WO2001039764A3 - Methods for treating conditions and illnesses associated with abnormal vasculature - Google Patents

Methods for treating conditions and illnesses associated with abnormal vasculature Download PDF

Info

Publication number
WO2001039764A3
WO2001039764A3 PCT/US2000/041110 US0041110W WO0139764A3 WO 2001039764 A3 WO2001039764 A3 WO 2001039764A3 US 0041110 W US0041110 W US 0041110W WO 0139764 A3 WO0139764 A3 WO 0139764A3
Authority
WO
WIPO (PCT)
Prior art keywords
dyes
methods
abnormal vasculature
treating conditions
illnesses associated
Prior art date
Application number
PCT/US2000/041110
Other languages
French (fr)
Other versions
WO2001039764A2 (en
Inventor
Robert W Flower
Abu Alam
Original Assignee
Akorn Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akorn Inc filed Critical Akorn Inc
Priority to AU41340/01A priority Critical patent/AU4134001A/en
Publication of WO2001039764A2 publication Critical patent/WO2001039764A2/en
Publication of WO2001039764A3 publication Critical patent/WO2001039764A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Use of radiation-absorbing dyes (e.g., indocyanine green (ICG), fluorescein, rose bengal) and photodynamic dyes (e.g., hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes, porfimer sodium, verteporfin, Photofrin II, PH-10, chlorins, zinc phthalocyanine, purpurins, pheophorbides, monoclonal antibody-dye conjugates of any of the foregoing dyes) for the treatment of conditions associated with abnormal vasculature, including, generally, lesions, and, more specifically, tumors (cancerous and benign) and choroidal neovascularization (CNV) associated with age-related macular degeneration (ARMD).
PCT/US2000/041110 1999-11-30 2000-10-10 Methods for treating conditions and illnesses associated with abnormal vasculature WO2001039764A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41340/01A AU4134001A (en) 1999-11-30 2000-10-10 Methods for treating conditions and illnesses associated with abnormal vasculature

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/452,117 1999-11-30
US09/452,117 US6443976B1 (en) 1999-11-30 1999-11-30 Methods for treating conditions and illnesses associated with abnormal vasculature

Publications (2)

Publication Number Publication Date
WO2001039764A2 WO2001039764A2 (en) 2001-06-07
WO2001039764A3 true WO2001039764A3 (en) 2002-01-10

Family

ID=23795111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041110 WO2001039764A2 (en) 1999-11-30 2000-10-10 Methods for treating conditions and illnesses associated with abnormal vasculature

Country Status (3)

