WO2001010342A1 - Thrombosis filter having a surface treatment - Google Patents
Thrombosis filter having a surface treatment Download PDFInfo
- Publication number
- WO2001010342A1 WO2001010342A1 PCT/US2000/018144 US0018144W WO0110342A1 WO 2001010342 A1 WO2001010342 A1 WO 2001010342A1 US 0018144 W US0018144 W US 0018144W WO 0110342 A1 WO0110342 A1 WO 0110342A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- surface treatment
- thrombosis filter
- struts
- filter element
- thrombosis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/0105—Open ended, i.e. legs gathered only at one side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2002/016—Filters implantable into blood vessels made from wire-like elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/005—Rosette-shaped, e.g. star-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0067—Three-dimensional shapes conical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0073—Quadric-shaped
- A61F2230/0078—Quadric-shaped hyperboloidal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0073—Quadric-shaped
- A61F2230/008—Quadric-shaped paraboloidal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Definitions
- the present invention generally pertains to intravascular devices.
- the present invention pertains to intravascular thrombosis filters.
- Pulmonary embolism is a recognized medical emergency, and is often caused by venous thrombosis.
- Physiological conditions such as venous intima damage, blood flow retention, and coagulation abnormalities are often the cause of venous thrombosis.
- Recognized treatments for venous thrombosis include anti-coagulant medication therapy, thrombolytic therapy, thrombectomy, and inferior vena cava thrombosis filtering or blocking procedures.
- an inferior vena cava thrombosis filtering or blocking procedure When an inferior vena cava thrombosis filtering or blocking procedure is selected, it can be performed using either a laparotomy procedure, or by percutaneously inserting a thrombosis filter.
- a laparotomy procedure is a surgical procedure performed under general anesthesia. Because it is necessary to discontinue anti-coagulant therapy prior to surgery, this procedure, itself, is susceptible to thrombosis formation.
- the second option is to intravenously insert a thrombosis filter into the vascular system.
- the thrombosis filter is mounted into the inferior vena cava in order to prevent large emboli from passing to the lungs. Since this procedure requires only a local anesthetic, percutaneous filter insertion is recognized as an effecateous procedure.
- Thrombosis filters become encapsulated to the vein wall through neointimal hyperplasia.
- Neointimal hyperplasia is the subsequent increase in endothelial cell production caused by the irritation of the lining membrane of the blood vessel. Neointima grows from the inner wall of the blood vessel, around the thrombosis filter and its anchors. This process can occur within two or three weeks after implantation, rendering many thrombosis filters unremovable by a single percutaneous process without significant vessel trauma.
- the present invention comprises a thrombosis filter having various surface treatments.
- the filter includes a body element, a plurality of struts, and a surface treatment.
- the body element serves as the support structure to which the plurality of struts are attached.
- the struts are attached to the body element and extend longitudinally and radially therefrom forming a generally conical structure.
- the struts themselves, are shaped and spaced apart in a manner which allows them to prevent emboli from passing into the lungs via the circulatory system when in use in a vessel lumen.
- Each individual strut has both a joining end and a free end. The joining end of the strut is secured to the body element. The free end of the strut, however, extends away from the body element and bears against the inner wall of the blood vessel.
- Vessel-engaging tips of various designs may be placed on the free end of a strut in order to facilitate the strut's engagement with the blood vessel wall.
- the combination of the body element with its plurality of struts radiating therefrom brace the thrombosis filter against the inner wall of the blood vessel within the blood vessel lumen.
- a surface treatment is applied to at least a portion of the thrombosis filter in order to regulate neointimal growth around the thrombosis filter and its anchor elements. Inhibiting the neointimal growth allows for the removal of the thrombosis filter with reduced retrieval forces and limited damage to the vessel wall.
- the surface treatment in preferred embodiments constitutes, in part, an anti-proliferative or an anti-angiogenesis drug.
- the drug is an anti-angiogenesis agent.
- Anti-angiogenesis agents are substances which have the ability to impede the local proliferation of blood vessels, thereby blocking the necessary "food supply” of the growing endothelial cell mass.
- This anti-angiogenesis drug may be coated directly upon portions of the thrombosis filter, itself, through a dipping or spraying process, or the drug may be incorporated into a polymeric material as a carrier which regulates the rate of drug release to the vessel wall.
- the thrombosis filter contains a first and a second surface treatment layer.
- the first surface treatment layer coated upon at least a portion of the thrombosis filter, possesses endothelial cell growth enhancing properties.
- the second surface treatment layer coated upon at least a portion of the first surface layer, includes an anti-proliferative or an anti-angiogenesis drug.
- the second surface treatment layer is dissolvable or generally biodegradable.
- the surface treatment may be applied directly to a portion of the filter or the surface treatment may be applied to a substrate which, in turn, is applied to a portion of the filter.
- the substrate is disposed about the free ends of the struts and may take the form of a pad, a tubular structure, or a band.
- FIG. 1 is a perspective view of a thrombosis filter in accordance with an exemplary embodiment of the present invention
- FIG. 2 is a plan view of the thrombosis filter of FIG. 1 positioned in a vascular lumen;
- FIG. 3 is a perspective view of an alternative thrombosis filter in accordance with the present invention.
- FIG. 4 is a side view of a wire strut selectively having a surface treatment
- FIG. 5 is a cross-sectional view taken at line 5-5 in FIG. 4
- FIG. 6 is an alternative cross-sectional view taken at line 5-5 in FIG. 4
- FIG. 7 is a partial perspective view of a vessel-engaging tip selectively coated with a surface treatment
- FIG. 8 is a perspective view of another alternative thrombosis filter having an alternative surface treatment in the form of a pad
- FIG. 9 is a perspective view of a vessel-engaging tip having an alternative surface treatment in the form of a tube
- FIG. 10 is a is a perspective view of a thrombosis filter having an alternative surface treatment in the form of a band.
- the present invention may be incorporated into a wide variety of thrombosis filters including the types illustrated in FIGs. 1, 3, and 8.
- the structure, function, and use of such thrombosis filters are generally described in U.S. Patent No. 5,601,595, which is assigned to the assignee of the present invention, and is hereby incorporated by reference.
- FIG. 1 illustrates a perspective view of a thrombosis filter 10A in accordance with the present invention.
- Thrombosis filter 10A includes first and second body elements 12 and 14, respectively.
- Each body element 12 and 14 includes a plurality of struts 16.
- Each strut includes a free end 18 and a joining end 20.
- Free end 18 terminates in a vessel-engaging tip portion 22, which may be attached to the strut free end 18 or formed therein.
- the vessel-engaging tip portion 22 preferably includes a sharpened portion 24 and an adjacent flexible pad portion 26.
- the joining ends 20 of struts 16 on both first and second body elements 12 and 14 are joined at hubs 28 and 30, respectively.
- FIG. 1 illustrates a perspective view of a thrombosis filter 10A in accordance with the present invention.
- FIG. 1 illustrates a perspective view of a thrombosis filter 10A in accordance with the present invention.
