WO2001007665A3 - Sequence determination of nucleic acids using electronic detection - Google Patents
Sequence determination of nucleic acids using electronic detection Download PDFInfo
- Publication number
- WO2001007665A3 WO2001007665A3 PCT/US2000/020476 US0020476W WO0107665A3 WO 2001007665 A3 WO2001007665 A3 WO 2001007665A3 US 0020476 W US0020476 W US 0020476W WO 0107665 A3 WO0107665 A3 WO 0107665A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acids
- sequence determination
- electronic detection
- snps
- mismatches
- Prior art date
Links
- 0 CCC(C)(CC)C(CC)(CC)C(C)(*)O*C(F)(F)F Chemical compound CCC(C)(CC)C(CC)(CC)C(C)(*)O*C(F)(F)F 0.000 description 5
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002380258A CA2380258C (en) | 1999-07-26 | 2000-07-26 | Sequence determination of nucleic acids using electronic detection |
JP2001512930A JP3926625B2 (en) | 1999-07-26 | 2000-07-26 | Nucleic acid sequencing using electronic detection |
DE60041072T DE60041072D1 (en) | 1999-07-26 | 2000-07-26 | EM PROOF |
AU66104/00A AU779220B2 (en) | 1999-07-26 | 2000-07-26 | Sequence determination of nucleic acids using electronic detection |
EP00953701A EP1218541B1 (en) | 1999-07-26 | 2000-07-26 | Sequence determination of nucleic acids using electronic detection |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14569599P | 1999-07-26 | 1999-07-26 | |
US60/145,695 | 1999-07-26 | ||
US19025900P | 2000-03-17 | 2000-03-17 | |
US60/190,259 | 2000-03-17 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2001007665A2 WO2001007665A2 (en) | 2001-02-01 |
WO2001007665A3 true WO2001007665A3 (en) | 2002-05-02 |
WO2001007665A9 WO2001007665A9 (en) | 2002-07-11 |
Family
ID=26843217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/020476 WO2001007665A2 (en) | 1999-07-26 | 2000-07-26 | Sequence determination of nucleic acids using electronic detection |
Country Status (9)
Country | Link |
---|---|
US (1) | US7935481B1 (en) |
EP (1) | EP1218541B1 (en) |
JP (1) | JP3926625B2 (en) |
AT (1) | ATE417127T1 (en) |
AU (1) | AU779220B2 (en) |
CA (1) | CA2380258C (en) |
DE (1) | DE60041072D1 (en) |
ES (1) | ES2319380T3 (en) |
WO (1) | WO2001007665A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8012743B2 (en) | 1998-10-27 | 2011-09-06 | Osmetech Technology Inc. | Detection of target analytes using particles and electrodes |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6518024B2 (en) | 1999-12-13 | 2003-02-11 | Motorola, Inc. | Electrochemical detection of single base extension |
CA2440146A1 (en) | 2001-03-30 | 2002-10-24 | Amersham Biosciences Ab | P450 single nucleotide polymorphism biochip analysis |
US20030143556A1 (en) * | 2001-04-03 | 2003-07-31 | Gary Blackburn | Nucleic acid reactions using labels with different redox potentials |
WO2003085082A2 (en) * | 2001-04-03 | 2003-10-16 | Clinical Micro Sensors, Inc. | Nucleic acid reactions using labels with different redox potentials |
DE10141691A1 (en) * | 2001-08-25 | 2003-03-13 | Friz Biochem Gmbh | Displacement assay for the detection of ligate-ligand association events |
WO2003018834A2 (en) | 2001-08-25 | 2003-03-06 | Friz Biochem Gmbh | Displacement assay for the detection of nucleic acid oligomer hybridization events |
GB0205455D0 (en) * | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
DE10261528B4 (en) * | 2002-12-23 | 2006-10-05 | Friz Biochem Gesellschaft Für Bioanalytik Mbh | Electrical substrate for use as carrier of biomolecules |
CA2524585A1 (en) | 2003-05-02 | 2004-11-11 | Centrum Mikrobiologii I Wirusologii Polskiej Akademii Nauk | Nucleoside derivative, modified oligonucleotide, method for their synthesis and applications thereof |
PL1859330T3 (en) * | 2005-01-28 | 2013-01-31 | Univ Duke | Apparatuses and methods for manipulating droplets on a printed circuit board |
EP2677309B9 (en) | 2006-12-14 | 2014-11-19 | Life Technologies Corporation | Methods for sequencing a nucleic acid using large scale FET arrays, configured to measure a limited pH range |
AT505495A1 (en) * | 2007-07-04 | 2009-01-15 | Arc Austrian Res Centers Gmbh | METHOD FOR IDENTIFYING AND QUANTIFYING ORGANIC AND BIOCHEMICAL SUBSTANCES |