Country Link
US (1) US6443976B1 (en)
AU (1) AU4134001A (en)
WO (1) WO2001039764A2 (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH685148A5 (en) * 1991-11-20 1995-04-13 Erik Larsen Apparatus for the photodynamic stimulation of cells.
WO1999059611A1 (en) * 1998-05-21 1999-11-25 The Trustees Of The University Of Pennsylvania Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
US6944493B2 (en) * 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
ATE406914T1 (en) * 2000-02-10 2008-09-15 Massachusetts Eye & Ear Infirm PHOTODYNAMIC THERAPY FOR THE TREATMENT OF EYE DISEASES
JP4133319B2 (en) 2000-07-14 2008-08-13 ノバダック テクノロジーズ インコーポレイテッド Compact fluorescent endoscope imaging system
WO2002062989A2 (en) * 2001-02-08 2002-08-15 Sequitur, Inc. Methods of light activated release 0f ligands from endosomes
US6875165B2 (en) * 2001-02-22 2005-04-05 Retinalabs, Inc. Method of radiation delivery to the eye
JP2003012547A (en) * 2001-06-27 2003-01-15 Meiji Seika Kaisha Ltd Diagnostic and therapeutic agent for insulin dependent diabetes mellitus
US6942655B2 (en) 2001-11-13 2005-09-13 Minu, Llc Method to treat age-related macular degeneration
US20030125314A1 (en) * 2001-12-03 2003-07-03 Edie Zusman Photodynamic therapy for the treatment of epilepsy
US20060241496A1 (en) 2002-01-15 2006-10-26 Xillix Technologies Corp. Filter for use with imaging endoscopes
KR100896477B1 (en) * 2002-03-20 2009-05-08 노바다크 테크놀러지즈 인코포레이티드 System and method for visualizing fluid flow through vessels
WO2004006816A2 (en) * 2002-07-17 2004-01-22 Novadaq Technologies Inc. Combined photocoagulation and photodynamic therapy
BR0315931A (en) * 2002-10-31 2005-09-13 Celgene Corp Method of treating, preventing or controlling macular degeneration and pharmaceutical composition
US20040110731A1 (en) * 2002-12-04 2004-06-10 Chan Agnes H. Photodynamic therapy for the treatment of non-melanoma skin cancer
US7354432B2 (en) * 2003-01-17 2008-04-08 Mcw Research Foundation, Inc. Red to near-infrared photobiomodulation treatment of the visual system in visual system disease or injury
CA2530166A1 (en) * 2003-03-07 2004-09-23 Randolph D. Glickman Antibody-targeted photodynamic therapy
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US7659301B2 (en) * 2003-04-15 2010-02-09 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US7941211B2 (en) * 2003-11-17 2011-05-10 Zeavision, Llc. Preloading with macular pigment to improve photodynamic treatment of retinal vascular disorders
BRPI0507690A (en) 2004-02-12 2007-07-24 Neovista Inc methods and apparatus for intraocular brachytherapy
US20050244500A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Intravitreal implants in conjuction with photodynamic therapy to improve vision
US20060052286A1 (en) * 2004-08-13 2006-03-09 Yale University Factor VII conjugates for selectively treating neovascularization disorders
US20080269730A1 (en) * 2005-04-14 2008-10-30 Dotson Robert S Ophthalmic Phototherapy Device and Associated Treatment Method
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
EP1743658A1 (en) 2005-07-14 2007-01-17 Schering Aktiengesellschaft Optical imaging of rheumatoid arthritis
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
WO2007059208A2 (en) 2005-11-15 2007-05-24 Neovista Inc. Methods and apparatus for intraocular brachytherapy
US20090303317A1 (en) 2006-02-07 2009-12-10 Novadaq Technologies Inc. Near infrared imaging
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
WO2007130465A2 (en) * 2006-05-02 2007-11-15 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
EP1854438B1 (en) * 2006-05-09 2018-07-04 IROC Services AG Ophthalmologic device for preventing myopia
CA2652251A1 (en) 2006-05-16 2007-11-29 Knopp Neurosciences, Inc. Compositions of r(+) and s(-) pramipexole and methods for using the same
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
WO2008070269A2 (en) 2006-10-06 2008-06-12 Novadaq Technologies, Inc. Methods, software and systems for imaging
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US8519148B2 (en) * 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
EP2644228A1 (en) * 2007-06-27 2013-10-02 The General Hospital Corporation Method and apparatus for optical inhibition of photodynamic therapy
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US20090236541A1 (en) * 2008-03-24 2009-09-24 General Electric Company System and Methods for Optical Imaging
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
ES2671710T3 (en) 2008-05-02 2018-06-08 Novadaq Technologies ULC Methods for the production and use of erythrocytes loaded with substances for the observation and treatment of microvascular hemodynamics
AU2009256236A1 (en) 2008-06-04 2009-12-10 Neovista, Inc. Handheld radiation delivery system for advancing a radiation source wire
US20100010482A1 (en) * 2008-06-23 2010-01-14 Ceramoptec Industries Inc. Enhanced Photodynamic Therapy Treatment and Instrument
KR20110071064A (en) 2008-08-19 2011-06-28 크놉 뉴로사이언시스 인코포레이티드 Compositions and methods of using (r)-pramipexole
US20100256125A1 (en) * 2009-04-06 2010-10-07 Zila Pharmaceuticals, Inc. Use of improved toluidine blue in photodynamic therapy
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
CA2765876A1 (en) * 2009-06-19 2010-12-23 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
KR101905237B1 (en) 2012-01-11 2018-10-05 시네론 메디컬 리미티드 Large area body shaping applicator
CA2914778A1 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
RS61539B1 (en) 2013-07-12 2021-04-29 Knopp Biosciences Llc Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
WO2015023786A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
CA2921381A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
EP3838341A1 (en) 2014-09-09 2021-06-23 Lumithera, Inc. Multi-wavelength phototherapy devices for the non-invasive treatment of damaged or diseased tissue
CA2963987A1 (en) 2014-09-29 2016-04-07 Novadaq Technologies Inc. Imaging a target fluorophore in a biological material in the presence of autofluorescence
KR102012880B1 (en) 2014-10-09 2019-08-22 노바다크 테크놀러지즈 유엘씨 Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
US10293122B2 (en) 2016-03-17 2019-05-21 Novadaq Technologies ULC Endoluminal introducer with contamination avoidance
US11140305B2 (en) 2017-02-10 2021-10-05 Stryker European Operations Limited Open-field handheld fluorescence imaging systems and methods
WO2018170134A1 (en) 2017-03-14 2018-09-20 Ohio State Innovation Foundation Methods and compositions related to a tissue factor-targeting igg3 immunoconjugates