- FIG. 1 illustrates a perspective view of
- FIG. 2 shows a side view of a thrombosis filter 10A deployed within a vessel lumen 50.
- FIG. 2 illustrates how the vessel-engaging tips 22 contact the vessel wall 52.
- sharpened portions 24 of vessel-engaging tips 22 engage the wall 52 of vessel lumen 50. Further engagement of sharpened portion 24 is resisted by the adjacent flexible pad portion 26 abutting the vessel wall 52.
- FIG. 3 is a perspective view of an alternative thrombosis filter 10B in accordance with the present invention. Similar to the filter 10A in FIG. 1, thrombosis filter 10B is designed to capture emboli circulating in the vascular system.
- the three basic units of thrombosis filter 10B are the body element 12B, the struts 16B, and vessel-engaging tips 24B. Unlike the filter 10A in FIG. 1, struts 16B of filter 10B intertwine as they radiate outwardly from the body element 12B, forming hooks as vessel-engaging tips 24B.
- FIG. 8 is a perspective view of another alternative thrombosis filter 10C in accordance with the present invention.
- the three basic units of thrombosis filter IOC are body portion 12C, struts 16C and vessel-engaging tips 24C. Unlike the struts 16B of filter 10B illustrated in FIG. 3, the struts 16C of filter IOC are not intertwined.
- thrombosis filter 10A of FIG. 1, the thrombosis filter 10B of FIG. 3, and the thrombosis filter IOC of FIG. 8 depict just a few of the modifications possible in optimizing the filtering process. Regardless of the modification, however, the basic units of one or more body portions, struts, and tips remain present.
- the nomenclature of filter 10A is used with reference to FIGs. 4-7 and the nomenclature of filter IOC is used with reference to FIGs. 8-10.
- each surface treatment described herein may be implemented on virtually any thrombosis filter including filters 10A, 10B, and IOC.
- FIG. 4 is a side view of a wire strut selectively having a surface treatment 40.
- Strut 16 is comprised of a bio-compatible material, preferably having shape memory or super elastic properties. Possible filter materials include Nitinol, stainless steel, tungsten, platinum, tantalum, chromium alloy, and silicone, among others.
- the shape of strut 16 varies upon use and preference. Variations in the struts 16 shape include round, ribbon, helical, serpentine, and straight, among others.
- FIG. 5 is a cross-sectional view taken at line 5-5 in FIG. 4. This view illustrates the surface treatment coating 40 on strut 16.
- the surface treatment 40 may cover the entire strut 16 or be present on selected portions.
- the surface treatment 40 may be present on the joining end 20, the free end 18, or the vessel-engaging tip 22 of strut 16, or any combination thereof.
- Surface treatment 40 may be present as a thin surface coating, or a visible layer.
- surface treatment 40 is comprised, in part, of an anti- proliferative or anti-angiogenic drug. Additional components may be added to the anti-proliferative or anti-angiogenic drug in order to alter the function of the surface treatment 40.
- the anti-proliferative or anti-angiogenic drug may also contain non- thrombogenic properties, or an additional anti-thrombogenic drug can be incorporated with the other drugs.
- anti-angiogenesis agents such as taxol may be included in the surface treatment 40 to impede endothelial cell growth around the thrombosis filter's 10A structure.
- phospholipid-based biomaterials such as phophorylcholine may be used in the surface treatment 40.
- surface treatment 40 is a dissolvable or biodegradable layer.
- the rate at which the surface treatment 40 dissolves is regulated by the structure and composition of the surface treatment 40, itself.
- the structure of surface treatment 40 is either amorphous, crystalline, or a combination of the two.
- the ability of surface treatment 40 to dissolve is proportional to amorphous and crystalline properties the surface treatment 40 possesses. By modifying the ratio of the two properties, the ability of surface treatment 40 to dissolve either increases or decreases. This process works likewise between hydrophobic and hydrophilic compositional material.
- the anti-proliferative or anti- angiogenic drug may be incorporated into a bio-compatible or biodegradable polymeric material forming surface treatment 40.
- polyethylene oxide (PEO), polypropylene oxide (PPO), polylactic acid (PLA), polyglycolic acid, and polycaprolactone, among others, are examples of such polymeric material. Either the homopolymer or the copolymer forms of these materials may be utilized in the incorporation with the anti-proliferative or anti-angiogenic drug.
- this surface treatment 40 is added to the structure of the thrombosis filter 10A, additional structural properties are also transferred. These properties include selective rigidity and superior wall engaging performance, among others.
- the anti-proliferative or anti-angiogenic drug, or drug in combination with a polymeric material can be sprayed or dip-coated onto the filter structure.
- Single or multiple coats may be applied, preferably in a solvent carrier which is evaporated to form the coated structure.
- the anti-proliferative or anti-angiogenic drug can be admixed with the polymer prior to application.
- Other therapeutic agents can also be admixed if desired.
- FIG. 6 is an alternative cross-sectional view taken at line 5-5 in FIG. 4 of an alternative embodiment of the present invention.
- the thrombosis filter 10A contains multiple (preferably two) surface treatment layers.
- the first surface treatment layer 40 coated upon portions of the thrombosis filter 10A, specifically strut 16, possesses endothelial cell growth enhancing properties.
- the second surface treatment layer 41 coated upon the first surface layer 40, includes an anti-proliferative or anti-angiogenic drug. In this arrangement, the second surface treatment layer 41 is dissolvable or biodegradable. If the thrombosis filter 10A remains engaged within the vessel lumen 50 (from FIG. 2) for an extended period, the second layer 41 will dissolve or be absorbed, exposing the first layer 40.
- the first layer 40 then promotes endothelial cell growth causing the eventual permanent encapsulation of the filter 10A within the blood vessel lumen 50.
- Endothelial cell growth enhancing materials can be included alone or in combination with a polymeric carrier, such as the substrate 42 described with reference to FIGs. 8-10.
- FIG. 7 is a partial perspective view of a preferred vessel-engaging tip portion 22 coupled with a surface treatment 40.
- Vessel-engaging tip portion 22 extends from or is attached to free end 18 of strut 16.
- the vessel-engaging tip portion 22 includes a sharpened portion 24 and an adjacent flexible pad portion 26.
- Surface treatment 40 may be applied to selective areas of the vessel-engaging tip portion 22. Areas of particular interest are the entire sharpened portion 24 and the portion of the adjacent flexible pad 26 which contacts the vessel wall. However, surface treatment 40 need not be limited to these described areas.
- FIGs. 8-10 illustrate perspective views of alternative embodiments of the present invention as applied to filter IOC.
- the three basic units of thrombosis filter 10C are body portion 12C, struts 16C, and vessel-engaging tips 24C.
- the various embodiments of FIGs. 8-10 generally relate to the surface treatment 40 and thus may be incorporated into any thrombosis filter, including filters 10A, 10B, and IOC.
- FIGs. 8-10 illustrate alternative embodiments of the surface treatment 40 wherein the surface treatment 40 is applied to a substrate 42, which in turn is applied to the filter IOC.