US8648605B2 (en) * | 2007-09-28 | 2014-02-11 | Hitachi Chemical Company, Ltd. | Sensor, sensor system, portable sensor system, method of analyzing metal ions, mounting substrate, method of analyzing plating preventing chemical species, method of analyzing produced compound, and method of analyzing monovalent copper chemical species |
KR100799593B1 (en) | 2007-10-08 | 2008-01-30 | 한국전자통신연구원 | Compounds for molecular electronic device having asymmetric disulfide anchoring group, synthesis of the same, and molecular electronic devices having molecular active layer obtained from the compounds |
KR100819059B1 (en) * | 2007-10-08 | 2008-04-03 | 한국전자통신연구원 | Compounds for molecular electronic device having asymmetric disulfide anchoring group, synthesis of the same, and molecular electronic devices having molecular active layer obtained from the compounds |
CA2740414A1 (en) * | 2008-10-14 | 2010-04-22 | Bioaccel | System and method for inferring str allelic genotype from snps |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
JP2012506557A (en) * | 2008-10-22 | 2012-03-15 | ライフ テクノロジーズ コーポレーション | Integrated sensor arrays for biological and chemical analysis |
US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
EP2912432B1 (en) | 2012-10-24 | 2018-07-04 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
EP3520895A1 (en) | 2013-03-15 | 2019-08-07 | Genmark Diagnostics Inc. | Fluid container with cantilevered lance |
US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
EP3218108B1 (en) | 2014-11-11 | 2020-09-02 | Genmark Diagnostics Inc. | Fluid sample processing cartridge and use thereof |
US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
US10605767B2 (en) | 2014-12-18 | 2020-03-31 | Life Technologies Corporation | High data rate integrated circuit with transmitter configuration |
EP3516401A1 (en) | 2016-09-19 | 2019-07-31 | Genmark Diagnostics Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
WO2019040769A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | Electrochemical detection of bacterial and/or fungal infections |
US20190062809A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | Electrochemical detection of bacterial and/or fungal infections |
WO2023237641A1 (en) * | 2022-06-07 | 2023-12-14 | F. Hoffmann-La Roche Ag | Ferrocene labelled primers for electrochemical detection |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040712A1 (en) * | 1995-06-07 | 1996-12-19 | California Institute Of Technology | Nucleic acid mediated electron transfer |
WO1998020162A2 (en) * | 1996-11-05 | 1998-05-14 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
WO1998031839A2 (en) * | 1997-01-21 | 1998-07-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
WO1998057159A1 (en) * | 1997-06-12 | 1998-12-17 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes |
WO1999057319A1 (en) * | 1998-05-06 | 1999-11-11 | Clinical Micro Sensors | Electronic detection of nucleic acids using monolayers |
WO1999067425A2 (en) * | 1998-06-23 | 1999-12-29 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
Family Cites Families (150)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1219824A (en) | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
US5241060A (en) | 1982-06-23 | 1993-08-31 | Enzo Diagnostics, Inc. | Base moiety-labeled detectable nucleatide |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
US5509410A (en) | 1983-06-06 | 1996-04-23 | Medisense, Inc. | Strip electrode including screen printing of a single layer |
GB8328520D0 (en) | 1983-10-25 | 1983-11-23 | Serono Diagnostics Ltd | Methods of assay |
WO1985002627A1 (en) | 1983-12-16 | 1985-06-20 | Genetics International, Inc. | Assay for nucleic acids |
US4849513A (en) | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
US4707352A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
US4943523A (en) | 1984-01-30 | 1990-07-24 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US5013831A (en) | 1984-01-30 | 1991-05-07 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4952685A (en) | 1984-01-30 | 1990-08-28 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4707440A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
US5002885A (en) | 1984-01-30 | 1991-03-26 | Enzo Biochem, Inc. | Detectable molecules, method preparation and use |
