inc, Steven R Leong, Juha Punnonen filed Critical Maxygen Inc
Priority to CA002389262A priority Critical patent/CA2389262A1/en
Priority to JP2001541012A priority patent/JP2003517305A/en
Priority to EP00982327A priority patent/EP1244689A2/en
Priority to AU19376/01A priority patent/AU1937601A/en
Publication of WO2001040257A2 publication Critical patent/WO2001040257A2/en
Publication of WO2001040257A3 publication Critical patent/WO2001040257A3/en
Priority to AU2006202896A priority patent/AU2006202896A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

New cytokine polypeptides, and nucleic acids encoding them, are provided. Compositions including these polypeptides and nucleic acids, recombinant cells comprising said polypeptides and nucleic acids, methods of making the polypeptides and nucleic acid, antibodies to the polypeptides, and methods of using the polypeptides and nucleic acids are provided. Integrated systems comprising the sequences of the nucleic acids or polypeptides are also provided.
PCT/US2000/032664 1999-12-02 2000-11-30 Modified il-12 subunits and nucleic acids encoding them WO2001040257A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002389262A CA2389262A1 (en) 1999-12-02 2000-11-30 Modified il-12 subunits and nucleic acids encoding them
JP2001541012A JP2003517305A (en) 1999-12-02 2000-11-30 Modified IL-12 subunits and nucleic acids encoding them
EP00982327A EP1244689A2 (en) 1999-12-02 2000-11-30 Cytokine polypeptides and nucleic acids
AU19376/01A AU1937601A (en) 1999-12-02 2000-11-30 Cytokine polypeptides and nucleic acids
AU2006202896A AU2006202896A1 (en) 1999-12-02 2006-07-06 Cytokine polypeptides and nucleic acids

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16903599P 1999-12-02 1999-12-02
US60/169,035 1999-12-02
US09/725,324 US7115712B1 (en) 1999-12-02 2000-11-28 Cytokine polypeptides
US09/725,324 2000-11-28

Publications (2)

Publication Number Publication Date
WO2001040257A2 WO2001040257A2 (en) 2001-06-07
WO2001040257A3 true WO2001040257A3 (en) 2001-11-29

Family

ID=26864699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032664 WO2001040257A2 (en) 1999-12-02 2000-11-30 Modified il-12 subunits and nucleic acids encoding them

Country Status (5)

Country Link
US (2) US7115712B1 (en)
EP (1) EP1244689A2 (en)
JP (1) JP2003517305A (en)
CA (1) CA2389262A1 (en)
WO (1) WO2001040257A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090142855A1 (en) * 2005-06-30 2009-06-04 Wei Tang Polynucleotides and Polypeptides of the IL-12 Family of Cytokines
CN101351475B (en) * 2005-12-30 2013-05-15 默克专利有限公司 Interleukin-12p40 variants with improved stability
EP2066693A2 (en) 2006-09-22 2009-06-10 St. Jude Children's Research Hospital Modulating regulatory t cell activity via interleukin 35
WO2011063198A2 (en) 2009-11-20 2011-05-26 St. Jude Children's Research Hospital Methods and compositions for modulating the activity of the interleukin-35 receptor complex

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Also Published As

Publication number Publication date
EP1244689A2 (en) 2002-10-02
JP2003517305A (en) 2003-05-27
US7115712B1 (en) 2006-10-03
WO2001040257A2 (en) 2001-06-07
US20060264615A1 (en) 2006-11-23
CA2389262A1 (en) 2001-06-07

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