- FIG. 8 illustrates the substrate 42 in the form of a pad 42A
- FIG. 9 illustrates the substrate 42 in the form of a tubular structure 42B
- FIG. 10 illustrates the substrate 42 in the form of a band 42C.
- substrates 42A, 42B, and 42C described herein are merely exemplary and many forms may be employed without departing from the scope or spirit of the invention.
- substrates 42A, 42B, and 42C may be genetically referred to as substrate 42.
- the substrate 42 is shown in the form of a pad 42A which is secured to the strut 16C.
- the surface treatment 40 is applied to the surface that comes into contact with the vessel wall 52.
- the pad 42 A may incorporate a hole 44 sized to accommodate the tip 24C of the strut 16C for attachment thereto.
- the substrate 42 is shown in the form of a tubular structure 42B which is secured to the strut 16C.
- the surface treatment 40 is applied to the exterior surface of the tube 42B such that the surface treatment 40 comes into contact with the vessel wall 52.
- the tubular structure 42B includes a lumen sized to accommodate the tip 24C of the strut 16C such that the tube may be slid onto the tip 24C of the strut 16C, much like a sock.
- the substrate 42 is shown in the form of a band 42C which is secured about the struts 16C when the filter 10C is in a collapsed state (as shown).
- the band 42C may include a plurality of holes 44 sized to accommodate the tips 24C of the struts 16C such that the band 42C may be loaded thereon.
- the band 42C may include a plurality of separation lines 46, preferably disposed between the holes 44.
- the separation lines 46 may be lines of weakness in the band 42C such as serrated lines.
- the band 42C separates along the separation lines 46 to essentially form a plurality of pads as discussed with reference to FIG. 8.
- the surface treatment 40 is preferably applied to the exterior surface of the band 42C such that the surface treatment 40 comes into contact with the vessel wall 52.
- Substrate 42 may be formed of a wide variety of suitable materials including the materials which form the struts 16 of the filter 10A and other polymer carriers.
- the surface treatment 40 may be sprayed, dipped, or otherwise coated onto the substrate 42 as described previously.
- the surface treatment 40 may be admixed or otherwise incorporated into the material of the substrate 42 such that the material of the substrate 42 functions as a carrier of the surface treatment material 40.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00945068A EP1207810B1 (en) | 1999-08-10 | 2000-06-30 | Thrombosis filter having a surface treatment |
CA002378977A CA2378977C (en) | 1999-08-10 | 2000-06-30 | Thrombosis filter having a surface treatment |
DE60021896T DE60021896T2 (en) | 1999-08-10 | 2000-06-30 | THROMBOSE FILTER WITH SURFACE TREATMENT |
AT00945068T ATE301436T1 (en) | 1999-08-10 | 2000-06-30 | THROMBOSIS FILTER WITH SURFACE TREATMENT |
JP2001514871A JP2003506140A (en) | 1999-08-10 | 2000-06-30 | Thrombus filter with surface treatment |
AU59060/00A AU5906000A (en) | 1999-08-10 | 2000-06-30 | Thrombosis filter having a surface treatment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/371,305 | 1999-08-10 | ||
US09/371,305 US6273901B1 (en) | 1999-08-10 | 1999-08-10 | Thrombosis filter having a surface treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001010342A1 true WO2001010342A1 (en) | 2001-02-15 |
Family
ID=23463414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/018144 WO2001010342A1 (en) | 1999-08-10 | 2000-06-30 | Thrombosis filter having a surface treatment |
Country Status (8)
Country | Link |
---|---|
US (2) | US6273901B1 (en) |
EP (1) | EP1207810B1 (en) |
JP (1) | JP2003506140A (en) |
AT (1) | ATE301436T1 (en) |
AU (1) | AU5906000A (en) |
CA (1) | CA2378977C (en) |
DE (1) | DE60021896T2 (en) |
WO (1) | WO2001010342A1 (en) |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1412014A2 (en) * | 2001-06-14 | 2004-04-28 | Cook Incorporated | Endovascular filter |
WO2006020942A1 (en) * | 2004-08-13 | 2006-02-23 | Delgado Reynolds M Iii | Method and apparatus for long-term assisting a left ventricle to pump blood |
EP1894543A1 (en) * | 2006-08-29 | 2008-03-05 | McGuckin, James F. Jr. | Vein filter |
WO2008022799A3 (en) * | 2006-08-25 | 2009-03-12 | Acandis Gmbh & Co Kg | Thrombosis filter with cover layer |
WO2009091968A1 (en) * | 2008-01-18 | 2009-07-23 | Med Institute, Inc. | Intravascular device attachment system having struts |
WO2010126889A1 (en) * | 2009-04-27 | 2010-11-04 | Med Institute, Inc. | Stent with protected barbs |
CN101143114B (en) * | 2006-09-14 | 2011-01-12 | 微创医疗器械(上海)有限公司 | Double-layer venous filter |
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US8999364B2 (en) | 2004-06-15 | 2015-04-07 | Nanyang Technological University | Implantable article, method of forming same and method for reducing thrombogenicity |
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US9308075B2 (en) | 2004-01-22 | 2016-04-12 | Argon Medical Devices, Inc. | Vessel filter |
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US9452039B2 (en) | 2012-02-23 | 2016-09-27 | Merit Medical Systems, Inc. | Vascular filter |
US9510929B2 (en) | 2004-01-22 | 2016-12-06 | Argon Medical Devices, Inc. | Vein filter |
US9572915B2 (en) | 2012-03-26 | 2017-02-21 | Procyrion, Inc. | Systems and methods for fluid flows and/or pressures for circulation and perfusion enhancement |
US9908143B2 (en) | 2008-06-20 | 2018-03-06 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US10076401B2 (en) | 2006-08-29 | 2018-09-18 | Argon Medical Devices, Inc. | Vein filter |
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US10722338B2 (en) | 2013-08-09 | 2020-07-28 | Merit Medical Systems, Inc. | Vascular filter delivery systems and methods |
US11235138B2 (en) | 2015-09-25 | 2022-02-01 | Procyrion, Inc. | Non-occluding intravascular blood pump providing reduced hemolysis |
US11324940B2 (en) | 2019-12-03 | 2022-05-10 | Procyrion, Inc. | Blood pumps |