US5175269A (en) | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
CA1260372A (en) | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
GB8417301D0 (en) | 1984-07-06 | 1984-08-08 | Serono Diagnostics Ltd | Assay |
US4755458A (en) | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US4713347A (en) | 1985-01-14 | 1987-12-15 | Sensor Diagnostics, Inc. | Measurement of ligand/anti-ligand interactions using bulk conductance |
US5112974A (en) | 1985-01-18 | 1992-05-12 | The Trustees Of Columbia University In The City Of New York | Mixed ligand complexes and uses thereof as binding agents to DNA |
GB8507706D0 (en) | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5595908A (en) | 1985-09-26 | 1997-01-21 | University Of Southern Mississipi | Piezoelectric device for detection of polynucleotide hybridization |
US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
US4876187A (en) | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
CA1273552A (en) | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
CA1254945A (en) | 1986-02-27 | 1989-05-30 | Marco F. Cardosi | Application of tetrathiafulvalenes in bioelectrochemical processes |
US4704193A (en) | 1986-05-14 | 1987-11-03 | Gte Laboratories Incorporated | Covalently coupled cofactor modified electrodes and methods of synthesis and use |
US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
US5175270A (en) | 1986-09-10 | 1992-12-29 | Polyprobe, Inc. | Reagents for detecting and assaying nucleic acid sequences |
ZA877772B (en) | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US4787963A (en) | 1987-05-04 | 1988-11-29 | Syntro Corporation | Method and means for annealing complementary nucleic acid molecules at an accelerated rate |
FI80476C (en) | 1987-10-09 | 1990-06-11 | Orion Yhtymae Oy | Improved hybridization process, used in the process and reagent packaging |
US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
US5082830A (en) | 1988-02-26 | 1992-01-21 | Enzo Biochem, Inc. | End labeled nucleotide probe |
US5308754A (en) | 1988-03-21 | 1994-05-03 | Kankare Jouko J | Electrogenerated luminescence in solution |
US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
US5185243A (en) * | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
SE462454B (en) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | METHOD FOR USE IN BIOSENSORS |
US5200051A (en) | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
DK175170B1 (en) | 1988-11-29 | 2004-06-21 | Sangtec Molecular Diagnostics | Method and Reagent Combination to Determine Nucleotide Sequences |
US5089112A (en) | 1989-03-20 | 1992-02-18 | Associated Universities, Inc. | Electrochemical biosensor based on immobilized enzymes and redox polymers |
US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US5156810A (en) | 1989-06-15 | 1992-10-20 | Biocircuits Corporation | Biosensors employing electrical, optical and mechanical signals |
US5491097A (en) | 1989-06-15 | 1996-02-13 | Biocircuits Corporation | Analyte detection with multilayered bioelectronic conductivity sensors |
US5015569A (en) | 1989-12-01 | 1991-05-14 | Board Of Trustees Of Leland Stanford University | Acceleration of nucleic acid hybridization |
CA2033692A1 (en) | 1990-01-25 | 1991-07-26 | Wilhelm Bannwarth | Energy transfer systems |
US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
US5776672A (en) | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
DE69125441T2 (en) | 1990-09-28 | 1997-11-06 | Toshiba Kawasaki Kk | Gene detection method |
DE4039677A1 (en) | 1990-12-12 | 1992-06-17 | Boehringer Mannheim Gmbh | UNIVERSAL BINDING FILM |
US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
US5180968A (en) | 1991-03-01 | 1993-01-19 | Research Foundation Of State University Of New York | Method and apparatus for compensation of double layer charging current in electrochemical cells |
US5888819A (en) | 1991-03-05 | 1999-03-30 | Molecular Tool, Inc. | Method for determining nucleotide identity through primer extension |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
RU1794088C (en) | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Method of dna nucleotide sequence determination and a device for its realization |