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024930A1 (en) * 1994-03-14 1995-09-21 Massachusetts Eye & Ear Infirmary Use of green porphyrins in ocular diagnosis and therapy
WO1997033619A1 (en) * 1996-03-11 1997-09-18 Qlt Phototherapeutics, Inc. Improved vision through photodynamic therapy of the eye
WO1998025648A2 (en) * 1996-12-11 1998-06-18 Pharmacyclics, Inc. Use of a texaphyrin in ocular diagnosis and therapy
WO2001026591A1 (en) * 1999-10-14 2001-04-19 Iridex Corporation Therapeutic use of long-pulse laser photocoagulation in combination with other treatment modalities

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE244492C (en)
US1048419A (en) 1911-03-27 1912-12-24 Allis Chalmers Controller.
NL241413A (en) 1957-06-05
GB1048419A (en) 1965-03-18 1966-11-16 Akad Wissenschaften Ddr Stabilised, aqueous, injectable solutions of indocyanine dyestuffs
US3736524A (en) 1971-06-01 1973-05-29 Eastman Kodak Co Laser media containing fluorinated alchols
US3944341A (en) 1972-09-25 1976-03-16 Retina Foundation Wide-angle ophthalmoscope and fundus camera
US3871772A (en) 1973-04-23 1975-03-18 Tropel Eye examining instrument aligning means and method therefor
US3893447A (en) 1973-06-04 1975-07-08 Univ Johns Hopkins Simultaneous angiography of the separate retinal and choroidal circulations
US4056310A (en) 1975-02-14 1977-11-01 Olympus Optical Co., Ltd. Method and device for ophthalmoscopy
JPS53144193A (en) 1977-05-20 1978-12-15 Canon Kk Ophthalmologic machine having operating distance detector
CA1120904A (en) 1978-11-06 1982-03-30 American Optical Corporation Endoscope
US4336809A (en) * 1980-03-17 1982-06-29 Burleigh Instruments, Inc. Human and animal tissue photoradiation system and method
US4799783A (en) 1981-03-09 1989-01-24 Canon Kabushiki Kaisha Eye fundus camera
US4412543A (en) 1981-04-09 1983-11-01 Xanar, Inc. Apparatus for determining the concentration of a fluorescent material in an eye
DE3124305C2 (en) 1981-06-20 1985-08-22 Ursula Prof. Dr. 8520 Erlangen Mayer Device for observing the fundus
US4369250A (en) 1981-07-31 1983-01-18 Sherwood Medical Industries Inc. Fatty acid determination
DE3141641A1 (en) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
GB2132378B (en) 1982-11-19 1986-05-21 Gwyndann Group Illumination of optical instruments
USRE34544E (en) * 1982-11-23 1994-02-15 The Beth Israel Hospital Association Method of treatment of artherosclerosis and balloon catheter the same
US4573778A (en) 1983-03-16 1986-03-04 Boston University Aqueous fluorophotometer
US4541438A (en) 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US4608990A (en) 1983-09-12 1986-09-02 Elings Virgil B Measuring skin perfusion
SE455646B (en) 1984-10-22 1988-07-25 Radians Innova Ab FLUORESCENT DEVICE
JPS6242892A (en) 1985-08-20 1987-02-24 三菱電機株式会社 Integrated circuit card
US5622713A (en) 1985-09-17 1997-04-22 The Regents Of The University Of California Method of detoxifying animal suffering from overdose
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US4762701A (en) 1986-10-31 1988-08-09 Smithkline Beckman Corporation In vivo cellular tracking
US4859584A (en) 1986-10-31 1989-08-22 Smithkline Beckman Corporation Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes
JPS63122421A (en) 1986-11-12 1988-05-26 株式会社東芝 Endoscope apparatus
