WO2001003598A1 - Naso-gastric reflectance spectroscopy probe - Google Patents

Naso-gastric reflectance spectroscopy probe Download PDF

Info

Publication number
WO2001003598A1
WO2001003598A1 PCT/US2000/018552 US0018552W WO0103598A1 WO 2001003598 A1 WO2001003598 A1 WO 2001003598A1 US 0018552 W US0018552 W US 0018552W WO 0103598 A1 WO0103598 A1 WO 0103598A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
probe
send
fibers
receive
Prior art date
Application number
PCT/US2000/018552
Other languages
French (fr)
Inventor
Mark S. Lewandowski
Joseph P. Ortner
Kenneth R. Quast
Mark A. Schmidt
Original Assignee
Hutchinson Technology Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Technology Incorporated filed Critical Hutchinson Technology Incorporated
Priority to EP00945211A priority Critical patent/EP1200001A1/en
Priority to JP2001508887A priority patent/JP2003504111A/en
Priority to AU59187/00A priority patent/AU5918700A/en
Publication of WO2001003598A1 publication Critical patent/WO2001003598A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4238—Evaluating particular parts, e.g. particular organs stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy

Definitions

  • the present invention is a spectroscopy probe
  • the present invention is a reflectance spectroscopy probe which can be used to monitor tissue in a patient's esophagus and stomach
  • the instrument shown in the Anderson et al patent includes an optical probe which is releasably connected to an electronics package
  • the probe is positioned on the tissue to be measured or analyzed
  • the probe is interfaced to the instrument electromcs through optical fibers and a probe connector
  • Light emitting diodes (LEDs) or other light sources in the instrument generate light at a number of different wavelengths
  • the light used to measure the characteristics of the tissue is coupled to the probe by one or more send optical fibers After being transmitted from the tissue-engaging surface of the probe into the tissue being measured, the light will travel through the tissue before being collected at the end of the receive optical fiber This collected light is then transmitted to the instrument through the probe connector and electronics package connector
  • the instrument also produces and transmits directly to the electronics package a reference light signal corresponding to each of the measurement light
  • spectrophotomet ⁇ c instruments include LEDs, broadband or other light sources mounted within the electronics package or monitor Probes used in connection with monitors of this type have optical connectors on the ends of the fibers opposite the tissue-engaging surface The optical connectors mate with associated connectors on the monitor to couple the light between the monitor and probe tip In other instruments of this type, the LEDs or other light sources are mounted withm the optical connector portion of the probe
  • the collected measurement light signals and reference light signals received by the electronics package are transmitted to a detector which produces electrical signals representative of these light signals at each wavelength of interest
  • a processor/controller then processes these signals to generate data representative of the measured tissue parameter
  • the measurement can be visually displayed on a display
  • Algorithms used to compute the tissue parameter data are generally known and described m the Anderson et al patent
  • the present invention is an improved probe for use with a spectrophotomet ⁇ c instrument
  • One embodiment of the probe includes an elongated flexible tube for insertion into a tubular body structure
  • the tube has a distal end and one or more send and receive optical fibers which extend through the tube
  • the send and receive fibers have ends which terminate on the side of the tube near the distal end
  • the tube is a naso-gast ⁇ c tube adapted to be inserted into a patient's stomach and esophagus, and includes suction apertures on the distal end
  • a vacuum can be drawn through the tube to cause the send and receive optical fibers to be positioned in measurement contact with the tissue BRIEF DESCRIPTION OF THE DRAWINGS
  • Figure 1 is an illustration of a naso-gast ⁇ c reflectance spectroscopy probe in accordance with the present invention
  • Figure 2 is a detailed cross sectional view of a portion of the tip of the probe shown in Figure 1
  • Figures 3-6 are detailed views of the fiber tip shown in Figure 2
  • a naso-gast ⁇ c reflectance spectroscopy probe 20 in accordance with the present invention which can be used to analyze tissues in the stomach and esophagus of a patient is illustrated generally in Figures 1 and 2
  • the probe 20 includes a flexible tube 22 having a tip 24 on its distal end 26
  • the tip 24 includes a plurality of suction apertures 28 which extend through the tip 24 into a suction lumen 30 within the tip 24 and tube 22
  • the suction lumen 30 is connected to a vacuum source connector 34
  • a fiber tip 36 is mounted in one of the suction apertures 28 Alternatively, the fiber tip 36 can be mounted in a hole added to the probe 20 and adapted specifically for receiving the fiber tip 36