US11351359B2 (en) | 2019-12-13 | 2022-06-07 | Procyrion, Inc. | Support structures for intravascular blood pumps |
US11931484B2 (en) | 2008-06-20 | 2024-03-19 | Razmodics Llc | Composite stent having multi-axial flexibility and method of manufacture thereof |
Families Citing this family (157)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070203520A1 (en) * | 1995-06-07 | 2007-08-30 | Dennis Griffin | Endovascular filter |
US6036702A (en) * | 1997-04-23 | 2000-03-14 | Vascular Science Inc. | Medical grafting connectors and fasteners |
US7491216B2 (en) | 1997-11-07 | 2009-02-17 | Salviac Limited | Filter element with retractable guidewire tip |
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US7314477B1 (en) | 1998-09-25 | 2008-01-01 | C.R. Bard Inc. | Removable embolus blood clot filter and filter delivery unit |
US6273911B1 (en) | 1999-04-22 | 2001-08-14 | Advanced Cardiovascular Systems, Inc. | Variable strength stent |
US6918921B2 (en) | 1999-05-07 | 2005-07-19 | Salviac Limited | Support frame for an embolic protection device |
US6964672B2 (en) | 1999-05-07 | 2005-11-15 | Salviac Limited | Support frame for an embolic protection device |
US6273901B1 (en) * | 1999-08-10 | 2001-08-14 | Scimed Life Systems, Inc. | Thrombosis filter having a surface treatment |
GB9920547D0 (en) * | 1999-08-31 | 1999-11-03 | Destiny Pharma Ltd | Coated implant |
US6660021B1 (en) | 1999-12-23 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Intravascular device and system |
US6402771B1 (en) | 1999-12-23 | 2002-06-11 | Guidant Endovascular Solutions | Snare |
US6575997B1 (en) | 1999-12-23 | 2003-06-10 | Endovascular Technologies, Inc. | Embolic basket |
US6695813B1 (en) | 1999-12-30 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Embolic protection devices |
US7918820B2 (en) | 1999-12-30 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Device for, and method of, blocking emboli in vessels such as blood arteries |
DE60138683D1 (en) * | 2000-01-25 | 2009-06-25 | Edwards Lifesciences Corp | BIOACTIVE COATINGS TO AVOID TISSUE GROWTH ON ARTIFICIAL HEART FLAPS |
US6540767B1 (en) * | 2000-02-08 | 2003-04-01 | Scimed Life Systems, Inc. | Recoilable thrombosis filtering device and method |
JP3849397B2 (en) * | 2000-03-23 | 2006-11-22 | ニプロ株式会社 | Venous filter |
GB2369575A (en) | 2000-04-20 | 2002-06-05 | Salviac Ltd | An embolic protection system |
US6676698B2 (en) | 2000-06-26 | 2004-01-13 | Rex Medicol, L.P. | Vascular device with valve for approximating vessel wall |
US6964670B1 (en) | 2000-07-13 | 2005-11-15 | Advanced Cardiovascular Systems, Inc. | Embolic protection guide wire |
WO2002011812A1 (en) * | 2000-08-04 | 2002-02-14 | Duke University | Temporary vascular filters and methods |
US6506203B1 (en) | 2000-12-19 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Low profile sheathless embolic protection system |
IL143007A0 (en) * | 2001-05-07 | 2002-04-21 | Rafael Medical Technologies In | Retrievable intravascular support structures |
US6623506B2 (en) * | 2001-06-18 | 2003-09-23 | Rex Medical, L.P | Vein filter |
CA2455349C (en) * | 2001-06-18 | 2011-02-15 | Rex Medical, L.P. | Vein filter |
US8282668B2 (en) * | 2001-06-18 | 2012-10-09 | Rex Medical, L.P. | Vein filter |
US7179275B2 (en) * | 2001-06-18 | 2007-02-20 | Rex Medical, L.P. | Vein filter |
US6793665B2 (en) | 2001-06-18 | 2004-09-21 | Rex Medical, L.P. | Multiple access vein filter |
US6783538B2 (en) | 2001-06-18 | 2004-08-31 | Rex Medical, L.P | Removable vein filter |
US6599307B1 (en) | 2001-06-29 | 2003-07-29 | Advanced Cardiovascular Systems, Inc. | Filter device for embolic protection systems |
US7338510B2 (en) | 2001-06-29 | 2008-03-04 | Advanced Cardiovascular Systems, Inc. | Variable thickness embolic filtering devices and method of manufacturing the same |
US6638294B1 (en) | 2001-08-30 | 2003-10-28 | Advanced Cardiovascular Systems, Inc. | Self furling umbrella frame for carotid filter |
US6592606B2 (en) | 2001-08-31 | 2003-07-15 | Advanced Cardiovascular Systems, Inc. | Hinged short cage for an embolic protection device |
US8262689B2 (en) | 2001-09-28 | 2012-09-11 | Advanced Cardiovascular Systems, Inc. | Embolic filtering devices |
EP1455686A2 (en) | 2001-12-21 | 2004-09-15 | Salviac Limited | A support frame for an embolic protection device |
US7241304B2 (en) | 2001-12-21 | 2007-07-10 | Advanced Cardiovascular Systems, Inc. | Flexible and conformable embolic filtering devices |
US9204956B2 (en) | 2002-02-20 | 2015-12-08 | C. R. Bard, Inc. | IVC filter with translating hooks |
US7303575B2 (en) * | 2002-08-01 | 2007-12-04 | Lumen Biomedical, Inc. | Embolism protection devices |
AU2003267164A1 (en) | 2002-09-12 | 2004-04-30 | Cook Incorporated | Retrievable filter |
US7252675B2 (en) | 2002-09-30 | 2007-08-07 | Advanced Cardiovascular, Inc. | Embolic filtering devices |
US7331973B2 (en) | 2002-09-30 | 2008-02-19 | Avdanced Cardiovascular Systems, Inc. | Guide wire with embolic filtering attachment |
US20040088000A1 (en) | 2002-10-31 | 2004-05-06 | Muller Paul F. | Single-wire expandable cages for embolic filtering devices |
AU2003297534A1 (en) * | 2002-12-24 | 2004-07-22 | Ovion, Inc. | Contraceptive device and delivery system |
US7763045B2 (en) | 2003-02-11 | 2010-07-27 | Cook Incorporated | Removable vena cava filter |
US8591540B2 (en) | 2003-02-27 | 2013-11-26 | Abbott Cardiovascular Systems Inc. | Embolic filtering devices |
US20040186510A1 (en) * | 2003-03-18 | 2004-09-23 | Scimed Life Systems, Inc. | Embolic protection ivc filter |
WO2004103209A2 (en) | 2003-05-19 | 2004-12-02 | Secant Medical Llc | Tissue distention device and related methods for therapeutic intervention |
US7879062B2 (en) * | 2003-07-22 | 2011-02-01 | Lumen Biomedical, Inc. | Fiber based embolism protection device |
US8048042B2 (en) * | 2003-07-22 | 2011-11-01 | Medtronic Vascular, Inc. | Medical articles incorporating surface capillary fiber |