US4835103A (en) 1986-11-24 1989-05-30 Boris Cercek Differential binding of membrane potential sensitive materials to lymphocytes
US4842401A (en) 1987-06-15 1989-06-27 The Board Of Trustees Of The Leland Stanford Jr. University Eye diagnosis process
DE3879172T2 (en) 1987-08-26 1993-08-26 Hage Sami G El DEVICE FOR DETERMINING THE CORNEA CONTOUR OF A HUMAN EYE.
US5072731A (en) 1987-09-01 1991-12-17 Massachusetts Institute Of Technology Apparatus for detecting cataractogenesis using quasielastic light scattering
DE3878123T2 (en) 1987-09-30 1993-06-17 Canon Kk DEVICE FOR Ophthalmology.
US5092331A (en) 1989-01-30 1992-03-03 Olympus Optical Co., Ltd. Fluorescence endoscopy and endoscopic device therefor
US5126235A (en) 1989-03-22 1992-06-30 Fuji Photo Film Co., Ltd. Full color recording material and a method of forming colored images
JPH02295539A (en) 1989-05-08 1990-12-06 Kowa Co Method and device for identifying blood vessel of eyeground
DE3926652A1 (en) 1989-08-11 1991-04-18 Rodenstock Instr Ophthalmic equipment for angiographic examination of eye - has detector with confocal shutter of dia. corresp. to that of beam focussed on image
JP2813899B2 (en) 1989-09-26 1998-10-22 仁 藤居 Ophthalmic measurement device
US5150292A (en) 1989-10-27 1992-09-22 Arch Development Corporation Method and system for determination of instantaneous and average blood flow rates from digital angiograms
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5438989A (en) 1990-08-10 1995-08-08 Hochman; Darryl Solid tumor, cortical function, and nerve tissue imaging methods and device
JPH04210042A (en) 1990-12-11 1992-07-31 Topcon Corp Eye ground camera for fluorescent photograph
EP0504881B2 (en) 1991-03-22 2000-11-08 Katsuro Tachibana Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same
US5413732A (en) 1991-08-19 1995-05-09 Abaxis, Inc. Reagent compositions for analytical testing
US5277913A (en) 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
US5225859A (en) 1991-10-10 1993-07-06 Hemozoin Scientific, Inc. Apparatus and method for capture and processing of ocular and retinal images
US5400791A (en) 1991-10-11 1995-03-28 Candela Laser Corporation Infrared fundus video angiography system
US5303709A (en) 1991-12-16 1994-04-19 Dreher Andreas W Retinal eye disease diagnostic system
US5648062A (en) 1992-01-09 1997-07-15 Nycomed Imaging As Contrast agents consisting of galactose particles
EP0554643A1 (en) 1992-02-05 1993-08-11 Istituto Nazionale Di Ottica High-sensitivity system for examining an object using a low intensity light source
IL103290A (en) 1992-09-25 1996-06-18 Ben Nun Joshua Ophthalmologic examination and/or treatment apparatus
IT1256604B (en) 1992-10-30 1995-12-12 Minnesota Mining & Mfg SILVER HALIDE PHOTOGRAPHIC ELEMENTS CONTAINING INFRARED SENSITIZING DYES
US5279298A (en) 1992-11-20 1994-01-18 The Johns Hopkins University Method and apparatus to identify and treat neovascular membranes in the eye
JP3260884B2 (en) 1993-02-05 2002-02-25 キヤノン株式会社 Labeled complex, analytical method using the same, method for detecting and quantifying biologically relevant substances
US5552452A (en) 1993-03-15 1996-09-03 Arch Development Corp. Organic tissue glue for closure of wounds
US5847002A (en) * 1993-04-16 1998-12-08 Hyal Pharmaceutical Corporation Compositions, for inhibition, control and regression of angiogenesis, containing hyaluronic acid and NSAID