US5171853A (en) | 1991-08-05 | 1992-12-15 | North Carolina State University | Process of cleaving nucleic acids with oxoruthenium(IV) complexes |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
US5849486A (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
US6051380A (en) | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
EP1067134B1 (en) | 1991-11-07 | 2004-07-28 | Nanotronics, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
AU658962B2 (en) | 1991-11-15 | 1995-05-04 | Igen, Inc. | Rapid assays for amplification products |
IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
US5391272A (en) | 1992-03-06 | 1995-02-21 | Andcare, Inc. | Electrochemical immunoassay methods |
DE69207580T2 (en) | 1992-03-23 | 1996-08-08 | Hoffmann La Roche | Procedure for DNA detection |
GB9210176D0 (en) | 1992-05-12 | 1992-06-24 | Cemu Bioteknik Ab | Chemical method |
GB9212010D0 (en) | 1992-06-05 | 1992-07-15 | Medisense Inc | Mediators to oxidoreductase enzymes |
US5710028A (en) | 1992-07-02 | 1998-01-20 | Eyal; Nurit | Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor |
IL102930A (en) | 1992-08-25 | 1997-03-18 | Yissum Res Dev Co | Electrobiochemical analytical method and electrodes |
US5633134A (en) * | 1992-10-06 | 1997-05-27 | Ig Laboratories, Inc. | Method for simultaneously detecting multiple mutations in a DNA sample |
US5312527A (en) | 1992-10-06 | 1994-05-17 | Concordia University | Voltammetric sequence-selective sensor for target polynucleotide sequences |
US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
EP0599337B1 (en) | 1992-11-27 | 2006-03-08 | Canon Kabushiki Kaisha | Method for detection of nucleic acid and probe therefor |
JPH06153997A (en) | 1992-11-27 | 1994-06-03 | Canon Inc | Method for detecting target nucleic acid by amplification of detected signal |
US5244560A (en) | 1992-12-29 | 1993-09-14 | The Regents Of The University Of California | Method of fabrication for capillary electrophoresis and electrochemical detector for the same |
US5403451A (en) | 1993-03-05 | 1995-04-04 | Riviello; John M. | Method and apparatus for pulsed electrochemical detection using polymer electroactive electrodes |
FR2703359B1 (en) | 1993-03-31 | 1995-06-23 | Cis Bio Int | Nucleotide (s) / electronic conductive polymer; its preparation process and its use. |
US5767259A (en) | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
US5616464A (en) | 1994-12-27 | 1997-04-01 | Naxcor | Nucleic acid sequence detection employing amplification probes |
EP0708840A1 (en) | 1993-06-17 | 1996-05-01 | ID Biomedical Corporation | Improved methods for detecting nucleic acid sequences |
AU7208394A (en) | 1993-06-17 | 1995-01-17 | Research Foundation Of The State University Of New York, The | Improved nucleic acid reactions |
SE501439C2 (en) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Method and apparatus for analyzing polynucleotide sequences |
US5861242A (en) | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
RU2041263C1 (en) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Method and apparatus for microdosing and dispensing of aqueous solutions onto carrier |
RU2041262C1 (en) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Method for immobilization of water soluble bioorganic compounds on capillary-porous carrier |
RU2041261C1 (en) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Method for manufacturing of matrix for detecting of mismatches |
EP0716713A1 (en) | 1993-08-18 | 1996-06-19 | Id Biomedical Corporation | Compositions and methods for detecting target nucleic acid sequences utilizing adjacent sequence-enzyme molecules |
AU7839594A (en) | 1993-09-20 | 1995-04-10 | Regents Of The University Of Colorado, The | Strategy for the production of rna from immobilized templates |
AU8102694A (en) | 1993-11-17 | 1995-06-06 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5952172A (en) | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5591578A (en) | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
IL108726A (en) | 1994-02-22 | 1999-12-31 | Yissum Res Dev Co | Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor |
US5871918A (en) | 1996-06-20 | 1999-02-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