  • One or more send optical fibers 38 and receive optical fibers 40 extend through the tube 22 and tip 24 of the probe 20 At the proximal end 32 of the tube 22 the send and receive fibers 38 and 40 extend from the tube 22 and can be coupled by connectors (not shown) to the monitor of a spectroscopy system (also not shown) At the distal end 26 of the tube 22, the ends of the send and receive fibers 38 and 40 are mounted in the fiber tip 36 with their end faces 42 and 44, respectively, generally flush with the outer surface 46 of the probe tip 24 Alternatively, side-firing optical fibers or mirrors (not shown) can be incorporated into the probe 20 to couple light between the end faces 42 and 44 of fibers 38 and 40, respectively, and the tissue being analyzed
  • Commercially available naso-gast ⁇ c tubes can be used for the tube 22 and tip 24 of the probe 20 A 14 French naso-gast ⁇ c tube from Davol (model no 0042140) was used for one embodiment of the invention The send and
  • the naso-gast ⁇ c probe 20 is inserted into the patient's stomach through his or her nose
  • the vacuum source connector is coupled to a vacuum source in a conventional manner, while the send and receive fibers 38 and 40 are connected to the instrument monitor
  • the probe tip 24, including the exposed end faces 42 and 44 of the send and receive fibers 38 and 40 will be drawn into engagement with the interior stomach wall
  • Light from the send fiber 38 can then be effectively coupled into the stomach wall tissue
  • light that has been transmitted through the tissue can be effectively collected by the receive fiber 40
  • Insertion of the fibers 38 and 40 and fiber tip 36 into the tube 22 has minimal impact on the tube 22 itself and is considerably more efficacious than a larger tube having a blunt tip on its end
  • the naso-gast ⁇ c probe 20 can be manufactured by bonding (e g , with epoxy) the send and receive fibers 38 and 40 to the fiber tip 36
  • the end faces 42 and 44 of the send and receive fibers 38 and 40, respectively, can then be cleaved and polished on the side of the fiber tip 36
  • the fiber tip 36 is then installed and bonded (e g , with epoxy) in the tip 24 of the naso-gast ⁇ c tube 22
  • the fibers 38 and 40 are threaded through the lumen 48 of the tube 22 After connectors are mounted to the proximal ends 32 of the send and receive optical fibers 38 and 40, the fiber end faces 42 and 44 are polished
  • the naso-gast ⁇ c reflectance spectroscopy probe 20 can be used to effectively illuminate and capture subsequent stomach tissue spectra Insertion of naso-gast ⁇ c tubes 22 through the nose and into the stomach of a patient is a medically accepted procedure
  • a clinician can monitor characteristics such as oxygen saturation levels in stomach tissue at the same time as the functions of the naso-gast ⁇ c tube 22 are being provided Due to their small diameter, the optical fibers 38 and 40 are readily incorporated into a lumen 48 of the tube 22 with minimal impact to its overall flexibility and primary functionality
  • the ability to add fibers into a conventional naso-gast ⁇ c tube reduces the need for a second mechanism for deploying the send and receive fibers into the stomach
  • the need to "bottom out” the tube tip 24 in the stomach cavity to force the end faces 42 and 44 of the fibers 38 and 40 into contact with the tissue is reduced Instead, the probe tip 24 need only reside along an mside surface of the stomach wall When the vacuum is initiated, the stomach wall will be drawn toward the tube 22, thereby providing the target site for tissue illumination and spectra capture
  • the optical fibers 38 and 40 can be made from plastic for maximum flexibility (e g , 400 ⁇ m in diameter) and coated with an opaque material to minimize cross-talk between send and receive channels
  • the invention can be effectively implemented in forms which differ from that described above
  • the send and receive fibers are not bonded to a common tip
  • the end faces of the send and receive fibers can then be spaced from one another by greater distances without the presence of a stiff holder extending between the fibers
  • the number of send and receive fibers need not be limited to one each
  • the effective upper limit on the number of fibers is a function of the diameter of the tube lumen through which the fibers extend and the concurrent reduction in the available suction or irrigation capability
  • Multiple send and receive locations are possible, thereby enabling the monitoring of tissue oxygenation or other characteristics at multiple sites using the same probe
  • Similar or different depths of the tissue can be monitored at the multiple sites
  • the fiber tip can be located at the very distal end of the tube Glass fibers can be substituted for the plastic fibers Different size diameter fibers can be used at the expense of decreasing flexibility of the tube or a reduction in the strength of the send and receive signals
  • the fibers and fiber tip can be located at the very distal end of the