US5394199A (en) 1993-05-17 1995-02-28 The Johns Hopkins University Methods and apparatus for improved visualization of choroidal blood flow and aberrant vascular structures in the eye using fluorescent dye angiography
US5643356A (en) 1993-08-05 1997-07-01 Kimberly-Clark Corporation Ink for ink jet printers
FR2710060B1 (en) 1993-09-17 1995-11-17 Rech Biolog Et Process for the preparation of substituted benz [e] indoles of high purity and their alkaline salts.
EP0649667B1 (en) 1993-10-20 2001-02-28 Antonella Aprile Carpenter Quantum energy therapeutic biostimulation apparatus
JP3320869B2 (en) 1993-12-22 2002-09-03 シスメックス株式会社 Leukocyte analysis reagent
US5798349A (en) 1994-03-14 1998-08-25 The General Hospital Corporation Use of green porphyrins to treat neovasculature in the eye
US5707986A (en) 1994-03-14 1998-01-13 Miller; Joan W. Angiographic method using green porphyrins in primate eyes
ZA952485B (en) 1994-03-28 1995-12-15 Nycomed Imaging As Liposomes
US5632767A (en) * 1994-09-09 1997-05-27 Rare Earth Medical, Inc. Loop diffusers for diffusion of optical radiation
US5908415A (en) * 1994-09-09 1999-06-01 Rare Earth Medical, Inc. Phototherapy methods and apparatus
US5716642A (en) 1995-01-10 1998-02-10 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents
US5576013A (en) 1995-03-21 1996-11-19 Eastern Virginia Medical School Treating vascular and neoplastic tissues
CN1090022C (en) 1995-04-04 2002-09-04 俄克拉荷马创伤治疗所 Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant
US6316007B1 (en) * 1995-04-04 2001-11-13 Wound Healing Of Oklahoma Combined physical and immunotherapy for cancer
US5691204A (en) 1995-04-21 1997-11-25 Abbott Laboratories Compositions and methods for the rapid analysis of reticulocytes
US5573750A (en) 1995-05-22 1996-11-12 Nanosystems L.L.C. Diagnostic imaging x-ray contrast agents
US5707608A (en) 1995-08-02 1998-01-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer
JP3845469B2 (en) 1996-02-21 2006-11-15 明治製菓株式会社 Administration agent for occlusion of neovascularization of the fundus
AU2118497A (en) 1996-02-29 1997-09-16 Cytopharm, Inc. A novel phototherapeutic method for treating cancer and/or dermatological diseases and conditions
WO1997033620A2 (en) 1996-03-15 1997-09-18 Pulsion Verw. Gmbh & Co. Medical Systems Kg Compounds for treating tumours
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
EP0954336B1 (en) 1996-06-04 2004-02-25 Pharmacyclics, Inc. Membrane incorporation of texaphyrins
US5804448A (en) 1996-10-29 1998-09-08 Toa Medical Electronics Co., Ltd. Method of staining cellular material and analyzing the same
US6165170A (en) * 1998-01-29 2000-12-26 International Business Machines Corporation Laser dermablator and dermablation
US6028099A (en) * 1998-03-13 2000-02-22 John Hopkins University, School Of Medicine Use of an inhibitor of the protein tyrosine kinase pathway in the treatment of choroidal neovascularization
AU2412800A (en) 1999-01-15 2000-08-01 Light Sciences Corporation Noninvasive vascular therapy
US6351663B1 (en) * 1999-09-10 2002-02-26 Akorn, Inc. Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation
US6319273B1 (en) * 1999-12-16 2001-11-20 Light Sciences Corporation Illuminating device for treating eye disease