US7662143B2 (en) * | 2003-07-29 | 2010-02-16 | Boston Scientific Scimed, Inc. | Apparatus and method for treating intravascular disease |
US7896898B2 (en) * | 2003-07-30 | 2011-03-01 | Boston Scientific Scimed, Inc. | Self-centering blood clot filter |
US7604650B2 (en) * | 2003-10-06 | 2009-10-20 | 3F Therapeutics, Inc. | Method and assembly for distal embolic protection |
EP1689482A1 (en) * | 2003-10-28 | 2006-08-16 | Peacock, James C., III | Embolic filter device and related systems and methods |
US7892251B1 (en) | 2003-11-12 | 2011-02-22 | Advanced Cardiovascular Systems, Inc. | Component for delivering and locking a medical device to a guide wire |
US7056286B2 (en) | 2003-11-12 | 2006-06-06 | Adrian Ravenscroft | Medical device anchor and delivery system |
US8231649B2 (en) * | 2004-01-20 | 2012-07-31 | Boston Scientific Scimed, Inc. | Retrievable blood clot filter with retractable anchoring members |
US7338512B2 (en) * | 2004-01-22 | 2008-03-04 | Rex Medical, L.P. | Vein filter |
US8211140B2 (en) | 2004-01-22 | 2012-07-03 | Rex Medical, L.P. | Vein filter |
US8062326B2 (en) | 2004-01-22 | 2011-11-22 | Rex Medical, L.P. | Vein filter |
US8162972B2 (en) | 2004-01-22 | 2012-04-24 | Rex Medical, Lp | Vein filter |
US7704266B2 (en) * | 2004-01-22 | 2010-04-27 | Rex Medical, L.P. | Vein filter |
US8308750B2 (en) * | 2004-03-10 | 2012-11-13 | Boston Scientific Scimed, Inc. | Removable intravascular devices and methods of making and using the same |
US7678129B1 (en) | 2004-03-19 | 2010-03-16 | Advanced Cardiovascular Systems, Inc. | Locking component for an embolic filter assembly |
JP4898988B2 (en) | 2004-04-16 | 2012-03-21 | クック メディカル テクノロジーズ エルエルシー | Retrievable vena cava filter with primary struts to enhance retrieval and delivery performance |
US8043322B2 (en) | 2004-04-16 | 2011-10-25 | Cook Medical Technologies Llc | Removable vena cava filter having inwardly positioned anchoring hooks in collapsed configuration |
DE602005025329D1 (en) | 2004-04-16 | 2011-01-27 | Cook William Europ | REMOVABLE VENA CAVA FILTER WITH ANCHORAGE DEVICE FOR REDUCED TRAUMATA |
ATE503438T1 (en) | 2004-04-16 | 2011-04-15 | Cook Inc | REMOVABLE VENA CAVA FILTER TO REDUCE TRAUMA IN FOLDED STATE |
US7722635B2 (en) * | 2004-06-25 | 2010-05-25 | Angiodynamics, Inc. | Blood clot filter |
US7544202B2 (en) * | 2004-06-25 | 2009-06-09 | Angiodynamics, Inc. | Retrievable blood clot filter |
US8529595B2 (en) | 2004-06-30 | 2013-09-10 | Boston Scientific Scimed, Inc. | Intravascular filter |
US7704267B2 (en) | 2004-08-04 | 2010-04-27 | C. R. Bard, Inc. | Non-entangling vena cava filter |
JP2008514293A (en) | 2004-09-27 | 2008-05-08 | クック インコーポレイテッド | Removable vena cava filter with struts with axial curvature |
ES2444590T3 (en) | 2004-09-27 | 2014-02-25 | Rex Medical, L.P. | Venous filter |
WO2006042114A1 (en) | 2004-10-06 | 2006-04-20 | Cook, Inc. | Emboli capturing device having a coil and method for capturing emboli |
US7794473B2 (en) | 2004-11-12 | 2010-09-14 | C.R. Bard, Inc. | Filter delivery system |
US20060149312A1 (en) * | 2004-12-30 | 2006-07-06 | Edward Arguello | Distal protection device with improved wall apposition |
US20060149313A1 (en) * | 2004-12-30 | 2006-07-06 | Edward Arguello | Distal protection apparatus with improved wall apposition |
US7854747B2 (en) | 2005-01-03 | 2010-12-21 | Crux Biomedical, Inc. | Endoluminal filter |
US8366743B2 (en) * | 2005-01-28 | 2013-02-05 | Lifetech Scientific (Shenzhen) Co., Ltd | Heart septal defect occlusion device |
US8267954B2 (en) | 2005-02-04 | 2012-09-18 | C. R. Bard, Inc. | Vascular filter with sensing capability |
US7998164B2 (en) * | 2005-03-11 | 2011-08-16 | Boston Scientific Scimed, Inc. | Intravascular filter with centering member |
US8221446B2 (en) | 2005-03-15 | 2012-07-17 | Cook Medical Technologies | Embolic protection device |
US8945169B2 (en) | 2005-03-15 | 2015-02-03 | Cook Medical Technologies Llc | Embolic protection device |
US20060224175A1 (en) * | 2005-03-29 | 2006-10-05 | Vrba Anthony C | Methods and apparatuses for disposition of a medical device onto an elongate medical device |
US9259305B2 (en) | 2005-03-31 | 2016-02-16 | Abbott Cardiovascular Systems Inc. | Guide wire locking mechanism for rapid exchange and other catheter systems |
US7947207B2 (en) | 2005-04-12 | 2011-05-24 | Abbott Cardiovascular Systems Inc. | Method for retaining a vascular stent on a catheter |
US7763198B2 (en) | 2005-04-12 | 2010-07-27 | Abbott Cardiovascular Systems Inc. | Method for retaining a vascular stent on a catheter |
US8025668B2 (en) * | 2005-04-28 | 2011-09-27 | C. R. Bard, Inc. | Medical device removal system |
US7967747B2 (en) * | 2005-05-10 | 2011-06-28 | Boston Scientific Scimed, Inc. | Filtering apparatus and methods of use |
US8574259B2 (en) * | 2005-05-10 | 2013-11-05 | Lifescreen Sciences Llc | Intravascular filter with drug reservoir |
MX2007013932A (en) | 2005-05-12 | 2008-01-28 | Bard Inc C R | Removable embolus blood clot filter. |
US7850708B2 (en) | 2005-06-20 | 2010-12-14 | Cook Incorporated | Embolic protection device having a reticulated body with staggered struts |
US8109962B2 (en) | 2005-06-20 | 2012-02-07 | Cook Medical Technologies Llc | Retrievable device having a reticulation portion with staggered struts |
US7771452B2 (en) | 2005-07-12 | 2010-08-10 | Cook Incorporated | Embolic protection device with a filter bag that disengages from a basket |
US7766934B2 (en) | 2005-07-12 | 2010-08-03 | Cook Incorporated | Embolic protection device with an integral basket and bag |
US8187298B2 (en) | 2005-08-04 | 2012-05-29 | Cook Medical Technologies Llc | Embolic protection device having inflatable frame |
US8062327B2 (en) | 2005-08-09 | 2011-11-22 | C. R. Bard, Inc. | Embolus blood clot filter and delivery system |
US8377092B2 (en) | 2005-09-16 | 2013-02-19 | Cook Medical Technologies Llc | Embolic protection device |
US7698691B2 (en) * | 2005-09-20 | 2010-04-13 | Microsoft Corporation | Server application state |
US8632562B2 (en) | 2005-10-03 | 2014-01-21 | Cook Medical Technologies Llc | Embolic protection device |
US8182508B2 (en) | 2005-10-04 | 2012-05-22 | Cook Medical Technologies Llc | Embolic protection device |
US20070082020A1 (en) * | 2005-10-11 | 2007-04-12 | Piccone Vincent A Jr | Blood clot filter having coating |
US8252017B2 (en) | 2005-10-18 | 2012-08-28 | Cook Medical Technologies Llc | Invertible filter for embolic protection |
US8216269B2 (en) | 2005-11-02 | 2012-07-10 | Cook Medical Technologies Llc | Embolic protection device having reduced profile |
US8152831B2 (en) | 2005-11-17 | 2012-04-10 | Cook Medical Technologies Llc | Foam embolic protection device |
US9131999B2 (en) | 2005-11-18 | 2015-09-15 | C.R. Bard Inc. | Vena cava filter with filament |
EP1965727A2 (en) * | 2005-12-30 | 2008-09-10 | C.R.Bard, Inc. | Embolus blood clot filter with post delivery actuation |
CA2633851A1 (en) | 2005-12-30 | 2007-07-12 | C.R. Bard Inc. | Embolus blood clot filter with floating filter basket |
US8317818B2 (en) * | 2005-12-30 | 2012-11-27 | C.R. Bard, Inc. | Removable blood clot filter with edge for cutting through the endothelium |
EP1991162A2 (en) * | 2005-12-30 | 2008-11-19 | C.R.Bard, Inc. | Embolus blood clot filter with bio-resorbable coated filter members |
EP1965852A4 (en) | 2005-12-30 | 2012-10-31 | Bard Inc C R | Embolus blood clot filter removal system and method |
US8734479B2 (en) * | 2005-12-30 | 2014-05-27 | C.R. Bard, Inc. | Embolus blood clot filter delivery system |
US9107733B2 (en) * | 2006-01-13 | 2015-08-18 | W. L. Gore & Associates, Inc. | Removable blood conduit filter |
CA2631295A1 (en) * | 2006-01-20 | 2007-07-26 | Angiodynamics, Inc. | Retrievable blood clot filter |
US8235047B2 (en) | 2006-03-30 | 2012-08-07 | Conceptus, Inc. | Methods and devices for deployment into a lumen |
WO2007133366A2 (en) | 2006-05-02 | 2007-11-22 | C. R. Bard, Inc. | Vena cava filter formed from a sheet |
CA2655158A1 (en) | 2006-06-05 | 2007-12-13 | C.R. Bard Inc. | Embolus blood clot filter utilizable with a single delivery system or a single retrieval system in one of a femoral or jugular access |
US8864809B2 (en) * | 2006-08-09 | 2014-10-21 | Coherex Medical, Inc. | Systems and devices for reducing the size of an internal tissue opening |
US20090270840A1 (en) * | 2008-03-28 | 2009-10-29 | Coherex Medical, Inc. | Delivery systems for a medical device and related methods |
US8529597B2 (en) | 2006-08-09 | 2013-09-10 | Coherex Medical, Inc. | Devices for reducing the size of an internal tissue opening |
US9138208B2 (en) | 2006-08-09 | 2015-09-22 | Coherex Medical, Inc. | Devices for reducing the size of an internal tissue opening |
US20080071307A1 (en) | 2006-09-19 | 2008-03-20 | Cook Incorporated | Apparatus and methods for in situ embolic protection |
WO2008073971A1 (en) * | 2006-12-12 | 2008-06-19 | C. R. Bard Inc. | Recoverable inferior vena cava filter |
WO2008076970A1 (en) | 2006-12-18 | 2008-06-26 | C.R. Bard Inc. | Jugular femoral vena cava filter system |
US9901434B2 (en) | 2007-02-27 | 2018-02-27 | Cook Medical Technologies Llc | Embolic protection device including a Z-stent waist band |
US8443808B2 (en) | 2007-03-19 | 2013-05-21 | Hologic, Inc. | Methods and apparatus for occlusion of body lumens |
US8795351B2 (en) * | 2007-04-13 | 2014-08-05 | C.R. Bard, Inc. | Migration resistant embolic filter |
US20080294189A1 (en) * | 2007-05-23 | 2008-11-27 | Moll Fransiscus L | Vein filter |
US8216209B2 (en) | 2007-05-31 | 2012-07-10 | Abbott Cardiovascular Systems Inc. | Method and apparatus for delivering an agent to a kidney |
US7867273B2 (en) | 2007-06-27 | 2011-01-11 | Abbott Laboratories | Endoprostheses for peripheral arteries and other body vessels |
US8007470B2 (en) * | 2007-07-10 | 2011-08-30 | Cook Medical Technologies Llc | Minimally invasive medical device and method for delivery of therapeutic or diagnostic agents into a vessel wall |
US8795318B2 (en) | 2007-09-07 | 2014-08-05 | Merit Medical Systems, Inc. | Percutaneous retrievable vascular filter |
US8252018B2 (en) | 2007-09-14 | 2012-08-28 | Cook Medical Technologies Llc | Helical embolic protection device |
US9138307B2 (en) | 2007-09-14 | 2015-09-22 | Cook Medical Technologies Llc | Expandable device for treatment of a stricture in a body vessel |
US8419748B2 (en) | 2007-09-14 | 2013-04-16 | Cook Medical Technologies Llc | Helical thrombus removal device |
US8246672B2 (en) | 2007-12-27 | 2012-08-21 | Cook Medical Technologies Llc | Endovascular graft with separately positionable and removable frame units |
US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
US8246648B2 (en) | 2008-11-10 | 2012-08-21 | Cook Medical Technologies Llc | Removable vena cava filter with improved leg |
US8388644B2 (en) | 2008-12-29 | 2013-03-05 | Cook Medical Technologies Llc | Embolic protection device and method of use |
KR20110126605A (en) * | 2009-02-03 | 2011-11-23 | 메리트 메디컬 시스템즈, 인크. | Percutaneous retrievable vascular filter |
AU2010278893B2 (en) | 2009-07-29 | 2014-02-27 | C.R. Bard, Inc. | Tubular filter |
EP2496189A4 (en) | 2009-11-04 | 2016-05-11 | Nitinol Devices And Components Inc | Alternating circumferential bridge stent design and methods for use thereof |
EP2624791B1 (en) | 2010-10-08 | 2017-06-21 | Confluent Medical Technologies, Inc. | Alternating circumferential bridge stent design |
US10022212B2 (en) | 2011-01-13 | 2018-07-17 | Cook Medical Technologies Llc | Temporary venous filter with anti-coagulant delivery method |
US8734480B2 (en) | 2011-08-05 | 2014-05-27 | Merit Medical Systems, Inc. | Vascular filter |
US10548706B2 (en) | 2012-01-13 | 2020-02-04 | Volcano Corporation | Retrieval snare device and method |
US10426501B2 (en) | 2012-01-13 | 2019-10-01 | Crux Biomedical, Inc. | Retrieval snare device and method |
US10213288B2 (en) | 2012-03-06 | 2019-02-26 | Crux Biomedical, Inc. | Distal protection filter |
US9168122B2 (en) * | 2012-04-26 | 2015-10-27 | Rex Medical, L.P. | Vascular device and method for valve leaflet apposition |
DK2863811T3 (en) | 2012-06-26 | 2017-12-11 | Vvt Medical Ltd | BLOOD VESSEL CONCLUSION DEVICES |
US20150142025A1 (en) * | 2012-06-26 | 2015-05-21 | V.V.T. Med Ltd. | Biodegradable blood vessel occlusion and narrowing |
US9414752B2 (en) | 2012-11-09 | 2016-08-16 | Elwha Llc | Embolism deflector |
US10350098B2 (en) | 2013-12-20 | 2019-07-16 | Volcano Corporation | Devices and methods for controlled endoluminal filter deployment |
US9668861B2 (en) | 2014-03-15 | 2017-06-06 | Rex Medical, L.P. | Vascular device for treating venous valve insufficiency |
US10117736B2 (en) | 2014-08-06 | 2018-11-06 | Cook Medical Technologies Llc | Low radial force filter |
CN107007377B (en) * | 2017-03-16 | 2019-09-10 | 杭州唯强医疗科技有限公司 | The vena cava filter of multiple filtration |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5601595A (en) | 1994-10-25 | 1997-02-11 | Scimed Life Systems, Inc. | Remobable thrombus filter |
US5626605A (en) * | 1991-12-30 | 1997-05-06 | Scimed Life Systems, Inc. | Thrombosis filter |
WO1997033552A1 (en) * | 1996-03-12 | 1997-09-18 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
US5722984A (en) * | 1996-01-16 | 1998-03-03 | Iso Stent, Inc. | Antithrombogenic radioactive coating for an intravascular stent |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334629A (en) | 1964-11-09 | 1967-08-08 | Bertram D Cohn | Occlusive device for inferior vena cava |
US3467102A (en) | 1967-04-18 | 1969-09-16 | Edwards Lab Inc | Leader type catheter |
US3540431A (en) | 1968-04-04 | 1970-11-17 | Kazi Mobin Uddin | Collapsible filter for fluid flowing in closed passageway |
US3868956A (en) | 1972-06-05 | 1975-03-04 | Ralph J Alfidi | Vessel implantable appliance and method of implanting it |
US3952747A (en) | 1974-03-28 | 1976-04-27 | Kimmell Jr Garman O | Filter and filter insertion instrument |
US4391797A (en) | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
US4675361A (en) | 1980-02-29 | 1987-06-23 | Thoratec Laboratories Corp. | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
US4430081A (en) | 1981-01-06 | 1984-02-07 | Cook, Inc. | Hemostasis sheath |
US4425908A (en) | 1981-10-22 | 1984-01-17 | Beth Israel Hospital | Blood clot filter |
SE430696B (en) | 1982-04-22 | 1983-12-05 | Astra Meditec Ab | PROCEDURE FOR THE PREPARATION OF A HYDROPHILIC COATING AND ANY PROCEDURE MANUFACTURED MEDICAL ARTICLE |
US4487808A (en) | 1982-04-22 | 1984-12-11 | Astra Meditec Aktiebolag | Medical article having a hydrophilic coating |
US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
US4643184A (en) | 1982-09-29 | 1987-02-17 | Mobin Uddin Kazi | Embolus trap |
US4494531A (en) | 1982-12-06 | 1985-01-22 | Cook, Incorporated | Expandable blood clot filter |
US4727873A (en) | 1984-04-17 | 1988-03-01 | Mobin Uddin Kazi | Embolus trap |
DK151404C (en) | 1984-05-23 | 1988-07-18 | Cook Europ Aps William | FULLY FILTER FOR IMPLANTATION IN A PATIENT'S BLOOD |
US4959074A (en) | 1984-08-23 | 1990-09-25 | Gergory Halpern | Method of hydrophilic coating of plastics |
US5037677A (en) | 1984-08-23 | 1991-08-06 | Gregory Halpern | Method of interlaminar grafting of coatings |
FR2570288B1 (en) | 1984-09-14 | 1988-11-25 | Celsa Composants Electr Sa | FILTER, PARTICULARLY FOR THE RETENTION OF BLOOD CLOTS, ITS MANUFACTURING METHOD AND DEVICES FOR ITS PLACEMENT |
FR2573646B1 (en) | 1984-11-29 | 1988-11-25 | Celsa Composants Electr Sa | PERFECTED FILTER, PARTICULARLY FOR THE RETENTION OF BLOOD CLOTS |
FR2580504B1 (en) | 1985-04-22 | 1987-07-10 | Pieronne Alain | FILTER FOR THE PARTIAL AND AT LEAST PROVISIONAL INTERRUPTION OF A VEIN AND CATHETER CARRYING THE FILTER |
US4662885A (en) | 1985-09-03 | 1987-05-05 | Becton, Dickinson And Company | Percutaneously deliverable intravascular filter prosthesis |
US4650466A (en) | 1985-11-01 | 1987-03-17 | Angiobrade Partners | Angioplasty device |
US4793348A (en) | 1986-11-15 | 1988-12-27 | Palmaz Julio C | Balloon expandable vena cava filter to prevent migration of lower extremity venous clots into the pulmonary circulation |
FR2606641B1 (en) | 1986-11-17 | 1991-07-12 | Promed | FILTERING DEVICE FOR BLOOD CLOTS |
US5037656A (en) | 1986-12-04 | 1991-08-06 | Millipore Corporation | Porous membrane having hydrophilic and cell growth promotions surface and process |
US4817600A (en) | 1987-05-22 | 1989-04-04 | Medi-Tech, Inc. | Implantable filter |
US4873978A (en) | 1987-12-04 | 1989-10-17 | Robert Ginsburg | Device and method for emboli retrieval |
FR2624747A1 (en) | 1987-12-18 | 1989-06-23 | Delsanti Gerard | REMOVABLE ENDO-ARTERIAL DEVICES FOR REPAIRING ARTERIAL WALL DECOLLEMENTS |
FR2632864B2 (en) | 1987-12-31 | 1990-10-19 | Biomat Sarl | ANTI-EMBOLIC ELASTIC FILTERING SYSTEM FOR CELLAR VEIN AND ASSEMBLY OF MEANS FOR ITS PLACEMENT |
US4943460A (en) | 1988-02-19 | 1990-07-24 | Snyder Laboratories, Inc. | Process for coating polymer surfaces and coated products produced using such process |
US4980231A (en) | 1988-02-19 | 1990-12-25 | Snyder Laboratories, Inc. | Process for coating polymer surfaces and coated products produced using such process |
US4925698A (en) | 1988-02-23 | 1990-05-15 | Tekmat Corporation | Surface modification of polymeric materials |
FR2632848A1 (en) | 1988-06-21 | 1989-12-22 | Lefebvre Jean Marie | FILTER FOR MEDICAL USE |
US4832055A (en) | 1988-07-08 | 1989-05-23 | Palestrant Aubrey M | Mechanically locking blood clot filter |
US5152777A (en) | 1989-01-25 | 1992-10-06 | Uresil Corporation | Device and method for providing protection from emboli and preventing occulsion of blood vessels |
US4969891A (en) | 1989-03-06 | 1990-11-13 | Gewertz Bruce L | Removable vascular filter |
US5026607A (en) | 1989-06-23 | 1991-06-25 | C. R. Bard, Inc. | Medical apparatus having protective, lubricious coating |
US5059205A (en) | 1989-09-07 | 1991-10-22 | Boston Scientific Corporation | Percutaneous anti-migration vena cava filter |
US5242462A (en) | 1989-09-07 | 1993-09-07 | Boston Scientific Corp. | Percutaneous anti-migration vena cava filter |