Abstract

A naso-gastric reflectance spectroscopy probe. The probe includes an elongated flexible tube for insertion into a tubular body structure. The tube has a distal end with a lumen and suction apertures. One or more send and receive optical fibers extend through the lumen and have distal ends which terminate on the side of the tube near the distal end. Proximal ends of the optical fibers are adapted to be connected to a spectroscopy instrument. When positioned in a patient's stomach through the esophagus, a vacuum can be drawn through the tube to cause the optical fibers to be positioned in measurement contact with the tissue.

Description

NASO-GASTRIC REFLECTANCE SPECTROSCOPY PROBE
FIELD OF THE INVENTION
The present invention is a spectroscopy probe In particular, the present invention is a reflectance spectroscopy probe which can be used to monitor tissue in a patient's esophagus and stomach
BACKGROUND OF THE INVENTION
Reflectance spectroscopy and other spectrophotometπc-type medical instruments are known and used in a variety of applications An instrument of this type is, for example, disclosed in the Anderson et al U S Patent 5,879,294 Briefly, the instrument shown in the Anderson et al patent includes an optical probe which is releasably connected to an electronics package In operation, the probe is positioned on the tissue to be measured or analyzed The probe is interfaced to the instrument electromcs through optical fibers and a probe connector Light emitting diodes (LEDs) or other light sources in the instrument generate light at a number of different wavelengths The light used to measure the characteristics of the tissue is coupled to the probe by one or more send optical fibers After being transmitted from the tissue-engaging surface of the probe into the tissue being measured, the light will travel through the tissue before being collected at the end of the receive optical fiber This collected light is then transmitted to the instrument through the probe connector and electronics package connector The instrument also produces and transmits directly to the electronics package a reference light signal corresponding to each of the measurement light signals (1 e , the reference light signals are not transmitted through the tissue)
Other embodiments of spectrophotometπc instruments (not shown) include LEDs, broadband or other light sources mounted within the electronics package or monitor Probes used in connection with monitors of this type have optical connectors on the ends of the fibers opposite the tissue-engaging surface The optical connectors mate with associated connectors on the monitor to couple the light between the monitor and probe tip In other instruments of this type, the LEDs or other light sources are mounted withm the optical connector portion of the probe
The collected measurement light signals and reference light signals received by the electronics package are transmitted to a detector which produces electrical signals representative of these light signals at each wavelength of interest A processor/controller then processes these signals to generate data representative of the measured tissue parameter The measurement can be visually displayed on a display Algorithms used to compute the tissue parameter data are generally known and described m the Anderson et al patent
The use of reflectance spectroscopy techniques to analyze tissue in a patient's stomach or other internal body portions would be efficacious Probes of the type described above, however, are not suitable for applications of this type There is, therefore, a continuing need for improved reflectance spectroscopy probes
SUMMARY OF THE INVENTION
The present invention is an improved probe for use with a spectrophotometπc instrument One embodiment of the probe includes an elongated flexible tube for insertion into a tubular body structure The tube has a distal end and one or more send and receive optical fibers which extend through the tube The send and receive fibers have ends which terminate on the side of the tube near the distal end In one particularly efficacious embodiment of the invention, the tube is a naso-gastπc tube adapted to be inserted into a patient's stomach and esophagus, and includes suction apertures on the distal end When positioned in the patient's stomach, a vacuum can be drawn through the tube to cause the send and receive optical fibers to be positioned in measurement contact with the tissue BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is an illustration of a naso-gastπc reflectance spectroscopy probe in accordance with the present invention
Figure 2 is a detailed cross sectional view of a portion of the tip of the probe shown in Figure 1
Figures 3-6 are detailed views of the fiber tip shown in Figure 2
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
A naso-gastπc reflectance spectroscopy probe 20 in accordance with the present invention which can be used to analyze tissues in the stomach and esophagus of a patient is illustrated generally in Figures 1 and 2 As shown, the probe 20 includes a flexible tube 22 having a tip 24 on its distal end 26 The tip 24 includes a plurality of suction apertures 28 which extend through the tip 24 into a suction lumen 30 within the tip 24 and tube 22 At the proximal end 32 of the tube 22 the suction lumen 30 is connected to a vacuum source connector 34 A fiber tip 36 is mounted in one of the suction apertures 28 Alternatively, the fiber tip 36 can be mounted in a hole added to the probe 20 and adapted specifically for receiving the fiber tip 36
One or more send optical fibers 38 and receive optical fibers 40 (one of each are shown in the illustrated embodiment) extend through the tube 22 and tip 24 of the probe 20 At the proximal end 32 of the tube 22 the send and receive fibers 38 and 40 extend from the tube 22 and can be coupled by connectors (not shown) to the monitor of a spectroscopy system (also not shown) At the distal end 26 of the tube 22, the ends of the send and receive fibers 38 and 40 are mounted in the fiber tip 36 with their end faces 42 and 44, respectively, generally flush with the outer surface 46 of the probe tip 24 Alternatively, side-firing optical fibers or mirrors (not shown) can be incorporated into the probe 20 to couple light between the end faces 42 and 44 of fibers 38 and 40, respectively, and the tissue being analyzed Commercially available naso-gastπc tubes can be used for the tube 22 and tip 24 of the probe 20 A 14 French naso-gastπc tube from Davol (model no 0042140) was used for one embodiment of the invention The send and receive fibers 38 and 40 extend from the fiber tip 36 through a fiber lumen 48 The fiber tip 36 is positioned in a suction aperture 28 near the distal end 26 of the probe tip 24 so the remaining suction apertures 28 remain fluidly connected to the vacuum source connector 34 Figures 3-6 are detailed illustrations of the fiber tip 36
During use, the naso-gastπc probe 20 is inserted into the patient's stomach through his or her nose The vacuum source connector is coupled to a vacuum source in a conventional manner, while the send and receive fibers 38 and 40 are connected to the instrument monitor When suction is applied to the probe 20, the probe tip 24, including the exposed end faces 42 and 44 of the send and receive fibers 38 and 40, will be drawn into engagement with the interior stomach wall Light from the send fiber 38 can then be effectively coupled into the stomach wall tissue Similarly, light that has been transmitted through the tissue can be effectively collected by the receive fiber 40 Insertion of the fibers 38 and 40 and fiber tip 36 into the tube 22 has minimal impact on the tube 22 itself and is considerably more efficacious than a larger tube having a blunt tip on its end
The naso-gastπc probe 20 can be manufactured by bonding (e g , with epoxy) the send and receive fibers 38 and 40 to the fiber tip 36 The end faces 42 and 44 of the send and receive fibers 38 and 40, respectively, can then be cleaved and polished on the side of the fiber tip 36 The fiber tip 36 is then installed and bonded (e g , with epoxy) in the tip 24 of the naso-gastπc tube 22 The fibers 38 and 40 are threaded through the lumen 48 of the tube 22 After connectors are mounted to the proximal ends 32 of the send and receive optical fibers 38 and 40, the fiber end faces 42 and 44 are polished
As noted above, the naso-gastπc reflectance spectroscopy probe 20 can be used to effectively illuminate and capture subsequent stomach tissue spectra Insertion of naso-gastπc tubes 22 through the nose and into the stomach of a patient is a medically accepted procedure With the invention, a clinician can monitor characteristics such as oxygen saturation levels in stomach tissue at the same time as the functions of the naso-gastπc tube 22 are being provided Due to their small diameter, the optical fibers 38 and 40 are readily incorporated into a lumen 48 of the tube 22 with minimal impact to its overall flexibility and primary functionality The ability to add fibers into a conventional naso-gastπc tube reduces the need for a second mechanism for deploying the send and receive fibers into the stomach
By polishing the send and receive fibers 38 and 40 flat along the side of the tube 22, the need to "bottom out" the tube tip 24 in the stomach cavity to force the end faces 42 and 44 of the fibers 38 and 40 into contact with the tissue is reduced Instead, the probe tip 24 need only reside along an mside surface of the stomach wall When the vacuum is initiated, the stomach wall will be drawn toward the tube 22, thereby providing the target site for tissue illumination and spectra capture The optical fibers 38 and 40 can be made from plastic for maximum flexibility (e g , 400μm in diameter) and coated with an opaque material to minimize cross-talk between send and receive channels
The invention can be effectively implemented in forms which differ from that described above For example, in other embodiments (not shown) of the invention the send and receive fibers are not bonded to a common tip The end faces of the send and receive fibers can then be spaced from one another by greater distances without the presence of a stiff holder extending between the fibers The number of send and receive fibers need not be limited to one each The effective upper limit on the number of fibers is a function of the diameter of the tube lumen through which the fibers extend and the concurrent reduction in the available suction or irrigation capability Multiple send and receive locations are possible, thereby enabling the monitoring of tissue oxygenation or other characteristics at multiple sites using the same probe Furthermore, depending on the spacing between the send and receive fibers, similar or different depths of the tissue can be monitored at the multiple sites The fiber tip can be located at the very distal end of the tube Glass fibers can be substituted for the plastic fibers Different size diameter fibers can be used at the expense of decreasing flexibility of the tube or a reduction in the strength of the send and receive signals The fibers and fiber tip can also be incorporated into intra-venous and intra-arterial catheters (e g , with smaller diameter fibers)
Although the present invention has been described with reference to preferred embodiments, those skilled in the art will recognize that changes can be made in form and detail without departing from the spirit and scope of the invention