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024930A1 (en) * 1994-03-14 1995-09-21 Massachusetts Eye & Ear Infirmary Use of green porphyrins in ocular diagnosis and therapy
WO1997033619A1 (en) * 1996-03-11 1997-09-18 Qlt Phototherapeutics, Inc. Improved vision through photodynamic therapy of the eye
WO1998025648A2 (en) * 1996-12-11 1998-06-18 Pharmacyclics, Inc. Use of a texaphyrin in ocular diagnosis and therapy
WO2001026591A1 (en) * 1999-10-14 2001-04-19 Iridex Corporation Therapeutic use of long-pulse laser photocoagulation in combination with other treatment modalities

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MENDELSOHN A D ET AL: "AMELIORATION OF EXPERIMENTAL LIPID KERATOPATHY BY PHOTOCHEMICALLY INDUCED THROMBOSIS OF FEEDER VESSELS", ARCHIVES OF OPHTHALMOLOGY,XX,XX, vol. 105, no. 7, July 1987 (1987-07-01), pages 983 - 988, XP000978670, ISSN: 0003-9950 *
SHIRAGA F ET AL: "FEEDER VESSEL PHOTOCOAGULATION OF SUBFOVEAL CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION", OPHTHALMOLOGY,US,J. B. LIPPINCOTT CO., PHILADELPHIA, PA, vol. 105, no. 4, April 1998 (1998-04-01), pages 662 - 669, XP000922526, ISSN: 0161-6420 *
VERINDER S NIRANKARI: "Laser Photocoagulation for Corneal Stromal Vascularization", TRANSACTIONS OF THE AMERICAN OPHTHALMOLOGICAL SOCIETY ANNUAL MEETING,CA,TORONTO, vol. 90, 1992, pages 595 - 669, XP002082566, ISSN: 0065-9533 *

Also Published As

Publication number Publication date
AU4134001A (en) 2001-06-12
US6443976B1 (en) 2002-09-03
WO2001039764A2 (en) 2001-06-07

Similar Documents

Publication Publication Date Title
WO2001039764A3 (en) Methods for treating conditions and illnesses associated with abnormal vasculature
Ethirajan et al. The role of porphyrin chemistry in tumor imaging and photodynamic therapy
Savellano et al. Targeting cells that overexpress the epidermal growth factor receptor with polyethylene glycolated BPD verteporfin photosensitizer immunoconjugates¶
Hasan et al. Photodynamic therapy of cancer
US7230088B2 (en) Compounds for dual photodiagnosis and therapy
Berg et al. Porphyrin‐related photosensitizers for cancer imaging and therapeutic applications
AU694450B2 (en) Phthalocyanine photosensitizers for photodynamic therapy and methods for their synthesis and use
US20060177457A1 (en) Dye-sulfenates for dual phototherapy
AU3497901A (en) Methods and compositions for treating conditions of the eye
US20080139786A1 (en) Dye compounds as photoactive agents
Mojzisova et al. Structural and physico-chemical determinants of the interactions of macrocyclic photosensitizers with cells
Lange et al. Photosensitizers for photodynamic therapy: Photochemistry in the service of oncology
CA2536069A1 (en) Use of green porphyrins in ocular diagnosis and therapy
van den Bergh Photodynamic therapy of age-related macular degeneration: History and principles
Gijsens et al. Photocytotoxic action of EGF-PVA-Sn (IV) chlorin e6 and EGF-dextran-Sn (IV) chlorin e6 internalizable conjugates on A431 cells.
EP1781170A1 (en) Adduct of fluorescent dye and tumor avid tetrapyrrole
Singh et al. Comparing a thioglycosylated chlorin and phthalocyanine as potential theranostic agents
Kobzev et al. Antibody-guided iodinated cyanine for near-IR photoimmunotherapy
Ogura et al. Improvement of tumor localization of photosensitizers for photodynamic therapy and its application for tumor diagnosis
Röder Photodynamic therapy
Yawalkar et al. Fundamentals of photodynamic therapy
US6806284B1 (en) Photosensitizers with ligand targeting properties for tumor therapy
Trivedi et al. Photodynamic therapy for cancer treatment
Star In vivo action spectra, absorption and fluorescence excitation spectra of photosensitizers for photodynamic therapy
Soncin et al. Pharmacokinetic and phototherapeutic properties of axially substituted Si (IV)-tetradibenzobarreleno-octabutoxyphthalocyanines

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP