WO2000068419A3 - Apparatus and process for monitoring and detecting small molecule-biomolecule interactions - Google Patents

Apparatus and process for monitoring and detecting small molecule-biomolecule interactions Download PDF

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Publication number
WO2000068419A3
WO2000068419A3 PCT/CA2000/000504 CA0000504W WO0068419A3 WO 2000068419 A3 WO2000068419 A3 WO 2000068419A3 CA 0000504 W CA0000504 W CA 0000504W WO 0068419 A3 WO0068419 A3 WO 0068419A3
Authority
WO
WIPO (PCT)
Prior art keywords
interaction
small molecule
monitoring
biomolecule
detecting small
Prior art date
Application number
PCT/CA2000/000504
Other languages
French (fr)
Other versions
WO2000068419A2 (en
Inventor
Mark Mcgovern
Michael Thompson
Original Assignee
Sensorchem Internat Corp
Mark Mcgovern
Michael Thompson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sensorchem Internat Corp, Mark Mcgovern, Michael Thompson filed Critical Sensorchem Internat Corp
Priority to CA002368315A priority Critical patent/CA2368315A1/en
Priority to EP00924999A priority patent/EP1190093A2/en
Priority to AU43880/00A priority patent/AU4388000A/en
Publication of WO2000068419A2 publication Critical patent/WO2000068419A2/en
Publication of WO2000068419A3 publication Critical patent/WO2000068419A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0255—(Bio)chemical reactions, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0422—Shear waves, transverse waves, horizontally polarised waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0423—Surface waves, e.g. Rayleigh waves, Love waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0426—Bulk waves, e.g. quartz crystal microbalance, torsional waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0427—Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever

Abstract

An apparatus (22) is provided for monitoring small molecule-biomolecule interactions. An oscillating substrate (10) has a wet surface (46) for contact with a liquid and for binding with a biomolecule and a dry surface (48). A detection apparatus (42, 44) determines the resonance frequency of said substrate before and after interaction. Thus, small molecules are monitored for interaction with biomolecules by contacting a solution containing the small molecule with immobilized biomolecules under test, and generating acoustic waves using an acoustic wave device. Interaction of the small molecules with the immobilized biomolecules causes a change in frequency, which can be detected and analyzed electronically to monitor the interaction.
PCT/CA2000/000504 1999-05-05 2000-05-05 Apparatus and process for monitoring and detecting small molecule-biomolecule interactions WO2000068419A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002368315A CA2368315A1 (en) 1999-05-05 2000-05-05 Apparatus and process for monitoring and detecting small molecule-biomolecule interactions
EP00924999A EP1190093A2 (en) 1999-05-05 2000-05-05 Apparatus and process for monitoring and detecting small molecule-biomolecule interactions
AU43880/00A AU4388000A (en) 1999-05-05 2000-05-05 Apparatus and process for monitoring and detecting small molecule-biomolecule interactions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,271,179 1999-05-05
CA 2271179 CA2271179A1 (en) 1999-05-05 1999-05-05 Process for monitoring and detecting small molecule - biomolecule interactions

Publications (2)

Publication Number Publication Date
WO2000068419A2 WO2000068419A2 (en) 2000-11-16
WO2000068419A3 true WO2000068419A3 (en) 2001-12-27

Family

ID=4163522

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000504 WO2000068419A2 (en) 1999-05-05 2000-05-05 Apparatus and process for monitoring and detecting small molecule-biomolecule interactions

Country Status (4)