Claims

WHAT IS CLAIMED IS:
1 A probe for use with a photospectrometπc instrument, including an elongated flexible tube having a distal end, for insertion into a body structure, and one or more optical send and receive fibers extending through the tube and having ends terminating on the side of the tube
2 The probe of claim 1 wherein the tube is a naso-gastπc tube adapted to be inserted into a patient's stomach through the esophagus and including suction apertures on the distal end
3 The probe of claim 2 and further including a fiber fixture mounted in the distal end of thje tube for positioning the send and receive fibers at a suction aperture
4 The probe of claim 1 and further including a fiber fixture mounted in the distal end of the tube for positioning the send and receive fibers
Figure imgf000009_0001
5 A method for using reflectance spectroscopy to monitor tissue within a body cavity, including positioning a flexible tube having send and receive optical fibers on its side surface in the body cavity adjacent to the tissue to be monitored, and drawing a vacuum through the flexible tube to cause the send and receive optical fibers to be positioned in measurement contact with the tissue
6. A probe for use with a spectroscopy instrument, comprising: a flexible tube having a distal end for insertion into a tubular body structure, including: a suction lumen; and one or more suction apertures extending through the tube into communication with the suction lumen; and one or more optical send and receive fibers extending through the tube and having ends terminating on the side of the tube near a suction aperture.
PCT/US2000/018552 1999-07-08 2000-07-07 Naso-gastric reflectance spectroscopy probe WO2001003598A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00945211A EP1200001A1 (en) 1999-07-08 2000-07-07 Naso-gastric reflectance spectroscopy probe
JP2001508887A JP2003504111A (en) 1999-07-08 2000-07-07 Nasogastric reflectance spectroscopy probe
AU59187/00A AU5918700A (en) 1999-07-08 2000-07-07 Naso-gastric reflectance spectroscopy probe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14282999P 1999-07-08 1999-07-08
US60/142,829 1999-07-08

Publications (1)

Publication Number Publication Date
WO2001003598A1 true WO2001003598A1 (en) 2001-01-18

Family

ID=22501460

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/018552 WO2001003598A1 (en) 1999-07-08 2000-07-07 Naso-gastric reflectance spectroscopy probe

Country Status (4)

Country Link
EP (1) EP1200001A1 (en)
JP (1) JP2003504111A (en)
AU (1) AU5918700A (en)
WO (1) WO2001003598A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2495479A (en) * 2011-10-03 2013-04-17 Babiesfirst Ltd Reflux probe
US9591999B2 (en) 2010-11-03 2017-03-14 University Of Washington Through Its Center For Commercialization Determination of tissue oxygenation in vivo
USRE49062E1 (en) 2012-04-12 2022-05-10 Amorepacific Corporation Foam having improved feeling during use