FR2720832A1 (en) | 1994-04-22 | 1995-12-08 | Francis Garnier | Electroactive electrodes and membranes based on bioactive peptides, for the recognition, extraction or release of biologically active species. |
SE9402116D0 (en) | 1994-06-15 | 1994-06-15 | Pharmacia Biosensor Ab | A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate |
GB9417211D0 (en) | 1994-08-25 | 1994-10-12 | Solicitor For The Affairs Of H | Nucleotide sequencing method |
AU703344B2 (en) | 1994-08-26 | 1999-03-25 | Igen International, Inc. | Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface |
US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
US5601982A (en) | 1995-02-07 | 1997-02-11 | Sargent; Jeannine P. | Method and apparatus for determining the sequence of polynucleotides |
US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
HUP9801679A3 (en) | 1995-03-10 | 2001-01-29 | Meso Scale Technologies Llc Co | Process and agent for multi-array, multi-specific electrochemiluminescence testing |
DE19515552A1 (en) | 1995-04-27 | 1996-10-31 | Europ Lab Molekularbiolog | Simultaneous sequencing of nucleic acids |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US5968745A (en) | 1995-06-27 | 1999-10-19 | The University Of North Carolina At Chapel Hill | Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof |
CN1192249A (en) | 1995-06-27 | 1998-09-02 | 查珀尔希尔北卡罗来纳大学 | Electrochemical detection of nucleic acid hybridization |
US5747255A (en) | 1995-09-29 | 1998-05-05 | Lynx Therapeutics, Inc. | Polynucleotide detection by isothermal amplification using cleavable oligonucleotides |
DE19536858C2 (en) | 1995-10-03 | 2000-04-13 | Danfoss As | Method and device for transporting a fluid through a channel |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
US5830341A (en) | 1996-01-23 | 1998-11-03 | Gilmartin; Markas A. T. | Electrodes and metallo isoindole ringed compounds |
US5795453A (en) | 1996-01-23 | 1998-08-18 | Gilmartin; Markas A. T. | Electrodes and metallo isoindole ringed compounds |
US5861247A (en) | 1996-01-26 | 1999-01-19 | University Of Chicago | Rapid method to detect duplex formation in sequencing by hybridization methods |
US5851772A (en) | 1996-01-29 | 1998-12-22 | University Of Chicago | Microchip method for the enrichment of specific DNA sequences |
DE69719817T2 (en) | 1996-04-25 | 2003-12-24 | Pence Inc | BIOSENSOR DEVICE AND METHOD |
US6107080A (en) | 1996-04-25 | 2000-08-22 | Mcgill University | Biosensor device and method |
AU4043497A (en) | 1996-07-29 | 1998-02-20 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US5874046A (en) | 1996-10-30 | 1999-02-23 | Raytheon Company | Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences |
US6096273A (en) * | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
US5942397A (en) | 1996-12-11 | 1999-08-24 | Tarlov; Michael J. | Surface immobilization of biopolymers |
WO1998028444A2 (en) | 1996-12-23 | 1998-07-02 | The University Of Chicago | Customized oligonucleotide microchips as multiple biosensors |
KR20000070821A (en) | 1997-02-06 | 2000-11-25 | 프란시스 제이 메이어 | Electrochemical probes for detection of molecular interactions and drug discovery |
WO1998049344A1 (en) | 1997-04-28 | 1998-11-05 | Lockheed Martin Energy Research Corporation | Method and apparatus for analyzing nucleic acids |
US6060327A (en) | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
DE69835516D1 (en) | 1997-05-16 | 2006-09-21 | Exact Sciences Corp | ELECTROPHORETIC ANALYSIS OF MOLECULES WITH IMMOBILIZED PROBES |
AU7833098A (en) | 1997-06-10 | 1998-12-30 | Beaird, Chyle E. | Multiple access computer monitoring system |
WO1999013109A1 (en) | 1997-09-11 | 1999-03-18 | Seq, Ltd. | Method for dna sequencing analysis |
SE9703314D0 (en) | 1997-09-15 | 1997-09-15 | Sangtec Medical Ab | Capacity affinity sensor |
DE19741716A1 (en) | 1997-09-22 | 1999-03-25 | Hoechst Ag | Recognition system |
US5945286A (en) | 1997-10-23 | 1999-08-31 | Motorola, Inc. | Electrochemical-based molecular detection apparatus and method |
US6203758B1 (en) | 1997-11-10 | 2001-03-20 | Bio-Pixel Ltd. | Micro-circuit system with array of functionalized micro-electrodes |
US5922617A (en) | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
US6686150B1 (en) * | 1998-01-27 | 2004-02-03 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