Country Link
EP (1) EP1190093A2 (en)
AU (1) AU4388000A (en)
CA (1) CA2271179A1 (en)
WO (1) WO2000068419A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2302827A1 (en) 2000-04-12 2001-10-12 Michelle Furtado Oligonucleotide and dna de-hybridization on surfaces
US7351575B2 (en) 2000-11-08 2008-04-01 Surface Logix, Inc. Methods for processing biological materials using peelable and resealable devices
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
US6803205B2 (en) 2000-11-08 2004-10-12 Surface Logix, Inc. Methods of measuring enzyme activity using peelable and resealable devices
US7371563B2 (en) 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US7001740B2 (en) 2000-11-08 2006-02-21 Surface Logix, Inc. Methods of arraying biological materials using peelable and resealable devices
US6967074B2 (en) 2000-11-08 2005-11-22 Surface Logix, Inc. Methods of detecting immobilized biomolecules
US20070292855A1 (en) * 2005-08-19 2007-12-20 Intel Corporation Method and CMOS-based device to analyze molecules and nanomaterials based on the electrical readout of specific binding events on functionalized electrodes
EP2102659B1 (en) * 2006-12-13 2012-10-31 Biosensor Applications Sweden AB (Publ) Continuously repeatable method of detecting antigens in test volume
CN101595387B (en) * 2006-12-13 2014-01-29 生物传感器应用国际有限公司 Continuously repeatable method of detecting antigens in test volume
EP2425468A4 (en) * 2009-04-29 2014-05-21 Univ Columbia Monolithic fbar-cmos structure such as for mass sensing
US9255912B2 (en) 2009-04-29 2016-02-09 The Trustees Of Columbia University In The City Of New York Monolithic FBAR-CMOS structure such as for mass sensing
WO2014062936A1 (en) 2012-10-17 2014-04-24 The Trustees Of Columbia University In The City Of New York Cmos-integrated jfet for dense low-noise bioelectronic platforms
WO2014210307A1 (en) 2013-06-26 2014-12-31 Edrees Hassan Co-integrated bulk acoustic wave resonators
JP6487190B2 (en) 2014-11-21 2019-03-20 サントル ナショナル ドゥラ ルシェルシュ シヤンティフィック Molecular detection system
US10600952B2 (en) * 2016-05-20 2020-03-24 Pulmostics Limited Surface acoustic wave sensor coating
GB201709659D0 (en) * 2017-06-16 2017-08-02 Found For Res And Tech Hellas Imbb-Forth Detecting nucleic acids in impure samples with an acoustic wave sensor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999284A (en) * 1988-04-06 1991-03-12 E. I. Du Pont De Nemours And Company Enzymatically amplified piezoelectric specific binding assay
US5374521A (en) * 1991-09-17 1994-12-20 Kipling; Arlin L. Acoustic reflection process for molecular sensing using a bulk acoustic wave quartz sensor
US5501986A (en) * 1988-04-06 1996-03-26 E. I. Du Pont De Nemours And Company Piezoelectric specific binding assay with mass amplified reagents
US5880552A (en) * 1997-05-27 1999-03-09 The United States Of America As Represented By The Secretary Of The Navy Diamond or diamond like carbon coated chemical sensors and a method of making same
WO1999020640A2 (en) * 1997-10-16 1999-04-29 Sensorchem International Corporation High surface density covalent immobilization of oligonucleotide monolayers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999284A (en) * 1988-04-06 1991-03-12 E. I. Du Pont De Nemours And Company Enzymatically amplified piezoelectric specific binding assay
US5501986A (en) * 1988-04-06 1996-03-26 E. I. Du Pont De Nemours And Company Piezoelectric specific binding assay with mass amplified reagents
US5374521A (en) * 1991-09-17 1994-12-20 Kipling; Arlin L. Acoustic reflection process for molecular sensing using a bulk acoustic wave quartz sensor
US5880552A (en) * 1997-05-27 1999-03-09 The United States Of America As Represented By The Secretary Of The Navy Diamond or diamond like carbon coated chemical sensors and a method of making same
WO1999020640A2 (en) * 1997-10-16 1999-04-29 Sensorchem International Corporation High surface density covalent immobilization of oligonucleotide monolayers

Also Published As

Publication number Publication date
WO2000068419A2 (en) 2000-11-16
EP1190093A2 (en) 2002-03-27
AU4388000A (en) 2000-11-21
CA2271179A1 (en) 2000-11-05

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