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674013A (en) * 1970-09-30 1972-07-04 American Optical Corp Fiberoptic catheter
US4537197A (en) * 1981-03-06 1985-08-27 Hulka Jaroslav F Disposable fetal oxygen monitor
US4646722A (en) * 1984-12-10 1987-03-03 Opielab, Inc. Protective endoscope sheath and method of installing same
US4785815A (en) * 1985-10-23 1988-11-22 Cordis Corporation Apparatus for locating and ablating cardiac conduction pathways
US5190538A (en) * 1991-04-22 1993-03-02 Trimedyne, Inc. Method and apparatus for subjecting a body site to a movable beam of laterally directed laser radiation
US5324282A (en) * 1989-10-25 1994-06-28 Dodick Jack M Surgical instrument with input power transducer
DE4408746A1 (en) * 1994-03-15 1995-09-21 Medolas Ges Fuer Medizintechni Laser catheter for bypass surgery
EP0801928A1 (en) * 1996-04-05 1997-10-22 Eclipse Surgical Technologies, Inc. Laser device with piercing tip for transmyocardial revascularization procedures

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674013A (en) * 1970-09-30 1972-07-04 American Optical Corp Fiberoptic catheter
US4537197A (en) * 1981-03-06 1985-08-27 Hulka Jaroslav F Disposable fetal oxygen monitor
US4646722A (en) * 1984-12-10 1987-03-03 Opielab, Inc. Protective endoscope sheath and method of installing same
US4785815A (en) * 1985-10-23 1988-11-22 Cordis Corporation Apparatus for locating and ablating cardiac conduction pathways
US5324282A (en) * 1989-10-25 1994-06-28 Dodick Jack M Surgical instrument with input power transducer
US5190538A (en) * 1991-04-22 1993-03-02 Trimedyne, Inc. Method and apparatus for subjecting a body site to a movable beam of laterally directed laser radiation
DE4408746A1 (en) * 1994-03-15 1995-09-21 Medolas Ges Fuer Medizintechni Laser catheter for bypass surgery
EP0801928A1 (en) * 1996-04-05 1997-10-22 Eclipse Surgical Technologies, Inc. Laser device with piercing tip for transmyocardial revascularization procedures

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9591999B2 (en) 2010-11-03 2017-03-14 University Of Washington Through Its Center For Commercialization Determination of tissue oxygenation in vivo
US10463286B2 (en) 2010-11-03 2019-11-05 University Of Washington Determination of tissue oxygenation in vivo
GB2495479A (en) * 2011-10-03 2013-04-17 Babiesfirst Ltd Reflux probe
GB2495479B (en) * 2011-10-03 2015-12-02 Babiesfirst Ltd Reflux probe
USRE49062E1 (en) 2012-04-12 2022-05-10 Amorepacific Corporation Foam having improved feeling during use

Also Published As

Publication number Publication date
JP2003504111A (en) 2003-02-04
AU5918700A (en) 2001-01-30
EP1200001A1 (en) 2002-05-02

Similar Documents

Publication Publication Date Title
US20040082842A1 (en) System for monitoring fetal status
US7706853B2 (en) Near infrared spectroscopy device with reusable portion
EP0939894B1 (en) Miniature spectrometer
EP1301119B1 (en) Probe and apparatus for measuring cerebral hemodynamics and oxygenation
US6285896B1 (en) Fetal pulse oximetry sensor
EP0992214B1 (en) Pulse oximeter and sensor optimized for low saturation
US6298253B1 (en) Method and device for measuring the absorption of radiation in a portion of tissue
EP2419005B1 (en) Needle with integrated fibers in the cutting facets of the bevel
JP4267048B2 (en) Physiological condition measuring device and needle forming method for physiological condition measuring device
US7945312B2 (en) Multisensor probe for tissue identification
CA2503197C (en) Method and apparatus for monitoring blood condition and cardiopulmonary function
US7729735B1 (en) System and method for venous oximetry using a catheter
US20040010204A1 (en) Electronic/fiberoptic tissue differentiation instrumentation
CA2156252A1 (en) Subcutaneous radiation reflection probe
US7149562B2 (en) Needle with fiberoptic capability
US20110218445A1 (en) Needle with integrated fibers
EP1547515A1 (en) Optical fibre catheter pulse oximeter
WO2001003598A1 (en) Naso-gastric reflectance spectroscopy probe
EP3681366B1 (en) Disposable miniature endoscopy system
US8078251B2 (en) Spring wing assembly for photoplethysmorgraphic sensor
US20130102863A1 (en) Non-Invasive Trans-Reflective Monitoring Apparatus
US20220346673A1 (en) Methods and apparatus for near infrared spectroscopy
US20230248223A1 (en) Endoscope and distal-end constituting portion of endoscope
WO2022130022A1 (en) Minimally invasive device with spectrophotometer

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2000945211

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 508887

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 2000945211

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000945211

Country of ref document: EP