US5035706A (en) | 1989-10-17 | 1991-07-30 | Cook Incorporated | Percutaneous stent and method for retrieval thereof |
GB2238485B (en) | 1989-11-28 | 1993-07-14 | Cook William Europ | A collapsible filter for introduction in a blood vessel of a patient |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
FR2660189B1 (en) | 1990-03-28 | 1992-07-31 | Lefebvre Jean Marie | DEVICE INTENDED TO BE IMPLANTED IN A VESSEL WITH SIDE LEGS WITH ANTAGONIST TEETH. |
US5071407A (en) | 1990-04-12 | 1991-12-10 | Schneider (U.S.A.) Inc. | Radially expandable fixation member |
WO1991017724A1 (en) | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
FR2663217B1 (en) | 1990-06-15 | 1992-10-16 | Antheor | FILTERING DEVICE FOR THE PREVENTION OF EMBOLIES. |
CA2048307C (en) | 1990-08-14 | 1998-08-18 | Rolf Gunther | Method and apparatus for filtering blood in a blood vessel of a patient |
US5160342A (en) | 1990-08-16 | 1992-11-03 | Evi Corp. | Endovascular filter and method for use thereof |
US5108419A (en) | 1990-08-16 | 1992-04-28 | Evi Corporation | Endovascular filter and method for use thereof |
SE467308B (en) | 1990-10-22 | 1992-06-29 | Berol Nobel Ab | SOLID SURFACE COATED WITH A HYDROPHILIC SURFACE WITH COVALENTLY BONDED BIOPOLYMERS, SET TO MAKE SUCH A SURFACE AND CONJUGATED THEREOF |
US5160790A (en) | 1990-11-01 | 1992-11-03 | C. R. Bard, Inc. | Lubricious hydrogel coatings |
US5147379A (en) | 1990-11-26 | 1992-09-15 | Louisiana State University And Agricultural And Mechanical College | Insertion instrument for vena cava filter |
US5102402A (en) | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
AU1579092A (en) | 1991-02-27 | 1992-10-06 | Nova Pharmaceutical Corporation | Anti-infective and anti-inflammatory releasing systems for medical devices |
DE69125828T2 (en) * | 1991-05-21 | 1997-07-31 | Hewlett Packard Gmbh | Process for pretreating the surface of a medical article |
US5330768A (en) | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
JP2573612Y2 (en) | 1991-12-30 | 1998-06-04 | ハナコメディカル株式会社 | Filter for thrombus filtration |
US5599352A (en) | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
US5383928A (en) | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5324304A (en) | 1992-06-18 | 1994-06-28 | William Cook Europe A/S | Introduction catheter set for a collapsible self-expandable implant |
US5578075B1 (en) | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5449382A (en) | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5443458A (en) | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
WO1994021308A1 (en) | 1993-03-18 | 1994-09-29 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
PT1118325E (en) | 1993-07-29 | 2006-05-31 | Us Health | USES OF PACLITAXEL AND ITS DERIVATIVES IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF RESTENOSE |
US5380299A (en) | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5709704A (en) * | 1994-11-30 | 1998-01-20 | Boston Scientific Corporation | Blood clot filtering |
US5702754A (en) | 1995-02-22 | 1997-12-30 | Meadox Medicals, Inc. | Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings |
US5605696A (en) | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US5669933A (en) | 1996-07-17 | 1997-09-23 | Nitinol Medical Technologies, Inc. | Removable embolus blood clot filter |
US5800525A (en) * | 1997-06-04 | 1998-09-01 | Vascular Science, Inc. | Blood filter |
US6156373A (en) * | 1999-05-03 | 2000-12-05 | Scimed Life Systems, Inc. | Medical device coating methods and devices |
US6273901B1 (en) * | 1999-08-10 | 2001-08-14 | Scimed Life Systems, Inc. | Thrombosis filter having a surface treatment |
-
1999
- 1999-08-10 US US09/371,305 patent/US6273901B1/en not_active Expired - Lifetime
-
2000
- 2000-06-30 EP EP00945068A patent/EP1207810B1/en not_active Expired - Lifetime
- 2000-06-30 JP JP2001514871A patent/JP2003506140A/en active Pending
- 2000-06-30 DE DE60021896T patent/DE60021896T2/en not_active Expired - Lifetime
- 2000-06-30 AU AU59060/00A patent/AU5906000A/en not_active Abandoned
- 2000-06-30 AT AT00945068T patent/ATE301436T1/en not_active IP Right Cessation
- 2000-06-30 WO PCT/US2000/018144 patent/WO2001010342A1/en active IP Right Grant
- 2000-06-30 CA CA002378977A patent/CA2378977C/en not_active Expired - Fee Related
-
2001
- 2001-07-18 US US09/908,318 patent/US6589266B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5626605A (en) * | 1991-12-30 | 1997-05-06 | Scimed Life Systems, Inc. | Thrombosis filter |
US5601595A (en) | 1994-10-25 | 1997-02-11 | Scimed Life Systems, Inc. | Remobable thrombus filter |
US5722984A (en) * | 1996-01-16 | 1998-03-03 | Iso Stent, Inc. | Antithrombogenic radioactive coating for an intravascular stent |
WO1997033552A1 (en) * | 1996-03-12 | 1997-09-18 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
Cited By (43)
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US9308075B2 (en) | 2004-01-22 | 2016-04-12 | Argon Medical Devices, Inc. | Vessel filter |
US8864793B2 (en) | 2004-01-22 | 2014-10-21 | Rex Medical, L.P. | Vein filter |
US9510929B2 (en) | 2004-01-22 | 2016-12-06 | Argon Medical Devices, Inc. | Vein filter |
US8999364B2 (en) | 2004-06-15 | 2015-04-07 | Nanyang Technological University | Implantable article, method of forming same and method for reducing thrombogenicity |
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US9028525B2 (en) | 2007-09-07 | 2015-05-12 | Merit Medical Systems, Inc. | Percutaneous retrievable vascular filter |
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Also Published As
Publication number | Publication date |
---|---|
DE60021896D1 (en) | 2005-09-15 |
JP2003506140A (en) | 2003-02-18 |
CA2378977C (en) | 2007-11-20 |
DE60021896T2 (en) | 2006-06-08 |
ATE301436T1 (en) | 2005-08-15 |
EP1207810B1 (en) | 2005-08-10 |
US6589266B2 (en) | 2003-07-08 |
AU5906000A (en) | 2001-03-05 |
EP1207810A1 (en) | 2002-05-29 |
CA2378977A1 (en) | 2001-02-15 |
US6273901B1 (en) | 2001-08-14 |
US20010039432A1 (en) | 2001-11-08 |
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