US7090804B2 (en) | 1998-01-27 | 2006-08-15 | Clinical Mirco Sensors, Inc. | Amplification of nucleic acids with electronic detection |
US6060023A (en) | 1998-03-31 | 2000-05-09 | Motorola, Inc. | Molecular sensing apparatus |
AU1241000A (en) * | 1998-10-27 | 2000-05-15 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US6361671B1 (en) | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
-
2000
- 2000-07-26 CA CA002380258A patent/CA2380258C/en not_active Expired - Fee Related
- 2000-07-26 WO PCT/US2000/020476 patent/WO2001007665A2/en active IP Right Grant
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- 2000-07-26 DE DE60041072T patent/DE60041072D1/en not_active Expired - Lifetime
- 2000-07-26 ES ES00953701T patent/ES2319380T3/en not_active Expired - Lifetime
- 2000-07-26 EP EP00953701A patent/EP1218541B1/en not_active Expired - Lifetime
- 2000-07-26 US US09/626,096 patent/US7935481B1/en active Active
- 2000-07-26 AU AU66104/00A patent/AU779220B2/en not_active Ceased
- 2000-07-26 AT AT00953701T patent/ATE417127T1/en not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040712A1 (en) * | 1995-06-07 | 1996-12-19 | California Institute Of Technology | Nucleic acid mediated electron transfer |
WO1998020162A2 (en) * | 1996-11-05 | 1998-05-14 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
WO1998031839A2 (en) * | 1997-01-21 | 1998-07-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
WO1998057159A1 (en) * | 1997-06-12 | 1998-12-17 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes |
WO1999057319A1 (en) * | 1998-05-06 | 1999-11-11 | Clinical Micro Sensors | Electronic detection of nucleic acids using monolayers |
WO1999067425A2 (en) * | 1998-06-23 | 1999-12-29 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
Non-Patent Citations (7)
Title |
---|
BEATTIE ET AL: "Genosensor technology", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY. WINSTON, US, vol. 39, no. 4, 18 November 1993 (1993-11-18), pages 719 - 722, XP002130664, ISSN: 0009-9147 * |
BROWN G ET AL: "Metallorganic labels for DNA sequencing and mapping", NEW JOURNAL OF CHEMISTRY, CNRS-GAUTHIER-VILLARS, MONTROUGE, FR, vol. 18, no. 3, March 1994 (1994-03-01), pages 317 - 326, XP002106965, ISSN: 1144-0546 * |
DROBYSHEV A ET AL: "Sequence analysis by hybridization with oligonucleotide microchip: identification of beta-thalassemia mutations", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 188, no. 1, 25 March 1997 (1997-03-25), pages 45 - 52, XP004115664, ISSN: 0378-1119 * |
GILLES P N ET AL: "SINGLE NUCLEOTIDE POLYMORPHIC DISCRIMINATION BY AN ELECTRONIC DOT BLOT ASSAY ON SEMICONDUCTOR MICROCHIPS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, April 1999 (1999-04-01), pages 365 - 370, XP002932605, ISSN: 1087-0156 * |
GRIFFIN T J T J ET AL: "Single-nucleotide polymorphism analysis by MALDI-TOF mass spectrometry", TRENDS IN BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 2, February 2000 (2000-02-01), pages 77 - 84, XP004187253, ISSN: 0167-7799 * |
O'DONNELL-MALONEY M J ET AL: "The development of microfabricated arrays for DNA sequencing and analysis", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 14, no. 10, 1 October 1996 (1996-10-01), pages 401 - 407, XP004035731, ISSN: 0167-7799 * |
YU C J ET AL: "Uridine-conjugated-ferrocene DNA oligonucleotides for electronic detection of nucleic acids", ABSTRACTS OF PAPERS. ACS NATIONAL MEETING, XX, XX, vol. 217, no. 1, 21 March 1999 (1999-03-21), pages 76, XP002106966 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8012743B2 (en) | 1998-10-27 | 2011-09-06 | Osmetech Technology Inc. | Detection of target analytes using particles and electrodes |
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WO2001007665A9 (en) | 2002-07-11 |
JP3926625B2 (en) | 2007-06-06 |
DE60041072D1 (en) | 2009-01-22 |
WO2001007665A2 (en) | 2001-02-01 |
JP2004500033A (en) | 2004-01-08 |
ATE417127T1 (en) | 2008-12-15 |
CA2380258A1 (en) | 2001-02-01 |
EP1218541B1 (en) | 2008-12-10 |
AU6610400A (en) | 2001-02-13 |
EP1218541A2 (en) | 2002-07-03 |
US7935481B1 (en) | 2011-05-03 |
CA2380258C (en) | 2008-07-15 |
ES2319380T3 (en) | 2009-05-07 |
AU779220B2 (en) | 2005-01-13 |
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